DE68919715D1 - Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. - Google Patents

Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien.

Info

Publication number
DE68919715D1
DE68919715D1 DE1989619715 DE68919715A DE68919715D1 DE 68919715 D1 DE68919715 D1 DE 68919715D1 DE 1989619715 DE1989619715 DE 1989619715 DE 68919715 A DE68919715 A DE 68919715A DE 68919715 D1 DE68919715 D1 DE 68919715D1
Authority
DE
Grant status
Grant
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1989619715
Other languages
English (en)
Other versions
DE68919715T2 (de )
Inventor
Stefan Miltenyi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MILTENYI BIOTEC GMBH, 51429 BERGISCH GLADBACH, DE
Original Assignee
Stefan Miltenyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • G01N33/5434Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/002High gradient magnetic separation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/005Pretreatment specially adapted for magnetic separation
    • B03C1/01Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/034Component parts; Auxiliary operations characterised by the magnetic circuit characterised by the matrix elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/12Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar
    • G01N2400/14Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar alpha-D-Glucans, i.e. having alpha 1,n (n=3,4,6) linkages between saccharide units, e.g. pullulan
    • G01N2400/22Dextran
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00Magnetic particle immunoreagent carriers
    • G01N2446/20Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00Magnetic particle immunoreagent carriers
    • G01N2446/30Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00Magnetic particle immunoreagent carriers
    • G01N2446/80Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/90Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/803Physical recovery methods, e.g. chromatography, grinding
DE1989619715 1988-12-28 1989-12-22 Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. Expired - Lifetime DE68919715T2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US29117788 true 1988-12-28 1988-12-28
PCT/EP1989/001602 WO1990007380A3 (en) 1988-12-28 1989-12-22 Methods and materials for high gradient magnetic separation of biological materials

Publications (2)

Publication Number Publication Date
DE68919715D1 true DE68919715D1 (de) 1995-01-12
DE68919715T2 DE68919715T2 (de) 1995-04-06

Family

ID=23119207

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1989619715 Expired - Lifetime DE68919715T2 (de) 1988-12-28 1989-12-22 Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien.

Country Status (5)

Country Link
US (2) US5411863A (de)
EP (1) EP0452342B1 (de)
DE (1) DE68919715T2 (de)
ES (1) ES2067018T3 (de)
WO (1) WO1990007380A3 (de)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020210A (en) * 1988-12-28 2000-02-01 Miltenvi Biotech Gmbh Methods and materials for high gradient magnetic separation of biological materials
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
ES2067018T3 (es) * 1988-12-28 1995-03-16 Stefan Miltenyi Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos.
US5622831A (en) * 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
JPH06510363A (de) * 1990-10-29 1994-11-17
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US5795470A (en) * 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
US5186827A (en) * 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US6664114B1 (en) 1992-08-03 2003-12-16 Sapidyne Instruments, Inc. Solid phase assay for detection of ligands
WO1994007138A1 (en) 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
WO1994020855A1 (en) * 1993-03-04 1994-09-15 Sapidyne, Inc. Assay flow apparatus and method
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
DE69516401T3 (de) 1994-03-10 2006-06-01 Oystein Fodstad Verfahren und vorrichtung zum nachweis spezifischer zielzellen in spezialisierten und gemischten zellpopulationen und in lösungen, die gemischte zellpopulationen enthalten
US5541072A (en) * 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
DE4416784A1 (de) * 1994-05-09 1995-11-30 Soft Gene Gmbh Methode zur Anreicherung von Zellen, die durch ballistischen Transfer modifiziert wurden
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
DE19516323C2 (de) * 1995-04-27 1997-02-27 Dirk Dipl Chem Guenther Verfahren zur Herstellung von magnetisierbaren Dispersionen und deren Verwendung
DE19520298A1 (de) * 1995-06-02 1996-12-05 Bayer Ag Sortiervorrichtung für biologische Zellen oder Viren
US5639669A (en) * 1995-06-07 1997-06-17 Ledley; Robert Separation of fetal cells from maternal blood
US5741714A (en) * 1995-07-18 1998-04-21 Immunivest Corporation Detection of bound analyte by magnetic partitioning and masking
DE19528029B4 (de) 1995-07-31 2008-01-10 Chemagen Biopolymer-Technologie Aktiengesellschaft Magnetische Polymerpartikel auf der Basis von Polyvinylalkohol, Verfahren für ihre Herstellung und Verwendung
US6190870B1 (en) 1995-08-28 2001-02-20 Amcell Corporation Efficient enrichment and detection of disseminated tumor cells
US6140040A (en) * 1995-10-06 2000-10-31 Advanced Minerals Corporation Method of mechanically separating microparticles suspended in fluids using particulate media
JP2000507230A (ja) 1996-03-13 2000-06-13 フォットスタ,オイスタイン 望ましくない標的細胞の破壊方法
DE19612001A1 (de) 1996-03-18 1997-09-25 Silica Gel Gmbh Adsorptions Te Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung
US5843633A (en) * 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
US6455678B1 (en) 1996-04-26 2002-09-24 Amcell Corporation Human hematopoietic stem and progenitor cell antigen
ES2313800T3 (es) * 1998-11-30 2009-03-01 Veridex, Llc Aparato y procedimiento de separacion magnetica.
US6660159B1 (en) 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
US6790366B2 (en) * 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
US6136182A (en) * 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
US6890426B2 (en) * 1996-06-07 2005-05-10 Immunivest Corporation Magnetic separation apparatus and methods
US7666308B2 (en) * 1996-06-07 2010-02-23 Veridex, Llc. Magnetic separation apparatus and methods
EP0920627B1 (de) * 1996-06-07 2004-05-12 Immunivest Corporation Magnetische trennung mit hilfe von externen und internen gradienten
CA2262685C (en) * 1996-08-05 2008-09-23 Schering Aktiengesellschaft Process and device for separating magnetic materials from pharmaceutical compositions, their starting or intermediate products and agents produced by means of this device
JP2001503859A (ja) * 1996-10-15 2001-03-21 バイオ―テック・イメイジング・インコーポレイテッド Hiv感染細胞の検出試薬系およびそのためのキット
US5817458A (en) * 1996-10-15 1998-10-06 The Avriel Group, Amcas Division Inc. Reagent system for detecting HIV-infected peripheral blood lymphocytes in whole blood
US5779892A (en) * 1996-11-15 1998-07-14 Miltenyi Biotec Gmbh Magnetic separator with magnetic compensated release mechanism for separating biological material
US5798206A (en) * 1997-01-10 1998-08-25 New York Blood Center Methods for screening of test compounds for inhibiting binding of a CD4-HIV 1 complex to a chemokine receptor
FR2758884B1 (fr) 1997-01-30 1999-04-02 Bio Merieux Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu
US6241894B1 (en) 1997-10-10 2001-06-05 Systemix High gradient magnetic device and method for cell separation or purification
CA2260991C (en) 1997-11-18 2009-03-24 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase
US6337215B1 (en) * 1997-12-01 2002-01-08 International Business Machines Corporation Magnetic particles having two antiparallel ferromagnetic layers and attached affinity recognition molecules
ES2279600T3 (es) * 1998-03-12 2007-08-16 Miltenyi Biotec Gmbh Sistema de microcolumna para separacion magnetica.
US7220596B2 (en) 1998-04-15 2007-05-22 Utah State University Real time detection of antigens
EP1078263B1 (de) 1998-05-11 2009-07-22 Miltenyi Biotech GmbH. Verfahren zur direkten auswahl von antigen-spezifischen t-zellen
US7364921B1 (en) 1999-01-06 2008-04-29 University Of Medicine And Dentistry Of New Jersey Method and apparatus for separating biological materials and other substances
US6159378A (en) * 1999-02-23 2000-12-12 Battelle Memorial Institute Apparatus and method for handling magnetic particles in a fluid
US6193892B1 (en) 1999-03-03 2001-02-27 Promega Corporation Magnetic separation assembly and method
US6312910B1 (en) 1999-04-09 2001-11-06 Shot, Inc. Multistage electromagnetic separator for purifying cells, chemicals and protein structures
DE19938372A1 (de) * 1999-08-09 2001-03-08 Diagnostikforschung Inst Verfahren und Vorrichtung zur Trennung magnetischer Teilchen
DE60026729D1 (de) * 1999-09-03 2006-05-11 Miltenyi Biotec Gmbh Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule
US7169618B2 (en) 2000-06-28 2007-01-30 Skold Technology Magnetic particles and methods of producing coated magnetic particles
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US7615340B2 (en) * 2000-10-03 2009-11-10 Minerva Biotechnologies Corporation Electronic detection of interaction and detection of interaction based on the interruption of flow
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
FR2817967B1 (fr) * 2000-12-08 2003-02-28 Diagast Procede de magnetisation de marqueurs chimiques ou biologiques
US20030095897A1 (en) * 2001-08-31 2003-05-22 Grate Jay W. Flow-controlled magnetic particle manipulation
EP1442115B9 (de) 2001-11-15 2009-12-16 Children's Medical Center Corporation Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon
US20030099954A1 (en) * 2001-11-26 2003-05-29 Stefan Miltenyi Apparatus and method for modification of magnetically immobilized biomolecules
US7232691B2 (en) * 2001-11-27 2007-06-19 Los Alamos National Security, Llc Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
WO2003049530A3 (en) * 2001-12-07 2004-09-30 Dyax Corp Method and apparatus for washing magnetically responsive particles
JP2005522679A (ja) * 2002-04-12 2005-07-28 インストゥルメンテイション ラボラトリー カンパニー イムノアッセイプローブ
US9435799B2 (en) * 2002-07-31 2016-09-06 Janssen Diagnostics, Inc. Methods and reagents for improved selection of biological materials
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
CA2494450A1 (en) 2002-08-27 2004-03-11 Stemcells, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US7601491B2 (en) * 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
DE10331439B3 (de) * 2003-07-10 2005-02-03 Micromod Partikeltechnologie Gmbh Magnetische Nanopartikel mit verbesserten Magneteigenschaften
DE112004002408T5 (de) * 2003-12-10 2007-01-04 University Of Utah Research Foundation, Salt Lake City Verfahren zur Gewinnung einer angereicherten Population von siRNA-exprimierenden Zellen
WO2005065267A3 (en) * 2003-12-24 2006-05-11 Massachusetts Inst Technology Magnetophoretic cell clarification
US8211386B2 (en) * 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US9790539B2 (en) * 2004-06-30 2017-10-17 Russell Biotech, Inc. Methods and reagents for improved selection of biological molecules
US20060024776A1 (en) * 2004-08-02 2006-02-02 Mcmillian Ray Magnetic particle capture of whole intact organisms from clinical samples
CA2575784A1 (en) * 2004-08-03 2006-02-16 Becton, Dickinson And Company Use of magnetic material to fractionate samples
US7897257B2 (en) * 2005-04-18 2011-03-01 Ge Healthcare Bio-Sciences Ab Magnetic beads comprising an outer coating of hydrophilic porous polymer and method of making thereof
EP1996931B1 (de) 2005-12-28 2013-11-27 The General Hospital Corporation Blutzellen-sortierungsverfahren und -systeme
US7862813B2 (en) 2006-07-29 2011-01-04 Bjork Jr Robert Lamar Bi-specific monoclonal antibody (specific for both CD3 and CD11b) therapeutic drug
US8168393B2 (en) 2007-02-16 2012-05-01 The Brigham And Women's Hospital, Inc. Compositions and methods for diagnosing tumors using LEDGF/p75
EP2227334B1 (de) 2007-12-07 2011-10-12 Miltenyi Biotec GmbH Zentrifuge zur trennung einer probe in mindestens zwei komponenten
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
EP2727998A3 (de) 2008-04-21 2014-08-13 Viacyte, Inc. Verfahren zur Aufreinigung von menschlichen embryonalen Stammzellen abgeleiteter pankreatischer Endodermzellen
WO2010006328A3 (en) * 2008-07-11 2010-04-22 The General Hospital Corporation Magnetic apparatus for blood separation
WO2010057039A3 (en) 2008-11-14 2010-12-02 Cythera, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
EP3187581A1 (de) 2008-12-23 2017-07-05 BOCO Silicon Valley, Inc. Zielpopulationen von oligodendrozyten-vorläuferzellen und verfahren zur herstellung und verwendung davon
GB0823553D0 (en) * 2008-12-24 2009-01-28 Immunosolv Ltd Cell separation technique
US8790916B2 (en) * 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
CN102470373B (zh) * 2009-07-17 2014-11-26 皇家飞利浦电子股份有限公司 用于富集磁性粒子的设备
US8083069B2 (en) * 2009-07-31 2011-12-27 General Electric Company High throughput magnetic isolation technique and device for biological materials
US8701893B2 (en) * 2009-12-23 2014-04-22 Industrial Technology Research Institute Magnetic separation device and method for separating magnetic substance in bio-samples
EP2390661B1 (de) 2010-05-02 2015-06-24 Miltenyi Biotec GmbH Verankerungs-/Erfassungsmittel zum Auswählen oder Analysieren einer CHO-Zelle entsprechend einem Produkt, das von der CHO-Zelle sezerniert wird
DE102011015321A1 (de) 2011-03-28 2012-10-04 Ralph Heindrichs Verfahren zur kontinuierlichen selektiven Separation von Partikeln mittels Magnetismus
US8993342B2 (en) 2011-04-11 2015-03-31 Industrial Technology Research Institute Magnetic separation unit, magnetic separation device and method for separating magnetic substance in bio-samples
CN103501912B (zh) 2011-04-27 2017-10-24 贝克顿·迪金森公司 用于分离样品中磁性标记部分的设备和方法
EP2597153B1 (de) 2011-11-25 2016-10-05 Miltenyi Biotec GmbH Zelltrennverfahren
EP2634195B1 (de) 2012-03-01 2017-02-01 Miltenyi Biotec GmbH Trennung von lebenden unberührten Neuronen
DE102012213032A1 (de) * 2012-07-25 2014-01-30 Siemens Aktiengesellschaft Verfahren zum Entwässern einer wasserhaltigen Zellkultur
EP3326721A1 (de) 2012-08-29 2018-05-30 Inguran, LLC Magnetische entfernung oder identifizierung von beschädigten oder beeinträchtigten spermatozoiden
EP2912189A4 (de) 2012-10-26 2016-10-26 Becton Dickinson Co Vorrichtungen und verfahren zur manipulation von komponenten in einer flüssigkeitsprobe
EP2787006B1 (de) 2013-04-02 2018-02-28 Miltenyi Biotec GmbH Anti-CD8 Antikörper mit kalziumabhängiger Bindung
EP3015172A4 (de) * 2013-06-28 2017-03-01 Nat Inst Advanced Ind Science & Tech Matrix für einen magnetabscheider und magnetabscheider
WO2016166568A1 (en) 2015-04-16 2016-10-20 Juno Therapeutics Gmbh Methods, kits and apparatus for expanding a population of cells
US20170037369A1 (en) 2014-04-23 2017-02-09 Juno Therapeutics, Inc. Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
EP3143410A1 (de) 2014-05-15 2017-03-22 Kellbenx Inc. Herstellung fetaler nukleierter erythrozyten für diagnostische tests
EP2955521A1 (de) 2014-06-11 2015-12-16 Centre Hospitalier Universitaire Vaudois (CHUV) Verfahren zur Trennung von Zellen
CA2962915A1 (en) 2014-08-28 2016-03-03 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for cd19
US20160206656A1 (en) 2014-10-20 2016-07-21 Juno Therapeutics, Inc. Methods and compositions for dosing in adoptive cell therapy
WO2016073602A3 (en) 2014-11-05 2016-06-30 Juno Therapeutics, Inc. Methods for transduction and cell processing
US20160158359A1 (en) 2014-12-03 2016-06-09 Juno Therapeutics, Inc. Methods and compositions for adoptive cell therapy
CN107428833A (zh) 2015-01-16 2017-12-01 朱诺治疗学股份有限公司 Ror1特异性抗体和嵌合抗原受体
WO2016196388A1 (en) 2015-05-29 2016-12-08 Juno Therapeutics, Inc. Composition and methods for regulating inhibitory interactions in genetically engineered cells
WO2017068421A1 (en) 2015-10-22 2017-04-27 Juno Therapeutics Gmbh Methods for culturing cells and kits and apparatus for same
CA3002742A1 (en) 2015-10-22 2017-04-27 Juno Therapeutics Gmbh Methods, kits, agents and apparatuses for transduction
CA3002751A1 (en) 2015-10-22 2017-04-27 Juno Therapeutics Gmbh Methods for culturing cells and kits and apparatus for same
WO2017079703A1 (en) 2015-11-05 2017-05-11 Juno Therapeutics, Inc. Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
CA3002990A1 (en) 2015-11-05 2017-05-11 Juno Therapeutics, Inc. Chimeric receptors containing traf-inducing domains and related compositions and methods
CA3007258A1 (en) 2015-12-03 2017-06-08 Mark L. Bonyhadi Compositions and methods for reducing immune responses against cell therapies
CA3007262A1 (en) 2015-12-03 2017-06-08 Lucas James Thompson Modified chimeric receptors and related compositions and methods
WO2017161212A1 (en) 2016-03-16 2017-09-21 Juno Therapeutics, Inc. Methods for adaptive design of a treatment regimen and related treatments
WO2017161208A1 (en) 2016-03-16 2017-09-21 Juno Therapeutics, Inc. Methods for determining dosing of a therapeutic agent and related treatments
WO2017165571A1 (en) 2016-03-22 2017-09-28 Seattle Children's Hospital (dba Seattle Children's Research Institute) Early intervention methods to prevent or ameliorate toxicity
WO2017214207A3 (en) 2016-06-06 2018-01-18 Juno Therapeutics, Inc. Methods for the treatment of b cell malignancies using adoptive cell therapy
WO2018005559A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
WO2018005556A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Mhc-e restricted epitopes, binding molecules and related methods and uses
WO2018023093A1 (en) 2016-07-29 2018-02-01 Juno Therapeutics, Inc. Immunomodulatory polypeptides and related compositions and methods
WO2018023100A3 (en) 2016-07-29 2018-03-08 Juno Therapeutics, Inc. Anti-idiotypic antibodies against anti-cd19 antibodies
WO2018023094A1 (en) 2016-07-29 2018-02-01 Juno Therapeutics, Inc. Methods for assessing the presence or absence of replication competent virus
WO2018039637A1 (en) 2016-08-26 2018-03-01 Juno Therapeutics, Inc. Methods of enumerating particles present in a cell composition
WO2018049420A1 (en) 2016-09-12 2018-03-15 Juno Therapeutics, Inc. Perfusion bioreactor bag assemblies
WO2018067618A1 (en) 2016-10-03 2018-04-12 Juno Therapeutics, Inc. Hpv-specific binding molecules
WO2018071873A2 (en) 2016-10-13 2018-04-19 Juno Therapeutics, Inc. Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators
WO2018085731A2 (en) 2016-11-03 2018-05-11 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and a btk inhibitor

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1235686A (en) * 1967-02-16 1971-06-16 Rolf Saxholm Improvements in diffusion testing and apparatus therefor
US3981776A (en) * 1967-02-16 1976-09-21 Rolf Saxholm Magnetically responsive, biologically active substance and associated methods and apparatus
US4992377B1 (en) * 1967-02-16 1996-10-15 Saxholm As Article for carrying out biological or chemical procedures containing magnetically responsive material
US4021308A (en) * 1967-02-16 1977-05-03 Rolf Saxholm Apparatus associated with magnetically responsive, biologically active substance for testing thereof
US4140582A (en) * 1969-05-03 1979-02-20 Rolf Saxholm Supporting element for use in microbiological, serological, immunological clinical-chemical and similar laboratory work
DK130690C (de) * 1969-05-03 1975-09-01 Saxholm Rolf
US3985608A (en) * 1969-05-03 1976-10-12 Rolf Saxholm Supporting element for use in microbiological, serological, immunological, clinical-chemical and similar laboratory work
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4018886A (en) * 1975-07-01 1977-04-19 General Electric Company Diagnostic method and device employing protein-coated magnetic particles
US4657868A (en) * 1980-01-15 1987-04-14 Rolf Saxholm Apparatus for testing reactions
US4213825A (en) * 1976-08-23 1980-07-22 Rolf Saxholm Apparatus for testing reactions
US4371624A (en) * 1976-08-23 1983-02-01 Rolf Saxholm Apparatus and testing reactions
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
US4375407A (en) * 1981-06-22 1983-03-01 The Franklin Institute High gradient magnetic separation device
DE3200988C2 (de) * 1982-01-14 1987-08-20 Thomas A. Dr. 6900 Heidelberg De Reed
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4526681A (en) * 1983-10-31 1985-07-02 Purdue Research Foundation Magnetic separation method utilizing a colloid of magnetic particles
US4677067A (en) * 1984-06-22 1987-06-30 Bio-Magnetech Corporation Magnetotactic bacteria in clinical assay, immunoassay, and cell separation procedures and the like
DE3522365A1 (de) * 1985-06-22 1987-01-02 Bayer Ag Trenngeraet fuer magnetische partikel aus fluessiger phase
US4666595A (en) * 1985-09-16 1987-05-19 Coulter Electronics, Inc. Apparatus for acoustically removing particles from a magnetic separation matrix
US4664796A (en) * 1985-09-16 1987-05-12 Coulter Electronics, Inc. Flux diverting flow chamber for high gradient magnetic separation of particles from a liquid medium
US4738777A (en) * 1986-06-12 1988-04-19 Amsted Industries Incorporated Pressure filter media mounting assembly
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
DE3624626A1 (de) * 1986-07-18 1988-01-28 Pilgrimm Herbert Verfahren zur abtrennung von stoffen aus einem stoffgemisch unter verwendung von magnetischen fluessigkeiten
ES2067018T3 (es) * 1988-12-28 1995-03-16 Stefan Miltenyi Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos.
US5411730A (en) * 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles

Also Published As

Publication number Publication date Type
US5411863A (en) 1995-05-02 grant
EP0452342B1 (de) 1994-11-30 grant
ES2067018T3 (es) 1995-03-16 grant
EP0452342A1 (de) 1991-10-23 application
WO1990007380A3 (en) 1990-09-07 application
US5543289A (en) 1996-08-06 grant
DE68919715T2 (de) 1995-04-06 grant
WO1990007380A2 (en) 1990-07-12 application

Similar Documents

Publication Publication Date Title
DE3530567A1 (de) Verfahren und vorrichtung zur werkzeugtastpruefung
DE3435059A1 (de) Verfahren und vorrichtung zur kontinuierlichen bestimmung der anisotropiezustaende von optisch aktiven materialien
DE3515615A1 (de) Verfahren und vorrichtung zur alkoholfermentation
DE3411264A1 (de) Verfahren und vorrichtung zur erzeugung von biogas
DE68908409T2 (de) Vorrichtung und verfahren zur herstellung von faserplatten.
DE3505091A1 (de) Verfahren und vorrichtung zur fluessigkeitsbehandlung von insbesondere gewebeschlaeuchen
DE3875389T2 (de) Apparat und verfahren zur schnellen bestimmung eines haematokrit-wertes.
DE3876018T2 (de) Verfahren und vorrichtung zur elektrothermischen atomisierung von proben.
DE69006213T2 (de) Verfahren und gerät zur nichtzerstörenden kennzeichnung von komposit-schichtkörpern.
DE69032811T2 (de) Verfahren und System zur modularen Multiplikation
DE68903601T2 (de) Verfahren zur hydroxylierung von phenolen und phenolaethern.
DE3434004A1 (de) Verfahren und vorrichtung zur muellvergasung
DE3402084A1 (de) Verfahren und vorrichtung zur spinnfasernformation
DE29714492U1 (de) Vorrichtung zur Cryokonservierung von biologischen Materialien
DE3304462A1 (de) Bohrloch-instrument sowie verfahren zur herstellung und benutzung desselben
DE3407154A1 (de) Verfahren und vorrichtung zur herstellung von zement
DE3872494T2 (de) Kraftfahrzeuginformationsuebertragungsvorrichtung und verfahren zur anwendung der vorrichtung.
DE68908035T2 (de) Verfahren und Vorrichtung zur quantitativen Bestimmung und Anzeige des absoluten Wertes einer Rückstreustrahlung.
DE69033739T2 (de) Verfahren und Vorrichtung zur Sputterbeschichtung gestufter Wafer - Fall B
DE3428968A1 (de) Verfahren und vorrichtung zur zerlegung von rohargon
DE68924563T2 (de) Verfahren und Vorrichtung zur Oberflächenanalyse.
DE3539541A1 (de) Fluessigkeitszusammensetzung und verfahren zur aufzeichnung
DE69022766T2 (de) Verfahren und Gerät zur Binärzählerprüfung.
DE3874041T2 (de) Vorrichtung und verfahren zur tiefsttemperaturmaterialbehandlung.
DE3586510T2 (de) Verfahren und vorrichtung zur bilduebertragung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MILTENYI BIOTEC GMBH, 51429 BERGISCH GLADBACH, DE

8381 Inventor (new situation)

Free format text: MILTENYI, STEFAN, 51429 BERGISCH GLADBACH, DE