DE69428952T2 - Thienopyrimidinderivate, ihre Herstellung und Verwendung - Google Patents

Thienopyrimidinderivate, ihre Herstellung und Verwendung

Info

Publication number
DE69428952T2
DE69428952T2 DE69428952T DE69428952T DE69428952T2 DE 69428952 T2 DE69428952 T2 DE 69428952T2 DE 69428952 T DE69428952 T DE 69428952T DE 69428952 T DE69428952 T DE 69428952T DE 69428952 T2 DE69428952 T2 DE 69428952T2
Authority
DE
Germany
Prior art keywords
mmol
compound
pyrimidine
dioxo
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69428952T
Other languages
German (de)
English (en)
Other versions
DE69428952D1 (de
Inventor
Nobuo Choh
Shuichi Furuya
Tetsuya Ohtaki
Toshifumi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69428952D1 publication Critical patent/DE69428952D1/de
Publication of DE69428952T2 publication Critical patent/DE69428952T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69428952T 1993-08-26 1994-08-24 Thienopyrimidinderivate, ihre Herstellung und Verwendung Expired - Fee Related DE69428952T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21197293 1993-08-26
JP14812694 1994-06-29

Publications (2)

Publication Number Publication Date
DE69428952D1 DE69428952D1 (de) 2001-12-13
DE69428952T2 true DE69428952T2 (de) 2002-06-27

Family

ID=26478451

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69428952T Expired - Fee Related DE69428952T2 (de) 1993-08-26 1994-08-24 Thienopyrimidinderivate, ihre Herstellung und Verwendung

Country Status (11)

Country Link
EP (1) EP0640606B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR950005311A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1106663A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE208393T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2130859A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69428952T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (2) FI943912L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU218939B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO307565B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2142275C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW276256B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140325A (en) * 1993-08-19 2000-10-31 Takeda Chemical Industries, Ltd. Thienopyrimidine derivatives, their production and use
US6048863A (en) 1994-04-19 2000-04-11 Takeda Chemical Industries, Ltd. Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use
UY23948A1 (es) * 1995-02-08 2001-10-25 Takeda Chemical Industries Ltd Derivados de anillos condensados de tiofeno su producción y uso.
AU6670196A (en) * 1995-08-17 1997-03-12 Takeda Chemical Industries Ltd. Thienopyrimidine derivatives, their production and use
EP0781774B1 (en) * 1995-12-08 2002-07-31 Takeda Chemical Industries, Ltd. Prolactin production inhibitory agents
US5828149A (en) * 1996-07-18 1998-10-27 Baker Hughes Incorported Lubricant inducer pump for electrical motor
WO1998018781A2 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
US6025371A (en) * 1996-10-28 2000-02-15 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US6413724B1 (en) 1996-10-28 2002-07-02 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US6984644B2 (en) 1997-05-28 2006-01-10 Astrazeneca Ab Treatment of skin disorders using thieno[2,3-D]pyrimidinediones
SE9702001D0 (sv) * 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
US6469014B1 (en) 1997-05-28 2002-10-22 Astrazeneca Ab Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
ES2211161T3 (es) 1998-08-28 2004-07-01 Astrazeneca Ab Tieno(2,3-d)pirimidindionas novedosas, procedimiento para su preparacion y uso de las mismas en terapia.
HN2000000051A (es) * 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
AU2001252825A1 (en) * 2000-05-04 2001-11-12 Astrazeneca Ab Thieno(2,3-d)pyrimidinediones and their use as pharmaceuticals
SK287554B6 (sk) * 2000-09-22 2011-01-04 N.V. Organon Bicyklické heteroaromatické zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
RU2225866C1 (ru) * 2002-11-18 2004-03-20 Халиуллин Азат Наилевич Калиевая соль 2-[5(6)-нитро-1-(тиетанил-3)-бензимидазолил-2-тио]уксусной кислоты, проявляющая кардиотоническую активность
BR112014011351B1 (pt) * 2011-11-11 2021-02-17 Gilead Apollo, Llc. inibidores de acc e usos dos mesmos
CN102920695B (zh) * 2012-11-16 2014-08-06 蔡进 苯并呋喃类内皮素受体拮抗剂及用途
JP6573968B2 (ja) * 2014-08-11 2019-09-11 ハイドラ バイオサイエンシズ インコーポレイテッドＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． ＴＲＰＣ５調節因子としての、精神神経障害の処置のためのチエノおよびフロ［２，３−ｄ］ピリミジン−２，４［１Ｈ，３Ｈ］−ジオン誘導体
WO2016081649A1 (en) * 2014-11-18 2016-05-26 Emory University Thieno[2,3-d]pyrimidin-4-one derivatives as nmdar modulators and uses related thereto
UY36586A (es) * 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
PL3379933T3 (pl) 2015-11-25 2023-07-24 Gilead Apollo, Llc KOMPOZYCJE GRZYBOBÓJCZE ZAWIERAJĄCE POCHODNE 2,4-DIOKSO-1,4-DIHYDROTIENO[2,3-d]PIRYMIDYNY
CN108290902B (zh) 2015-11-25 2021-08-31 吉利德阿波罗公司 酯类acc抑制剂及其用途
MX2018006287A (es) 2015-11-25 2018-09-07 Gilead Apollo Llc Inhibidores de acc de triazol y usos de los mismos.
US20170166582A1 (en) 2015-11-25 2017-06-15 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
AU2017226267B2 (en) 2016-03-02 2021-06-24 Gilead Apollo, Llc Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof
US20180280394A1 (en) 2017-03-28 2018-10-04 Gilead Sciences, Inc. Methods of treating liver disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02225485A (ja) * 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk チエノピリミジン―３―酢酸誘導体
US5082838A (en) * 1989-06-21 1992-01-21 Takeda Chemical Industries, Ltd. Sulfur-containing fused pyrimidine derivatives, their production and use
CA2036618C (en) * 1990-02-22 2002-10-29 Akira Morimoto Fused thiophene derivatives, their production and use
DE4008726A1 (de) * 1990-03-19 1991-09-26 Basf Ag Thieno(2,3-d)pyrimidinderivate
TW270116B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1991-04-25 1996-02-11 Hoffmann La Roche

Also Published As

Publication number Publication date
CA2130859A1 (en) 1995-02-27
KR950005311A (ko) 1995-03-20
NO943146L (no) 1995-02-27
ATE208393T1 (de) 2001-11-15
RU94030480A (ru) 1996-10-10
CN1106663A (zh) 1995-08-16
FI943912A7 (fi) 1995-06-05
RU2142275C1 (ru) 1999-12-10
TW276256B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1996-05-21
FI943912L (fi) 1995-06-05
NO943146D0 (no) 1994-08-25
EP0640606A1 (en) 1995-03-01
FI943912A0 (fi) 1994-08-25
HU9402453D0 (en) 1994-10-28
EP0640606B1 (en) 2001-11-07
FI990387A0 (fi) 1999-02-23
DE69428952D1 (de) 2001-12-13
HUT71116A (en) 1995-11-28
NO307565B1 (no) 2000-04-25
HU218939B (hu) 2001-01-29
FI990387A7 (fi) 1999-02-23

Similar Documents

Publication Publication Date Title
DE69428952T2 (de) Thienopyrimidinderivate, ihre Herstellung und Verwendung
DE69613860T2 (de) Pyrazol-derivate, verfahren für ihre herstellung und sie enthaltende zusammensetzungen
DE69108138T2 (de) Imidazopyridinderivate und ihre Verwendung.
DE69331688T2 (de) Pyridopyrimidinderivate, ihre Herstellung und Verwendung
US5159083A (en) Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
DE60118564T2 (de) Propan-1,3-dion-derivate
DE69903923T2 (de) Bizyklische pyrrolderivate als mcp-1 inhibitoren
DE69213544T2 (de) Benzisothiazol- und Benzisoxazol-3-carboxamide, Verfahren zu deren Herstellung und ihre Anwendung als antipsychotische Arzneimittel
JP4445262B2 (ja) 抗炎症剤としてのイミダゾール誘導体
DE69329296T2 (de) Pyrazolopyrimidine als crf antagonisten
DE69919887T2 (de) Pyrazolopyridin derivative als selektive cox-2 inhibitoren
DE60107687T2 (de) Cyclpentanoindole, mischungen derartige verbindungen enthaltend und behandlungsmethoden
DE69120100T2 (de) Annelierte Thiophen-Derivate, ihre Herstellung und Verwendung
JP3000674B2 (ja) ジヒドロピラゾロピロール類
DE69528257T2 (de) KONDENSIERTE HETEROCYCLISCHE VERBINDUNG, DEREN HERSTELLUNG UND VERWENDUNG ALS GnRH ANTAGONISTEN
DE69719191T2 (de) Tetrahydroisoquinoline derivate als modulatoren von dopamine d3 rezeptoren
EP0736525B1 (de) Benzonitrile als 5-HT Agonisten und Antagonisten
DE69704060T2 (de) Tetrahydroisochinolinderivate und ihre pharmazeutische anwendung
DE69321471T2 (de) Dioxcyclobutenderivate als angiotensin ii antagonisten
SK284108B6 (sk) 2,3-Disubstituované 4(3H)-chinazolinóny, ich použitie a farmaceutické kompozície s ich obsahom
DE19955794A1 (de) Pyrrolidin-Derivate-CCR-3-Rezeptor-Antagonisten
DE60025848T2 (de) Pyrimidin-derivate als selective inhibitoren von cox-2
DE602004003952T2 (de) Substituierte tetrahydrobenzothienopyrimidinamine verbindungen geeignet zur behandlung von hyper-proliferative disorders
EP0352581A2 (de) Aethylendiaminmonoamid-Derivate
DE60219009T2 (de) Pyrazol-derivative als inhibitoren der reversen hiv-transkriptase

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP

8339 Ceased/non-payment of the annual fee