DE59814423D1 - METHOD FOR PRODUCING HUMANEOUS BLOOD CYTOKINES - Google Patents

METHOD FOR PRODUCING HUMANEOUS BLOOD CYTOKINES

Info

Publication number
DE59814423D1
DE59814423D1 DE59814423T DE59814423T DE59814423D1 DE 59814423 D1 DE59814423 D1 DE 59814423D1 DE 59814423 T DE59814423 T DE 59814423T DE 59814423 T DE59814423 T DE 59814423T DE 59814423 D1 DE59814423 D1 DE 59814423D1
Authority
DE
Germany
Prior art keywords
aliquot
cells
humaneous
producing
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59814423T
Other languages
German (de)
Inventor
Nikolaus W Klehr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/EP1998/006757 external-priority patent/WO1999021887A2/en
Application granted granted Critical
Publication of DE59814423D1 publication Critical patent/DE59814423D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

A method for preparing autologous human blood cytokines comprises: (a) treating whole blood from a donor to separate a preparation comprising white blood cells, plasma and an antigen especially tumour cells from erythrocytes; (b) dividing the preparation into first and second aliquots; (c) demasking the cells in the first aliquot rendering the tumour cells recognisable as foreign by the donor's immune system; and (d) incubating the first aliquot with the second aliquot. Also claimed is a cytokine-containing product obtained by the above method.
DE59814423T 1997-10-23 1998-10-23 METHOD FOR PRODUCING HUMANEOUS BLOOD CYTOKINES Expired - Lifetime DE59814423D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19746865 1997-10-23
DE19821843A DE19821843A1 (en) 1997-10-23 1998-05-15 Preparation of autologous human blood cytokine(s)
PCT/EP1998/006757 WO1999021887A2 (en) 1997-10-23 1998-10-23 Method for the production of human blood cytokines

Publications (1)

Publication Number Publication Date
DE59814423D1 true DE59814423D1 (en) 2010-01-28

Family

ID=7846417

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19821843A Withdrawn DE19821843A1 (en) 1997-10-23 1998-05-15 Preparation of autologous human blood cytokine(s)
DE59814423T Expired - Lifetime DE59814423D1 (en) 1997-10-23 1998-10-23 METHOD FOR PRODUCING HUMANEOUS BLOOD CYTOKINES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19821843A Withdrawn DE19821843A1 (en) 1997-10-23 1998-05-15 Preparation of autologous human blood cytokine(s)

Country Status (2)

Country Link
AT (1) ATE452144T1 (en)
DE (2) DE19821843A1 (en)

Also Published As

Publication number Publication date
DE19821843A1 (en) 1999-04-29
ATE452144T1 (en) 2010-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition