DE68922602D1 - Polypeptide mit hormonwachstumsbefreiender wirkung. - Google Patents
Polypeptide mit hormonwachstumsbefreiender wirkung.Info
- Publication number
- DE68922602D1 DE68922602D1 DE68922602T DE68922602T DE68922602D1 DE 68922602 D1 DE68922602 D1 DE 68922602D1 DE 68922602 T DE68922602 T DE 68922602T DE 68922602 T DE68922602 T DE 68922602T DE 68922602 D1 DE68922602 D1 DE 68922602D1
- Authority
- DE
- Germany
- Prior art keywords
- polypeptides
- releasing effect
- hormone growth
- growth releasing
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 230000003578 releasing effect Effects 0.000 title 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 2
- 108010051696 Growth Hormone Proteins 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000122 growth hormone Substances 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14926788A | 1988-01-28 | 1988-01-28 | |
PCT/US1989/000201 WO1989007110A1 (en) | 1988-01-28 | 1989-01-18 | Polypeptide compounds having growth hormone releasing activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68922602D1 true DE68922602D1 (de) | 1995-06-14 |
DE68922602T2 DE68922602T2 (de) | 1995-12-07 |
Family
ID=22529506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68922602T Expired - Fee Related DE68922602T2 (de) | 1988-01-28 | 1989-01-18 | Polypeptide mit hormonwachstumsbefreiender wirkung. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5534494A (de) |
EP (1) | EP0400051B1 (de) |
JP (1) | JPH03502329A (de) |
AT (1) | ATE122357T1 (de) |
AU (1) | AU637316B2 (de) |
DE (1) | DE68922602T2 (de) |
NZ (1) | NZ227788A (de) |
WO (1) | WO1989007110A1 (de) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU628322B2 (en) * | 1988-01-28 | 1992-09-17 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
US5668254A (en) * | 1990-05-11 | 1997-09-16 | Romano Deghenghi | D-2-alkyl-tryptophan and peptides containing same |
US5872100A (en) * | 1990-05-11 | 1999-02-16 | Deghenghi; Romano | Peptides containing D-2-Alkyl-Tryptophan |
CA2086416A1 (en) * | 1990-07-24 | 1992-01-25 | John C. Hubbs | Process for synthesizing peptides |
US5486505A (en) * | 1990-07-24 | 1996-01-23 | Polygen Holding Corporation | Polypeptide compounds having growth hormone releasing activity |
IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
AU676525B2 (en) * | 1992-11-06 | 1997-03-13 | Merck & Co., Inc. | Substituted dipeptide analogs promote release of growth hormone |
SE9300937L (sv) * | 1993-03-19 | 1994-09-20 | Anne Fjellestad Paulsen | Komposition för oral administrering av peptider |
JP3810083B2 (ja) * | 1994-09-27 | 2006-08-16 | アーダナ・バイオサイエンス・リミテツド | 成長因子の放出を促進し得る2−アルキルトリプトファン含有ペプチド化合物 |
US6531314B1 (en) | 1996-12-10 | 2003-03-11 | Merck & Co., Inc. | Growth hormone secretagogue receptor family |
US6242199B1 (en) | 1995-12-13 | 2001-06-05 | Merck & Co., Inc. | Assays for growth hormone secretagogue receptors |
JP4116097B2 (ja) | 1997-06-20 | 2008-07-09 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン放出特性をもつ化合物 |
US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6682908B1 (en) | 1998-07-10 | 2004-01-27 | Merck & Co., Inc. | Mouse growth hormone secretagogue receptor |
CA2333857A1 (en) | 1998-07-13 | 2000-01-20 | Merck & Co., Inc. | Growth hormone secretagogue related receptors and nucleic acids |
EP1112282A4 (de) | 1998-08-10 | 2002-10-31 | Merck & Co Inc | Rezeptor des wachstumshormon-sekretionsförderers aus dem hund |
WO2000048623A1 (en) | 1999-02-18 | 2000-08-24 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
UA73530C2 (uk) | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
EP1159964B1 (de) | 2000-05-31 | 2009-10-28 | Pfizer Products Inc. | Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts |
HU229233B1 (en) * | 2000-06-13 | 2013-09-30 | Aeterna Zentaris Gmbh | Growth hormone secretagogues |
US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
US7268113B2 (en) | 2001-02-02 | 2007-09-11 | Conjuchem Biotechnologies Inc. | Long lasting growth hormone releasing factor derivatives |
US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
US6831102B2 (en) | 2001-12-07 | 2004-12-14 | Bristol-Myers Squibb Company | Phenyl naphthol ligands for thyroid hormone receptor |
US7015219B2 (en) | 2001-12-19 | 2006-03-21 | Bristol-Myers Squibb Company | 3-aryl-hydroxybenzoxazines and 3, 4-dihydro-3-aryl-hydroxybenzoxazines as selective estrogen receptor beta modulators |
US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
US7381730B2 (en) | 2002-03-15 | 2008-06-03 | Bristol-Myers Squibb Company | 3-arylquinazoline derivatives as selective estrogen receptor beta modulators |
WO2003094845A2 (en) | 2002-05-08 | 2003-11-20 | Bristol-Myers Squibb Company | Pyridine-based thyroid receptor ligands |
US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
WO2004017986A1 (en) | 2002-08-23 | 2004-03-04 | Valorisation-Recherche, Societe En Commandite | Growth hormone-releasing peptides in the treatment of prevention of atherosclerosis and hypercholesterolemia |
MY139563A (en) | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
WO2004045518A2 (en) | 2002-11-15 | 2004-06-03 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
TW200504021A (en) | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
WO2004069793A2 (en) | 2003-01-28 | 2004-08-19 | Bristol-Myers Squibb Company | Novel 2-substituted cyclic amines as calcium sensing receptor modulators |
US7205322B2 (en) | 2003-02-12 | 2007-04-17 | Bristol-Myers Squibb Company | Thiazolidine compounds as calcium sensing receptor modulators |
US7557143B2 (en) | 2003-04-18 | 2009-07-07 | Bristol-Myers Squibb Company | Thyroid receptor ligands |
US7459460B2 (en) | 2003-05-28 | 2008-12-02 | Bristol-Myers Squibb Company | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators |
US7265145B2 (en) | 2003-05-28 | 2007-09-04 | Bristol-Myers Squibb Company | Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
US20080261873A1 (en) | 2004-08-18 | 2008-10-23 | Elixir Pharmaceuticals, Inc. | Growth-Hormone Secretagogues |
US8143425B2 (en) | 2004-10-12 | 2012-03-27 | Bristol-Myers Squibb Company | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
US7456188B1 (en) | 2005-04-28 | 2008-11-25 | Bristol-Myers Squibb Company | C-5 substituted quinazolinone derivatives as selective estrogen receptor beta modulators |
EP1757290A1 (de) | 2005-08-16 | 2007-02-28 | Zentaris GmbH | Triazolderivate als Liganden der Wachstumshormonrezeptoren |
CN101299920A (zh) | 2005-08-31 | 2008-11-05 | 田纳西大学研究基金会 | 用选择性雄激素受体调节剂治疗肾病、烧伤、创伤和脊髓损伤 |
CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
BRPI0713179A2 (pt) | 2006-07-12 | 2012-03-27 | Univ Tennessee Res Foundation | processo para substituição e uso de compostos substitutos de acilanilidea |
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US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
BRPI0714526A2 (pt) | 2006-08-24 | 2013-04-30 | Univ Tennessee Res Foundation | acilanilidas substituÍdas e seus mÉtodos de uso |
US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
EP2644618B1 (de) | 2007-02-09 | 2016-08-17 | Ocera Therapeutics, Inc. | Intermediaten für die Synthese von Makrozyklische Ghrelin-Rezeptormodulatoren |
EP2155769B1 (de) | 2007-05-04 | 2012-06-27 | Katholieke Universiteit Leuven KU Leuven Research & Development | Schutz gegen gewebedegeneration |
US7994127B2 (en) | 2007-06-08 | 2011-08-09 | Massachusetts Institute Of Technology | Treatment of rett syndrome |
US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
EP2103602A1 (de) | 2008-03-17 | 2009-09-23 | AEterna Zentaris GmbH | Neuartige 1,2,4-Triazol-Derivate und Herstellungsverfahren dafür |
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US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
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Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4372884A (en) * | 1975-08-06 | 1983-02-08 | The Salk Institute For Biological Studies | Pharmaceutically active peptides |
US4061626A (en) * | 1976-04-29 | 1977-12-06 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
US4105603A (en) * | 1977-03-28 | 1978-08-08 | The Salk Institute For Biological Studies | Peptides which effect release of hormones |
US4127529A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel eicosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said eicosapeptides |
US4127528A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel derivatives of alpha-endorphin, intermediates therefor and compositions and methods employing said derivatives |
US4127540A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel derivatives of δ-endorphins, intermediates therefor, and compositions and methods employing said derivatives |
US4312857A (en) * | 1977-06-16 | 1982-01-26 | The United States Of America As Represented By The Veterans Administration | Novel derivatives of beta-endorphin, intermediates therefor and compositions and methods employing said derivatives |
US4127519A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Octadecapeptides, intermediates therefor, and compositions and methods employing said octadecapeptides |
US4127517A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel docosapeptides, intermediates therefore and pharmaceutical compositions and methods employing said docosapeptides |
US4127523A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel undecapeptides, intermediates therefor, and compositions and methods employing said undecapeptides |
US4127536A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tricosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said tricosapeptides |
US4127524A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel dodecapeptides, intermediates therefor, and compositions and methods employing said dodecapeptides |
US4139504A (en) * | 1977-06-16 | 1979-02-13 | Coy David Howard | Novel nonapeptides, intermediates therefor, and compositions and methods employing said nonapeptides |
US4127520A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel nonadecapeptides, intermediates therefor, and compositions and methods employing said nonadecapeptides |
US4127532A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel heptapeptides, intermediates therefor, and compositions and methods employing said heptapeptides |
US4127537A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tetracosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said tetracosapeptides |
US4127531A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel hexapeptides, intermediates therefor, and compositions and methods employing said hexapeptides |
US4127526A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tetradecapeptides, intermediates therefor, and compositions and methods employing said tetradecapeptides |
US4127534A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tripeptides, intermediates therefor and pharmaceutical compositions and methods employing said tripeptides |
US4127530A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel heneicosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said heneicosapeptides |
US4127522A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel triacontapeptides, intermediates therefor and pharmaceutical compositions and methods employing said triacontapeptides |
US4127535A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel dipeptides, intermediates therefor, and compositions and methods employing said dipeptides |
US4127525A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel tridecapeptides, intermediates therefor, and compositions and methods employing said tridecapeptides |
US4127538A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel pentacosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said pentacosapeptides |
US4127527A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel pentadecapeptides, intermediates therefor, and compositions and methods employing said pentadecapeptides |
US4127518A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel derivatives of gamma-endorphins, intermediates therefor, and compositions and methods employing said derivatives |
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US4127521A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel octacosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said octacosapeptides |
US4127533A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel octapeptides, intermediates therefor, and compositions and methods employing said octapeptides |
US4127541A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel decapeptides, intermediates therefor, and compositions and methods employing said decapeptides |
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US4223021A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
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US4223019A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4228158A (en) * | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4228156A (en) * | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4226857A (en) * | 1979-03-30 | 1980-10-07 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4228157A (en) * | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4223020A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
AU5680180A (en) * | 1979-03-30 | 1980-10-02 | Beckman Instruments, Inc. | Peptides |
CA1175810A (en) * | 1979-03-30 | 1984-10-09 | Frank A. Momany | Synthetic peptides having pituitary growth hormone releasing activity |
NL8005121A (nl) * | 1979-09-20 | 1981-03-24 | Erba Farmitalia | Biologisch actieve peptiden. |
US4316891A (en) * | 1980-06-14 | 1982-02-23 | The Salk Institute For Biological Studies | Extended N-terminal somatostatin |
US4393050A (en) * | 1981-04-29 | 1983-07-12 | The Salk Institute For Biological Studies | Analogs of extended N-terminal somatostatin |
JPS58501861A (ja) * | 1981-12-28 | 1983-11-04 | ベツクマン・インストルメンツ・インコ−ポレ−テツド | 下垂体成長ホルモン放出活性を有する合成ペプチド |
US4410513A (en) * | 1981-12-28 | 1983-10-18 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4410512A (en) * | 1981-12-28 | 1983-10-18 | Beckman Instruments, Inc. | Combinations having synergistic pituitary growth hormone releasing activity |
US4428942A (en) * | 1982-05-17 | 1984-01-31 | The Salk Institute For Biological Studies | Analogs of somatostatin |
US4517181A (en) * | 1982-09-15 | 1985-05-14 | The Salk Institute For Biological Studies | Mammalian PGRF |
US4595676A (en) * | 1983-04-26 | 1986-06-17 | The Salk Institute For Biological Studies | Rat hypothalamic GRF |
US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
US4529595A (en) * | 1983-01-13 | 1985-07-16 | The Salk Institute For Biological Studies | GRF Analogs |
US4491541A (en) * | 1982-11-10 | 1985-01-01 | Farmitalia Carlo Erba | Peptides |
US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
US4505897A (en) * | 1983-04-18 | 1985-03-19 | The Administrators Of The Tulane Educational Fund | Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith |
US4508711A (en) * | 1983-04-18 | 1985-04-02 | American Cyanamid Company | Cyclic pentapeptide displaying somatostatin antagonism and method of treatment of mammals therewith |
US4628043A (en) * | 1983-04-26 | 1986-12-09 | The Salk Institute For Biological Studies | Hypothalamic GRF agonists |
US4605643A (en) * | 1984-03-02 | 1986-08-12 | The Salk Institute For Biological Studies | Ovine GRF |
US4610976A (en) * | 1983-08-29 | 1986-09-09 | The Salk Institute For Biological Studies | Porcine GRF |
US4585756A (en) * | 1983-10-12 | 1986-04-29 | The Salk Institute For Biological Studies | Bovine GRF |
US4626523A (en) * | 1983-09-13 | 1986-12-02 | The Salk Institute For Biological Studies | GRF analogs II |
US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
US4562175A (en) * | 1984-02-03 | 1985-12-31 | Ding Chang | Synthetic peptides |
US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
US4622312A (en) * | 1984-09-24 | 1986-11-11 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
IL79134A (en) * | 1985-07-29 | 1991-06-10 | American Cyanamid Co | Continuous release peptide implants for parenteral administration |
US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
-
1989
- 1989-01-18 EP EP89902569A patent/EP0400051B1/de not_active Expired - Lifetime
- 1989-01-18 WO PCT/US1989/000201 patent/WO1989007110A1/en active IP Right Grant
- 1989-01-18 AT AT89902569T patent/ATE122357T1/de not_active IP Right Cessation
- 1989-01-18 JP JP1502383A patent/JPH03502329A/ja active Pending
- 1989-01-18 AU AU30659/89A patent/AU637316B2/en not_active Ceased
- 1989-01-18 DE DE68922602T patent/DE68922602T2/de not_active Expired - Fee Related
- 1989-01-30 NZ NZ227788A patent/NZ227788A/xx unknown
-
1994
- 1994-04-21 US US08/231,986 patent/US5534494A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU3065989A (en) | 1989-08-25 |
ATE122357T1 (de) | 1995-05-15 |
US5534494A (en) | 1996-07-09 |
NZ227788A (en) | 1991-10-25 |
WO1989007110A1 (en) | 1989-08-10 |
EP0400051A1 (de) | 1990-12-05 |
JPH03502329A (ja) | 1991-05-30 |
DE68922602T2 (de) | 1995-12-07 |
EP0400051B1 (de) | 1995-05-10 |
AU637316B2 (en) | 1993-05-27 |
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