DE69732716T2 - Kalibriermittel für vorrichtungen zum messen von störsubstanzen in serum- und plasma-proben - Google Patents
Kalibriermittel für vorrichtungen zum messen von störsubstanzen in serum- und plasma-proben Download PDFInfo
- Publication number
- DE69732716T2 DE69732716T2 DE69732716T DE69732716T DE69732716T2 DE 69732716 T2 DE69732716 T2 DE 69732716T2 DE 69732716 T DE69732716 T DE 69732716T DE 69732716 T DE69732716 T DE 69732716T DE 69732716 T2 DE69732716 T2 DE 69732716T2
- Authority
- DE
- Germany
- Prior art keywords
- substance
- quality control
- control material
- mimics
- material according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000002966 serum Anatomy 0.000 title description 12
- 239000000463 material Substances 0.000 claims description 56
- 239000000126 substance Substances 0.000 claims description 55
- 238000003908 quality control method Methods 0.000 claims description 49
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 42
- 235000009328 Amaranthus caudatus Nutrition 0.000 claims description 18
- 240000001592 Amaranthus caudatus Species 0.000 claims description 18
- 102000001554 Hemoglobins Human genes 0.000 claims description 18
- 108010054147 Hemoglobins Proteins 0.000 claims description 18
- 235000012735 amaranth Nutrition 0.000 claims description 18
- 239000004178 amaranth Substances 0.000 claims description 18
- 238000010521 absorption reaction Methods 0.000 claims description 16
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 claims description 15
- 229960003531 phenolsulfonphthalein Drugs 0.000 claims description 15
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 claims description 12
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 claims description 12
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 claims description 12
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 10
- 230000003278 mimic effect Effects 0.000 claims description 10
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 6
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 claims description 5
- 229940012189 methyl orange Drugs 0.000 claims description 5
- JUQPZRLQQYSMEQ-UHFFFAOYSA-N CI Basic red 9 Chemical compound [Cl-].C1=CC(N)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=[NH2+])C=C1 JUQPZRLQQYSMEQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000008351 acetate buffer Substances 0.000 claims description 4
- 229940052223 basic fuchsin Drugs 0.000 claims description 4
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 4
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims description 3
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 claims description 3
- 229960000907 methylthioninium chloride Drugs 0.000 claims description 3
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims description 3
- 108010076830 Thionins Proteins 0.000 claims description 2
- WLDHEUZGFKACJH-UHFFFAOYSA-K amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1N=NC1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-UHFFFAOYSA-K 0.000 claims 4
- 239000012491 analyte Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 6
- 238000011481 absorbance measurement Methods 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- 238000004164 analytical calibration Methods 0.000 description 4
- 206010018910 Haemolysis Diseases 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000003637 basic solution Substances 0.000 description 2
- 239000003809 bile pigment Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229960000355 copper sulfate Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000036796 hyperbilirubinemia Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229940028435 intralipid Drugs 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229940021317 other blood product in atc Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/15—Reference solutions for assays of biological material containing dyes to mimic optical absorption of, e.g. hemoglobin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/102499—Blood gas standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/103332—Bilirubin or uric acid standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9612264 | 1996-06-12 | ||
| GBGB9612264.3A GB9612264D0 (en) | 1996-06-12 | 1996-06-12 | Quality control material for monitoring calibration of instruments designed to measure serum and plasma specimen integrity |
| PCT/CA1997/000418 WO1997047972A1 (en) | 1996-06-12 | 1997-06-12 | Calibrator material for instruments which measure interferents in serum and plasma specimens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69732716D1 DE69732716D1 (de) | 2005-04-14 |
| DE69732716T2 true DE69732716T2 (de) | 2006-04-13 |
Family
ID=10795161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69732716T Expired - Lifetime DE69732716T2 (de) | 1996-06-12 | 1997-06-12 | Kalibriermittel für vorrichtungen zum messen von störsubstanzen in serum- und plasma-proben |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6372503B1 (https=) |
| EP (1) | EP0975976B1 (https=) |
| JP (1) | JP4158056B2 (https=) |
| DE (1) | DE69732716T2 (https=) |
| GB (1) | GB9612264D0 (https=) |
| WO (1) | WO1997047972A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157282B2 (en) * | 1996-06-12 | 2007-01-02 | Spectromedical Inc. | Quality control material for reagentless measurement of analytes |
| US6828152B2 (en) | 1996-06-12 | 2004-12-07 | Spectromedical Inc. | Quality control material for reagentless measurement of analytes |
| US20050037505A1 (en) * | 2000-05-11 | 2005-02-17 | James Samsoondar | Spectroscopic method and apparatus for analyte measurement |
| US6651015B2 (en) | 1999-11-23 | 2003-11-18 | James Samsoondar | Method for calibrating spectrophotometric apparatus |
| US7449339B2 (en) | 1999-11-23 | 2008-11-11 | Nir Diagnostics Inc. | Spectroscopic method and apparatus for total hemoglobin measurement |
| US6470279B1 (en) | 1999-11-23 | 2002-10-22 | James Samsoondar | Method for calibrating spectrophotometric apparatus with synthetic fluids to measure plasma and serum analytes |
| US6711516B2 (en) | 1999-11-23 | 2004-03-23 | Spectromedical Inc. | Method for calibrating spectrophotometric apparatus |
| US6611777B2 (en) | 1999-11-23 | 2003-08-26 | James Samsoondar | Method for calibrating spectrophotometric apparatus |
| US6949384B2 (en) | 2001-12-21 | 2005-09-27 | Spectromedical Inc. | Method for monitoring degradation of Hb-based blood substitutes |
| GB2385663B (en) * | 2001-12-21 | 2006-08-02 | James Samsoondar | Quality control material for reagentless measurement of analytes |
| US7613488B1 (en) | 2002-12-20 | 2009-11-03 | Niresults Inc. | Apparatus and methods for compensation of blood volume effects on NIR spectroscopic measurements of blood analytes |
| CA2579001C (en) * | 2004-09-01 | 2014-07-08 | Maine Standards Company, Llc | Novel stable lipid standards |
| US7312083B2 (en) * | 2005-06-07 | 2007-12-25 | Beckman Coulter, Inc. | Control value assignment method |
| US7521244B2 (en) * | 2006-10-26 | 2009-04-21 | Bionostics, Inc. | Standard reference solutions |
| US20100117666A1 (en) * | 2006-12-28 | 2010-05-13 | Wada Henry G | Method and System for Internal Standardization of Assays |
| EP2281191A4 (en) | 2008-04-30 | 2011-10-05 | Instrumentation Lab Co | BILIRUBIN REFERENCE MATERIAL AT HÄMOGLOBINBASIS |
| JP5859439B2 (ja) | 2009-08-13 | 2016-02-10 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 臨床分析機によって分析される液体サンプルおよび容器の中の干渉物質および物理的寸法を確定するための方法ならびに装置 |
| JP2012090862A (ja) * | 2010-10-28 | 2012-05-17 | Fujifilm Corp | 光音響検査用探触子および光音響検査装置 |
| JP6374148B2 (ja) * | 2013-08-30 | 2018-08-15 | シスメックス株式会社 | 検体分析装置及び検体分析方法 |
| DE102017001484A1 (de) * | 2017-02-16 | 2018-08-16 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Anordnung zum Kalibrieren von Vorrichtungen zur Erkennung von Blut oder Blutbestandteilen in einer Flüssigkeit |
| US11161109B2 (en) | 2019-09-19 | 2021-11-02 | Invidx Corp. | Point-of-care testing cartridge with sliding cap |
| US11327084B2 (en) | 2019-09-19 | 2022-05-10 | Invidx Corp. | Joint hematology and biochemistry point-of-care testing system |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3705110A (en) * | 1971-04-21 | 1972-12-05 | Baxter Laboratories Inc | Calibrating fluid for automated hematology instruments |
| US4116336A (en) * | 1975-05-30 | 1978-09-26 | Radiometer A/S | Package containing a reference liquid for blood gas equipment |
| US4001142A (en) * | 1975-07-25 | 1977-01-04 | Warner-Lambert Company | Blood gas control |
| US4069016A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Assay for bilirubin |
| DE2931810A1 (de) * | 1979-08-06 | 1981-02-19 | Degussa | Temperaturstabilisiertes siliciumdioxid-mischoxid, das verfahren zu seiner herstellung und verwendung |
| US4603044A (en) * | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
| JPS6027861A (ja) | 1983-07-21 | 1985-02-12 | コ−ニング・グラス・ワ−クス | コオキシメトリ−特性制御組成物 |
| US5310679A (en) * | 1985-05-13 | 1994-05-10 | Artiss Joseph D | Composition for reducing turbidity in samples of biological fluids |
| DK282085D0 (da) | 1985-06-21 | 1985-06-21 | Radiometer As | Fremgangsmaade og apparat til bestemmelse af blodkomponenter |
| US4772561A (en) * | 1985-12-23 | 1988-09-20 | Miles Inc. | Test device and method of determining concentration of a sample component |
| US4753888A (en) * | 1986-04-09 | 1988-06-28 | Bionostics, Inc. | Multiple control standard for blood analysis |
| US5134284A (en) * | 1991-04-25 | 1992-07-28 | Volgyesi George A | Method of testing the accuracy of pulse oximeters and device therefor |
| US5278073A (en) * | 1991-05-08 | 1994-01-11 | Streck Laboratories, Inc. | Method of bilirubin assay |
| US5447838A (en) * | 1992-08-05 | 1995-09-05 | Hybritech Incorporated | Protein-dye conjugate for confirmation of correct dilution of calibrators |
-
1996
- 1996-06-12 GB GBGB9612264.3A patent/GB9612264D0/en active Pending
-
1997
- 1997-06-12 US US09/147,373 patent/US6372503B1/en not_active Expired - Lifetime
- 1997-06-12 WO PCT/CA1997/000418 patent/WO1997047972A1/en not_active Ceased
- 1997-06-12 JP JP50101898A patent/JP4158056B2/ja not_active Expired - Fee Related
- 1997-06-12 DE DE69732716T patent/DE69732716T2/de not_active Expired - Lifetime
- 1997-06-12 EP EP97924842A patent/EP0975976B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997047972A1 (en) | 1997-12-18 |
| JP2000512752A (ja) | 2000-09-26 |
| JP4158056B2 (ja) | 2008-10-01 |
| EP0975976A1 (en) | 2000-02-02 |
| DE69732716D1 (de) | 2005-04-14 |
| GB9612264D0 (en) | 1996-08-14 |
| US6372503B1 (en) | 2002-04-16 |
| EP0975976B1 (en) | 2005-03-09 |
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| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NIRESULTS INC., TORONTO, ONTARIO, CA |