DE69207526D1 - Tramadol N-Oxid, dessen Enantiomere und Zusammensetzungen davon, und deren Verwendung - Google Patents

Tramadol N-Oxid, dessen Enantiomere und Zusammensetzungen davon, und deren Verwendung

Info

Publication number
DE69207526D1
DE69207526D1 DE69207526T DE69207526T DE69207526D1 DE 69207526 D1 DE69207526 D1 DE 69207526D1 DE 69207526 T DE69207526 T DE 69207526T DE 69207526 T DE69207526 T DE 69207526T DE 69207526 D1 DE69207526 D1 DE 69207526D1
Authority
DE
Germany
Prior art keywords
tramadol
compositions
oxide
enantiomers
oxide material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69207526T
Other languages
English (en)
Other versions
DE69207526T2 (de
Inventor
Cynthia A Maryanoff
Frank J Villani
Robert B Raffa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho McNeil Pharmaceutical Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc filed Critical McNeilab Inc
Application granted granted Critical
Publication of DE69207526D1 publication Critical patent/DE69207526D1/de
Publication of DE69207526T2 publication Critical patent/DE69207526T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Catching Or Destruction (AREA)
DE69207526T 1991-09-13 1992-09-11 Tramadol N-Oxid, dessen Enantiomere und Zusammensetzungen davon, und deren Verwendung Expired - Lifetime DE69207526T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/759,259 US5223541A (en) 1991-09-13 1991-09-13 Tramadol n-oxide material, enantiomers and compositions thereof, and their use

Publications (2)

Publication Number Publication Date
DE69207526D1 true DE69207526D1 (de) 1996-02-22
DE69207526T2 DE69207526T2 (de) 1996-07-04

Family

ID=25054992

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69207526T Expired - Lifetime DE69207526T2 (de) 1991-09-13 1992-09-11 Tramadol N-Oxid, dessen Enantiomere und Zusammensetzungen davon, und deren Verwendung

Country Status (23)

Country Link
US (1) US5223541A (de)
EP (1) EP0532348B1 (de)
JP (1) JP3115119B2 (de)
KR (1) KR100241859B1 (de)
CN (1) CN1032533C (de)
AT (1) ATE132852T1 (de)
AU (1) AU651000B2 (de)
CA (1) CA2078028C (de)
DE (1) DE69207526T2 (de)
DK (1) DK0532348T3 (de)
ES (1) ES2086079T3 (de)
FI (1) FI111717B (de)
GR (1) GR3019345T3 (de)
HU (1) HU214321B (de)
IL (1) IL103154A (de)
MX (1) MX9205219A (de)
MY (1) MY121910A (de)
NO (1) NO178105C (de)
NZ (1) NZ244309A (de)
SG (1) SG63550A1 (de)
TW (1) TW221968B (de)
ZA (1) ZA926968B (de)
ZW (1) ZW14592A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG80535A1 (en) 1991-09-06 2001-05-22 Mcneilab Inc Composition comprising a tramadol material and acetaminophen and its use
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US7740881B1 (en) 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
IL110014A (en) 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US6017963A (en) * 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
WO1999003820A1 (en) 1997-07-15 1999-01-28 Russinsky Limited Tramadol, salts thereof and process for their preparation
US6156342A (en) * 1998-05-26 2000-12-05 Andex Pharmaceuticals, Inc. Controlled release oral dosage form
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
PT1623703E (pt) 1999-10-29 2012-01-09 Euro Celtique Sa Formulações de hidrocodona de libertação controlada
DE10000312A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
EP2283829A1 (de) 2000-10-30 2011-02-16 Euro-Celtique S.A. Hydrocodon-Formulierungen mit gesteuerter Freisetzung
ES2265495T3 (es) 2001-03-16 2007-02-16 Dmi Biosciences, Inc. Uso de tramadol para el retardo de la eyaculacion.
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
UA81224C2 (uk) 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
US6649783B2 (en) 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
US9092841B2 (en) 2004-06-09 2015-07-28 Cognex Technology And Investment Llc Method and apparatus for visual detection and inspection of objects
US7940687B2 (en) 2005-11-16 2011-05-10 Qualcomm Incorporated Efficient partitioning of control and data fields
ES2384481T3 (es) 2007-02-12 2012-07-05 Dmi Biosciences, Inc. Tratamiento de la eyaculación precoz y la disfunción eréctil co-morbidas
US20080261991A1 (en) 2007-02-12 2008-10-23 Dmi Biosciences, Inc. Reducing Side Effects of Tramadol
EA201070055A1 (ru) * 2007-06-26 2010-06-30 Солвей Фармасьютикалс Б.В. N-оксиды венлафаксина и о-десметил венлафаксина в качестве пролекарств
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
US10475492B1 (en) 2018-07-27 2019-11-12 Macronix International Co., Ltd. Circuit and method for read latency control

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US4017637A (en) * 1973-03-26 1977-04-12 American Home Products Corporation Benzylamine analgesics
DE3515349A1 (de) * 1985-04-27 1986-10-30 Messerschmitt-Bölkow-Blohm GmbH, 8012 Ottobrunn Elektrischer geber zur messung mechanischer groessen

Also Published As

Publication number Publication date
FI924084A0 (fi) 1992-09-11
GR3019345T3 (en) 1996-06-30
CA2078028C (en) 2003-04-29
AU2355792A (en) 1993-03-18
US5223541A (en) 1993-06-29
IL103154A (en) 1996-09-12
EP0532348A2 (de) 1993-03-17
SG63550A1 (en) 1999-03-30
ATE132852T1 (de) 1996-01-15
TW221968B (de) 1994-04-01
CA2078028A1 (en) 1993-03-14
DK0532348T3 (da) 1996-02-05
MX9205219A (es) 1994-02-28
FI111717B (fi) 2003-09-15
NO923530L (no) 1993-03-15
DE69207526T2 (de) 1996-07-04
KR100241859B1 (ko) 2000-02-01
CN1071913A (zh) 1993-05-12
KR930005969A (ko) 1993-04-20
NO923530D0 (no) 1992-09-11
HU9202918D0 (en) 1992-11-30
JP3115119B2 (ja) 2000-12-04
FI924084A (fi) 1993-03-14
ZW14592A1 (en) 1994-05-11
NO178105B (no) 1995-10-16
NO178105C (no) 1996-01-24
AU651000B2 (en) 1994-07-07
EP0532348B1 (de) 1996-01-10
NZ244309A (en) 1994-10-26
ZA926968B (en) 1994-03-11
MY121910A (en) 2006-03-31
CN1032533C (zh) 1996-08-14
HUT65476A (en) 1994-06-28
EP0532348A3 (en) 1993-05-26
HU214321B (hu) 1998-03-02
JPH06122668A (ja) 1994-05-06
ES2086079T3 (es) 1996-06-16
IL103154A0 (en) 1993-02-21

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ATE132852T1 (de) Tramadol n-oxid, dessen enantiomere und zusammensetzungen davon, und deren verwendung
DE122004000032I2 (de) Zusammensetzung die eine Tramadol-Verbindung und Acetaminophen enth{lt, und ihre Verwendung
ATE145330T1 (de) Zusammensetzungen, die tramadol und irgendein kodein, oxykoden oder hydrokoden enthalten, und deren verwendung
SG55086A1 (en) Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
MY114755A (en) Composition comprising a tramadol material and acetaminophen and its use.

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