New! View global litigation for patent families

DE69735998D1 - Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht - Google Patents

Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht

Info

Publication number
DE69735998D1
DE69735998D1 DE1997635998 DE69735998A DE69735998D1 DE 69735998 D1 DE69735998 D1 DE 69735998D1 DE 1997635998 DE1997635998 DE 1997635998 DE 69735998 A DE69735998 A DE 69735998A DE 69735998 D1 DE69735998 D1 DE 69735998D1
Authority
DE
Grant status
Grant
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1997635998
Other languages
English (en)
Other versions
DE69735998T2 (de )
Inventor
B Hunziker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHAW, ROBERT FRANCIS, GREENBRAE, CALIF., US
Original Assignee
Shaw Robert F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/108Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1841Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51Lyases (4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/106Fibrin; Fibrinogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30756Cartilage endoprostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • A61L2300/414Growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45Mixtures of two or more drugs, e.g. synergistic mixtures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/06Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/944Gel
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/953Shaped forms adapted for noningestible use other than suppository type, e.g. films, inserts
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/964Sustained or differential release type
    • Y10S514/965Discrete particles in supporting matrix
DE1997635998 1991-01-31 1997-06-24 Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht Expired - Fee Related DE69735998D1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US08672618 US5853746A (en) 1991-01-31 1996-06-28 Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
PCT/US1997/011208 WO1998000183A3 (en) 1996-06-28 1997-06-24 Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier

Publications (1)

Publication Number Publication Date
DE69735998D1 true DE69735998D1 (de) 2006-07-06

Family

ID=24699317

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1997635998 Expired - Lifetime DE69735998T2 (de) 1991-01-31 1997-06-24 Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht
DE1997635998 Expired - Fee Related DE69735998D1 (de) 1991-01-31 1997-06-24 Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1997635998 Expired - Lifetime DE69735998T2 (de) 1991-01-31 1997-06-24 Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht

Country Status (7)

Country Link
US (1) US5853746A (de)
EP (1) EP0912204B1 (de)
KR (1) KR20000022182A (de)
CN (1) CN1321681C (de)
DE (2) DE69735998T2 (de)
ES (1) ES2267145T3 (de)
WO (1) WO1998000183A3 (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US20020173806A1 (en) * 1996-08-30 2002-11-21 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
WO1998034655A1 (en) * 1997-02-07 1998-08-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
DE19752900A1 (de) * 1997-11-28 1999-06-02 Biotechnolog Forschung Gmbh Knochenmatrix und/oder osteogene Zellen, deren Verwendung, therapeutische Zubereitung und Kit
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
EP1067959A2 (de) * 1998-04-03 2001-01-17 Chiron Corporation Verwendung von igf1 zur behandlng von knorpelkrankheiten
US20020116063A1 (en) * 1999-08-02 2002-08-22 Bruno Giannetti Kit for chondrocyte cell transplantation
WO2000009179A3 (en) * 1998-08-14 2000-06-02 Verigen Transplantation Serv Methods, instruments and materials for chondrocyte cell transplantation
WO2002022014A1 (en) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
US7239908B1 (en) * 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
DE69941304D1 (de) 1998-09-14 2009-10-01 Univ R Zustandsbestimmung eines gelenks und schadenvorsorge
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
EP1867348B1 (de) 1999-03-25 2012-05-16 Metabolix, Inc. Medizinische Geräte und Anwendungen aus Polyhydroxyalkanoat-Polymeren
ES2239608T3 (es) * 1999-07-28 2005-10-01 Interface Biotech A/S Reparacion in vitro de defectos de hueso y/o cartilago.
DE19957388A1 (de) 1999-11-24 2001-06-13 Michael Sittinger Chondroinduktive und implantierbare Substrate zur Knorpelheilung und -protektion
EP1498089A1 (de) 1999-12-15 2005-01-19 Zimmer GmbH Präparat für die Reparatur von Knorpel- oder Knorpel/Knochen-Defekten in menschlichen oder tierischen Gelenken
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
EP1319217B1 (de) 2000-09-14 2008-11-12 The Board Of Trustees Of The Leland Stanford Junior University Verfahren zur manipulation medizinischer bilder
WO2002022013A1 (en) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Assessing condition of a joint and cartilage loss
KR20040008125A (ko) * 2001-01-30 2004-01-28 오르쏘젠 인크. 활액 유도된 조직 또는 세포를 사용하여 관절 연골 내의결함 또는 병변을 치료 및 수복하기 위한 조성물 및 방법
US8623026B2 (en) 2006-02-06 2014-01-07 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
US7618451B2 (en) 2001-05-25 2009-11-17 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty
US8500740B2 (en) 2006-02-06 2013-08-06 Conformis, Inc. Patient-specific joint arthroplasty devices for ligament repair
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
CA2447694A1 (en) 2001-05-25 2002-12-05 Imaging Therapeutics, Inc. Methods and compositions for articular resurfacing
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8234097B2 (en) 2001-05-25 2012-07-31 Conformis, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
WO2003041568A3 (en) * 2001-11-15 2005-04-28 Charles W Hewitt A three-dimensional matrix for producing living tissue equivalents
US7381426B2 (en) * 2002-01-24 2008-06-03 Southwest Research Institute Targeted delivery of bioactive factors to the systemic skeleton
US20040136968A1 (en) * 2002-09-27 2004-07-15 Verigen Ag Autologous cells on a support matrix for tissue repair
JP2006501977A (ja) 2002-10-07 2006-01-19 コンフォーミス・インコーポレイテッドConforMIS, Inc. 関節表面に適合する3次元外形を伴う最小限侵襲性関節インプラント
JP2006505366A (ja) 2002-11-07 2006-02-16 コンフォーミス・インコーポレイテッドConforMIS, Inc. 半月板サイズおよび形状の決定および工夫した処置の方法
CN100558398C (zh) 2002-11-26 2009-11-11 拜奥康有限公司 修饰的钠尿化合物、缀合物及其应用
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
USRE43258E1 (en) 2003-04-29 2012-03-20 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
WO2004110308A3 (en) 2003-06-11 2006-10-26 Osteotech Inc Osteoimplants and methods for their manufacture
US20050202067A1 (en) * 2003-10-28 2005-09-15 Gkss Forschungszentrum Matrix structure and hybrid matrix system for inducing a neofacia, their use and method for generating a neofacia
EP2338442B1 (de) * 2003-12-11 2013-01-30 Isto Technologies Inc. Teilchenförmiges Knorpelsystem
CA2571656A1 (en) * 2004-06-23 2006-01-05 Angiotech Biomaterials Corporation Methods and crosslinked polymer compositions for cartilage repair
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2006050213A3 (en) * 2004-10-29 2006-08-24 Alexander E Michalow Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
US7270655B2 (en) * 2005-01-14 2007-09-18 Haidukewych George J Autologous material delivery apparatus and method
US7825083B2 (en) * 2005-02-10 2010-11-02 Spine Wave, Inc. Synovial fluid barrier
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
WO2007025290A3 (en) 2005-08-26 2007-10-18 H Davis Adkisson Iv Implants and methods for repair, replacement and treatment of joint disease
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corp. Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
JP5368102B2 (ja) * 2005-11-17 2013-12-18 バイオミメティック セラピューティクス, インコーポレイテッド rhPDGF−BB及び生体適合性マトリックスを用いた顎顔面骨強化
EP2649951A3 (de) 2006-02-06 2013-12-25 ConforMIS, Inc. Vom Patienten auswählbare Gelenkarthroplastie-Vorrichtungen und chirurgische Instrumente
ES2443581T3 (es) * 2006-02-09 2014-02-19 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
JP5484047B2 (ja) 2006-06-30 2014-05-07 バイオミメティック セラピューティクス, エルエルシー 回旋筋腱板傷害を処置するためのpdgf−生体マトリックス組成物および方法
EP2086598B1 (de) 2006-11-03 2015-05-27 BioMimetic Therapeutics, LLC Zusammensetzungen und verfahren für behandlungen von arthrodese
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8870871B2 (en) * 2007-01-17 2014-10-28 University Of Massachusetts Lowell Biodegradable bone plates and bonding systems
US7888462B2 (en) * 2007-01-22 2011-02-15 Acologix, Inc. Peptide composition and a method of promoting cartilage formation
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
WO2008101090A3 (en) 2007-02-14 2008-11-27 Conformis Inc Implant device and method for manufacture
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
CA2684040C (en) 2007-04-12 2016-12-06 Isto Technologies, Inc. Method of forming an implant using a mold that mimics the shape of the tissue defect site and implant formed therefrom
WO2008157412A3 (en) 2007-06-13 2009-04-09 Raymond A Bojarski Surgical cutting guide
EP2259807B1 (de) 2008-02-07 2013-04-24 Biomimetic Therapeutics, Inc. Zusammensetzungen zur distraktionsosteogenese
WO2009111626A3 (en) 2008-03-05 2010-01-14 Conformis, Inc. Implants for altering wear patterns of articular surfaces
EP2303193A4 (de) 2008-05-12 2012-03-21 Conformis Inc Vorrichtungen und verfahren zur behandlung von fazetten- und anderen gelenken
WO2010030714A8 (en) 2008-09-09 2011-03-10 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8808303B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US8808297B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
JP6144049B2 (ja) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス,リミテッド ライアビリティ カンパニー 腱障害を処置するための血小板由来成長因子組成物及び方法
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9717779B2 (en) * 2011-01-31 2017-08-01 Warsaw Orthopedic, Inc. Implantable matrix having optimum ligand concentrations
EP2754419A3 (de) 2011-02-15 2014-10-08 Conformis, Inc. Patientenadaptierte und verbesserte orthopädische Implantate, Entwürfe und zugehörige Instrumente
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
US9675471B2 (en) 2012-06-11 2017-06-13 Conformis, Inc. Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components
CA2878808A1 (en) * 2012-07-11 2014-01-16 Osiris Therapeutics, Inc. Methods of manufacturing cartilage products

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001116A (en) * 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4994443A (en) * 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
GB2137209B (en) * 1983-03-23 1986-10-15 Univ Ramot Repair of cartilage and of bones
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
DE3686927D1 (de) * 1985-02-26 1992-11-12 Univ Johns Hopkins Neovaskularisierungsinhibitoren und deren herstellung.
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US4846835A (en) * 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US4904259A (en) * 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US4950483A (en) * 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
DE69122956D1 (de) * 1990-01-25 1996-12-05 Childrens Hosp Medical Center Verfahren und zusammensetzungen zur hemmung der angiogenese
DE4006609A1 (de) * 1990-03-02 1991-09-26 Max Planck Gesellschaft Inhibitor der proliferation von endothelzellen
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
WO1992010210A1 (en) * 1990-12-14 1992-06-25 E.I. Du Pont De Nemours And Company Inhibition of angiogenesis by il-1
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5382514A (en) * 1992-03-31 1995-01-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services In vivo angiogenesis assay
US5368051A (en) * 1993-06-30 1994-11-29 Dunn; Allan R. Method of regenerating articular cartilage
KR101222904B1 (ko) * 1993-07-19 2013-01-17 안지오테크 파마슈티칼즈, 인코포레이티드 항맥관형성 조성물, 당해 조성물로 피복된 스텐트 및 당해 스텐트의 제조방법
EP0637450A3 (de) * 1993-08-04 1995-04-05 Collagen Corp Verfahren und Zusammensetzung zur Wiederbelebung von Nerbgewebe.
JPH09508892A (ja) * 1993-11-17 1997-09-09 チルドレンズ メディカル センター コーポレイション ヘパリナーゼを用いる血管形成の阻害方法
DE69530914T2 (de) * 1994-02-17 2004-03-11 New York Blood Center, Inc. Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung

Also Published As

Publication number Publication date Type
WO1998000183A3 (en) 1998-02-12 application
WO1998000183A2 (en) 1998-01-08 application
CN1321681C (zh) 2007-06-20 grant
EP0912204A2 (de) 1999-05-06 application
JP2000513721A (ja) 2000-10-17 application
EP0912204B1 (de) 2006-05-31 grant
DE69735998T2 (de) 2007-03-15 grant
CN1226839A (zh) 1999-08-25 application
KR20000022182A (ko) 2000-04-25 application
US5853746A (en) 1998-12-29 grant
ES2267145T3 (es) 2007-03-01 grant

Similar Documents

Publication Publication Date Title
DE29716635U1 (de) Distraktionsvorrichtung zur Behandlung von Knochendefekten
DE29515615U1 (de) Arbeitskabinensystem zur Reinigung und Oberflächenbehandlung von Gegenständen
DE69801558T2 (de) Vorrichtungen und verfahren zur gewinnung vom frischhonig, und dazu gehörende direkte filtrierung
DE29808006U1 (de) Sprühvorrichtung zur Behandlung von Schnitt- und Fräskanten
DE9409347U1 (de) Vorrichtung zur Reinigung und Aufbereitung von Schmutzwässern
DE69718080T2 (de) Pflasterstein zur Reinigung von NOx
DE69625883T2 (de) Zusammensetzung zur Reinigung und/oder Desinfektion von medizinischen Geräten
DE29819234U1 (de) Neue Zusammensetzung zur Behandlung von trockener Haut
DE29611440U1 (de) Vorrichtung zur partiellen Behandlung von Oberflächen
DE69511393T2 (de) Polymerzusammensetzung und verfahren zur behandlung von metalloberflächen
DE69518030T2 (de) Zusammensetzung und Verfahren zur Füllung von Zähnen
DE69316390T2 (de) Bekleidung zur vermeidung von knochenbrüchen und verfahren
DE69403737T2 (de) Organosiloxan-Zusammensetzung und Herstellungsverfahren
DE69712290T2 (de) Bakterien enthaltende mikropartikel und herstellungsverfahren
DE69708606T2 (de) Verfahren und system zur verbesserung der handsauberkeit
DE19882865T1 (de) System und Verfahren zur schnellen Erstellung von Tabellen großer Datenmengen
DE69820404T2 (de) Schlaufanordnung, gerät und verfahren zur trennung von flüssigkeitsbestandteilen
DE69403372T2 (de) Poliermittel und Verfahren zur Behandlung von calciumcarbonathaltigen Oberflachen
DE69905553T2 (de) Verfahren zur herstellung von substituierten 2-benzo(b)thiophenekarbonsäuren und deren salzen
DE69426485T2 (de) Verfahren und System zur Behandlung von verunreinigtem Wasser
DE59703500D1 (de) Verfahren zum Transport und zur Lagerung von Phenol
DE29603927U1 (de) Untersocken und Handschuhe, präpariert zur Bekämpfung von Schwitzfüßen und Schwitzhänden
DE50014518D1 (de) Verfahren zur charakterisierung und zur auftrennung von molekularen assoziaten
DE69712057D1 (de) Neue vorrichtungen zur transdermalen verabreichung von trimegestone
DE69840195D1 (de) Verfahren und zusammensetzungen zur behinderung der vervielfältigung von hiv-1

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SHAW, ROBERT FRANCIS, GREENBRAE, CALIF., US

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee