DE69122956D1 - Verfahren und zusammensetzungen zur hemmung der angiogenese - Google Patents

Verfahren und zusammensetzungen zur hemmung der angiogenese

Info

Publication number
DE69122956D1
DE69122956D1 DE69122956T DE69122956T DE69122956D1 DE 69122956 D1 DE69122956 D1 DE 69122956D1 DE 69122956 T DE69122956 T DE 69122956T DE 69122956 T DE69122956 T DE 69122956T DE 69122956 D1 DE69122956 D1 DE 69122956D1
Authority
DE
Germany
Prior art keywords
collagenase
inhibitor
compositions
specific
inhibiting angiogenesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69122956T
Other languages
English (en)
Other versions
DE69122956T2 (de
Inventor
Marsha Moses
Judith Sudhalter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cincinnati Childrens Hospital Medical Center
Original Assignee
Cincinnati Childrens Hospital Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Childrens Hospital Medical Center filed Critical Cincinnati Childrens Hospital Medical Center
Publication of DE69122956D1 publication Critical patent/DE69122956D1/de
Application granted granted Critical
Publication of DE69122956T2 publication Critical patent/DE69122956T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69122956T 1990-01-25 1991-01-25 Verfahren und zusammensetzungen zur hemmung der angiogenese Expired - Fee Related DE69122956T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47006790A 1990-01-25 1990-01-25
US59155990A 1990-10-02 1990-10-02
PCT/US1991/000559 WO1991011193A1 (en) 1990-01-25 1991-01-25 Method and compositions for inhibiting angiogenesis

Publications (2)

Publication Number Publication Date
DE69122956D1 true DE69122956D1 (de) 1996-12-05
DE69122956T2 DE69122956T2 (de) 1997-05-22

Family

ID=27042958

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69122956T Expired - Fee Related DE69122956T2 (de) 1990-01-25 1991-01-25 Verfahren und zusammensetzungen zur hemmung der angiogenese

Country Status (10)

Country Link
EP (1) EP0512071B1 (de)
JP (1) JPH06509791A (de)
AT (1) ATE144710T1 (de)
AU (1) AU652744B2 (de)
CA (1) CA2074725A1 (de)
DE (1) DE69122956T2 (de)
DK (1) DK0512071T3 (de)
ES (1) ES2093699T3 (de)
GR (1) GR3021925T3 (de)
WO (1) WO1991011193A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
DE4106570A1 (de) * 1991-03-01 1992-09-03 Max Planck Gesellschaft Neue inhibitoren der endothelzell-proliferation
WO1995003036A1 (en) * 1993-07-19 1995-02-02 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
AU728873B2 (en) * 1993-07-19 2001-01-18 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
AU771815B2 (en) * 1993-07-19 2004-04-01 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
US5837680A (en) * 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
US6120847A (en) * 1999-01-08 2000-09-19 Scimed Life Systems, Inc. Surface treatment method for stent coating
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
US6156373A (en) * 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
DE20122506U1 (de) 2000-10-16 2005-12-08 Conor Medsystems, Inc., Menlo Park Ausdehnbare medizinische Vorrichtung zur Abgabe eines nützlichen Agens
US20040073294A1 (en) 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
EP1545588A4 (de) * 2002-07-23 2007-12-05 Ludwig Inst Cancer Res Verfahren und zusammensetzungen f r die aktivierung oder hemmung von vegf-d und vegf-c
EP1610823B1 (de) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantierbares medizinprodukt mit kontinuierlichem mittel-konzentrationsgefälle
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
KR101539700B1 (ko) * 2012-09-05 2015-07-28 아주대학교산학협력단 연골세포 유래 세포외 기질막을 이용한 신생혈관질환 치료용 조성물 및 각막 또는 결막 이식재
WO2014038866A1 (ko) * 2012-09-05 2014-03-13 아주대학교산학협력단 연골세포 유래 세포외 기질막을 이용한 신생혈관질환 치료용 조성물 및 각막 또는 결막 이식재

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
US4766111A (en) * 1985-10-31 1988-08-23 Trustees Of Boston University Lipids with plasmin inhibitory properties
US5260059A (en) * 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor

Also Published As

Publication number Publication date
AU7335191A (en) 1991-08-21
EP0512071A4 (en) 1993-05-05
JPH06509791A (ja) 1994-11-02
ATE144710T1 (de) 1996-11-15
CA2074725A1 (en) 1991-07-26
EP0512071B1 (de) 1996-10-30
AU652744B2 (en) 1994-09-08
DK0512071T3 (da) 1996-11-25
EP0512071A1 (de) 1992-11-11
DE69122956T2 (de) 1997-05-22
ES2093699T3 (es) 1997-01-01
GR3021925T3 (en) 1997-03-31
WO1991011193A1 (en) 1991-08-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee