Connect public, paid and private patent data with Google Patents Public Datasets

Pharmazeutische zusammensetzung

Info

Publication number
DE60127002D1
DE60127002D1 DE2001627002 DE60127002A DE60127002D1 DE 60127002 D1 DE60127002 D1 DE 60127002D1 DE 2001627002 DE2001627002 DE 2001627002 DE 60127002 A DE60127002 A DE 60127002A DE 60127002 D1 DE60127002 D1 DE 60127002D1
Authority
DE
Grant status
Grant
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE2001627002
Other languages
English (en)
Other versions
DE60127002T2 (de )
Inventor
Giuseppe Alvaro
Fabio Romano Di
Paolo Maragni
Marisa Tampieri
Maria Elvira Tranquillini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
DE2001627002 2000-10-17 2001-10-12 Pharmazeutische zusammensetzung Active DE60127002D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0025354A GB0025354D0 (en) 2000-10-17 2000-10-17 Chemical compounds

Publications (1)

Publication Number Publication Date
DE60127002D1 true DE60127002D1 (de) 2007-04-12

Family

ID=9901397

Family Applications (5)

Application Number Title Priority Date Filing Date
DE2001606287 Active DE60106287T2 (de) 2000-10-17 2001-10-12 Chemische verbindungen
DE2001606287 Active DE60106287D1 (de) 2000-10-17 2001-10-12 Chemische verbindungen
DE2001627002 Active DE60127002T2 (de) 2000-10-17 2001-10-12 Pharmazeutische zusammensetzung
DE2001627002 Active DE60127002D1 (de) 2000-10-17 2001-10-12 Pharmazeutische zusammensetzung
DE2001642197 Active DE60142197D1 (de) 2000-10-17 2001-10-12 Pharmazeutische Zusammensetzung

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE2001606287 Active DE60106287T2 (de) 2000-10-17 2001-10-12 Chemische verbindungen
DE2001606287 Active DE60106287D1 (de) 2000-10-17 2001-10-12 Chemische verbindungen
DE2001627002 Active DE60127002T2 (de) 2000-10-17 2001-10-12 Pharmazeutische zusammensetzung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2001642197 Active DE60142197D1 (de) 2000-10-17 2001-10-12 Pharmazeutische Zusammensetzung

Country Status (11)

Country Link
US (5) US7119092B2 (de)
JP (1) JP3940359B2 (de)
KR (1) KR100847414B1 (de)
CN (1) CN1231468C (de)
CA (1) CA2425876C (de)
DE (5) DE60106287T2 (de)
DK (2) DK1326832T3 (de)
EP (4) EP1752449A1 (de)
ES (3) ES2282794T3 (de)
GB (1) GB0025354D0 (de)
WO (1) WO2002032867A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
GB0108595D0 (en) 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
GB0119797D0 (en) 2001-08-14 2001-10-03 Glaxo Group Ltd Chemical compounds
EP1472222A1 (de) 2002-02-08 2004-11-03 Glaxo Group Limited Piperidylcarbonsäure amidderivate und deren verwendung zur behandlung von durch tachykinin vermittelten erkrankungen
GB0203020D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
CN100430378C (zh) * 2002-05-29 2008-11-05 田边制药株式会社 新哌啶化合物
JP4079727B2 (ja) 2002-09-06 2008-04-23 セントラル硝子株式会社 光学活性1−(フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル)アルキルアミンn−モノアルキル誘導体とその製造方法
ES2297275T3 (es) 2002-12-23 2008-05-01 Janssen Pharmaceutica Nv Derivados de 1-piperidin-3-il-4-piperidin-4-il-piperazina sustituida y su uso como antagonistas de la neurocinina.
CA2509090C (en) * 2002-12-23 2012-01-24 Janssen Pharmaceutica N.V. Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists
KR101049073B1 (ko) 2002-12-23 2011-07-15 얀센 파마슈티카 엔.브이. 치환된 1-피페리딘-4-일-4-피롤리딘-3-일-피페라진 유도체및 그의 뉴로키닌 길항제로서의 용도
EP1581517B1 (de) * 2002-12-23 2007-02-21 Janssen Pharmaceutica N.V. Substituierte 1-piperidin-4-yl-4-azetidin-3-yl-piperazinderivate und deren verwendung als neurokininantagonisten
WO2004067093A3 (en) * 2003-01-27 2004-10-28 Glaxo Group Ltd Nk1 receptor antagonists for the treatment of functional dyspepsia
US20040242639A1 (en) * 2003-03-31 2004-12-02 Bharat Lagu Phospholipase C inhibitors for use in treating inflammatory disorders
WO2004087654A3 (en) * 2003-03-31 2005-01-27 Janssen Pharmaceutica Nv Phospholipase c inhibitors for use in treating inflammatory disorders
WO2004087685A3 (en) * 2003-03-31 2004-12-16 Janssen Pharmaceutica Nv Phospholipase c inhibitors for use in treating inflammatory disorders
FR2853648B1 (fr) * 2003-04-11 2006-08-18 Fournier Lab Sa Nouveaux derives de benzenesulfonamides et leur utilisation en therapeutique
GB0308968D0 (en) * 2003-04-17 2003-05-28 Glaxo Group Ltd Medicaments
US20080070924A1 (en) * 2003-06-10 2008-03-20 Frans Eduard Janssens Novel Formulations For Opioid-Based Treatments Of Pain Comprising 1-(1,2-Disubstituted Piperidinyl)-4-Substituted Piperazine Derivatives
WO2004110996A1 (en) * 2003-06-19 2004-12-23 Pfizer Products Inc. Nk1 antagonist
WO2005097774A1 (en) * 2004-04-08 2005-10-20 Janssen Pharmaceutica N.V. Substituted 4-alkyl- and 4-alkanoyl-piperidine derivatives and their use as neurokinin antagonists
WO2006062110A1 (ja) * 2004-12-06 2006-06-15 Banyu Pharmaceutical Co., Ltd. ピペラジン誘導体
GB0426942D0 (en) * 2004-12-08 2005-01-12 Glaxo Group Ltd Medicament
DE602006016244D1 (de) 2005-03-08 2010-09-30 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin-(nk1)-antagonisten
GB0514707D0 (en) * 2005-07-18 2005-08-24 Glaxo Group Ltd Chemical compounds
GB0514705D0 (en) * 2005-07-18 2005-08-24 Glaxo Group Ltd Chemical compounds
GB0514704D0 (en) * 2005-07-18 2005-08-24 Glaxo Group Ltd Chemical compounds
JP4904945B2 (ja) 2006-06-30 2012-03-28 セントラル硝子株式会社 光学活性1−(フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル)アルキルアミンn−モノアルキル誘導体の製造方法
EP2129381A1 (de) 2007-01-24 2009-12-09 Glaxo Group Limited Pharmazeutische zubereitungen enthaltend 3,5-diamino-6-(2,3-dichlophenyl)-1,2,4-triazin or r(-)-2,4-diamino-5-(2,3dichlorophenyl)-6-fluoromethyl pyrimidin und einen nk1- rezeptor-antagonisten
JP5647519B2 (ja) 2007-09-13 2014-12-24 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化カテコールおよびベンゾ[d][1,3]ジオキソールおよびその誘導体の合成
GB0812849D0 (en) * 2008-07-14 2008-08-20 Glaxo Wellcome Mfg Pte Ltd Novel compounds
DK2729147T3 (da) 2011-07-04 2017-12-18 Irbm - Science Park S P A Nk-1-receptorantagonister til behandling af hornhindeneovaskularisering
DK2817312T3 (da) 2012-02-22 2016-04-11 Leo Pharma As Hidtil ukendte neurokinin-1-receptorantagonistforbindelser
WO2015024203A1 (en) * 2013-08-20 2015-02-26 Leo Pharma A/S Novel neurokinin 1 receptor antagonist compounds ii

