DE69122388D1 - Vorrichtung zum dosieren eines pulverförmigen medikaments für die inhalation - Google Patents

Vorrichtung zum dosieren eines pulverförmigen medikaments für die inhalation

Info

Publication number
DE69122388D1
DE69122388D1 DE69122388T DE69122388T DE69122388D1 DE 69122388 D1 DE69122388 D1 DE 69122388D1 DE 69122388 T DE69122388 T DE 69122388T DE 69122388 T DE69122388 T DE 69122388T DE 69122388 D1 DE69122388 D1 DE 69122388D1
Authority
DE
Germany
Prior art keywords
shaft
pct
container
inhalation
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69122388T
Other languages
English (en)
Other versions
DE69122388T2 (de
Inventor
Tapio Lankinen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Oy
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of DE69122388D1 publication Critical patent/DE69122388D1/de
Application granted granted Critical
Publication of DE69122388T2 publication Critical patent/DE69122388T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/062—Desiccants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Catching Or Destruction (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69122388T 1991-04-15 1991-04-15 Vorrichtung zum dosieren eines pulverförmigen medikaments für die inhalation Expired - Fee Related DE69122388T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/FI1991/000113 WO1992018188A1 (en) 1991-04-15 1991-04-15 Device intended for measuring a dose of powdered medicament for inhalation

Publications (2)

Publication Number Publication Date
DE69122388D1 true DE69122388D1 (de) 1996-10-31
DE69122388T2 DE69122388T2 (de) 1997-03-27

Family

ID=8556505

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69122388T Expired - Fee Related DE69122388T2 (de) 1991-04-15 1991-04-15 Vorrichtung zum dosieren eines pulverförmigen medikaments für die inhalation
DE4193534T Withdrawn DE4193534T1 (de) 1991-04-15 1991-04-15 Vorrichtung zum Abmessen einer Dosis pulverförmigen Arzneimittels für die Inhalation

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE4193534T Withdrawn DE4193534T1 (de) 1991-04-15 1991-04-15 Vorrichtung zum Abmessen einer Dosis pulverförmigen Arzneimittels für die Inhalation

Country Status (16)

Country Link
US (2) US5295479A (de)
EP (1) EP0533683B1 (de)
KR (1) KR960002186B1 (de)
AT (1) ATE143273T1 (de)
AU (1) AU650873B2 (de)
BR (1) BR9106690A (de)
DE (2) DE69122388T2 (de)
DK (1) DK0533683T3 (de)
ES (1) ES2093702T3 (de)
GR (1) GR3022073T3 (de)
HK (1) HK1006813A1 (de)
LT (1) LT3557B (de)
LV (1) LV10205B (de)
NO (1) NO175136C (de)
RU (1) RU2093197C1 (de)
WO (1) WO1992018188A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE189124T1 (de) * 1991-07-02 2000-02-15 Inhale Inc Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
GB9203761D0 (en) * 1992-02-21 1992-04-08 Innovata Biomed Ltd Inhaler
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6673335B1 (en) * 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
DE4239402A1 (de) * 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5524613A (en) * 1993-08-25 1996-06-11 Habley Medical Technology Corporation Controlled multi-pharmaceutical inhaler
GB9326574D0 (en) * 1993-12-31 1994-03-02 King S College London Dry power inhalers
AU689217B2 (en) * 1994-03-07 1998-03-26 Novartis Ag Methods and compositions for pulmonary delivery of insulin
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
WO1996008303A1 (fr) * 1994-09-14 1996-03-21 Nippondenso Co., Ltd. Filtre desodorisant
US6065471A (en) * 1994-09-16 2000-05-23 Laboratoire Glaxo Wellcome Inhalation device
CN1318104C (zh) 1994-09-21 2007-05-30 耐科塔医药公司 送料管组件
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
JP3299971B2 (ja) * 1995-06-21 2002-07-08 アスタ メディカ アクチエンゲゼルシャフト 一体的に形成された調量装置を備えた薬用粉末カートリッジおよび粉末薬剤吸入器
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5699789A (en) * 1996-03-11 1997-12-23 Hendricks; Mark R. Dry powder inhaler
US6123070A (en) * 1996-06-07 2000-09-26 Valois S.A. Device for enhancing the emptying of an inhaler metering chamber
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
ES2209379T3 (es) * 1998-01-03 2004-06-16 Innovata Biomed Limited Procedimiento de relleno.
US6257233B1 (en) * 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
FI990915A0 (fi) * 1999-04-23 1999-04-23 Orion Yhtymae Oyj Jauheinhalaattori
MXPA01012533A (es) * 1999-06-05 2003-10-14 Innovata Biomed Ltd Sistema de suministro.
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
WO2001021238A2 (en) * 1999-09-17 2001-03-29 Orion Corporation Moisture protected powder inhaler
GB9924780D0 (en) * 1999-10-21 1999-12-22 Glaxo Group Ltd Medicament dispenser
GB9924808D0 (en) 1999-10-21 1999-12-22 Glaxo Group Ltd Medicament dispenser
WO2001041850A1 (en) * 1999-12-07 2001-06-14 Orion Corporation Multidose powder inhaler
AU2001263098A1 (en) 2000-05-12 2001-11-26 Iep Pharmaceutical Devices, Inc. Powder/liquid metering valve
US7575761B2 (en) * 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
ES2291452T3 (es) * 2001-02-06 2008-03-01 Innovata Biomed Limited Formulacion bimodal de polvo seco para inhalacion.
GB0128148D0 (en) 2001-11-23 2002-01-16 Innovata Biomed Ltd Assembly
BR0303652A (pt) * 2002-03-22 2004-07-13 Clinical Designs Ltd Acessório de lata
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
GB0304000D0 (en) * 2003-02-21 2003-03-26 Clinical Designs Ltd Dispenser
GB0327112D0 (en) * 2003-11-21 2003-12-24 Clincial Designs Ltd Dispenser and reservoir
GB0328859D0 (en) * 2003-12-12 2004-01-14 Clinical Designs Ltd Dispenser and counter
JP2007533387A (ja) 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
GB0409197D0 (en) 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
GB0425518D0 (en) 2004-11-19 2004-12-22 Clinical Designs Ltd Substance source
GB0428204D0 (en) 2004-12-23 2005-01-26 Clinical Designs Ltd Medicament container
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
GB0518400D0 (en) 2005-09-09 2005-10-19 Clinical Designs Ltd Dispenser
WO2009029028A1 (en) * 2007-08-24 2009-03-05 Astrazeneca Ab Breath- triggered inhaler with dose counter
WO2009046215A2 (en) * 2007-10-02 2009-04-09 Lab International Srl Safety and abuse deterrent improved device
CA2709071C (en) 2007-12-14 2016-11-15 Labogroup S.A.S. Delivering aerosolizable food products
GB0904059D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
GB0904040D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
WO2010135340A2 (en) 2009-05-18 2010-11-25 3M Innovative Properties Company Dry powder inhalers
KR101716079B1 (ko) * 2016-03-25 2017-03-14 이현희 주방공사를 위한 주방모형활용방법
JP7446309B2 (ja) * 2019-01-14 2024-03-08 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 乾燥粉末吸入器

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US31530A (en) * 1861-02-26 Grain measuk
US68760A (en) * 1867-09-10 Charles e
US137093A (en) * 1873-03-25 Improvement in compound s and apparatus for the cure of asthma
US202625A (en) * 1878-04-23 Improvement in corn-planters
US2603215A (en) * 1949-02-12 1952-07-15 American Cyanamid Co Drug inhalator
US2534636A (en) * 1949-02-12 1950-12-19 American Cyanamid Co Powder dispenser
US2590832A (en) * 1949-03-29 1952-03-25 Frederick M Turnbull Inhaler with closure
GB704167A (en) * 1950-03-30 1954-02-17 Herbert Hammermann Anaesthesia apparatus
US3029002A (en) * 1958-06-02 1962-04-10 Resta S Gregoire Metering dispenser
US3204833A (en) * 1964-02-18 1965-09-07 Weitzner Adolph Never open container with a dispensing and measuring device
YU41046B (en) * 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
DE2502251A1 (de) * 1975-01-17 1976-07-22 Schering Ag Vorrichtung zur inhalation pulverfoermiger feststoffe
US4084729A (en) * 1975-08-28 1978-04-18 Maryland Cup Corporation Dispensing valve
US4274403A (en) * 1979-08-29 1981-06-23 Struve Roger L Inhaler
EP0028162B1 (de) * 1979-10-30 1985-01-23 Riker Laboratories, Inc. Atmungsbetätigte Vorrichtungen zum Verabreichen pulverförmiger Medikamente
FI79947C (fi) * 1981-07-08 1990-04-10 Draco Ab Perforerat membran foer anvaendning som uppmaetnings- och transportorgan vid en doserande andningsapparat.
EP0069715B1 (de) * 1981-07-08 1986-11-05 Aktiebolaget Draco Pulverinhalator
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
US4576157A (en) * 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
FI69962C (fi) * 1983-12-28 1986-09-12 Huhtamaeki Oy Inhalationsanordning
US4709837A (en) * 1984-05-01 1987-12-01 Merck & Co., Inc. Filter assembly for dry powder filling machine
FI69963C (fi) * 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
US4805811A (en) * 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
SE453566B (sv) * 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
SU1503827A1 (ru) * 1987-02-27 1989-08-30 Горьковский Научно-Исследовательский Педиатрический Институт Устройство дл введени лекарственных порошков
GB8804069D0 (en) * 1988-02-22 1988-03-23 Britains Petite Ltd Dispensers for powdered medication
DE69012458T3 (de) * 1989-05-31 2000-01-20 Fisons Plc, Ipswich Medikament und Inhalationsvorrichtung dafür.
CA1317194C (en) * 1989-05-31 1993-05-04 Yves Cloutier Device for specific inhalation challenge, method of use and improved generator of particules
US5239991A (en) * 1989-06-21 1993-08-31 Fisons Plc Disposable powder medicament inhalation device with peel-off cover
GB8919131D0 (en) * 1989-08-23 1989-10-04 Riker Laboratories Inc Inhaler
IT1237118B (it) * 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
DE4004904A1 (de) * 1990-02-16 1990-09-13 Gerhard Brendel Trommel-applikator
IT1240750B (it) * 1990-04-12 1993-12-17 Chiesi Farma Spa Dispositivo per la somministrazione di sostanze medicamentose in polvere
GB9025654D0 (en) * 1990-11-26 1991-01-09 Riker Laboratories Inc Device
NL9002706A (nl) * 1990-12-10 1992-07-01 Pharmachemie Bv Inrichting ten gebruike bij het inhaleren van in staafvormige capsules verpakte poedervormige stoffen.
US5320093A (en) * 1990-12-21 1994-06-14 Brigham And Women's Hospital Rapid anesthesia emergence system using closed-loop PCO2 control
US5243970A (en) * 1991-04-15 1993-09-14 Schering Corporation Dosing device for administering metered amounts of powdered medicaments to patients
US5320258A (en) * 1991-05-09 1994-06-14 Paul Kermit D Inlet port for rotary feeders
FR2676929B1 (fr) * 1991-05-30 1994-02-11 Aerosols Bouchage Ste Fse Inhalateur de poudres.
US5337740A (en) * 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5287850A (en) * 1991-08-20 1994-02-22 Habley Medical Technology Corporation Timing and velocity controlled powered pharmaceutical inhaler
US5341801A (en) * 1991-12-03 1994-08-30 Sandoz Ltd. Inhaler
DE4211475A1 (de) * 1991-12-14 1993-06-17 Asta Medica Ag Pulverinhalator
US5320094A (en) * 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
US5355872B1 (en) * 1992-03-04 1998-10-20 John H Riggs Low flow rate nebulizer apparatus and method of nebulization
US5239993A (en) * 1992-08-26 1993-08-31 Glaxo Inc. Dosage inhalator providing optimized compound inhalation trajectory
US5318015A (en) * 1992-09-03 1994-06-07 Sven Mansson Inhaler having ejector structure that provides primary and secondary atomization of an actuated dose of medicament
US5349946A (en) * 1992-10-07 1994-09-27 Mccomb R Carter Microprocessor controlled flow regulated molecular humidifier
US5318016A (en) * 1993-03-30 1994-06-07 We Pharmaceuticals, Inc. Inhalation device
US5349947A (en) * 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow

Also Published As

Publication number Publication date
DE4193534T1 (de) 1997-07-24
DK0533683T3 (da) 1997-01-13
US5295479A (en) 1994-03-22
ES2093702T3 (es) 1997-01-01
BR9106690A (pt) 1993-06-29
AU650873B2 (en) 1994-07-07
EP0533683B1 (de) 1996-09-25
GR3022073T3 (en) 1997-03-31
KR930700175A (ko) 1993-03-13
NO175136B (no) 1994-05-30
HK1006813A1 (en) 1999-03-19
LV10205A (lv) 1994-10-20
KR960002186B1 (ko) 1996-02-13
EP0533683A1 (de) 1993-03-31
ATE143273T1 (de) 1996-10-15
WO1992018188A1 (en) 1992-10-29
USRE35552E (en) 1997-07-08
LV10205B (en) 1995-06-20
RU2093197C1 (ru) 1997-10-20
NO175136C (no) 1994-09-07
NO924730D0 (no) 1992-12-08
AU7663291A (en) 1992-11-17
NO924730L (no) 1992-12-08
DE69122388T2 (de) 1997-03-27
LTIP929A (en) 1995-03-27
LT3557B (en) 1995-12-27

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8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: GROSSE, BOCKHORNI, SCHUMACHER, 45133 ESSEN

8328 Change in the person/name/address of the agent

Representative=s name: GROSSE, SCHUMACHER, KNAUER, VON HIRSCHHAUSEN, 4513

8339 Ceased/non-payment of the annual fee