DE60217835D1 - Plasmaglucosylceramiddefizienz als risikofaktor für thrombose und modulator von anticoagulant protein c - Google Patents

Plasmaglucosylceramiddefizienz als risikofaktor für thrombose und modulator von anticoagulant protein c

Info

Publication number
DE60217835D1
DE60217835D1 DE60217835T DE60217835T DE60217835D1 DE 60217835 D1 DE60217835 D1 DE 60217835D1 DE 60217835 T DE60217835 T DE 60217835T DE 60217835 T DE60217835 T DE 60217835T DE 60217835 D1 DE60217835 D1 DE 60217835D1
Authority
DE
Germany
Prior art keywords
glccer
protein
gb3cer
methods
risikofaktor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60217835T
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German (de)
English (en)
Inventor
John H Griffin
Hiroshi Deguchi
Jose Fernandez
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Individual
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Individual
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Filing date
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Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60217835D1 publication Critical patent/DE60217835D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE60217835T 2001-02-28 2002-02-28 Plasmaglucosylceramiddefizienz als risikofaktor für thrombose und modulator von anticoagulant protein c Expired - Fee Related DE60217835D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27210301P 2001-02-28 2001-02-28
US27804501P 2001-03-22 2001-03-22
PCT/US2002/006340 WO2002102325A2 (fr) 2001-02-28 2002-02-28 Utilisation de la deficience en glucosylceramides plasmiques comme facteur de risque pour la thrombose et modulateur de la proteine c anticoagulante

Publications (1)

Publication Number Publication Date
DE60217835D1 true DE60217835D1 (en) 2007-03-15

Family

ID=26955302

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60217835T Expired - Fee Related DE60217835D1 (en) 2001-02-28 2002-02-28 Plasmaglucosylceramiddefizienz als risikofaktor für thrombose und modulator von anticoagulant protein c

Country Status (6)

Country Link
US (2) US6756208B2 (fr)
EP (1) EP1370570B1 (fr)
AT (1) ATE352309T1 (fr)
AU (1) AU2002326291A1 (fr)
DE (1) DE60217835D1 (fr)
WO (1) WO2002102325A2 (fr)

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US20040171522A1 (en) * 2003-02-27 2004-09-02 Yaron Ilan Regulation of immune responses by manipulation of intermediary metabolite levels
WO2005032462A2 (fr) 2003-02-27 2005-04-14 Enzo Therapeutics, Inc. Traitement au glucocerebroside d'une maladie
US20070184058A1 (en) * 2003-02-27 2007-08-09 Yaron Ilan Glucocerebroside treatment of pulmonary or respiratory diseases or disorders
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SG150552A1 (en) * 2004-03-17 2009-03-30 Chiron Corp Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor (tfpi)
US20080305100A1 (en) * 2004-07-23 2008-12-11 Zlokovic Berislav V Activated Protein C Inhibits Undesirable Effects of Plasminogen Activator in the Brain
WO2006109312A2 (fr) * 2005-04-15 2006-10-19 Vascular Biogenics Ltd. Compositions contenant des peptides derives de la glycoproteine i beta 2 pour la prevention et le traitement de maladie cardiovasculaire
TW200801483A (en) 2006-03-09 2008-01-01 Alltech Associates Inc Evaporative light scattering detector
US20080194527A1 (en) * 2007-02-14 2008-08-14 Tcp Innovations Ltd Compositions and combinations 2
US20090286740A1 (en) * 2008-05-15 2009-11-19 Fibrex Medical Research & Development Gmbh Peptides and derivatives thereof, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition
WO2011027344A2 (fr) * 2009-09-01 2011-03-10 Hadasit Medical Research Services And Development Ltd. Combinaison de vitamine e et de bêta-glycosphingolipides dans des compositions, méthodes de prévention et de traitement des troubles hépatiques
JP5739898B2 (ja) * 2009-11-17 2015-06-24 ベイラー リサーチ インスティテュートＢａｙｌｏｒ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 心疾患マーカーとしての尿中トリアオシルセラミド（ｇｂ３）
US20110136858A1 (en) * 2009-12-04 2011-06-09 Grainger David J Preferred Combination Therapy
WO2011091299A1 (fr) * 2010-01-21 2011-07-28 Paul Bradley Addis Composition pour accident vasculaire cérébral périnatal et néonatal
US20120178105A1 (en) * 2011-01-10 2012-07-12 Genzyme Corporation Detection of globotriaosylceramide (glc) in human urine samples using an antibody sandwich
CN102798598A (zh) * 2011-05-25 2012-11-28 兆科药业（合肥）有限公司 一种检测磷脂依赖性凝血因子x激活物酶活性的方法
WO2013078422A2 (fr) 2011-11-23 2013-05-30 Therapeuticsmd, Inc. Préparations et thérapies de substitution pour hormonothérapie naturelle combinée
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN104122396A (zh) * 2013-04-23 2014-10-29 中国科学院上海生命科学研究院 维生素k依赖性蛋白s作为糖尿病标志物的应用
CN103308636B (zh) * 2013-04-28 2014-04-09 山东信立泰药业有限公司 一种D-(+)-α-(2-噻吩乙胺基)-α-(2-氯苯基)乙酸甲酯或其盐的质量控制方法及其在氯吡格雷生产中的应用
US20170035791A1 (en) * 2014-04-14 2017-02-09 Natural Shield Israel 2016 Ltd Combination of beta-glucosylceramide and polyethoxylated castor oil and other adjuvants for controling blood sugar levels, immunoprotection and hepatoprotection
WO2015179782A1 (fr) 2014-05-22 2015-11-26 Therapeuticsmd, Inc. Formulations d'hormones substitutives combinées naturelles et traitement hormonal substitutif
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US11058750B2 (en) * 2015-12-03 2021-07-13 Mor Research Applications Ltd. Compositions and methods for treatment of ocular diseases
WO2017173071A1 (fr) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Composition pharmaceutique d'hormone stéroïde
WO2017173044A1 (fr) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Compositions d'hormones stéroïdes dans des huiles à chaîne moyenne
US11505556B2 (en) * 2017-12-12 2022-11-22 Xalud Therapeutics, Inc. Halogenated derivatives of morphinans and uses thereof
CN108931595B (zh) * 2018-06-20 2021-05-11 广东省测试分析研究所（中国广州分析测试中心） 一种明胶型凝胶糖果中磷脂酰丝氨酸含量的测定方法
CN108836897A (zh) * 2018-08-21 2018-11-20 湖南博隽生物医药有限公司 一种含有玫瑰精油的化妆品及其制备方法
EP3632427A1 (fr) 2018-10-01 2020-04-08 Mehdi Namdar Nouveaux agents pour une utilisation dans le traitement de l'arythmie cardiaque
CN109700998B (zh) * 2019-02-25 2022-02-08 曾湘红 一种复方肌肤损伤再生修复剂及其制备方法
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CN112375133A (zh) * 2020-09-18 2021-02-19 江苏艾迪药业股份有限公司 亲和层析柱纯化凝血酶调节蛋白的方法
CN113243338A (zh) * 2021-05-14 2021-08-13 福州大学 一种小鼠缺血性卒中模型的构建与评估方法

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US6492337B1 (en) * 1997-12-30 2002-12-10 A+ Science Ab Galactosylceramide, glucosylceramide, lactosylceramide, and specific catchers therefor for use in the prophylaxis or therapy of prediabetes, diabetes and/or associated complication
JP2002521435A (ja) * 1998-07-27 2002-07-16 ジョンズ・ホプキンス・ユニバーシティ ラクトシルセラミドによって調節される病態を治療する方法
KR20020005614A (ko) 1999-03-11 2002-01-17 블레어 큐. 퍼거슨 Ｘａ 인자 저해제와 아스피린, 조직 플라스미노겐활성화인자(ＴＰＡ), ＧＰⅡｂ／Ⅲａ 길항제, 저분자량헤파린 또는 헤파린의 병용에 의한 혈전증 치료

Also Published As

Publication number Publication date
WO2002102325A2 (fr) 2002-12-27
AU2002326291A1 (en) 2003-01-02
ATE352309T1 (de) 2007-02-15
EP1370570B1 (fr) 2007-01-24
EP1370570A4 (fr) 2004-10-13
US20040132688A1 (en) 2004-07-08
EP1370570A2 (fr) 2003-12-17
WO2002102325A3 (fr) 2003-09-12
US6756208B2 (en) 2004-06-29
US20020177563A1 (en) 2002-11-28

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8339 Ceased/non-payment of the annual fee