DE50002229D1 - METHOD AND DEVICE FOR INCREASING AND / OR REDUCING THE CONCENTRATION OF IMMUNO-MODULATING EFFECTS IN SUBSTANCES - Google Patents

METHOD AND DEVICE FOR INCREASING AND / OR REDUCING THE CONCENTRATION OF IMMUNO-MODULATING EFFECTS IN SUBSTANCES

Info

Publication number
DE50002229D1
DE50002229D1 DE50002229T DE50002229T DE50002229D1 DE 50002229 D1 DE50002229 D1 DE 50002229D1 DE 50002229 T DE50002229 T DE 50002229T DE 50002229 T DE50002229 T DE 50002229T DE 50002229 D1 DE50002229 D1 DE 50002229D1
Authority
DE
Germany
Prior art keywords
concentration
immunomodulatory
substance mixture
active substances
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50002229T
Other languages
German (de)
Inventor
Jens Altrichter
Jens Freytag
Steffen Mitzner
Jan Stange
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artcline 18057 Rostock De GmbH
Original Assignee
Teraklin AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teraklin AG filed Critical Teraklin AG
Application granted granted Critical
Publication of DE50002229D1 publication Critical patent/DE50002229D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to a method for increasing and/or decreasing the concentration of immunomodulatory-active substances in substance mixtures which contain potentially immunomodulatory-active substances. The aim of the invention is to provide a method, which is improved with regard to prior art methods, for altering the concentration of immunomodulatory-active substances in a substance mixture or in a solution. To this end, the substance mixture is introduced into a bioreactor and is brought into contact with cells therein. The cells are selected such that they comprise receptors for at least one species chosen from a group G1 of immunomodulatory-active substances, whose concentration in the substance mixture should be decreased, and such that they are capable of absorbing these species, and/or the cells are selected such that they produce at least one species chosen from another group G2 of immunomodulatory-active substances, whose concentration in the substance mixture should be increased, and such that they are capable of releasing these species into the substance mixture. In addition, the substance mixture is subsequently separated from the cells and removed from the bioreactor. The invention also relates to a corresponding device for carrying out said method.
DE50002229T 2000-01-14 2000-01-14 METHOD AND DEVICE FOR INCREASING AND / OR REDUCING THE CONCENTRATION OF IMMUNO-MODULATING EFFECTS IN SUBSTANCES Expired - Lifetime DE50002229D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DE2000/000130 WO2001051068A1 (en) 2000-01-14 2000-01-14 Method and device for increasing and/or decreasing the concentration of immunomodulatory-active substances in substance mixtures

Publications (1)

Publication Number Publication Date
DE50002229D1 true DE50002229D1 (en) 2003-06-18

Family

ID=5647402

Family Applications (1)

Application Number Title Priority Date Filing Date
DE50002229T Expired - Lifetime DE50002229D1 (en) 2000-01-14 2000-01-14 METHOD AND DEVICE FOR INCREASING AND / OR REDUCING THE CONCENTRATION OF IMMUNO-MODULATING EFFECTS IN SUBSTANCES

Country Status (6)

Country Link
EP (1) EP1246631B1 (en)
JP (1) JP2003519503A (en)
AT (1) ATE240112T1 (en)
DE (1) DE50002229D1 (en)
ES (1) ES2199784T3 (en)
WO (1) WO2001051068A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008010691A1 (en) 2008-02-22 2009-08-27 Universität Rostock Bioäquivalenzdialyse
DE102021124752A1 (en) * 2021-09-24 2023-03-30 Ad Lentus GmbH Autologous therapeutic and method of making the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5022988A (en) * 1988-05-06 1991-06-11 Applied Immunesciences Device for plasma modification--composition and remodeling
ATE140726T1 (en) * 1992-02-07 1996-08-15 Monsanto Co BIOLOGICAL ARTIFICIAL LIVER
DE19831873A1 (en) * 1998-07-16 2000-03-30 Jens Altrichter Process for therapeutic immuno-modulation comprises the use of cells with immuno-modulatory activity in an extra-corporeal circulation

Also Published As

Publication number Publication date
ES2199784T3 (en) 2004-03-01
ATE240112T1 (en) 2003-05-15
EP1246631B1 (en) 2003-05-14
WO2001051068A1 (en) 2001-07-19
JP2003519503A (en) 2003-06-24
EP1246631A1 (en) 2002-10-09

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GAMBRO LUNDIA AB, LUND, SE

8328 Change in the person/name/address of the agent

Representative=s name: DR. WEBER, DIPL.-PHYS. SEIFFERT, DR. LIEKE, 65183

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ARTCLINE GMBH, 18057 ROSTOCK, DE