DE69735230D1 - Sulfonamid-substituierte asparaginsäuren als inhibitoren von interleukin-1beta-konvertierenden enzymen - Google Patents
Sulfonamid-substituierte asparaginsäuren als inhibitoren von interleukin-1beta-konvertierenden enzymenInfo
- Publication number
- DE69735230D1 DE69735230D1 DE69735230T DE69735230T DE69735230D1 DE 69735230 D1 DE69735230 D1 DE 69735230D1 DE 69735230 T DE69735230 T DE 69735230T DE 69735230 T DE69735230 T DE 69735230T DE 69735230 D1 DE69735230 D1 DE 69735230D1
- Authority
- DE
- Germany
- Prior art keywords
- interleukin
- inhibitors
- pct
- asparaginic
- sulphonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2832396P | 1996-10-11 | 1996-10-11 | |
PCT/US1997/018406 WO1998016504A2 (en) | 1996-10-11 | 1997-10-09 | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1β CONVERTING ENZYME INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69735230D1 true DE69735230D1 (de) | 2006-04-20 |
Family
ID=21842812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69735230T Expired - Lifetime DE69735230D1 (de) | 1996-10-11 | 1997-10-09 | Sulfonamid-substituierte asparaginsäuren als inhibitoren von interleukin-1beta-konvertierenden enzymen |
Country Status (14)
Country | Link |
---|---|
US (1) | US6083981A (de) |
EP (1) | EP0932600B1 (de) |
JP (1) | JP2001502330A (de) |
KR (1) | KR20000049050A (de) |
AT (1) | ATE317381T1 (de) |
AU (1) | AU742746B2 (de) |
BR (1) | BR9713314A (de) |
CA (1) | CA2268103A1 (de) |
DE (1) | DE69735230D1 (de) |
IL (1) | IL129124A0 (de) |
NO (1) | NO315042B1 (de) |
NZ (1) | NZ334887A (de) |
PL (1) | PL332704A1 (de) |
WO (1) | WO1998016504A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1341779T1 (sl) | 2000-12-13 | 2006-12-31 | Wyeth Corp | Heterociklicni sulfonamidni inhibitorji produkcije beta amiloida |
EP1392280A4 (de) * | 2001-05-10 | 2005-11-30 | Warner Lambert Co | Arylsulfonamidether und anwendungsverfahren dafür |
CN100556450C (zh) * | 2001-05-16 | 2009-11-04 | 耶达研究发展有限公司 | Il-18抑制剂在治疗或预防脓毒症中的应用 |
JP2007528405A (ja) * | 2004-03-11 | 2007-10-11 | イーラン ファーマスーティカルズ、インコーポレイテッド | N−置換ベンゼンスルホンアミド |
US20060128696A1 (en) | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
JPWO2005110450A1 (ja) * | 2004-05-17 | 2008-03-21 | 学校法人慶應義塾 | 医薬組成物及び治療方法 |
US7531570B2 (en) | 2004-05-27 | 2009-05-12 | Vertex Pharmaceuticals Incorporated | Treatment of diseases using ICE inhibitors |
JP4827986B2 (ja) | 2007-06-08 | 2011-11-30 | マンカインド コーポレ−ション | IRE−1αインヒビター |
WO2009019115A1 (en) | 2007-08-03 | 2009-02-12 | Sanofi-Aventis | Caspase imaging probes |
US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
EP2635906A4 (de) | 2010-11-05 | 2014-04-02 | Univ Brandeis | Ice-hemmende verbindungen und ihre verwendungen |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
EP2848696A1 (de) | 2013-09-13 | 2015-03-18 | Sanofi-Aventis Deutschland GmbH | Caspase-1-Bildgebungssonden |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE69226820T2 (de) * | 1991-06-21 | 1999-05-12 | Merck & Co., Inc., Rahway, N.J. | Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen |
GB9200420D0 (en) * | 1992-01-09 | 1992-02-26 | James Black Foundation The Lim | Amino acid derivatives |
AU703451B2 (en) * | 1994-03-31 | 1999-03-25 | Vertex Pharmaceuticals Incorporated | N-(pyrimidinyl)-aspartic acid analogs as interleukin-1beta converting enzyme inhibitors |
US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
-
1997
- 1997-10-09 JP JP10518482A patent/JP2001502330A/ja not_active Abandoned
- 1997-10-09 DE DE69735230T patent/DE69735230D1/de not_active Expired - Lifetime
- 1997-10-09 IL IL12912497A patent/IL129124A0/xx unknown
- 1997-10-09 EP EP97910909A patent/EP0932600B1/de not_active Expired - Lifetime
- 1997-10-09 AU AU48172/97A patent/AU742746B2/en not_active Ceased
- 1997-10-09 PL PL97332704A patent/PL332704A1/xx unknown
- 1997-10-09 BR BR9713314-0A patent/BR9713314A/pt not_active Application Discontinuation
- 1997-10-09 KR KR1019990703119A patent/KR20000049050A/ko not_active Application Discontinuation
- 1997-10-09 CA CA002268103A patent/CA2268103A1/en not_active Abandoned
- 1997-10-09 US US09/284,425 patent/US6083981A/en not_active Expired - Fee Related
- 1997-10-09 WO PCT/US1997/018406 patent/WO1998016504A2/en active IP Right Grant
- 1997-10-09 NZ NZ334887A patent/NZ334887A/xx unknown
- 1997-10-09 AT AT97910909T patent/ATE317381T1/de not_active IP Right Cessation
-
1999
- 1999-04-09 NO NO19991678A patent/NO315042B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9713314A (pt) | 2000-01-25 |
NZ334887A (en) | 2000-09-29 |
WO1998016504A3 (en) | 1998-06-25 |
EP0932600A2 (de) | 1999-08-04 |
US6083981A (en) | 2000-07-04 |
JP2001502330A (ja) | 2001-02-20 |
NO991678L (no) | 1999-04-12 |
IL129124A0 (en) | 2000-02-17 |
CA2268103A1 (en) | 1998-04-23 |
EP0932600B1 (de) | 2006-02-08 |
AU742746B2 (en) | 2002-01-10 |
ATE317381T1 (de) | 2006-02-15 |
PL332704A1 (en) | 1999-09-27 |
NO315042B1 (no) | 2003-06-30 |
WO1998016504A2 (en) | 1998-04-23 |
AU4817297A (en) | 1998-05-11 |
KR20000049050A (ko) | 2000-07-25 |
NO991678D0 (no) | 1999-04-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |