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DE69737592D1 - Mittel gegen juckreiz - Google Patents

Mittel gegen juckreiz

Info

Publication number
DE69737592D1
DE69737592D1 DE1997637592 DE69737592A DE69737592D1 DE 69737592 D1 DE69737592 D1 DE 69737592D1 DE 1997637592 DE1997637592 DE 1997637592 DE 69737592 A DE69737592 A DE 69737592A DE 69737592 D1 DE69737592 D1 DE 69737592D1
Authority
DE
Grant status
Grant
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1997637592
Other languages
English (en)
Other versions
DE69737592T2 (de )
Inventor
Hiroshi Nagase
Jun Utsumi
Takashi Endoh
Toshiaki Tanaka
Junzo Kamei
Kuniaki Kawamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
DE1997637592 1996-11-25 1997-11-21 Mittel gegen juckreiz Expired - Lifetime DE69737592D1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP31347696 1996-11-25
PCT/JP1997/004267 WO1998023290A1 (en) 1996-11-25 1997-11-21 Antipruritic agent

Publications (1)

Publication Number Publication Date
DE69737592D1 true DE69737592D1 (de) 2007-05-24

Family

ID=18041771

Family Applications (6)

Application Number Title Priority Date Filing Date
DE1997637592 Expired - Lifetime DE69737592D1 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
DE1997637592 Expired - Lifetime DE69737592T2 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
DE1997632868 Expired - Lifetime DE69732868D1 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz
DE1997632868 Expired - Lifetime DE69732868T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz
DE1997628585 Expired - Lifetime DE69728585T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz
DE1997628585 Expired - Lifetime DE69728585D1 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz

Family Applications After (5)

Application Number Title Priority Date Filing Date
DE1997637592 Expired - Lifetime DE69737592T2 (de) 1996-11-25 1997-11-21 Mittel gegen juckreiz
DE1997632868 Expired - Lifetime DE69732868D1 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz
DE1997632868 Expired - Lifetime DE69732868T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz
DE1997628585 Expired - Lifetime DE69728585T2 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz
DE1997628585 Expired - Lifetime DE69728585D1 (de) 1996-11-25 1997-11-21 Mittel gegen Juckreiz

Country Status (9)

Country Link
US (2) US6174891B1 (de)
EP (5) EP1310255B1 (de)
JP (1) JP3531170B2 (de)
CN (3) CN1180844C (de)
CA (1) CA2244256C (de)
DE (6) DE69737592D1 (de)
DK (1) DK0897726T3 (de)
ES (3) ES2215158T3 (de)
WO (1) WO1998023290A1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
WO1998027985A1 (en) * 1996-12-24 1998-07-02 Elkhoury George F Topical application of opioid drugs such as morphine for relief of itching and skin disease or irritation
CA2288828A1 (en) * 1997-07-14 1999-01-28 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
JP3211027B2 (ja) * 1998-11-13 2001-09-25 丸石製薬株式会社 カプサイシン含有外用剤
WO2001014382A1 (en) * 1999-08-23 2001-03-01 Toray Industries, Inc. Analgesics containing as the active ingredient quaternary ammonium salt derivatives of morphinan
EP1219624B1 (de) * 1999-08-24 2008-07-09 Toray Industries, Inc. Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes
WO2001074819A1 (en) * 2000-04-03 2001-10-11 Toray Industries, Inc. Analgesics containing morphinan n-oxide derivatives as the active ingredient
JP2002249442A (ja) * 2001-02-21 2002-09-06 Fumakilla Ltd アレルギー減感作治療薬
EP1380306B1 (de) 2001-03-30 2009-03-04 Toray Industries, Inc. Mittel zur behandlung des syndroms der unruhigen beine
US7294688B2 (en) 2001-04-30 2007-11-13 Nanogen Inc. Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons
US6617308B2 (en) 2001-04-30 2003-09-09 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons
EP1402899A4 (de) * 2001-05-08 2009-03-11 Toray Industries Mittel zur behandlung von sepsis
US6844438B2 (en) 2001-08-15 2005-01-18 Mclean Hospital Corporation N-substituted derivatives of morphinan and uses thereof
CA2464528A1 (en) * 2001-11-02 2003-05-15 Elan Corporation, Plc Pharmaceutical composition
EP1496053B1 (de) 2002-03-29 2012-06-20 Santen Pharmaceutical Co., Ltd. Ein Kappa-opioid-Rezeptoragonist enthaltend ein 2-Phenylbenzothiazolinderivat
WO2004026262A3 (en) * 2002-09-23 2004-06-10 Verion Inc Abuse-resistant pharmaceutical compositions
WO2004029059A1 (en) * 2002-09-25 2004-04-08 Euro-Celtique S.A. N-substituted hydromorphones and the use thereof
ES2317219T3 (es) 2004-03-30 2009-04-16 Toray Industries, Inc. Derivados de morfinano como agentes antiprurito.
US7704522B2 (en) 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP1809104A4 (de) * 2004-09-23 2009-04-29 Alexander Michalow Verfahren zum regeln von neurotransmittersystemen durch gegenadaptationen
US20060159748A1 (en) * 2004-12-23 2006-07-20 Rajesh Jain Oral immediate release formulation of a poorly water-soluble active substance
US7453122B2 (en) * 2005-02-08 2008-11-18 Taiwan Semiconductor Manufacturing Co., Ltd. SOI MOSFET device with reduced polysilicon loading on active area
CN101137658B (zh) 2005-03-10 2011-06-08 东丽株式会社 用于与多发性硬化症伴随的搔痒的止痒剂
RU2397173C2 (ru) * 2005-04-06 2010-08-20 Торей Индастриз, Инк. Кристаллические производные морфинана и способ их получения
KR20080065664A (ko) 2005-11-09 2008-07-14 도레이 가부시끼가이샤 기능성 장장해의 치료 또는 예방제
CN101340911B (zh) * 2005-12-21 2013-01-02 东丽株式会社 镇咳剂
US8115002B2 (en) * 2006-09-20 2012-02-14 Mallinckrodt Llc Preparation of substituted morphinan-6-ones and salts and intermediates thereof
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
CA2707757C (en) * 2007-03-06 2017-01-03 Peter X. Wang Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
CA2685126C (en) 2007-04-24 2015-04-14 Toray Industries, Inc. Therapeutic or prophylactic agent for dyskinesia
KR101491656B1 (ko) 2007-04-26 2015-02-09 도레이 카부시키가이샤 4,5-에폭시모르피난 유도체를 함유하는 안정한 고형 제제
US8183256B2 (en) * 2007-06-22 2012-05-22 Toray Industries, Inc. Remedy or preventive for integration dysfunction syndrome
US20100222309A1 (en) * 2007-10-05 2010-09-02 Toray Industries, Inc. Skin property-improving therapeutic agent comprising a morphinan derivative or any of its pharmacologically permissible acid addition salts as an active ingredient
WO2009138734A3 (en) * 2008-05-14 2010-01-07 Serentis Limited Use of opioid compounds in peripheral pain, wound healing and scar formation
ES2641887T3 (es) * 2008-05-27 2017-11-14 Mallinckrodt Llc Procesos y compuestos para la preparación de normorfinanos
EP2331508B1 (de) * 2008-09-03 2014-11-12 Mallinckrodt LLC Substituierte berbine und verfahren zu ihrer synthese
CA2740476C (en) 2008-10-24 2016-04-05 Toray Industries, Inc. Stable tablet containing 4,5-epoxymorphinan derivative
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398807A1 (de) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxymorphinan- oder (+)-6-aminomorphinanderivate
JP5784507B2 (ja) * 2009-02-23 2015-09-24 マリンクロッド エルエルシー (+)−モルフィナニウム第四級塩およびその生成方法
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
WO2011009020A3 (en) 2009-07-16 2011-03-10 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
KR101732042B1 (ko) 2010-01-29 2017-05-02 도레이 카부시키가이샤 담도 질환의 치료 또는 예방제
WO2012105475A1 (ja) 2011-01-31 2012-08-09 東レ株式会社 悪液質の治療又は予防剤
JP2014526467A (ja) 2011-09-08 2014-10-06 マリンクロッド エルエルシー 中間体の単離なしでのアルカロイドの調製
JP6064252B2 (ja) * 2012-01-19 2017-01-25 三笠製薬株式会社 そう痒症改善経皮吸収貼付剤
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
WO2016052617A1 (ja) * 2014-09-30 2016-04-07 国立大学法人筑波大学 ナルフラフィン含有局所適用製剤

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NL8601188A (nl) * 1985-05-23 1986-12-16 Sandoz Ag Morfinanderivaten, therapeutische preparaten die deze derivaten bevatten en werkwijzen voor het bereiden van deze derivaten.
US5021413B1 (en) * 1988-08-24 1994-12-13 Sankyo Co Analgesic thiomorpholins, their preparation, and pharmaceutical compositions containing them
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JPH06122677A (ja) * 1992-08-28 1994-05-06 Sankyo Co Ltd 光学活性なカルボン酸アミド誘導体
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US5760023A (en) 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
CA2288828A1 (en) * 1997-07-14 1999-01-28 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith

Also Published As

Publication number Publication date Type
ES2215158T3 (es) 2004-10-01 grant
CA2244256A1 (en) 1998-06-04 application
JP3531170B2 (ja) 2004-05-24 grant
EP1312361A1 (de) 2003-05-21 application
DE69732868D1 (de) 2005-04-28 grant
ES2236630T3 (es) 2005-07-16 grant
EP1310255B1 (de) 2004-04-07 grant
ES2285733T3 (es) 2007-11-16 grant
CA2244256C (en) 2006-07-11 grant
EP0897726A4 (de) 2003-05-28 application
CN1214634A (zh) 1999-04-21 application
CN1291717C (zh) 2006-12-27 grant
EP0897726A1 (de) 1999-02-24 application
EP1310255A1 (de) 2003-05-14 application
US6316461B1 (en) 2001-11-13 grant
DE69728585D1 (de) 2004-05-13 grant
EP1327444A1 (de) 2003-07-16 application
DE69737592T2 (de) 2008-01-03 grant
DE69732868T2 (de) 2006-04-13 grant
EP1310251A1 (de) 2003-05-14 application
CN1180844C (zh) 2004-12-22 grant
EP1327444B1 (de) 2005-03-23 grant
CN1535687A (zh) 2004-10-13 application
WO1998023290A1 (en) 1998-06-04 application
DE69728585T2 (de) 2004-08-05 grant
DK0897726T3 (da) 2007-08-13 grant
EP0897726B1 (de) 2007-04-11 grant
CN1530111A (zh) 2004-09-22 application
US6174891B1 (en) 2001-01-16 grant

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Legal Events

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