DE69225757D1 - Lyophilische monoklonale antikörperpräparationen - Google Patents
Lyophilische monoklonale antikörperpräparationenInfo
- Publication number
- DE69225757D1 DE69225757D1 DE69225757T DE69225757T DE69225757D1 DE 69225757 D1 DE69225757 D1 DE 69225757D1 DE 69225757 T DE69225757 T DE 69225757T DE 69225757 T DE69225757 T DE 69225757T DE 69225757 D1 DE69225757 D1 DE 69225757D1
- Authority
- DE
- Germany
- Prior art keywords
- lyophilic
- monoclonal antibody
- antibody preparations
- preparations
- monoclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4343191 | 1991-03-08 | ||
PCT/JP1992/000226 WO1992015331A1 (fr) | 1991-03-08 | 1992-02-28 | Preparation lyophilisee d'anticorps monoclonaux |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69225757D1 true DE69225757D1 (de) | 1998-07-09 |
DE69225757T2 DE69225757T2 (de) | 1998-12-03 |
Family
ID=12663510
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232617T Expired - Fee Related DE69232617T2 (de) | 1991-03-08 | 1992-02-28 | Gefriergetrocknete Zubereitung, die einen monoklonalen Antikörper enthält |
DE69225757T Expired - Fee Related DE69225757T2 (de) | 1991-03-08 | 1992-02-28 | Lyophilische monoklonale antikörperpräparationen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232617T Expired - Fee Related DE69232617T2 (de) | 1991-03-08 | 1992-02-28 | Gefriergetrocknete Zubereitung, die einen monoklonalen Antikörper enthält |
Country Status (10)
Country | Link |
---|---|
US (1) | US5908826A (de) |
EP (2) | EP0531539B1 (de) |
JP (1) | JPH0565233A (de) |
AU (1) | AU645187B2 (de) |
CA (1) | CA2082169A1 (de) |
DE (2) | DE69232617T2 (de) |
DK (2) | DK0531539T3 (de) |
FI (1) | FI924982A (de) |
NO (1) | NO924279D0 (de) |
WO (1) | WO1992015331A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
GB9122820D0 (en) * | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
CN102416176A (zh) * | 1995-07-27 | 2012-04-18 | 基因技术股份有限公司 | 稳定等渗的冻干蛋白质制剂 |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
JP2014148555A (ja) * | 1995-07-27 | 2014-08-21 | Genentech Inc | タンパク質の処方 |
JP3624543B2 (ja) * | 1996-05-02 | 2005-03-02 | 東ソー株式会社 | 免疫反応試薬及びその製造方法 |
EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
AU2444899A (en) * | 1998-01-22 | 1999-08-09 | Astrazeneca Ab | Pharmaceutical formulation comprising an antibody and a citrate buffer |
US6750330B1 (en) * | 1998-05-14 | 2004-06-15 | Ashley Davis | Lyophilized tubulins |
US20030124119A1 (en) * | 1999-12-28 | 2003-07-03 | Tadao Yamazaki | Stable antibody compositions and injection preparations |
JP5490972B2 (ja) * | 2000-08-04 | 2014-05-14 | 中外製薬株式会社 | タンパク質注射製剤 |
CA2423227C (en) | 2000-10-12 | 2011-11-29 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
GB0113179D0 (en) * | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
ES2338218T3 (es) * | 2001-07-25 | 2010-05-05 | Facet Biotech Corporation | Formulacion farmacologica liofilizada estable de anticuerpos igg daclizumab. |
US20040002451A1 (en) | 2002-06-20 | 2004-01-01 | Bruce Kerwin | Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
ES2609010T3 (es) | 2003-04-04 | 2017-04-18 | Genentech, Inc. | Formulaciones de anticuerpos y de proteínas a concentración elevada |
TW200510532A (en) | 2003-07-15 | 2005-03-16 | Chugai Pharmaceutical Co Ltd | IgM production by transformed cell and method of quantifying the same |
WO2005035573A1 (ja) | 2003-10-09 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | タンパク質溶液の安定化方法 |
EP1688432B1 (de) * | 2003-10-09 | 2011-08-03 | Chugai Seiyaku Kabushiki Kaisha | Stabilisierte lösung mit hoher igm-konzentration |
ES2553987T3 (es) * | 2003-12-25 | 2015-12-15 | Kyowa Hakko Kirin Co., Ltd. | Preparación farmacéutica de base acuosa estable que contiene anticuerpo |
EP1888637A2 (de) * | 2005-05-19 | 2008-02-20 | Amgen Inc. | Zusammensetzungen und verfahren zur erhöhung der stabilität von antikörpern |
MX2007015476A (es) | 2005-06-14 | 2008-02-25 | Amgen Inc | Formulaciones de proteina autoamortiguadoras. |
WO2007074880A1 (ja) * | 2005-12-28 | 2007-07-05 | Chugai Seiyaku Kabushiki Kaisha | 抗体含有安定化製剤 |
AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
CA2665567C (en) * | 2006-10-06 | 2012-07-03 | Amgen Inc. | Stable formulations |
EP2094247B1 (de) * | 2006-10-20 | 2022-06-29 | Amgen Inc. | Stabile polypeptid-formulierungen |
JP2010522208A (ja) * | 2007-03-22 | 2010-07-01 | イムクローン・リミテッド・ライアビリティ・カンパニー | 安定な抗体処方物 |
JP5322405B2 (ja) * | 2007-06-07 | 2013-10-23 | 小林製薬株式会社 | タンパク質含有組成物 |
CN102414221A (zh) | 2009-03-06 | 2012-04-11 | 健泰科生物技术公司 | 抗体配制剂 |
NZ702494A (en) | 2010-03-01 | 2016-09-30 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
WO2012028683A1 (en) | 2010-09-02 | 2012-03-08 | Novartis Ag | Antibody gel system for sustained drug delivery |
TWI604851B (zh) | 2010-11-05 | 2017-11-11 | 諾華公司 | Il-17抗體用於製備治療強直性脊椎炎之藥物之用途 |
HUE029457T2 (en) | 2010-11-11 | 2017-02-28 | Abbvie Biotechnology Ltd | Liquid formulations containing a high concentration of ANTI-TNF-alpha antibody |
JP2012158615A (ja) * | 2012-05-28 | 2012-08-23 | Kobayashi Pharmaceutical Co Ltd | 還元糖によるタンパク質変性を抑制する方法 |
US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
WO2015185998A2 (en) | 2014-04-11 | 2015-12-10 | Acerta Pharma B.V. | Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase |
US9937171B2 (en) | 2014-04-11 | 2018-04-10 | Acerta Pharma B.V. | Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
TW201618774A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | 使用btk抑制劑透過調變腫瘤微環境來治療實體腫瘤及其他疾病之方法 |
WO2016055982A1 (en) | 2014-10-10 | 2016-04-14 | Acerta Pharma B.V. | Quinoline and quinazoline compounds |
WO2016087994A1 (en) | 2014-12-05 | 2016-06-09 | Acerta Pharma B.V. | Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment |
PT3334747T (pt) | 2015-08-13 | 2023-12-12 | Amgen Inc | Formulação de gonadotrofina líquida estável |
EP3865485A1 (de) | 2015-11-06 | 2021-08-18 | Acerta Pharma B.V. | Imidazopyrazinhemmer der bruton-tyrosinkinase |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2149304A (en) * | 1936-04-20 | 1939-03-07 | Sharp & Dohme Inc | Lyophilic biologically active substances |
SU700132A1 (ru) * | 1978-06-30 | 1979-11-30 | Томский Ордена Трудового Красного Знамени Научно-Исследовательский Институт Вакцин И Сывороток | Способ получени сухого препарата иммуноглобулина |
JPS57140724A (en) * | 1981-02-25 | 1982-08-31 | Green Cross Corp:The | Heat-treatment of aqueous solution containing cold insoluble globulin |
JPS58167518A (ja) * | 1982-03-29 | 1983-10-03 | Nippon Sekijiyuujishiya | ゼラチン誘導体添加静注用人免疫グロブリンの製造法 |
JPS6035263A (ja) * | 1983-08-05 | 1985-02-23 | Wako Pure Chem Ind Ltd | 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬 |
JPS60146833A (ja) * | 1984-01-10 | 1985-08-02 | Green Cross Corp:The | モノクロ−ナル抗体製剤 |
JP2565303B2 (ja) * | 1984-05-25 | 1996-12-18 | 三井東圧化学株式会社 | 緑膿菌感染症の予防治療剤 |
US4650772A (en) * | 1984-08-09 | 1987-03-17 | Abbott Laboratories | Monoclonal antibody stabilization |
JPH0669961B2 (ja) * | 1984-09-25 | 1994-09-07 | 株式会社ミドリ十字 | 免疫グロブリンの加熱処理方法 |
JPS61176532A (ja) * | 1985-01-30 | 1986-08-08 | Green Cross Corp:The | プラスミノ−ゲンアクチベ−タ−前駆体の安定化方法 |
JPH0825902B2 (ja) * | 1985-02-21 | 1996-03-13 | 株式会社ミドリ十字 | γ−グロブリンの加熱処理方法 |
JPH0825903B2 (ja) * | 1985-05-16 | 1996-03-13 | 株式会社ミドリ十字 | γ―グロブリン含有水溶液 |
JPS6178731A (ja) * | 1985-05-20 | 1986-04-22 | Green Cross Corp:The | 加熱処理免疫グロブリン製剤 |
DE3619565A1 (de) * | 1986-06-11 | 1987-12-17 | Behringwerke Ag | Verfahren zur herstellung einer pasteurisierten immunglobulinpraeparation |
JPS6388197A (ja) * | 1986-09-30 | 1988-04-19 | Tosoh Corp | モノクロナル抗体の安定化方法 |
EP0327648B1 (de) * | 1986-12-15 | 1993-06-09 | MITSUI TOATSU CHEMICALS, Inc. | Menschlicher monoklonaler antikörper und arzneimittel zur prophylaxe und behandlung von infektiösen krankheiten |
ES2045027T3 (es) * | 1987-08-10 | 1994-01-16 | Miles Inc | Igm purificadas. |
WO1989011298A1 (en) * | 1988-05-27 | 1989-11-30 | Centocor, Inc. | Formulation for antibody reagents |
EP0465513A1 (de) * | 1989-03-27 | 1992-01-15 | Centocor, Inc. | Formulierungen zur stabilisierung von igm-antikörpern |
JPH0384461A (ja) * | 1989-08-28 | 1991-04-10 | Green Cross Corp:The | 免疫学的凝集反応試薬及びその製法 |
JPH0911350A (ja) * | 1995-06-30 | 1997-01-14 | Olympus Optical Co Ltd | エネルギー硬化型樹脂を用いた光学素子の製造方法 |
-
1992
- 1992-02-27 JP JP4041015A patent/JPH0565233A/ja active Pending
- 1992-02-28 CA CA002082169A patent/CA2082169A1/en not_active Abandoned
- 1992-02-28 DK DK92906211T patent/DK0531539T3/da active
- 1992-02-28 WO PCT/JP1992/000226 patent/WO1992015331A1/ja active IP Right Grant
- 1992-02-28 EP EP92906211A patent/EP0531539B1/de not_active Expired - Lifetime
- 1992-02-28 EP EP97120255A patent/EP0841067B1/de not_active Revoked
- 1992-02-28 DK DK97120255T patent/DK0841067T3/da active
- 1992-02-28 DE DE69232617T patent/DE69232617T2/de not_active Expired - Fee Related
- 1992-02-28 AU AU13375/92A patent/AU645187B2/en not_active Ceased
- 1992-02-28 DE DE69225757T patent/DE69225757T2/de not_active Expired - Fee Related
- 1992-11-04 FI FI924982A patent/FI924982A/fi not_active Application Discontinuation
- 1992-11-06 NO NO924279A patent/NO924279D0/no unknown
-
1994
- 1994-11-14 US US08/340,319 patent/US5908826A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH0565233A (ja) | 1993-03-19 |
FI924982A0 (fi) | 1992-11-04 |
DE69225757T2 (de) | 1998-12-03 |
US5908826A (en) | 1999-06-01 |
EP0841067A1 (de) | 1998-05-13 |
DE69232617D1 (de) | 2002-06-27 |
NO924279L (no) | 1992-11-06 |
DK0841067T3 (da) | 2002-07-15 |
NO924279D0 (no) | 1992-11-06 |
CA2082169A1 (en) | 1992-09-09 |
DE69232617T2 (de) | 2002-10-31 |
WO1992015331A1 (fr) | 1992-09-17 |
EP0531539B1 (de) | 1998-06-03 |
EP0531539A4 (de) | 1995-04-05 |
AU645187B2 (en) | 1994-01-06 |
DK0531539T3 (da) | 1998-10-12 |
EP0841067B1 (de) | 2002-05-22 |
AU1337592A (en) | 1992-10-06 |
FI924982A (fi) | 1992-11-04 |
EP0531539A1 (de) | 1993-03-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |