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Verfahren für die sequenzierung von synthetischen oligonukleotiden, welche internukleotid-bindungen enthalten, die nicht vom phosphodiester-typ sind

Info

Publication number
DE69301570D1
DE69301570D1 DE1993601570 DE69301570A DE69301570D1 DE 69301570 D1 DE69301570 D1 DE 69301570D1 DE 1993601570 DE1993601570 DE 1993601570 DE 69301570 A DE69301570 A DE 69301570A DE 69301570 D1 DE69301570 D1 DE 69301570D1
Authority
DE
Grant status
Grant
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1993601570
Other languages
English (en)
Other versions
DE69301570T2 (de )
Inventor
Sudhir Agrawal
Jin Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Idera Pharmaceuticals Inc
Original Assignee
Idera Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6846Common amplification features
    • C12Q1/6853Common amplification features using modified primers or templates
    • C12Q1/6855Ligating adaptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
DE1993601570 1992-10-06 1993-10-06 Verfahren für die sequenzierung von synthetischen oligonukleotiden, welche internukleotid-bindungen enthalten, die nicht vom phosphodiester-typ sind Expired - Fee Related DE69301570D1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US07958133 US5403709A (en) 1992-10-06 1992-10-06 Method for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkages
PCT/US1993/009592 WO1994008052A1 (en) 1992-10-06 1993-10-06 Methods for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkages

Publications (1)

Publication Number Publication Date
DE69301570D1 true DE69301570D1 (de) 1996-03-28

Family

ID=25500629

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1993601570 Expired - Fee Related DE69301570D1 (de) 1992-10-06 1993-10-06 Verfahren für die sequenzierung von synthetischen oligonukleotiden, welche internukleotid-bindungen enthalten, die nicht vom phosphodiester-typ sind
DE1993601570 Expired - Lifetime DE69301570T2 (de) 1992-10-06 1993-10-06 Verfahren für die sequenzierung von synthetischen oligonukleotiden, welche internukleotid-bindungen enthalten, die nicht vom phosphodiester-typ sind

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1993601570 Expired - Lifetime DE69301570T2 (de) 1992-10-06 1993-10-06 Verfahren für die sequenzierung von synthetischen oligonukleotiden, welche internukleotid-bindungen enthalten, die nicht vom phosphodiester-typ sind

Country Status (10)

Country Link
US (2) US5403709A (de)
JP (1) JPH08504571A (de)
CA (1) CA2146365A1 (de)
DE (2) DE69301570D1 (de)
DK (1) DK0664836T3 (de)
EP (1) EP0664836B1 (de)
ES (1) ES2083299T3 (de)
FI (1) FI951612A (de)
RU (1) RU95110871A (de)
WO (1) WO1994008052A1 (de)

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EP0600965B1 (de) * 1991-08-28 1998-02-18 Boehringer Mannheim Gmbh Primer für matrizenabhängige enzymatische nukleinsäuresynthesen
US5525470A (en) * 1994-01-26 1996-06-11 Hybridon, Inc. Method of sequencing [short] oligonucleotides
US5589330A (en) * 1994-07-28 1996-12-31 Genzyme Corporation High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides
US6645943B1 (en) * 1994-10-25 2003-11-11 Hybridon, Inc. Method of down-regulating gene expression
US6608035B1 (en) * 1994-10-25 2003-08-19 Hybridon, Inc. Method of down-regulating gene expression
EP0718409A3 (de) * 1994-12-22 1999-02-03 Hitachi, Ltd. DNS vorbereitungsverfahren
WO1997027206A1 (en) * 1996-01-26 1997-07-31 Codon Pharmaceuticals, Inc. Oligonucleotide analogs
US5851804A (en) * 1996-05-06 1998-12-22 Apollon, Inc. Chimeric kanamycin resistance gene
US6291164B1 (en) * 1996-11-22 2001-09-18 Invitrogen Corporation Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
US20040072210A1 (en) * 1997-07-07 2004-04-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) * 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6218118B1 (en) 1998-07-09 2001-04-17 Agilent Technologies, Inc. Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry
CA2360929A1 (en) 1999-02-05 2000-08-10 Amersham Pharmacia Biotech Uk Limited Genomic analysis method
US7501245B2 (en) * 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
EP1072679A3 (de) * 1999-07-20 2002-07-31 Agilent Technologies, Inc. (a Delaware corporation) Methode zur Herstelung von Nucleinsäuremolekülen mit einer reduzierten Sekundärstruktur
WO2003074738A8 (en) * 2000-01-18 2003-12-04 Michael Bittner Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
CA2440754A1 (en) 2001-03-12 2002-09-19 Stephen Quake Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
US20040219532A1 (en) * 2003-04-30 2004-11-04 Sampson Jeffrey R. Internal references measurements
US20050239089A1 (en) * 2003-06-06 2005-10-27 Johnson Martin D Mobility cassettes
US20050170367A1 (en) * 2003-06-10 2005-08-04 Quake Stephen R. Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
EP1716254B1 (de) 2004-02-19 2010-04-07 Helicos Biosciences Corporation Verfahren zur analyse von polynukleotidsequenzen
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US20050239085A1 (en) * 2004-04-23 2005-10-27 Buzby Philip R Methods for nucleic acid sequence determination
US20050260609A1 (en) * 2004-05-24 2005-11-24 Lapidus Stanley N Methods and devices for sequencing nucleic acids
US7635562B2 (en) * 2004-05-25 2009-12-22 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
US20060024678A1 (en) * 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
US20060118754A1 (en) * 2004-12-08 2006-06-08 Lapen Daniel C Stabilizing a polyelectrolyte multilayer
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US20060172328A1 (en) * 2005-01-05 2006-08-03 Buzby Philip R Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
US7482120B2 (en) * 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US20070117104A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US20070117102A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US20070117103A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US7476734B2 (en) * 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US20090305248A1 (en) * 2005-12-15 2009-12-10 Lander Eric G Methods for increasing accuracy of nucleic acid sequencing
US20080309926A1 (en) * 2006-03-08 2008-12-18 Aaron Weber Systems and methods for reducing detected intensity non uniformity in a laser beam
US7397546B2 (en) * 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4521509A (en) * 1982-11-24 1985-06-04 Research Corporation Method for degrading DNA
US4797355A (en) * 1985-06-13 1989-01-10 Amgen Inc. Methods for attaching polynucleotides to supports
EP0224126A3 (de) * 1985-11-25 1989-02-01 The University of Calgary Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren
EP0372524A3 (de) * 1988-12-07 1991-10-09 The General Hospital Corporation Verfahren zur Anreicherung und zum Klonen von DNS, das einer Insertion oder einer Deletion entspricht

Also Published As

Publication number Publication date Type
EP0664836B1 (de) 1996-02-14 grant
JPH08504571A (ja) 1996-05-21 application
US5403709A (en) 1995-04-04 grant
FI951612A (fi) 1995-05-10 application
CA2146365A1 (en) 1994-04-14 application
FI951612A0 (fi) 1995-04-05 application
US5652103A (en) 1997-07-29 grant
FI951612D0 (de) grant
RU95110871A (ru) 1997-06-10 application
WO1994008052A1 (en) 1994-04-14 application
ES2083299T3 (es) 1996-04-01 grant
DK664836T3 (de) grant
DE69301570T2 (de) 1996-06-27 grant
EP0664836A1 (de) 1995-08-02 application
DK0664836T3 (da) 1996-03-11 grant

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