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US536020A (en) * 1894-04-09 1895-03-19 Washing or bathing apparatus
US4110327A (en) 1974-05-09 1978-08-29 Toyama Chemical Co., Ltd. 2,3 Diketo-piperazinocarbonylamino alkanoic acids and derivatives
US4087424A (en) 1974-05-09 1978-05-02 Toyama Chemical Co., Ltd. Novel penicillins and cephalosporins and process for producing the same
US4219554A (en) 1974-05-09 1980-08-26 Toyama Chemical Company, Limited Novel penicillins and cephalosporins and process for producing same
GB1508064A (en) 1974-05-09 1978-04-19 Toyama Chemical Co Ltd Amino acid derivatives
US4112090A (en) 1974-05-09 1978-09-05 Toyama Chemical Co., Ltd. Novel penicillins and cephalosporins and process for producing the same
US4379152A (en) 1974-05-09 1983-04-05 Toyama Chemical Co., Ltd. Cephalosporins
US4410522A (en) 1974-05-09 1983-10-18 Toyama Chemical Co., Ltd. Cephalosporins
US4327097A (en) 1974-05-09 1982-04-27 Toyama Chemical Co., Ltd. Novel penicillins
DE2941880C2 (de) 1978-10-20 1989-04-20 Aktiebolaget Ferrosan, Malmoe, Se
JPS57118587A (en) 1981-11-26 1982-07-23 Toyama Chem Co Ltd Novel penicillin
US5028610A (en) 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
GB8709666D0 (en) 1987-04-23 1987-05-28 Beecham Group Plc Compounds
GB8713061D0 (en) 1987-06-04 1987-07-08 Beecham Group Plc Compounds
US5109014A (en) 1990-12-10 1992-04-28 Jacobson Richard M N-aryl-3-aryl-4-substituted-2,3,4,5-tetrahydro-1H-pyrazole-1-carboxamides
CA2083505C (en) 1991-03-22 2003-06-10 Anders Bjork New use of diphenylbutyl-piperazinecarboxamides in the treatment of substance disorders
EP0919245A3 (de) 1991-09-20 2000-11-15 Glaxo Group Limited NK-1 Rezeptor Antagonist mit einem systemischen antiinflammatorischen Kortikosteroid zur Behandlung von Emesis
EP0545478A1 (de) 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclische Verbindungen als Tachykininantagoniste
US5334387A (en) * 1993-02-23 1994-08-02 Colgate-Palmolive Company Topical composition comprising mono and dialkyl phosphates with a cosurfactant
US5563127A (en) 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
US5348955A (en) 1993-06-22 1994-09-20 Merck & Co., Inc. N,N-diacylpiperazines
EP0655422B1 (de) 1993-11-26 1998-08-12 Deutsche Rockwool Mineralwoll-GmbH Verfahren zum Herstellen einer Schmelze für die Mineralfaserherstellung
EP0655442B1 (de) * 1993-11-29 2001-05-23 Fujisawa Pharmaceutical Co., Ltd. Piperazinderivate als Tachykinin Antagonisten
JP3073770B2 (ja) 1994-03-04 2000-08-07 メルク エンド カンパニー インコーポレーテッド モルホリンタキキニン受容体拮抗薬のプロドラッグ
US5464788A (en) 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
WO1996002503A1 (fr) 1994-07-15 1996-02-01 Meiji Seika Kabushiki Kaisha Nouveaux composes ayant un effet inhibant l'agregation plaquettaire
DE4425146A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
WO1996003378A1 (en) 1994-07-26 1996-02-08 Sankyo Company, Limited N-phenylated amide and urea derivatives
DE19520499C2 (de) 1994-09-17 2003-06-18 Boehringer Ingelheim Kg Neurokinin-Antagonisten, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende pharmazeutische Zusammensetzungen sowie ihre Verwendung
US5696123A (en) 1994-09-17 1997-12-09 Boehringer Ingelheim Kg Neurokinin antagonists
WO1996010562A1 (en) 1994-09-30 1996-04-11 Novartis Ag 1-acyl-4-aliphatylaminopiperidine compounds
DE69534213T2 (de) 1994-10-25 2006-01-12 Astrazeneca Ab Therapeutisch wirksame Heterocyclen
US5998444A (en) 1995-10-24 1999-12-07 Zeneca Ltd. Piperidinyl compounds as NK1 or NK2 antagonists
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
US5576317A (en) 1994-12-09 1996-11-19 Pfizer Inc. NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
US5700801A (en) 1994-12-23 1997-12-23 Karl Thomae, Gmbh Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
JPH10511374A (ja) 1994-12-23 1998-11-04 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ピペラジン誘導体、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
DE69631370T2 (de) 1995-02-23 2004-11-04 Schering Corp. Benzylpiperidine und -piperazine als muscarinantagonisten
DK0862566T3 (da) 1995-10-30 2000-06-13 Janssen Pharmaceutica Nv 1-(1,2-Disubstitueret piperidinyl)-4-substituerede piperazindeivater
DE19608665A1 (de) 1996-03-06 1997-09-11 Boehringer Ingelheim Kg Neue Arylglycinamidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6057323A (en) 1996-03-08 2000-05-02 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
JP2000507579A (ja) 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
US5859012A (en) 1996-04-03 1999-01-12 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507576A (ja) 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
EP0921801A1 (de) 1996-04-03 1999-06-16 MERCK & CO., INC. Inhibitoren der farnesyl-protein-transferase
WO1998001133A1 (fr) 1996-07-08 1998-01-15 Yamanouchi Pharmaceutical Co., Ltd. Inhibiteurs de la resorption osseuse
US6117855A (en) 1996-10-07 2000-09-12 Merck Sharp & Dohme Ltd. Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
US5929077A (en) 1996-11-08 1999-07-27 Leftheris; Katerina Thioproline-containing inhibitors of farnesyl protein transferase
US5977104A (en) 1996-12-02 1999-11-02 Merck Sharp & Dohme Ltd. Use of NK-1 receptor antagonists for treating bipolar disorders
US6114315A (en) 1996-12-02 2000-09-05 Merck Sharp & Dohme Ltd. Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety
JP2001504852A (ja) 1996-12-02 2001-04-10 メルク シヤープ エンド ドーム リミテツド 双極性障害の治療のためのnk−1受容体拮抗薬の使用
EP0993457A1 (de) 1997-06-17 2000-04-19 Fujisawa Pharmaceutical Co., Ltd. Aroyl-piperazin derivate, deren herstellung und deren verwendung als tachykinin-antagonisten
EP1014984A1 (de) 1997-08-27 2000-07-05 MERCK & CO., INC. Prenyl-protein transferase inhibitoren
EP1034164B1 (de) 1997-11-24 2004-05-19 MERCK & CO., INC. Beta-alanin-derivate als zell-adhäsions-inhibitoren
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
US6253732B1 (en) * 1999-11-11 2001-07-03 Ford Global Technologies, Inc. Electronic throttle return mechanism with a two-spring and two-lever default mechanism
GB0025354D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US20030022891A1 (en) 2000-12-01 2003-01-30 Anandan Palani MCH antagonists and their use in the treatment of obesity
GB0203022D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
JP4674086B2 (ja) 2002-10-08 2011-04-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap 置換された1,4−ジ−ピペリジン−4−イル−ピペラジン誘導体およびニューロキニンアンタゴニストとしてのそれらの使用

Also Published As

Publication number Publication date Type
DE60142197D1 (de) 2010-07-01 grant
US7060702B2 (en) 2006-06-13 grant
WO2002032867A1 (en) 2002-04-25 application
EP1524266A1 (de) 2005-04-20 application
US20060142302A1 (en) 2006-06-29 application
EP1921064B1 (de) 2010-05-19 grant
DK1326832T3 (da) 2005-01-31 grant
EP1524266B1 (de) 2007-02-28 grant
JP2004511544A (ja) 2004-04-15 application
EP1326832A1 (de) 2003-07-16 application
EP1921064A1 (de) 2008-05-14 application
US20050137208A1 (en) 2005-06-23 application
CA2425876C (en) 2009-07-07 grant
DE60106287D1 (de) 2004-11-11 grant
US20040014770A1 (en) 2004-01-22 application
US20100081667A1 (en) 2010-04-01 application
CA2425876A1 (en) 2002-04-25 application
US20080021041A1 (en) 2008-01-24 application
ES2282794T3 (es) 2007-10-16 grant
ES2227287T3 (es) 2005-04-01 grant
DE60127002T2 (de) 2007-10-31 grant
EP1752449A1 (de) 2007-02-14 application
EP1326832B1 (de) 2004-10-06 grant
ES2346108T3 (es) 2010-10-08 grant
US7119092B2 (en) 2006-10-10 grant
JP3940359B2 (ja) 2007-07-04 grant
DK1524266T3 (da) 2007-06-25 grant
KR100847414B1 (ko) 2008-07-18 grant
CN1231468C (zh) 2005-12-14 grant
US7294630B2 (en) 2007-11-13 grant
CN1483025A (zh) 2004-03-17 application
GB0025354D0 (en) 2000-11-29 grant
KR20030036932A (ko) 2003-05-09 application
DE60106287T2 (de) 2006-02-23 grant
US7648990B2 (en) 2010-01-19 grant

Similar Documents

Publication Publication Date Title
DE29815536U1 (de) Alkoholfreie pharmazeutische Zubereitung
DE60113503T2 (de) Anti-rückschlag-katheter
DE10196080T1 (de) Feinstzerkleinerungsmahlmaschine
DE60100092T2 (de) Einsteckverriegelungselement
FI20011478A (fi) Farmaseuttinen koostumus
DE50108432D1 (de) Endlagenabschaltvorrichtung
DE10193689D2 (de) Retardpartikeldispersion
DE10057218B4 (de) Durchströmungsverschraubung
DE60113289D1 (de) Schergelzusammensetzungen
DE60131191D1 (de) Hautdurchdringungsgaskollektor
DE60105715D1 (de) Etikettierkontrollvorrichtung
DE50100211D1 (de) Rohrperforationsvorrichtung
DE60117783D1 (de) Naphthamidin-urokinasinhibitoren
DE50112451D1 (de) Befestigunsvorrichtung
DE60127373D1 (de) Fluidumverdrängungsmaschine
DE50107313D1 (de) Lichtleitfaserverbindungsgehäuse
DE50006952D1 (de) Tubenabpackvorrichtung
DE60104088D1 (de) Kraftstoffinertisierungssystem
DE60128892D1 (de) Schraubgewinderohrverbindung
DE60009889D1 (de) Gipsverzögererzusammensetzung
DE60112184D1 (de) Ejektorzyklus
DE60103268D1 (de) Hochdruckumformspülanlage
DE60113739D1 (de) Glascontainerplungervorrichtung
DE50112965D1 (de) Apoptotika
DE60104981D1 (de) Magnetronsversorgungssteuermittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition