DE60206151D1 - Gene und proteine für polyketide biosynthese - Google Patents

Gene und proteine für polyketide biosynthese

Info

Publication number
DE60206151D1
DE60206151D1 DE60206151T DE60206151T DE60206151D1 DE 60206151 D1 DE60206151 D1 DE 60206151D1 DE 60206151 T DE60206151 T DE 60206151T DE 60206151 T DE60206151 T DE 60206151T DE 60206151 D1 DE60206151 D1 DE 60206151D1
Authority
DE
Germany
Prior art keywords
genes
proteins
lactimidomycin
dorrigocin
polyketide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60206151T
Other languages
English (en)
Inventor
M Farnet
Emmanuel Zazopoulos
Alfredo Staffa
Xianshu Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thallion Pharmaceuticals Inc
Original Assignee
Ecopia Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecopia Biosciences Inc filed Critical Ecopia Biosciences Inc
Application granted granted Critical
Publication of DE60206151D1 publication Critical patent/DE60206151D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DE60206151T 2001-04-26 2002-04-26 Gene und proteine für polyketide biosynthese Expired - Lifetime DE60206151D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28634601P 2001-04-26 2001-04-26
PCT/CA2002/000591 WO2002088176A2 (en) 2001-04-26 2002-04-26 Genes and proteins for the biosynthesis of polyketides

Publications (1)

Publication Number Publication Date
DE60206151D1 true DE60206151D1 (de) 2005-10-20

Family

ID=23098188

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60206151T Expired - Lifetime DE60206151D1 (de) 2001-04-26 2002-04-26 Gene und proteine für polyketide biosynthese

Country Status (8)

Country Link
US (1) US20030171562A1 (de)
EP (1) EP1381685B1 (de)
JP (1) JP2004535175A (de)
AT (1) ATE304594T1 (de)
AU (1) AU2002254822A1 (de)
CA (1) CA2415339A1 (de)
DE (1) DE60206151D1 (de)
WO (1) WO2002088176A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884608B2 (en) * 2001-12-26 2005-04-26 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
WO2004087672A1 (en) 2003-03-28 2004-10-14 Cornell Research Foundation, Inc. Migrastatin analog compositions and uses thereof
US8957056B2 (en) 2004-05-25 2015-02-17 Sloan-Kettering Instiute For Cancer Research Migrastatin analogs in the treatment of cancer
WO2006034478A2 (en) 2004-09-23 2006-03-30 Sloan-Kettering Institute For Cancer Research Isomigrastatin analogs in the treatment of cancer
US20060211736A1 (en) * 2005-01-13 2006-09-21 Wisconsin Alumni Research Foundation Glutarimide-containing polyketide analogs and methods thereof
US20070026488A1 (en) * 2005-07-27 2007-02-01 Targett Nancy M Biosynthesis of bryostatins by polyketide synthases (PKS)
JP7041898B2 (ja) 2016-12-27 2022-03-25 ザ ロックフェラー ユニバーシティー 広域中和抗ｈｉｖ－１抗体およびその使用方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874748A (en) * 1986-03-24 1989-10-17 Abbott Laboratories Cloning vectors for streptomyces and use thereof in macrolide antibiotic production
US5149639A (en) * 1986-03-24 1992-09-22 Abbott Laboratories Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production
US5063155A (en) * 1988-03-28 1991-11-05 Eli Lilly And Company Method for producing 2"'-o-demethyltylosin
US5098837A (en) * 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
DK0725778T3 (da) * 1993-09-20 2001-12-17 Univ Leland Stanford Junior Rekombinant produktion af hidtil ukendte polyketider
US5484799A (en) * 1993-12-09 1996-01-16 Abbott Laboratories Antifungal dorrigocin derivatives
US6927286B1 (en) * 1999-01-06 2005-08-09 The Regents Of The University Of California Bleomycin gene cluster components and their uses
JP2003506022A (ja) * 1999-07-30 2003-02-18 メルク エンド カムパニー インコーポレーテッド アベルメクチンアグリコングリコシル化に関するストレプトマイセスアベルミチリスの遺伝子のクローニング
US7257562B2 (en) * 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters

Also Published As

Publication number Publication date
ATE304594T1 (de) 2005-09-15
US20030171562A1 (en) 2003-09-11
WO2002088176A2 (en) 2002-11-07
EP1381685A2 (de) 2004-01-21
CA2415339A1 (en) 2002-11-07
WO2002088176A3 (en) 2003-05-30
EP1381685B1 (de) 2005-09-14
AU2002254822A1 (en) 2002-11-11
JP2004535175A (ja) 2004-11-25

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Legal Events

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