DE69827810D1 - Methode zum durchforsten von banken mittels chimären bindungspetiden - Google Patents

Methode zum durchforsten von banken mittels chimären bindungspetiden

Info

Publication number
DE69827810D1
DE69827810D1 DE69827810T DE69827810T DE69827810D1 DE 69827810 D1 DE69827810 D1 DE 69827810D1 DE 69827810 T DE69827810 T DE 69827810T DE 69827810 T DE69827810 T DE 69827810T DE 69827810 D1 DE69827810 D1 DE 69827810D1
Authority
DE
Germany
Prior art keywords
dna
fusion protein
carrier package
peptide
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69827810T
Other languages
English (en)
Other versions
DE69827810T2 (de
Inventor
Duncan Mcgregor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rowett Research Services Ltd
Original Assignee
Rowett Research Services Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rowett Research Services Ltd filed Critical Rowett Research Services Ltd
Application granted granted Critical
Publication of DE69827810D1 publication Critical patent/DE69827810D1/de
Publication of DE69827810T2 publication Critical patent/DE69827810T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69827810T 1997-09-02 1998-09-02 Methode zum durchforsten von banken mittels chimären bindungspetiden Expired - Lifetime DE69827810T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9718455.0A GB9718455D0 (en) 1997-09-02 1997-09-02 Chimeric binding peptide library screening method
GB9718455 1997-09-02
PCT/GB1998/002630 WO1999011785A1 (en) 1997-09-02 1998-09-02 Chimeric binding peptide library screening method

Publications (2)

Publication Number Publication Date
DE69827810D1 true DE69827810D1 (de) 2004-12-30
DE69827810T2 DE69827810T2 (de) 2005-11-10

Family

ID=10818309

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69827810T Expired - Lifetime DE69827810T2 (de) 1997-09-02 1998-09-02 Methode zum durchforsten von banken mittels chimären bindungspetiden

Country Status (9)

Country Link
US (2) US7312074B1 (de)
EP (1) EP1009827B1 (de)
JP (1) JP4221148B2 (de)
AT (1) ATE283359T1 (de)
AU (1) AU741002B2 (de)
CA (1) CA2301826C (de)
DE (1) DE69827810T2 (de)
GB (1) GB9718455D0 (de)
WO (1) WO1999011785A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2385118A1 (de) * 2002-09-06 2011-11-09 Isogenica Limited In-vitro-Peptidexpressionsbibliothek
AU2003276403B2 (en) 2002-11-09 2010-04-15 Adaptimmune Limited T cell receptor display
GB0418651D0 (en) 2004-08-20 2004-09-22 Medical Res Council Method
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
EP2556171B1 (de) 2010-04-05 2015-09-02 Prognosys Biosciences, Inc. Räumlich kodierte biologische assays
EP3150750B1 (de) * 2011-04-08 2018-12-26 Prognosys Biosciences, Inc. Peptidkonstrukte und testsysteme dafür
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP3511423B2 (de) 2012-10-17 2024-05-29 Spatial Transcriptomics AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
EP3736573A1 (de) 2013-03-15 2020-11-11 Prognosys Biosciences, Inc. Verfahren zum nachweis von peptid/mhc/tcr-bindung
LT3013984T (lt) 2013-06-25 2023-06-12 Prognosys Biosciences, Inc. Biologinių taikinių erdvinių modelių mėginyje nustatymo būdai
WO2015070037A2 (en) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
BR112016021004A2 (pt) 2014-03-14 2018-01-23 Immunocore Limited biblioteca de partículas; receptor de células t (tcr) isolado não natural; uso de uma biblioteca; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; ácido nucleico; método de construção de uma biblioteca de partículas; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; e partícula
ES2972835T3 (es) 2015-04-10 2024-06-17 10X Genomics Sweden Ab Análisis multiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos
GB201516274D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516269D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516275D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
GB201516270D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516272D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516265D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
US20230102101A1 (en) * 2020-03-05 2023-03-30 Merck Sharp & Dohme Llc Human-like heavy chain antibody variable domain (vhh) display libraries

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5597693A (en) * 1989-03-17 1997-01-28 The Salk Institute For Biological Studies Hormone response element compositions and assay
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU665190B2 (en) * 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US6451527B1 (en) * 1997-08-29 2002-09-17 Selective Genetics, Inc. Methods using genetic package display for selecting internalizing ligands for gene delivery

Also Published As

Publication number Publication date
CA2301826A1 (en) 1999-03-11
EP1009827A1 (de) 2000-06-21
AU741002B2 (en) 2001-11-22
CA2301826C (en) 2011-02-15
WO1999011785A1 (en) 1999-03-11
DE69827810T2 (de) 2005-11-10
JP2001514853A (ja) 2001-09-18
US20080220981A1 (en) 2008-09-11
US7312074B1 (en) 2007-12-25
GB9718455D0 (en) 1997-11-05
EP1009827B1 (de) 2004-11-24
US8735146B2 (en) 2014-05-27
AU8877898A (en) 1999-03-22
JP4221148B2 (ja) 2009-02-12
ATE283359T1 (de) 2004-12-15

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