DE60216776D1 - Neue piperidin-2,6-dion bisulfatsalze und deren verwendung für die behandlung stressbezogener gemütserkrankungen - Google Patents

Neue piperidin-2,6-dion bisulfatsalze und deren verwendung für die behandlung stressbezogener gemütserkrankungen

Info

Publication number
DE60216776D1
DE60216776D1 DE60216776T DE60216776T DE60216776D1 DE 60216776 D1 DE60216776 D1 DE 60216776D1 DE 60216776 T DE60216776 T DE 60216776T DE 60216776 T DE60216776 T DE 60216776T DE 60216776 D1 DE60216776 D1 DE 60216776D1
Authority
DE
Germany
Prior art keywords
stress
treatment
bisulphate
dion
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60216776T
Other languages
English (en)
Other versions
DE60216776T2 (de
Inventor
Ward Gittos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prestwick Pharmaceuticals Inc
Original Assignee
Prestwick Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prestwick Pharmaceuticals Inc filed Critical Prestwick Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60216776D1 publication Critical patent/DE60216776D1/de
Publication of DE60216776T2 publication Critical patent/DE60216776T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE60216776T 2001-08-28 2002-08-22 Neue piperidin-2,6-dion bisulfatsalze und deren verwendung für die behandlung stressbezogener gemütserkrankungen Expired - Lifetime DE60216776T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0120821 2001-08-28
GB0120821A GB2379216A (en) 2001-08-28 2001-08-28 Piperidin-2,6-dione salts useful for the treatment of stress-related affective disorders
PCT/GB2002/003869 WO2003020275A1 (en) 2001-08-28 2002-08-22 Novel piperidin-2,6-dione bisulphate salts and their use for the treatment of stress-related affective disorders

Publications (2)

Publication Number Publication Date
DE60216776D1 true DE60216776D1 (de) 2007-01-25
DE60216776T2 DE60216776T2 (de) 2007-10-04

Family

ID=9921084

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60216776T Expired - Lifetime DE60216776T2 (de) 2001-08-28 2002-08-22 Neue piperidin-2,6-dion bisulfatsalze und deren verwendung für die behandlung stressbezogener gemütserkrankungen

Country Status (19)

Country Link
US (1) US7189742B2 (de)
EP (1) EP1420788B1 (de)
JP (1) JP2005502677A (de)
KR (1) KR100906893B1 (de)
CN (1) CN100506229C (de)
AT (1) ATE347891T1 (de)
AU (1) AU2002321522B2 (de)
BR (1) BR0212175A (de)
CA (1) CA2459009C (de)
CY (1) CY1105979T1 (de)
DE (1) DE60216776T2 (de)
DK (1) DK1420788T3 (de)
ES (1) ES2275898T3 (de)
GB (1) GB2379216A (de)
IL (2) IL160615A0 (de)
MX (1) MXPA04001777A (de)
NZ (1) NZ531345A (de)
PT (1) PT1420788E (de)
WO (1) WO2003020275A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0219639D0 (en) * 2002-08-22 2002-10-02 Prestwick Scient Capital Inc Novel piperidin-2,6-dione salts and their use for the treatment of stress-related affective disorders
US7560861B2 (en) 2004-05-03 2009-07-14 Lg Electronics Inc. Organic electro-luminescence display device with an organic electro-luminescence array and fabricating method thereof
KR100938296B1 (ko) * 2005-03-15 2010-01-22 에프. 호프만-라 로슈 아게 5ｈｔ5ａ 수용체 길항제로서의2-아닐리노-3,4-다이하이드로-퀴나졸린의 용도
GB0518763D0 (en) * 2005-09-14 2005-10-19 Prestwick Pharmaceuticals Inc Treatment of hypertension
KR101401612B1 (ko) * 2012-04-30 2014-06-02 재단법인 전남생물산업진흥원 석류 추출물을 유효성분으로 포함하는 스트레스성 질환의 치료 및 예방용 조성물
US20160051639A1 (en) * 2014-08-25 2016-02-25 Aimmune Therapeutics, Inc. Egg protein formulations and methods of manufacture thereof
WO2017087691A1 (en) 2015-11-17 2017-05-26 The Trustees Of Columbia University In The City Of New York Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms
WO2019094596A1 (en) 2017-11-09 2019-05-16 The Trustees Of Columbia University In The City Of New York Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3693729A (en) * 1970-02-19 1972-09-26 Global Marine Inc Air cushion drilling vehicle
GB1455687A (en) * 1972-12-28 1976-11-17 Aspro Nicholas Ltd Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
EP0216555B1 (de) * 1985-09-11 1992-09-02 Btg International Limited Verwendung von Dioxopiperidin-Derivaten zur Behandlung von Anxietas, zur Herabsetzung von chronischen abnormal hohen Gehirn-Spiegeln Serotonins oder 5-Hydroxy-Indolessigsäure und zur Behandlung von bakteriellen oder viralen Infektionen
EP0263594B1 (de) * 1986-09-08 1992-06-24 Btg International Limited Dioxopiperidin-Derivate enthaltende anxiolytische Zusammensetzungen
US5104990A (en) * 1990-02-27 1992-04-14 G. D. Searle & Co. Process for the preparation of 3-aryl-3-aminoalkyl-2,6-dioxohexahydropyridines

Also Published As

Publication number Publication date
DE60216776T2 (de) 2007-10-04
CA2459009C (en) 2010-04-06
IL160615A0 (en) 2004-07-25
IL160615A (en) 2008-08-07
KR100906893B1 (ko) 2009-07-08
JP2005502677A (ja) 2005-01-27
MXPA04001777A (es) 2004-11-22
DK1420788T3 (da) 2007-02-26
GB0120821D0 (en) 2001-10-17
US7189742B2 (en) 2007-03-13
US20040249159A1 (en) 2004-12-09
GB2379216A (en) 2003-03-05
ATE347891T1 (de) 2007-01-15
CN1549715A (zh) 2004-11-24
EP1420788A1 (de) 2004-05-26
ES2275898T3 (es) 2007-06-16
CN100506229C (zh) 2009-07-01
WO2003020275A1 (en) 2003-03-13
BR0212175A (pt) 2004-07-20
NZ531345A (en) 2005-07-29
CA2459009A1 (en) 2003-03-13
PT1420788E (pt) 2007-03-30
EP1420788B1 (de) 2006-12-13
AU2002321522B2 (en) 2006-10-12
CY1105979T1 (el) 2011-04-06
KR20040031000A (ko) 2004-04-09

Similar Documents

Publication Publication Date Title
BR0213778A (pt) Composição, método de tratamento de um ser humano ou animal que sofre de doenças, e, uso da composição
HUP0302966A2 (hu) Karboxamid-vegyületek és alkalmazásuk humán 11CBY receptor antagonistákként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
BR0206513A (pt) Composição, métodos de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de qualquer um dos compostos, composição farmacêutica, e, processo para preparar compostos
DK1446387T3 (da) Substituerede aryl, 1,4-pyrazinderivater
DE60238149D1 (de) Arylsulfonamid-Derivate zur Verwendung als CCR3-Antagonisten bei der Behandlung von inflammatorischen und immunologischen Erkrankungen
CY1105979T1 (el) Νεα οξινα θειικα αλατα πιπepιδινο-2,6-διονων και η χρηση τους για την αντιμετωπιση σχετιζομενων με το στρες συναισθηματικων διαταραχων
NO20071574L (no) Arylsulfonylstilbenderivater for behandling av insomni og beslektede tilstander.
NO20051967L (no) 3,4-disubstituerte pyroler og deres anvendelse ved behandling av inflammatoriske sykdommer.
ATE305451T1 (de) 1-arenesulfonyl-2-aryl-pyrrolidin und piperidin derivative zur behandlung von cns-erkrankungen disorders
CY1105541T1 (el) Παμοϊκα αλατα πιπεριδινο-2,6-διονων και η χρηση τους για την αντιμετωπιση σχετιζομενων με το στρες συναισθηματικων διαταραχων
NO20035116D0 (no) 4-(fenylpiperidin-4-yliden-metyl)-benzamidderivater og deres anvendelse forbehandling av smerte, angst eller gastrointestinale forstyrrelser
NO20035115D0 (no) 4-(fenylpiperidin-4-yliden-metyl)-benzamidderivater og deres anvendelse forbehandling av smerte, angst eller gastrointestinale forstyrrelser
BR0201569A (pt) 4-(2-piridil) piperizinas possuindo uma atividade agonista do receptor 5ht7
DE60117122D1 (de) Verwendung von mirtazapin zur behandlung von schlafstörungen
NO20035117D0 (no) 4-(fenylpiperidin-4-yliden-metyl)-benzamidderivater og deres anvendelse forbehandling av smerte, angst eller gastrointestinale forstyrrelser
ATE287400T1 (de) 4-(phenylpiperidin-4-ylidenmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
ATE294780T1 (de) Arylpiperidin- und aryl-1,2,5,6- tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität
NO941256L (no) 3-(N-isopropyl-N-n-propylamino)-5-(N-isopropyl)karbamoylkroman
BR0206918A (pt) Uso de iloperidona
NO20055514L (no) Piperazinderivater og deres anvendelse ved behandling av neurologiske og psykiatriske sykdommer
ATE228126T1 (de) 2- 4-(4-(4,5-dichlor-2-methylimidazol-1- yl)butyl)piperazin-1-yl -5-fluorpyrimidin, seine herstellung und therapeutische verwendung
DE602004019133D1 (de) Verwendung von 1,2-diazadibenzoäe,hüazulenen zur herstellung von pharmazeutischen formulierungen für die behandlung und prävention von erkrankungen und störungen des zentralen nervensystems
NO20053612L (no) 1,2,4-triaminobenzenderivater nyttige for behandling av forstyrrelser i sentralnervesystemet
SE0103647D0 (sv) Therapeutic chromone compounds
TR200301671A2 (tr) Sitalopram'ın yeni üretim formülasyonu.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition