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DE59511027D1 - 3'-Modifizierte Oligonucleotid-Derivate - Google Patents

3'-Modifizierte Oligonucleotid-Derivate

Info

Publication number
DE59511027D1
DE59511027D1 DE1995511027 DE59511027A DE59511027D1 DE 59511027 D1 DE59511027 D1 DE 59511027D1 DE 1995511027 DE1995511027 DE 1995511027 DE 59511027 A DE59511027 A DE 59511027A DE 59511027 D1 DE59511027 D1 DE 59511027D1
Authority
DE
Grant status
Grant
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1995511027
Other languages
English (en)
Inventor
Dr Peyman
Dr Uhlmann
Carolin Carolus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi-Aventis Deutschland GmbH
Original Assignee
Sanofi-Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/40Succinic acid esters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Hybridisation probes
DE1995511027 1994-06-15 1995-06-09 3'-Modifizierte Oligonucleotid-Derivate Expired - Lifetime DE59511027D1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19944420737 DE4420737A1 (de) 1994-06-15 1994-06-15 Neue 3'-Modifizierte Oligonucleotid-Derivate
DE19944424263 DE4424263A1 (de) 1994-07-09 1994-07-09 Neue 3'-Modifizierte Oligonucleotid-Derivate
DE1995511027 DE59511027D1 (de) 1994-06-15 1995-06-09 3'-Modifizierte Oligonucleotid-Derivate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1995511027 DE59511027D1 (de) 1994-06-15 1995-06-09 3'-Modifizierte Oligonucleotid-Derivate

Publications (1)

Publication Number Publication Date
DE59511027D1 true DE59511027D1 (de) 2006-01-19

Family

ID=25937419

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1995511027 Expired - Lifetime DE59511027D1 (de) 1994-06-15 1995-06-09 3'-Modifizierte Oligonucleotid-Derivate

Country Status (7)

Country Link
US (1) US5696248A (de)
EP (1) EP0688784B1 (de)
JP (1) JP4398517B2 (de)
CA (2) CA2151801C (de)
DE (1) DE59511027D1 (de)
DK (1) DK0688784T3 (de)
ES (1) ES2253740T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US7309692B1 (en) 1996-07-08 2007-12-18 Board Of Regents, The University Of Texas System Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US6977244B2 (en) 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
CN1304572C (zh) * 1997-05-05 2007-03-14 萨诺费-阿文蒂斯德国有限公司 与人Ha-ras基因片段互补的经修饰的反义核苷酸
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US5968826A (en) * 1998-10-05 1999-10-19 Isis Pharmaceuticals Inc. Antisense inhibition of integrin α4 expression
WO2000040592A8 (en) * 1998-12-30 2000-11-09 Oligos Etc Inc Acid stable backbone modified end-blocked nucleic acids and therapeutic uses thereof
DE10019252A1 (de) * 2000-04-18 2001-10-31 Klaus Karl Degitz Polydesoxyribonukleotide zur Hemmung der ICAM-1-Genexpression
CA2471967A1 (en) * 2002-01-03 2003-07-31 Board Of Regents, The University Of Texas System Wt1 antisense oligos for the inhibition of breast cancer
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
JP5414961B2 (ja) 2002-08-19 2014-02-12 コーリー ファーマシューティカル グループ,インコーポレイテッド 免疫刺激性核酸
CA2502015A1 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5' cpg nucleic acids and methods of use
WO2004092412A3 (en) 2003-03-31 2005-03-03 Roche Diagnostics Gmbh Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
CA2540949A1 (en) 2003-10-30 2005-05-12 Coley Pharmaceutical Gmbh C-class oligonucleotide analogs with enhanced immunostimulatory potency
RU2393223C2 (ru) 2004-10-20 2010-06-27 Коли Фармасьютикал Груп, Инк. Полумягкие иммуностимулирующие олигонуклеотиды с-класса
CA2584614A1 (en) 2004-10-20 2006-08-24 Antisense Therapeutics Ltd Antisense modulation of integrin .alpha.4 expression
CN101517082B (zh) 2006-09-27 2014-01-22 科勒制药有限责任公司 具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物
US8916531B2 (en) 2007-11-20 2014-12-23 Isis Pharmaceuticals, Inc. Modulation of CD40 expression
WO2011032095A1 (en) * 2009-09-11 2011-03-17 Segetis, Inc. Ketal esters of oxocarboxylic acids and process of making

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI115214B (fi) * 1992-01-22 2005-03-31 Hoechst Ag Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use

Also Published As

Publication number Publication date Type
CA2151801A1 (en) 1995-12-16 application
JPH0827178A (ja) 1996-01-30 application
ES2253740T3 (es) 2006-06-01 grant
CA2151801C (en) 2008-08-19 grant
CA2628883A1 (en) 1995-12-16 application
US5696248A (en) 1997-12-09 grant
JP4398517B2 (ja) 2010-01-13 grant
DK0688784T3 (da) 2006-04-18 grant
CA2628883C (en) 2011-02-15 grant
EP0688784A2 (de) 1995-12-27 application
EP0688784B1 (de) 2005-12-14 grant
EP0688784A3 (de) 1997-01-22 application

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Legal Events

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8364 No opposition during term of opposition