DE69618268D1 - Verfahren zur enzymatischen Herstellung eines Synthese-Zwischenprodukt von Befloxatone - Google Patents

Verfahren zur enzymatischen Herstellung eines Synthese-Zwischenprodukt von Befloxatone

Info

Publication number
DE69618268D1
DE69618268D1 DE69618268T DE69618268T DE69618268D1 DE 69618268 D1 DE69618268 D1 DE 69618268D1 DE 69618268 T DE69618268 T DE 69618268T DE 69618268 T DE69618268 T DE 69618268T DE 69618268 D1 DE69618268 D1 DE 69618268D1
Authority
DE
Germany
Prior art keywords
befloxatone
synthesis intermediate
enzymatic production
trifluoro
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69618268T
Other languages
English (en)
Other versions
DE69618268T2 (de
Inventor
Arlette Tixidre
Lydia Zard
Guy Rossey
Andre Bourbon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of DE69618268D1 publication Critical patent/DE69618268D1/de
Application granted granted Critical
Publication of DE69618268T2 publication Critical patent/DE69618268T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE69618268T 1995-04-07 1996-04-01 Verfahren zur enzymatischen Herstellung eines Synthese-Zwischenprodukt von Befloxatone Expired - Lifetime DE69618268T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9504141A FR2732679B1 (fr) 1995-04-07 1995-04-07 Procede de preparation enzymatique d'un intermediaire de synthese de la befloxatone

Publications (2)

Publication Number Publication Date
DE69618268D1 true DE69618268D1 (de) 2002-02-07
DE69618268T2 DE69618268T2 (de) 2002-08-29

Family

ID=9477856

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69618268T Expired - Lifetime DE69618268T2 (de) 1995-04-07 1996-04-01 Verfahren zur enzymatischen Herstellung eines Synthese-Zwischenprodukt von Befloxatone

Country Status (7)

Country Link
US (1) US5716841A (de)
EP (1) EP0736606B1 (de)
JP (1) JP4017686B2 (de)
AT (1) ATE211505T1 (de)
DE (1) DE69618268T2 (de)
ES (1) ES2170841T3 (de)
FR (1) FR2732679B1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6893861B1 (en) * 1998-02-18 2005-05-17 Lonza Ag Method for producing trifluoro-3(r)-hydroxybutyric acid derivatives
US6642409B2 (en) 2000-01-27 2003-11-04 Central Glass Company, Limited Process for producing 4,4,4-trifluoro-3-hydroxybutyric acid derivatives
JP4015450B2 (ja) 2001-05-18 2007-11-28 高砂香料工業株式会社 光学活性アルコールの製造方法
DE10164269A1 (de) * 2001-12-19 2003-07-03 Asca Gmbh Angewandte Synthesec Verfahren zur kinetischen Racematspaltung von Alkoholen mit einem oder mehreren stereogenen Zentren

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0716437B2 (ja) * 1987-09-18 1995-03-01 日本碍子株式会社 光学活性体の合成法
JP2641935B2 (ja) * 1987-09-28 1997-08-20 ノボ‐ノルディスク アクティーゼルスカブ リパーゼの固定化方法
JPH0240343A (ja) * 1988-07-29 1990-02-09 Meito Sangyo Kk 含フッ素ポリエステル及びその製造方法
FR2653017B1 (fr) * 1989-10-17 1995-05-05 Delalande Sa Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.
JP2852545B2 (ja) * 1989-11-14 1999-02-03 チッソ株式会社 複数の不斉点を持つ光学活性化合物および製造法
JPH03254694A (ja) * 1990-03-01 1991-11-13 Kurita Water Ind Ltd 光学活性な含フッ素アルコールの製造方法
JP3171484B2 (ja) * 1991-05-31 2001-05-28 昭和シェル石油株式会社 光学活性フッ素含有アルコールの製法
EP0577446A3 (de) * 1992-05-28 1995-04-05 Showa Shell Sekiyu Verfahren zur Herstellung von optisch-aktiven Halogen-enthaltenden Alkoholen.
ES2141354T3 (es) * 1994-06-13 2000-03-16 Mitsubishi Rayon Co Procedimiento para la obtencion de derivados de acidos carboxilicos, opticamente activos, con substitucion alfa.
JP3794702B2 (ja) * 1994-10-12 2006-07-12 バンダービルト・ユニバーシテイ キラル−α−第３級カルボン酸エステルの酵素的調製法
US5696299A (en) * 1994-10-26 1997-12-09 The Nisshin Oil Mills, Ltd. Optical resolution for producing optically active alcohol
JP2666890B2 (ja) * 1995-06-07 1997-10-22 工業技術院長 光学活性（＋）−４，４，４−トリフルオロ−３−（インドール−３−）酪酸の製造方法

Also Published As

Publication number Publication date
EP0736606A1 (de) 1996-10-09
FR2732679B1 (fr) 1997-04-30
EP0736606B1 (de) 2002-01-02
ATE211505T1 (de) 2002-01-15
JP4017686B2 (ja) 2007-12-05
FR2732679A1 (fr) 1996-10-11
US5716841A (en) 1998-02-10
ES2170841T3 (es) 2002-08-16
JPH08289799A (ja) 1996-11-05
DE69618268T2 (de) 2002-08-29

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR