DE69224027T2 - Bisaminierte Zyklohexapeptide - Google Patents

Bisaminierte Zyklohexapeptide

Info

Publication number
DE69224027T2
DE69224027T2 DE69224027T DE69224027T DE69224027T2 DE 69224027 T2 DE69224027 T2 DE 69224027T2 DE 69224027 T DE69224027 T DE 69224027T DE 69224027 T DE69224027 T DE 69224027T DE 69224027 T2 DE69224027 T2 DE 69224027T2
Authority
DE
Germany
Prior art keywords
compound
seq
alkyl
sequence
hplc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69224027T
Other languages
German (de)
English (en)
Other versions
DE69224027D1 (de
Inventor
Frances Aileen Bouffard
James F Dropinski
Robert A Zambias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69224027D1 publication Critical patent/DE69224027D1/de
Publication of DE69224027T2 publication Critical patent/DE69224027T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69224027T 1991-10-01 1992-10-01 Bisaminierte Zyklohexapeptide Expired - Fee Related DE69224027T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77102791A 1991-10-01 1991-10-01
US07/936,558 US6030944A (en) 1991-10-01 1992-09-03 Cyclohexapeptidyl bisamine compounds

Publications (2)

Publication Number Publication Date
DE69224027D1 DE69224027D1 (de) 1998-02-19
DE69224027T2 true DE69224027T2 (de) 1998-08-13

Family

ID=27118389

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69224027T Expired - Fee Related DE69224027T2 (de) 1991-10-01 1992-10-01 Bisaminierte Zyklohexapeptide

Country Status (9)

Country Link
US (1) US6030944A (https=)
EP (1) EP0535967B1 (https=)
JP (1) JPH0794470B2 (https=)
AT (1) ATE162200T1 (https=)
CA (1) CA2079187C (https=)
DE (1) DE69224027T2 (https=)
DK (1) DK0535967T3 (https=)
ES (1) ES2111616T3 (https=)
GR (1) GR3025914T3 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
WO1996022784A1 (en) * 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
EP0862579A1 (en) * 1995-11-09 1998-09-09 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
EP1785432A1 (en) 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20090324635A1 (en) * 2008-06-25 2009-12-31 Ferenc Korodi Caspofungin free of caspofungin impurity A
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
WO2012119065A2 (en) * 2011-03-03 2012-09-07 Seachaid Pharmaceuticals, Inc. Antifungal agents and uses thereof
SI3677252T1 (sl) * 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
WO2016201283A1 (en) * 2015-06-12 2016-12-15 Cidara Therapeutics, Inc. Antifungal agents
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
MA43825A (fr) 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
JP7779651B2 (ja) 2017-07-12 2025-12-03 ナップ ファーマシューティカル グループ リミテッド 真菌感染症の処置のための組成物及び方法
EP3620462A1 (en) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Process for the preparation of caspofungin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173629A (en) * 1975-07-08 1979-11-06 Sandoz Ltd. Antibiotic S 31794/F-1
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320054A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912H nucleus
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4968608A (en) * 1987-10-07 1990-11-06 Merck & Co., Inc. Process for antifungal fermentation product
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
US5021403A (en) * 1990-03-19 1991-06-04 Merck & Co., Inc. Antibiotic agents
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii

Also Published As

Publication number Publication date
CA2079187A1 (en) 1993-04-02
EP0535967A2 (en) 1993-04-07
ATE162200T1 (de) 1998-01-15
EP0535967A3 (https=) 1994-04-06
DK0535967T3 (da) 1998-02-09
GR3025914T3 (en) 1998-04-30
JPH05239094A (ja) 1993-09-17
EP0535967B1 (en) 1998-01-14
US6030944A (en) 2000-02-29
CA2079187C (en) 2000-09-19
ES2111616T3 (es) 1998-03-16
DE69224027D1 (de) 1998-02-19
JPH0794470B2 (ja) 1995-10-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee