DE68907876D1 - Substanz dc 113 und verfahren zu ihrer herstellung. - Google Patents
Substanz dc 113 und verfahren zu ihrer herstellung.Info
- Publication number
- DE68907876D1 DE68907876D1 DE8989124068T DE68907876T DE68907876D1 DE 68907876 D1 DE68907876 D1 DE 68907876D1 DE 8989124068 T DE8989124068 T DE 8989124068T DE 68907876 T DE68907876 T DE 68907876T DE 68907876 D1 DE68907876 D1 DE 68907876D1
- Authority
- DE
- Germany
- Prior art keywords
- substance
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63332304A JP2598116B2 (ja) | 1988-12-28 | 1988-12-28 | 新規物質dc113 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68907876D1 true DE68907876D1 (de) | 1993-09-02 |
DE68907876T2 DE68907876T2 (de) | 1994-02-24 |
Family
ID=18253463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE89124068T Expired - Fee Related DE68907876T2 (de) | 1988-12-28 | 1989-12-28 | Substanz DC 113 und Verfahren zu ihrer Herstellung. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5101038A (de) |
EP (1) | EP0376300B1 (de) |
JP (1) | JP2598116B2 (de) |
CA (1) | CA2006821C (de) |
DE (1) | DE68907876T2 (de) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0520435A3 (en) * | 1991-06-28 | 1993-05-05 | Kyowa Hakko Kogyo Co., Ltd. | Dc-89 derivatives |
JP3514490B2 (ja) * | 1992-08-21 | 2004-03-31 | 杏林製薬株式会社 | トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法 |
US5388158A (en) * | 1992-11-20 | 1995-02-07 | Pitney Bowes Inc. | Secure document and method and apparatus for producing and authenticating same |
CN101671335A (zh) | 2001-05-31 | 2010-03-17 | 梅达莱克斯公司 | 细胞毒素、其有用的前体药物、连接基团和稳定剂 |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
WO2005112919A2 (en) * | 2004-05-19 | 2005-12-01 | Medarex, Inc. | Self-immolative linkers and drug conjugates |
CA2598522A1 (en) * | 2005-02-18 | 2006-08-24 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen (psma) |
US8323645B2 (en) | 2005-03-24 | 2012-12-04 | Millennium Pharmaceuticals, Inc. | Antibodies that bind OV064 and methods of use therefor |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
ES2416136T3 (es) | 2005-09-26 | 2013-07-30 | Medarex, Inc. | Conjugados de anticuerpo-fármaco y su uso |
RS52100B (en) | 2005-10-26 | 2012-06-30 | Medarex, Inc. | PROCEDURES AND UNITS FOR PREPARING ANALOG CC-1065 |
CA2627190A1 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
KR101552735B1 (ko) | 2006-12-01 | 2015-09-14 | 메다렉스, 엘.엘.시. | 씨디22에 결합하는 인간 항체 및 이의 용도 |
CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
CA2672468A1 (en) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind cd70 and uses thereof |
TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
US8664407B2 (en) * | 2007-02-21 | 2014-03-04 | Medarex, LLC | Chemical linkers with single amino acids and conjugates thereof |
EP2185188B1 (de) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Ortsspezifische bindung von wirkstoffen oder anderen mitteln an gentechnisch hergestellte antikörper mit c-terminalen erweiterungen |
PT2195017E (pt) | 2007-10-01 | 2014-12-31 | Bristol Myers Squibb Co | Anticorpos humanos que se ligam à mesotelina e utilizações dos mesmos |
TW200930407A (en) * | 2007-11-30 | 2009-07-16 | Medarex Inc | Conjugates of anti-RG-1 antibodies |
CA2939492C (en) | 2009-05-13 | 2019-03-19 | Genzyme Corporation | Anti-human cd52 immunoglobulins |
WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
US20120231004A1 (en) | 2009-10-13 | 2012-09-13 | Oxford Biotherapeutic Ltd. | Antibodies |
WO2012016227A2 (en) | 2010-07-29 | 2012-02-02 | Xencor, Inc. | Antibodies with modified isoelectric points |
EP3828205A1 (de) | 2010-10-01 | 2021-06-02 | Oxford BioTherapeutics Ltd | Anti-ror1-antikörper |
JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
CN106110332B (zh) | 2011-06-10 | 2018-11-30 | 梅尔莎纳医疗公司 | 蛋白质-聚合物-药物共轭物 |
MY160826A (en) | 2011-06-28 | 2017-03-31 | Berlin-Chemie Ag | Antibodies to bone marrow stromal antigen 1 |
WO2013022855A1 (en) | 2011-08-05 | 2013-02-14 | Xencor, Inc. | Antibodies with modified isoelectric points and immunofiltering |
WO2013055809A1 (en) | 2011-10-10 | 2013-04-18 | Xencor, Inc. | A method for purifying antibodies |
US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
CA2892863C (en) | 2012-12-10 | 2022-03-15 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
US9872918B2 (en) | 2012-12-12 | 2018-01-23 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
AU2014205086B2 (en) | 2013-01-14 | 2019-04-18 | Xencor, Inc. | Novel heterodimeric proteins |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
EP2945969A1 (de) | 2013-01-15 | 2015-11-25 | Xencor, Inc. | Schnelle beseitigung von antigenkomplexen unter verwendung neuartiger antikörper |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
EP2970486B1 (de) | 2013-03-15 | 2018-05-16 | Xencor, Inc. | Modulation von t-zellen mit bispezifischen antikörpern und fc-fusionen |
LT2951203T (lt) | 2013-03-15 | 2019-09-10 | Xencor, Inc. | Heterodimeriniai baltymai |
AR095199A1 (es) | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
MX2016004659A (es) | 2013-10-11 | 2017-08-02 | Asana Biosciences Llc | Conjugados proteina-polimero-farmaco. |
UA119047C2 (uk) | 2013-10-11 | 2019-04-25 | Берлін-Хемі Аг | Кон'юговане антитіло до ly75 для лікування раку |
JP6420331B2 (ja) | 2013-10-11 | 2018-11-07 | メルサナ セラピューティクス,インコーポレイティド | タンパク質−高分子−薬剤コンジュゲート |
US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
RS59907B1 (sr) | 2014-03-28 | 2020-03-31 | Xencor Inc | Bispecifična antitela koja se vezuju za cd38 i cd3 |
CA2956178A1 (en) | 2014-07-24 | 2016-01-28 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
RS62332B1 (sr) | 2014-11-26 | 2021-10-29 | Xencor Inc | Heterodimerna antitela koja vezuju cd3 i cd20 |
CA2968878A1 (en) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd38 |
WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
WO2016141387A1 (en) | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
CA2991973C (en) | 2015-07-12 | 2021-12-07 | Suzhou M-Conj Biotech Co., Ltd. | Bridge linkers for conjugation of a cell-binding molecule |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
EP3387013B1 (de) | 2015-12-07 | 2022-06-08 | Xencor, Inc. | Cd3 und psma bindende heterodimere antikörper |
US10787518B2 (en) | 2016-06-14 | 2020-09-29 | Xencor, Inc. | Bispecific checkpoint inhibitor antibodies |
WO2018005706A1 (en) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
US10550185B2 (en) | 2016-10-14 | 2020-02-04 | Xencor, Inc. | Bispecific heterodimeric fusion proteins containing IL-15-IL-15Rα Fc-fusion proteins and PD-1 antibody fragments |
CN116143678A (zh) | 2016-11-14 | 2023-05-23 | 杭州多禧生物科技有限公司 | 偶联连接体,含有此连接体的细胞结合分子-药物偶联物及其制备和应用 |
US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
CN111315414A (zh) | 2017-06-22 | 2020-06-19 | 梅尔莎纳医疗公司 | 产生载药聚合物支架和蛋白-聚合物-药物缀合物的方法 |
JP2020529832A (ja) | 2017-06-30 | 2020-10-15 | ゼンコア インコーポレイテッド | IL−15/IL−15Rαおよび抗原結合ドメインを含む標的化ヘテロダイマーFc融合タンパク質 |
WO2019094637A1 (en) | 2017-11-08 | 2019-05-16 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-pd-1 sequences |
US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
CN111655718A (zh) | 2017-12-19 | 2020-09-11 | Xencor股份有限公司 | 经过工程化的il-2 fc融合蛋白 |
AU2019247415A1 (en) | 2018-04-04 | 2020-10-22 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
MX2020010910A (es) | 2018-04-18 | 2021-02-09 | Xencor Inc | Proteinas de fusion heterodimericas dirigidas a pd-1 que contienen proteinas de fusion il-15 / il-15ra fc y dominios de union al antigeno pd-1 y usos de los mismos. |
WO2019204655A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
UY38289A (es) | 2018-07-02 | 2020-01-31 | Amgen Inc | Proteína de unión al antígeno anti-steap1 |
JP2022503959A (ja) | 2018-10-03 | 2022-01-12 | ゼンコア インコーポレイテッド | Il-12ヘテロ二量体fc-融合タンパク質 |
MX2021004906A (es) | 2018-10-29 | 2021-09-10 | Mersana Therapeutics Inc | Conjugados de anticuerpo modificado con cisteína-fármaco con enlazadores que contienen péptidos. |
US11472890B2 (en) | 2019-03-01 | 2022-10-18 | Xencor, Inc. | Heterodimeric antibodies that bind ENPP3 and CD3 |
US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
AU2022232375A1 (en) | 2021-03-09 | 2023-09-21 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
EP4305065A1 (de) | 2021-03-10 | 2024-01-17 | Xencor, Inc. | Cd3 und gpc3 bindende heterodimere antikörper |
WO2024013723A1 (en) | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4169888A (en) * | 1977-10-17 | 1979-10-02 | The Upjohn Company | Composition of matter and process |
US4423230A (en) * | 1980-11-18 | 1983-12-27 | The Upjohn Company | Preparation of an intermediate for N-(methylsulfonyl)-1,2,8,8a-cyclopropa[c][1,2-b:-4,3-b']dipyrol-4(5H)-one |
US4400518A (en) * | 1980-11-18 | 1983-08-23 | The Upjohn Company | Composition of matter and process |
US4423228A (en) * | 1980-11-18 | 1983-12-27 | The Upjohn Company | Process for preparing N-(methyl-sulfonyl)-1,2,8,8a-cyclopropa[c]benzo[1,2-b:4,3-b']dipyrrol-4(5H)-one |
US4423229A (en) * | 1980-11-18 | 1983-12-27 | The Upjohn Company | Composition of matter and process |
IT1143242B (it) * | 1980-11-18 | 1986-10-22 | Upjohn Co | 1,2,8,ba-ciclopropa(c)-benzo(1,2-b-4,3-b)dipirrol-4(5h)-one antibatte ricamente attivo e relativo metodo di preparazione |
US4413132A (en) * | 1980-11-18 | 1983-11-01 | The Upjohn Company | Antibiotic CC-1065 indoline intermediates |
CA1238907A (en) * | 1984-02-21 | 1988-07-05 | Robert C. Kelly | 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds |
EP0271581B1 (de) * | 1986-04-17 | 1993-01-13 | Kyowa Hakko Kogyo Co., Ltd. | Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren |
EP0318056A3 (de) * | 1987-11-27 | 1990-12-19 | Meiji Seika Kaisha Ltd. | Antibiotika und Verfahren zu deren Herstellung |
JP2553166B2 (ja) * | 1988-10-21 | 1996-11-13 | 協和醗酵工業株式会社 | Dc−88aの製造法 |
-
1988
- 1988-12-28 JP JP63332304A patent/JP2598116B2/ja not_active Expired - Lifetime
-
1989
- 1989-12-28 EP EP89124068A patent/EP0376300B1/de not_active Expired - Lifetime
- 1989-12-28 DE DE89124068T patent/DE68907876T2/de not_active Expired - Fee Related
- 1989-12-28 US US07/458,543 patent/US5101038A/en not_active Expired - Lifetime
- 1989-12-28 CA CA002006821A patent/CA2006821C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE68907876T2 (de) | 1994-02-24 |
EP0376300B1 (de) | 1993-07-28 |
JPH02177890A (ja) | 1990-07-10 |
EP0376300A1 (de) | 1990-07-04 |
CA2006821C (en) | 1995-11-28 |
CA2006821A1 (en) | 1990-06-28 |
JP2598116B2 (ja) | 1997-04-09 |
US5101038A (en) | 1992-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE68907876D1 (de) | Substanz dc 113 und verfahren zu ihrer herstellung. | |
DE3682874D1 (de) | Pyranoindolizinderivate und verfahren zu ihrer herstellung. | |
DE3866744D1 (de) | Copolyaether-imide und verfahren zu ihrer herstellung. | |
DE3782994D1 (de) | Erythromycin-a-derivate und verfahren zu ihrer herstellung. | |
DE3786781D1 (de) | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-en-2-carbonsaeure-derivate und verfahren zu deren herstellung. | |
DE68917798D1 (de) | Anschlussstruktur und Verfahren zu deren Herstellung. | |
DE3775294D1 (de) | Implantatwerkstoff und verfahren zu seiner herstellung. | |
DE3878475D1 (de) | Organopolysiloxanemulsion und verfahren zu ihrer herstellung. | |
ATE220666T1 (de) | 4-diphenylmethylpiperidine und verfahren zu ihrer herstellung | |
DE3881294D1 (de) | Supraleitende anordnung und verfahren zu ihrer herstellung. | |
DE3877709D1 (de) | Indan-derivate und verfahren zu deren herstellung. | |
DE3878880D1 (de) | Metall-keramik-verbindung und verfahren zu ihrer herstellung. | |
DE68905844D1 (de) | Thermochromische reissverschlussteile und verfahren zu ihrer herstellung. | |
DE3850632D1 (de) | Supraleiterelement und Verfahren zu seiner Herstellung. | |
DE3853900D1 (de) | Supraleitendes Material und Verfahren zu seiner Herstellung. | |
DE3879335D1 (de) | Trifluorbenzolverbindungen und verfahren zu ihrer herstellung. | |
DE3765181D1 (de) | Isocarbacycline und verfahren zu ihrer herstellung. | |
DE3673515D1 (de) | Gonatrien-derivate und verfahren zu ihrer herstellung. | |
DE3778517D1 (de) | 7-brom-beta-carbolin-derivate und verfahren zu ihrer herstellung. | |
DE3867957D1 (de) | Modifiziertes polytetrafluoraethylen und verfahren zu seiner herstellung. | |
DE3677259D1 (de) | Chinazolinonverbindungen und verfahren zu ihrer herstellung. | |
AT399879B (de) | Dihydro-pyrimido-thiazin-derivate und verfahren zu ihrer herstellung | |
DE3878578D1 (de) | Benzimidazol-derivate und verfahren zu ihrer herstellung. | |
DE3777245D1 (de) | Protein und verfahren zu dessen herstellung. | |
DE3765239D1 (de) | Acetylketendialkylacetale und verfahren zu ihrer herstellung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |