DE602006005902D1 - Pyy-agonisten und anwendungen davon - Google Patents

Pyy-agonisten und anwendungen davon

Info

Publication number
DE602006005902D1
DE602006005902D1 DE602006005902T DE602006005902T DE602006005902D1 DE 602006005902 D1 DE602006005902 D1 DE 602006005902D1 DE 602006005902 T DE602006005902 T DE 602006005902T DE 602006005902 T DE602006005902 T DE 602006005902T DE 602006005902 D1 DE602006005902 D1 DE 602006005902D1
Authority
DE
Germany
Prior art keywords
applications
pyy agonists
pyy
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006005902T
Other languages
English (en)
Inventor
Rory Francis Finn
Ned Roger Siegel
Neena Lynne Summers
Nancy Ann Nardone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of DE602006005902D1 publication Critical patent/DE602006005902D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE602006005902T 2005-02-04 2006-01-30 Pyy-agonisten und anwendungen davon Active DE602006005902D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65036605P 2005-02-04 2005-02-04
US73365605P 2005-11-04 2005-11-04
PCT/IB2006/000270 WO2006082517A1 (en) 2005-02-04 2006-01-30 Pyy agonists and uses thereof

Publications (1)

Publication Number Publication Date
DE602006005902D1 true DE602006005902D1 (de) 2009-05-07

Family

ID=36175074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006005902T Active DE602006005902D1 (de) 2005-02-04 2006-01-30 Pyy-agonisten und anwendungen davon

Country Status (33)

Country Link
US (3) US20060178501A1 (de)
EP (2) EP2078729A1 (de)
JP (1) JP4314304B2 (de)
KR (1) KR100892545B1 (de)
AP (1) AP2007004069A0 (de)
AR (1) AR052108A1 (de)
AT (1) ATE426614T1 (de)
AU (1) AU2006211039A1 (de)
BR (1) BRPI0606142A2 (de)
CA (1) CA2596977C (de)
CY (1) CY1109054T1 (de)
DE (1) DE602006005902D1 (de)
DK (1) DK1846445T3 (de)
DO (1) DOP2006000025A (de)
EA (1) EA011882B1 (de)
ES (1) ES2322293T3 (de)
GT (1) GT200600038A (de)
HR (1) HRP20090245T1 (de)
IL (1) IL184324A0 (de)
MA (1) MA29243B1 (de)
MX (1) MX2007009389A (de)
NL (2) NL1031067C2 (de)
NO (1) NO20074498L (de)
PA (1) PA8660701A1 (de)
PE (1) PE20061412A1 (de)
PL (1) PL1846445T3 (de)
PT (1) PT1846445E (de)
RS (1) RS50966B (de)
SI (1) SI1846445T1 (de)
TN (1) TNSN07305A1 (de)
TW (1) TWI310038B (de)
UY (1) UY29357A1 (de)
WO (1) WO2006082517A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0212985A (pt) 2001-09-24 2005-08-30 Imp College Innovations Ltd Uso de pyy ou de um agonista do mesmo na preparação de medicamentos para tratamento de distúrbios associados com excesso de peso
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
SG155777A1 (en) 2003-04-09 2009-10-29 Neose Technologies Inc Glycopegylation methods and proteins/peptides produced by the methods
US20080146782A1 (en) * 2006-10-04 2008-06-19 Neose Technologies, Inc. Glycerol linked pegylated sugars and glycopeptides
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
WO2005070138A2 (en) 2004-01-08 2005-08-04 Neose Technologies, Inc. O-linked glycosylation of peptides
JP2007530569A (ja) * 2004-03-23 2007-11-01 アムジエン・インコーポレーテツド 化学修飾タンパク質組成物及び方法
EP1771066A2 (de) 2004-07-13 2007-04-11 Neose Technologies, Inc. Remodellierung von verzweigtem peg und klykolysierung von glucagonähnlichem peptide-1 glp-1
CA2585758C (en) 2004-10-29 2017-08-01 Neose Technologies, Inc. Remodeling and glycopegylation of fibroblast growth factor (fgf)
ES2449195T3 (es) 2005-01-10 2014-03-18 Ratiopharm Gmbh Factor estimulante de colonias de granulocitos glicopegilado
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
MX2007015819A (es) * 2005-06-13 2008-02-22 Nastech Pharm Co Suministro de derivados peptidicos a traves de la mucosa.
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
EP1929860A4 (de) 2005-08-31 2010-12-29 Kaneka Corp Transgener vogel mit fremdgen enthaltend eine sequenz, die für ein von der katze abstammendes protein codiert, sowie verfahren zu seiner herstellung
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
WO2007085887A1 (en) * 2006-01-27 2007-08-02 Pfizer Products Inc. Pyy agonists and uses thereof
WO2008011633A2 (en) 2006-07-21 2008-01-24 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
JP2008069073A (ja) * 2006-09-12 2008-03-27 Yokohama Tlo Co Ltd ラクトフェリン複合体及びその製造方法
WO2008057683A2 (en) 2006-10-03 2008-05-15 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
PL2144923T3 (pl) 2007-04-03 2013-12-31 Biogenerix Ag Sposoby leczenia z użyciem glikopegilowanego G-CSF
ES2551123T3 (es) 2007-06-12 2015-11-16 Ratiopharm Gmbh Proceso mejorado para la producción de azúcares de nucleótido
AU2009219232B2 (en) 2008-02-27 2014-02-27 Novo Nordisk A/S Conjugated Factor VIII molecules
WO2010016936A1 (en) * 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Pharmaceutical compositions of analogues of glucose-dependent insulinotropic polypeptide
KR20110091720A (ko) * 2008-11-04 2011-08-12 얀센 파마슈티카 엔.브이. Ｃｒｈｒ2 펩티드 작용제 및 이의 용도
WO2010067233A1 (en) 2008-12-08 2010-06-17 Pfizer Inc. 1,2,4 triazolo [4, 3 -a] [1,5] benzodiazepin-5 (6h) -ones as agonists of the cholecystokinin-1 receptor (cck-ir)
JP2012515760A (ja) 2009-01-20 2012-07-12 ファイザー・インク 置換ピラジノンアミド
WO2010086820A1 (en) 2009-02-02 2010-08-05 Pfizer Inc. 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof
WO2010089685A1 (en) 2009-02-03 2010-08-12 Pfizer Inc. 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives
CA2749893A1 (en) 2009-02-04 2010-08-12 Pfizer Inc. 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives
CA2754685A1 (en) 2009-03-11 2010-09-16 Pfizer Inc. Substituted indazole amides
CN102388038B (zh) 2009-03-11 2014-04-23 辉瑞大药厂 用作葡糖激酶活化剂的苯并呋喃基衍生物
EP2408780A2 (de) 2009-03-20 2012-01-25 Pfizer Inc. 3-oxa-7-azabicyclo[3.3.1]nonane
KR20120061063A (ko) 2009-06-05 2012-06-12 화이자 인코포레이티드 Ｇｐｒ 119 조절제로서의 ｌ-(피페리딘-4-일)-피라졸 유도체
US20130072427A1 (en) 2009-09-23 2013-03-21 Pfizer Inc. Gpr 119 modulators
US8669380B2 (en) 2009-11-02 2014-03-11 Pfizer Inc. Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
JP2013510191A (ja) 2009-11-10 2013-03-21 ファイザー・インク Ｎ−２ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害薬
CU24077B1 (es) 2009-11-10 2015-03-30 Pfizer DERIVADOS DE N1-PIRAZOLOESPIROCETONA ÚTILES COMO INHIBIDORES DE ACETIL-CoA CARBOXILASA
US20120295845A1 (en) 2009-11-23 2012-11-22 Pfizer Inc Imidazo-pyrazoles as gpr119 inhibitors
RU2524341C2 (ru) 2010-03-19 2014-07-27 Пфайзер Инк. Производные 2,3-дигидро-1н-инден-1-ил-2,7-диазаспиро[3.5]нонана и их применение в качестве антагонистов или обратных агонистов грелинового рецептора
WO2011158149A1 (en) 2010-06-18 2011-12-22 Pfizer Inc. 2-(3,5-disubstitutedphenyl)pyrimidin-4(3h)-one derivatives
SI2621493T1 (sl) 2010-09-30 2016-10-28 Pfizer Inc. Zaviralci N1-pirazolospiroketon acetil-CoA-karboksilaze
NZ609527A (en) 2010-10-29 2014-03-28 Pfizer N1/n2-lactam acetyl-coa carboxylase inhibitors
KR101506829B1 (ko) 2010-12-23 2015-03-30 화이자 인코포레이티드 글루카곤 수용체 조절제
LT2673260T (lt) 2011-02-08 2016-10-25 Pfizer Inc. Gliukagono receptoriaus moduliatorius
SI2699576T1 (sl) 2011-04-22 2016-02-29 Pfizer Inc. Derivati pirazolospiroketonov za uporabo kot zaviralci acetil-CoA karboksilaze
WO2013011402A1 (en) 2011-07-15 2013-01-24 Pfizer Inc. Gpr 119 modulators
RU2013157388A (ru) 2011-07-22 2015-08-27 Пфайзер Инк. Хинолинильные модуляторы глюкагонового рецептора
JP6043355B2 (ja) 2011-08-31 2016-12-14 ファイザー・インク ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
CA2864872C (en) 2012-02-24 2022-07-05 Alteogen Inc. Modified antibody in which motif comprising cysteine residue is bound
WO2013150416A1 (en) 2012-04-06 2013-10-10 Pfizer Inc. Diacylglycerol acyltransferase 2 inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6110937B2 (ja) 2012-05-04 2017-04-05 ファイザー・インク ＡＰＰ、ＢＡＣＥ１、およびＢＡＣＥ２の阻害剤としての複素環式置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
CA2882389A1 (en) 2012-09-20 2014-03-27 Pfizer Inc. Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
EP2931731A1 (de) 2012-12-11 2015-10-21 Pfizer Inc. Hexahydropyrano-[3,4-d]-[1,3]-thiazin-2-aminverbindungen als bace1-inhibitoren
EP2935282A1 (de) 2012-12-19 2015-10-28 Pfizer Inc. Carbocyclisch und heterocyclisch substituierte hexahydropyrano[3,4-d]-[1,3]thiazin-2-amin-verbindungen
EP2956458B1 (de) 2013-02-13 2017-08-09 Pfizer Inc Heteroarylsubstituierte hexahydropyrano[3,4-d][1,3]thiazin-2-amin-verbindungen
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
PE20151808A1 (es) 2013-05-02 2015-12-16 Glaxosmithkline Ip Dev Ltd Peptidos terapeuticos
ES2665153T3 (es) 2013-10-09 2018-04-24 Pfizer Inc. Antagonistas del receptor EP3 de prostaglandina
RU2016129516A (ru) * 2013-12-20 2018-01-25 Ф. Хоффманн-Ля Рош Аг ПРИМЕНЕНИЕ ПЕПТИДИЛГЛИЦИН-α-АМИДИРУЮЩЕЙ МОНООКСИДАЗЫ (РАМ) ДЛЯ С-КОНЦЕВОГО АМИДИРОВАНИЯ
WO2015140658A1 (en) 2014-03-17 2015-09-24 Pfizer Inc. Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders
EP3129388A1 (de) 2014-04-10 2017-02-15 Pfizer Inc. 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yl-amide
WO2016092413A1 (en) 2014-12-10 2016-06-16 Pfizer Inc. Indole and indazole compounds that activate ampk
JP2017538769A (ja) 2014-12-22 2017-12-28 ファイザー・インク プロスタグランジンｅｐ３受容体の拮抗薬
WO2016124687A1 (en) * 2015-02-04 2016-08-11 Novo Nordisk A/S Selective pyy compounds and uses thereof
UA125334C2 (uk) 2015-06-17 2022-02-23 Пфайзер Інк. Трициклічні сполуки та їх застосування як інгібіторів фосфодіестерази
WO2017051276A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
JP2018531924A (ja) 2015-09-24 2018-11-01 ファイザー・インク テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用
WO2017051294A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
MD3397631T2 (ro) 2015-12-29 2021-08-31 Pfizer 3-Azabiciclo[3.1.0] hexani substituiţi drept inhibitori de cetohexokinază
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
US20210171598A1 (en) 2017-12-01 2021-06-10 University Of Copenhagen Peptide hormone with one or more o-glycans
CA3098304A1 (en) * 2018-04-26 2019-10-31 Colorado State University Research Foundation Methods and compositions for tracking vegetation
CN112955147A (zh) 2018-08-31 2021-06-11 辉瑞公司 用于治疗nash/nafld和相关疾病的组合
WO2020234726A1 (en) 2019-05-20 2020-11-26 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
WO2023283392A1 (en) * 2021-07-08 2023-01-12 Gila Therapeutics, Inc. Compositions and methods for activating a neural receptor
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US176630A (en) * 1876-04-25 Improvement in wagon-locks
US244041A (en) * 1881-07-12 Machine for blocking and shaping hats
US176643A (en) * 1876-04-25 Improvement in ironing-tables
US141985A (en) * 1873-08-19 Improvement in sewing-machine tables
US2919901A (en) * 1957-01-25 1960-01-05 Thor Power Tool Co Drill system with suction
US4908713A (en) * 1981-12-14 1990-03-13 Levine Michael R VCR Programmer
US5508815A (en) * 1981-12-14 1996-04-16 Smart Vcr Limited Partnership Schedule display system for video recorder programming
US4586158A (en) * 1983-02-22 1986-04-29 International Business Machines Corp. Screen management system
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
US4708934A (en) 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
DE3588239T3 (de) 1985-03-30 2007-03-08 Kauffman, Stuart A., Santa Fe Verfahren zum Erhalten von DNS, RNS, Peptiden, Polypeptiden oder Proteinen durch DMS-Rekombinant-Verfahren
US4821097A (en) * 1987-03-05 1989-04-11 General Instrument Corporation Apparatus and method for providing digital audio on the sound carrier of a standard television signal
US5789234A (en) 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US4930160A (en) * 1987-09-02 1990-05-29 Vogel Peter S Automatic censorship of video programs
US4984152A (en) * 1987-10-06 1991-01-08 Bell Communications Research, Inc. System for controlling computer processing utilizing a multifunctional cursor with decoupling of pointer and image functionalities in space and time
US4827250A (en) * 1987-10-26 1989-05-02 Tektronix, Inc. Graphics display system having data transform circuit
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US4991011A (en) * 1988-12-23 1991-02-05 Scientific-Atlanta, Inc. Interactive television terminal with programmable background audio or video
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
US5727060A (en) * 1989-10-30 1998-03-10 Starsight Telecast, Inc. Television schedule system
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
JP2938569B2 (ja) 1990-08-29 1999-08-23 ジェンファーム インターナショナル，インコーポレイティド 異種免疫グロブリンを作る方法及びトランスジェニックマウス
US5293357A (en) * 1990-09-10 1994-03-08 The Superguide Corporation Method and apparatus for controlling a television program recording device
US5247347A (en) * 1991-09-27 1993-09-21 Bell Atlantic Network Services, Inc. Pstn architecture for video-on-demand services
JP2654283B2 (ja) * 1991-09-30 1997-09-17 株式会社東芝 アイコン表示方法
US5317391A (en) * 1991-11-29 1994-05-31 Scientific-Atlanta, Inc. Method and apparatus for providing message information to subscribers in a cable television system
US5291554A (en) * 1992-05-28 1994-03-01 Tv Answer, Inc. Shared-price custom video rentals via interactive TV
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
CA2140638C (en) 1992-07-24 2010-05-04 Raju Kucherlapati Generation of xenogeneic antibodies
JPH06139671A (ja) * 1992-10-27 1994-05-20 Sony Corp 記録再生システム
KR100246247B1 (ko) * 1992-10-30 2000-05-01 야마오카 다께오 자동포장 및 밀봉장치내의 절단유닛
US5592551A (en) * 1992-12-01 1997-01-07 Scientific-Atlanta, Inc. Method and apparatus for providing interactive electronic programming guide
US5715515A (en) * 1992-12-02 1998-02-03 Scientific-Atlanta, Inc. Method and apparatus for downloading on-screen graphics and captions to a television terminal
US5410326A (en) * 1992-12-04 1995-04-25 Goldstein; Steven W. Programmable remote control device for interacting with a plurality of remotely controlled devices
KR100295386B1 (ko) * 1992-12-09 2001-09-22 마크 홀린저 케이블 텔레비전 전달 시스템을 위한 세트 탑터미날
US5600364A (en) * 1992-12-09 1997-02-04 Discovery Communications, Inc. Network controller for cable television delivery systems
US5483277A (en) * 1992-12-15 1996-01-09 Alcatel Network Systems Simplified set-top converter for broadband switched network
US5598524A (en) * 1993-03-03 1997-01-28 Apple Computer, Inc. Method and apparatus for improved manipulation of data between an application program and the files system on a computer-controlled display system
NZ265452A (en) * 1993-03-29 1997-09-22 Univ Cincinnati Analogues of peptide yy, dimers and pharmaceutical compositions
US5594509A (en) * 1993-06-22 1997-01-14 Apple Computer, Inc. Method and apparatus for audio-visual interface for the display of multiple levels of information on a display
US5621456A (en) * 1993-06-22 1997-04-15 Apple Computer, Inc. Methods and apparatus for audio-visual interface for the display of multiple program categories
US5414455A (en) * 1993-07-07 1995-05-09 Digital Equipment Corporation Segmented video on demand system
US5410344A (en) * 1993-09-22 1995-04-25 Arrowsmith Technologies, Inc. Apparatus and method of selecting video programs based on viewers' preferences
US5398071A (en) * 1993-11-02 1995-03-14 Texas Instruments Incorporated Film-to-video format detection for digital television
US5481542A (en) * 1993-11-10 1996-01-02 Scientific-Atlanta, Inc. Interactive information services control system
US5422674A (en) * 1993-12-22 1995-06-06 Digital Equipment Corporation Remote display of an image by transmitting compressed video frames representing background and overlay portions thereof
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
JPH07244781A (ja) * 1994-03-07 1995-09-19 C S K Sogo Kenkyusho:Kk ソフトウェアレンタル方法および装置ならびに流通媒体
US5629732A (en) * 1994-03-29 1997-05-13 The Trustees Of Columbia University In The City Of New York Viewer controllable on-demand multimedia service
US5512958A (en) * 1994-04-29 1996-04-30 Matsushita Electric Corporation Of America System for controlling the effects of noise in television receivers
US5521631A (en) * 1994-05-25 1996-05-28 Spectravision, Inc. Interactive digital video services system with store and forward capabilities
JP3575063B2 (ja) * 1994-07-04 2004-10-06 ソニー株式会社 再生装置、再生方法
US5596106A (en) 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
DE69521374T2 (de) * 1994-08-24 2001-10-11 Hyundai Electronics America Videoserver und diesen verwendendes System
US5682325A (en) * 1994-09-12 1997-10-28 Bell Atlantic Network Services, Inc. Level 1 gateway for video tone networks
US5619249A (en) * 1994-09-14 1997-04-08 Time Warner Entertainment Company, L.P. Telecasting service for providing video programs on demand with an interactive interface for facilitating viewer selection of video programs
DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
US5614940A (en) * 1994-10-21 1997-03-25 Intel Corporation Method and apparatus for providing broadcast information with indexing
US5521186A (en) 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors
RO118715B1 (ro) 1994-10-27 2003-09-30 Janssen Pharmaceutica Nv Inhibitori ai sintezei apolipoproteinei-b
US5724521A (en) * 1994-11-03 1998-03-03 Intel Corporation Method and apparatus for providing electronic advertisements to end users in a consumer best-fit pricing manner
US5623613A (en) * 1994-11-29 1997-04-22 Microsoft Corporation System for displaying programming information
US5912227A (en) * 1995-01-27 1999-06-15 North Carolina State University Method of enhancing nutrient uptake
US5619247A (en) * 1995-02-24 1997-04-08 Smart Vcr Limited Partnership Stored program pay-per-play
US5632681A (en) * 1995-03-07 1997-05-27 International Business Machines Corporation Universal electronic video game renting/distributing system
US5651010A (en) * 1995-03-16 1997-07-22 Bell Atlantic Network Services, Inc. Simultaneous overlapping broadcasting of digital programs
EP0822830B1 (de) 1995-04-27 2008-04-02 Amgen Fremont Inc. Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
US5721829A (en) * 1995-05-05 1998-02-24 Microsoft Corporation System for automatic pause/resume of content delivered on a channel in response to switching to and from that channel and resuming so that a portion of the content is repeated
US6558708B1 (en) * 1995-05-17 2003-05-06 Cedars-Sinai Medical Center Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
US5740549A (en) * 1995-06-12 1998-04-14 Pointcast, Inc. Information and advertising distribution system and method
US5751282A (en) * 1995-06-13 1998-05-12 Microsoft Corporation System and method for calling video on demand using an electronic programming guide
US5724106A (en) * 1995-07-17 1998-03-03 Gateway 2000, Inc. Hand held remote control device with trigger button
US5745837A (en) * 1995-08-25 1998-04-28 Terayon Corporation Apparatus and method for digital data transmission over a CATV system using an ATM transport protocol and SCDMA
US5737028A (en) * 1995-11-01 1998-04-07 International Business Machines Corporation Previous channel listing with cursor controlled user interface for television video displays
US5919901A (en) * 1996-04-08 1999-07-06 Bayer Corporation Neuropeptide Y receptor Y5 and nucleic acid sequences
US5721897A (en) * 1996-04-09 1998-02-24 Rubinstein; Seymour I. Browse by prompted keyword phrases with an improved user interface
US5721827A (en) * 1996-10-02 1998-02-24 James Logan System for electrically distributing personalized information
CA2764753C (en) * 1996-12-10 2015-08-04 United Video Properties, Inc. Internet television program guide system
US6654933B1 (en) * 1999-09-21 2003-11-25 Kasenna, Inc. System and method for media stream indexing
ES2375330T3 (es) 1997-04-16 2012-02-28 Unigene Laboratories, Inc. Expresión directa de péptidos en medios de cultivo.
IL121230A (en) * 1997-07-03 2004-05-12 Nds Ltd Intelligent electronic program guide
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
AU750025B2 (en) 1997-09-26 2002-07-11 Athersys, Inc. Expression of endogenous genes by non-homologous recombination of a vector construct with cellular DNA
US6046167A (en) * 1998-03-25 2000-04-04 University Of Cincinnati Peptide YY analogs
US6505348B1 (en) * 1998-07-29 2003-01-07 Starsight Telecast, Inc. Multiple interactive electronic program guide system and methods
US6360053B1 (en) * 1998-08-07 2002-03-19 Replaytv, Inc. Method and apparatus for fast forwarding and rewinding in a video recording device
KR100652994B1 (ko) 1998-09-11 2006-11-30 아방티 파르마 소시에테 아노님 아제티딘 유도체, 이의 제조방법 및 이를 함유하는 약제
US20020026638A1 (en) * 2000-08-31 2002-02-28 Eldering Charles A. Internet-based electronic program guide advertisement insertion method and apparatus
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
US7396809B1 (en) * 1999-02-10 2008-07-08 Curis, Inc. Methods and reagents for treating glucose metabolic disorders
US7086077B2 (en) * 1999-04-01 2006-08-01 Sedna Patent Services, Llc Service rate change method and apparatus
US7150031B1 (en) * 2000-06-09 2006-12-12 Scientific-Atlanta, Inc. System and method for reminders of upcoming rentable media offerings
US6986156B1 (en) * 1999-06-11 2006-01-10 Scientific Atlanta, Inc Systems and methods for adaptive scheduling and dynamic bandwidth resource allocation management in a digital broadband delivery system
US7010801B1 (en) * 1999-06-11 2006-03-07 Scientific-Atlanta, Inc. Video on demand system with parameter-controlled bandwidth deallocation
US6832386B1 (en) * 1999-06-11 2004-12-14 Scientific-Atlanta, Inc. System and method for allowing a user to quickly navigate within a program guide to an established reference point
US7228556B2 (en) * 1999-12-21 2007-06-05 Tivo Inc. Distributed, interactive television program guide; system and method
US20030030679A1 (en) * 2000-01-06 2003-02-13 Anuj Kumar Jain User-definable images in bookmarks
AU2001253055A1 (en) * 2000-03-31 2001-10-15 Liquid Engines, Inc. Electronic matching engine for matching desired characteristics with item attributes
DE60110770T2 (de) * 2000-03-31 2006-02-23 United Video Properties, Inc., Tulsa Interaktives mediasystem und methode zur presentation von berichten während pausen
US20020007485A1 (en) * 2000-04-03 2002-01-17 Rodriguez Arturo A. Television service enhancements
GB0008691D0 (en) * 2000-04-07 2000-05-31 Post Impressions Systems Ltd Input and output systems for data processing
US7934232B1 (en) * 2000-05-04 2011-04-26 Jerding Dean F Navigation paradigm for access to television services
US8069259B2 (en) * 2000-06-09 2011-11-29 Rodriguez Arturo A Managing removal of media titles from a list
US7685520B2 (en) * 2000-06-22 2010-03-23 Intel Corporation Electronic programming guide with selectable categories
US7962370B2 (en) * 2000-06-29 2011-06-14 Rodriguez Arturo A Methods in a media service system for transaction processing
JP4356226B2 (ja) * 2000-09-12 2009-11-04 ソニー株式会社 サーバ装置、配信システム、配信方法、及び端末装置
US8302127B2 (en) * 2000-09-25 2012-10-30 Thomson Licensing System and method for personalized TV
ES2261483T3 (es) * 2000-10-11 2006-11-16 United Video Properties, Inc. Sistemas y metodos de construccion de listas de medios de usuario.
US20020049978A1 (en) * 2000-10-20 2002-04-25 Rodriguez Arturo A. System and method for access and placement of media content information items on a screen display with a remote control device
US6924291B2 (en) 2001-01-23 2005-08-02 Merck & Co., Inc. Process for making spiro isobenzofuranone compounds
NZ524633A (en) 2001-03-22 2005-02-25 Solvay Pharmaceuticals B 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
EP2128246B1 (de) 2001-04-19 2014-03-12 The Scripps Research Institute Verfahren und Zusammensetzungen zur Herstellung von orthogonalen TRNA-Aminoacyl-TRNA-Synthetase-Paaren
SK287806B6 (sk) 2001-06-28 2011-10-04 Pfizer Products Inc. Triamid-substituované indoly, benzofurány a benzotiofény ako inhibítory mikrozómového proteínu prenášajúceho triglyceridu (MTP) a/alebo sekrécie apolipoproteínu B (Apo B)
US8006262B2 (en) * 2001-06-29 2011-08-23 Rodriguez Arturo A Graphic user interfaces for purchasable and recordable media (PRM) downloads
BR0212985A (pt) * 2001-09-24 2005-08-30 Imp College Innovations Ltd Uso de pyy ou de um agonista do mesmo na preparação de medicamentos para tratamento de distúrbios associados com excesso de peso
US7142590B2 (en) * 2001-10-11 2006-11-28 Utstarcom Inc. Method and system for oversubscribing a DSL modem
US20030074257A1 (en) * 2001-10-12 2003-04-17 Michael Saveliev Method and apparatus for advertising adjacent to a beverage dispenser to facilitate advertising income device placement in high traffic venues
US7334251B2 (en) * 2002-02-11 2008-02-19 Scientific-Atlanta, Inc. Management of television advertising
WO2003075660A1 (en) 2002-03-06 2003-09-18 Merck & Co., Inc. Method of treatment or prevention of obesity
WO2003082190A2 (en) 2002-03-26 2003-10-09 Merck & Co., Inc. Spirocyclic amides as cannabinoid receptor modulators
JP4202319B2 (ja) 2002-07-29 2008-12-24 エフ．ホフマン−ラ ロシュ アーゲー 新規ベンゾジオキソール
DE60316829T2 (de) 2002-08-02 2008-07-10 Merck & Co., Inc. Substituierte furo[2,3-b]pyridin-derivate
US7129239B2 (en) 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
MY134457A (en) 2002-11-22 2007-12-31 Merck & Co Inc Substituted amides
EP1581245A2 (de) * 2002-12-17 2005-10-05 Nastech Pharmaceutical Company Inc. Zusammensetzungen und verfahren für verstärkte mukosale abgabe von y2-rezeptorbindenden peptiden sowie verfahren zur behandlung und prävention von adipositas
US7186692B2 (en) 2002-12-17 2007-03-06 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity
AU2003289118A1 (en) * 2002-12-18 2004-07-09 International Business Machines Corporation Web service providing system, server device for the same, control method for controlling computer system as server device for web service providing system, program for executing the control method, and recording medium
US7329658B2 (en) 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US20070027073A1 (en) * 2003-04-08 2007-02-01 Menachem Rubinstein Long-acting derivatives of pyy agonists
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
MXPA05012278A (es) 2003-05-14 2006-02-10 Emisphere Tech Inc Composiciones para suministrar peptido yy y combatientes pyy.
ES2425221T3 (es) 2003-05-30 2013-10-14 Amylin Pharmaceuticals, Llc Nuevos métodos y composiciones para suministro por vía transmucosa potenciado de péptidos y proteínas
US7274740B2 (en) * 2003-06-25 2007-09-25 Sharp Laboratories Of America, Inc. Wireless video transmission system
US20050091693A1 (en) * 2003-10-22 2005-04-28 Rochelle Communications, Inc. Dual mode set-top box that optimizes the delivery and user selection of audio or video programming over data networks
US7151097B2 (en) 2003-11-07 2006-12-19 Pfizer Inc. Bicyclic pyrazolyl and imidazolyl compounds and uses thereof
EP1716137A1 (de) 2004-02-04 2006-11-02 Pfizer Products Incorporated Substituierte chinolinverbindung
EP1789440A4 (de) * 2004-02-11 2008-03-12 Amylin Pharmaceuticals Inc Pankreas-polypeptidfamilienmotive und diese enthaltende polypeptide
WO2005080424A2 (en) * 2004-02-23 2005-09-01 Rheoscience A/S Peptide yy analogues
US7954129B2 (en) * 2004-09-24 2011-05-31 Smartvue Corporation Wireless video surveillance system and method with remote viewing
US20060088105A1 (en) * 2004-10-27 2006-04-27 Bo Shen Method and system for generating multiple transcoded outputs based on a single input
US7620065B2 (en) * 2005-07-22 2009-11-17 Trellia Networks, Inc. Mobile connectivity solution
US8189472B2 (en) * 2005-09-07 2012-05-29 Mcdonald James F Optimizing bandwidth utilization to a subscriber premises

Also Published As

Publication number Publication date
CA2596977A1 (en) 2006-08-10
KR20070094829A (ko) 2007-09-21
IL184324A0 (en) 2007-10-31
NL1031067C2 (nl) 2007-03-13
EA011882B1 (ru) 2009-06-30
MA29243B1 (fr) 2008-02-01
DK1846445T3 (da) 2009-05-04
JP2008528050A (ja) 2008-07-31
EP2078729A1 (de) 2009-07-15
TW200639180A (en) 2006-11-16
CY1109054T1 (el) 2014-07-02
PE20061412A1 (es) 2007-03-08
NL1033469C2 (nl) 2007-10-23
UY29357A1 (es) 2006-10-02
TNSN07305A1 (fr) 2008-12-31
ES2322293T3 (es) 2009-06-18
CA2596977C (en) 2010-11-02
RS50966B (sr) 2010-10-31
NL1031067A1 (nl) 2006-08-07
US20090170778A1 (en) 2009-07-02
GT200600038A (es) 2006-09-13
EP1846445B1 (de) 2009-03-25
PA8660701A1 (es) 2006-09-22
SI1846445T1 (sl) 2009-06-30
PT1846445E (pt) 2009-05-14
JP4314304B2 (ja) 2009-08-12
MX2007009389A (es) 2008-02-12
PL1846445T3 (pl) 2009-07-31
KR100892545B1 (ko) 2009-04-09
AU2006211039A1 (en) 2006-08-10
NL1033469A1 (nl) 2007-06-06
AP2007004069A0 (en) 2007-08-31
US20090171071A1 (en) 2009-07-02
AR052108A1 (es) 2007-02-28
WO2006082517A1 (en) 2006-08-10
US20060178501A1 (en) 2006-08-10
HRP20090245T1 (en) 2009-07-31
EA200701439A1 (ru) 2008-02-28
NO20074498L (no) 2007-11-02
EP1846445A1 (de) 2007-10-24
TWI310038B (en) 2009-05-21
BRPI0606142A2 (pt) 2009-06-02
DOP2006000025A (es) 2006-09-15
ATE426614T1 (de) 2009-04-15

Similar Documents

Publication Publication Date Title
DE602006005902D1 (de) Pyy-agonisten und anwendungen davon
ATE442368T1 (de) 3-amino-2-arylpropylazaindole und anwendungen davon
DK1717469T3 (da) Lejeelement
ATE521638T1 (de) Gegen angiopoietin-2 gerichtete antikörper und anwendungen davon
DE602006007563D1 (de) Agonisten
DE602006020061D1 (de) Mucin-glycoprotein und anwendung davon
DE602005019098D1 (de) Tetralin- und indanderivate und deren anwendungen
DK2079485T3 (da) Phenylpropionamidforbindelser og anvendelsen deraf
DE602006011600D1 (de) Audiocodierungseinrichtung und audiocodierungsverfahren
ITPD20060384A1 (it) Dispositivo di manipolazione
DE602006014957D1 (de) Audiocodierungseinrichtung und audiocodierungsverfahren
DE602008003575D1 (de) Piperidinverbindungen und anwendungen davon
DE602006015540D1 (de) Durchführung und buchse
DE602005016976D1 (de) Informationssendevorrichtung und informationssendeverfahren
DE602006001781D1 (de) Verbinder und Verbinderanordnung
DE602006016225D1 (de) Verbinder und Verbinderanordnung
DE502006001206D1 (de) Objektiv und Mikroskop
DE602006002451D1 (de) Adapterhülse und entsprechende Zusammenbau und Montageverfahren
DE602006003075D1 (de) Uracilen und 3-sulfonylisoxazolinen
DE112006002272T8 (de) Katheter und Katheter-Kit
DE602006004152D1 (de) Verbinder und Verbinderanordnung
DE602006017883D1 (de) Pipd-papier und daraus hergestellte komponenten
DE602006001091D1 (de) Verbinder und Verbinderanordnung
FI20055133A0 (fi) Iskulaite
DE602007006966D1 (de) Pyrazoloä1,5-aüpyrimidine, verfahren, anwendungen und zusammensetzungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition