DE3485649D1 - Verfahren zur herstellung von antikoerperzusammensetzungen von therapeutischen mitteln mit verlaengerter serumhalbwertzeit. - Google Patents
Verfahren zur herstellung von antikoerperzusammensetzungen von therapeutischen mitteln mit verlaengerter serumhalbwertzeit.Info
- Publication number
- DE3485649D1 DE3485649D1 DE8484306027T DE3485649T DE3485649D1 DE 3485649 D1 DE3485649 D1 DE 3485649D1 DE 8484306027 T DE8484306027 T DE 8484306027T DE 3485649 T DE3485649 T DE 3485649T DE 3485649 D1 DE3485649 D1 DE 3485649D1
- Authority
- DE
- Germany
- Prior art keywords
- serum half
- value
- therapeutic agents
- antibody compositions
- producing antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08323428A GB2148299B (en) | 1983-09-01 | 1983-09-01 | Antibody compositions of therapeutic agents having an extended serum half-life |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3485649D1 true DE3485649D1 (de) | 1992-05-21 |
Family
ID=10548161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484306027T Expired - Fee Related DE3485649D1 (de) | 1983-09-01 | 1984-09-03 | Verfahren zur herstellung von antikoerperzusammensetzungen von therapeutischen mitteln mit verlaengerter serumhalbwertzeit. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5055289A (de) |
EP (1) | EP0136835B1 (de) |
JP (1) | JPH0717519B2 (de) |
AT (1) | ATE74766T1 (de) |
AU (1) | AU593208B2 (de) |
CA (1) | CA1249222A (de) |
DE (1) | DE3485649D1 (de) |
DK (1) | DK191985D0 (de) |
FI (1) | FI85441C (de) |
GB (1) | GB2148299B (de) |
WO (1) | WO1985000974A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5453269A (en) * | 1986-04-14 | 1995-09-26 | The General Hospital Corporation | Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use |
US4894227A (en) * | 1986-08-01 | 1990-01-16 | Cetus Corporation | Composition of immunotoxins with interleukin-2 |
FR2604092B1 (fr) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
US5009888A (en) * | 1987-04-13 | 1991-04-23 | Genzyme Corporation | Therapeutic enzyme-antibody complexes |
ATE106250T1 (de) * | 1987-07-07 | 1994-06-15 | Hybrisens Ltd | Verwendung von antikörper-antigen-wechselwirkung zum schutz oder modulation der biologischen aktivität. |
JPH03503840A (ja) * | 1988-01-15 | 1991-08-29 | セントコアー,インコーポレーテッド | 異種連結抗体およびその治療的使用 |
US5322678A (en) * | 1988-02-17 | 1994-06-21 | Neorx Corporation | Alteration of pharmacokinetics of proteins by charge modification |
US5372812A (en) * | 1988-04-04 | 1994-12-13 | The General Hospital Corporation | Composition and method for acceleration of clot lysis |
US5582862A (en) | 1988-04-04 | 1996-12-10 | General Hospital Corporation | Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin |
US5225540A (en) * | 1988-04-26 | 1993-07-06 | Du Pont Merck Pharmaceutical Company | Monoclonal antibodies to tissue plasminogen activator (t-pa) which prolong its functional half-life |
GB8813527D0 (en) * | 1988-06-08 | 1988-07-13 | Glennie M J | Bispecific antibodies |
US5686579A (en) * | 1988-06-21 | 1997-11-11 | Hybrisens, Ltd. | Use of antibody/antigen interactions to protect biologically active proteins and peptides |
ATE113846T1 (de) * | 1988-06-21 | 1994-11-15 | Genentech Inc | Therapeutische zusammensetzungen für die behandlung von myocard-infarkten. |
IE62463B1 (en) * | 1988-07-07 | 1995-02-08 | Res Dev Foundation | Immunoconjugates for cancer diagnosis and therapy |
US5763573A (en) * | 1988-08-10 | 1998-06-09 | Chiron Corporation | GTPase activating protein fragments |
US5760203A (en) * | 1988-08-10 | 1998-06-02 | Chiron Corporation | Gap gene sequences |
US5811265A (en) * | 1988-08-19 | 1998-09-22 | The General Hospital Corporation | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use |
US5609869A (en) * | 1988-08-19 | 1997-03-11 | The General Hospital Corporation | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use |
KR900005995A (ko) * | 1988-10-31 | 1990-05-07 | 우메모또 요시마사 | 변형 인터류킨-2 및 그의 제조방법 |
IE63847B1 (en) * | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US6267964B1 (en) | 1989-08-01 | 2001-07-31 | Affibody Technology Sweden Ab | Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives |
SE509359C2 (sv) * | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
ATE106251T1 (de) * | 1990-02-06 | 1994-06-15 | Takeda Chemical Industries Ltd | Immunkomplexe. |
US5506134A (en) * | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
NZ263102A (en) * | 1993-03-19 | 1997-05-26 | Immunex Corp | Pharmaceutical compositions comprising a ligand protein such as interleukin-4 and a soluble receptor protein that binds thereto |
JP2001502895A (ja) * | 1996-09-20 | 2001-03-06 | ザ・ジェネラル・ホスピタル・コーポレイション | アルファ―2―抗プラスミンに対するキメラ、ヒト化および一本鎖抗体 |
US6313089B1 (en) | 1997-08-20 | 2001-11-06 | Duke University | Complexes of apolipoprotein E and ciliary neurotrophic factor (CNTF) and methods of use |
AU9676598A (en) * | 1997-09-30 | 1999-04-23 | Duke University | Apolipoprotein e/growth factor complexes and methods of use |
DE60239522D1 (de) * | 2001-01-09 | 2011-05-05 | Baylor Res Inst Dallas | Verfahren zur behandlung von autoimmunerkrankungen bei einem probanden und diagnostische in-vitro-assays |
ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
US7101977B2 (en) | 2001-07-17 | 2006-09-05 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
WO2003059251A2 (en) * | 2001-10-22 | 2003-07-24 | The Scripps Research Institute | Antibody targeting compounds |
AU2002337954C1 (en) * | 2001-10-22 | 2008-10-23 | The Scripps Research Institute | Integrin targeting compounds |
US20080008713A1 (en) * | 2002-06-28 | 2008-01-10 | Domantis Limited | Single domain antibodies against tnfr1 and methods of use therefor |
US20070298041A1 (en) * | 2002-06-28 | 2007-12-27 | Tomlinson Ian M | Ligands That Enhance Endogenous Compounds |
US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
US20060002935A1 (en) * | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
JP2006520584A (ja) | 2002-11-08 | 2006-09-14 | アブリンクス エン.ヴェー. | 安定化単一ドメイン抗体 |
US20040175359A1 (en) * | 2002-11-12 | 2004-09-09 | Desjarlais John Rudolph | Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity |
EP1426382A1 (de) * | 2002-12-06 | 2004-06-09 | Aventis Behring GmbH | Antivirales menschliches Serum Albumin |
EP1731168A1 (de) * | 2004-03-30 | 2006-12-13 | Takeda Pharmaceutical Company Limited | Antikörper-arzneimittel |
KR20070083809A (ko) * | 2004-10-07 | 2007-08-24 | 유니베르시태트 취리히 | 건선 예방 및 치료용 ⅰ형 인터페론 차단제 |
EP1863847A2 (de) * | 2004-12-02 | 2007-12-12 | Domantis Limited | Anti-il-1r1 antikörper und deren therapeutische verwendung |
GB0521621D0 (en) | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
US7888481B2 (en) * | 2005-02-10 | 2011-02-15 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
WO2006086586A2 (en) | 2005-02-10 | 2006-08-17 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
BRPI0619224A2 (pt) * | 2005-12-01 | 2017-06-20 | Domantis Ltd | monômero de anticorpo de domínio, ligando, ácidos nucleicos isolado e recombinante, vetor, célula hospedeira, método para produzir um monômero de dab de ligando, composição farmacêutica, dispositivo de liberação de medicamento, uso de um monômero de anticorpo de domínio, e, método para tratar uma doença inflamatória, artrite ou doença respiratória |
WO2007063308A2 (en) * | 2005-12-01 | 2007-06-07 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
KR20100018040A (ko) * | 2007-06-06 | 2010-02-16 | 도만티스 리미티드 | 프로테아제 내성 폴리펩티드를 선택하는 방법 |
GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
US7625555B2 (en) | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
BRPI0912570B8 (pt) | 2008-05-07 | 2021-05-25 | Argos Therapeutics Inc | anticorpo anti-ifn-alfa humanizado, ou um fragmento de ligação ao antígeno do mesmo, composição terapêutica e seus usos |
DK2613776T3 (da) | 2010-09-01 | 2020-10-19 | Univ Jefferson | Sammensætning og fremgangsmåde til muskelreparation og -regenerering |
EP2537933A1 (de) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Auf IL-15- und IL-15Ralpha-Sushi-Domäne basierende Immunozytokine |
CN109022465B (zh) | 2011-10-28 | 2022-04-29 | 特瓦制药澳大利亚私人有限公司 | 多肽构建体及其用途 |
HUE058364T2 (hu) | 2013-04-19 | 2022-07-28 | Cytune Pharma | Citokinbõl származó kezelés redukált vaszkuláris permeabilitási szindrómával |
KR102094022B1 (ko) | 2013-04-29 | 2020-03-30 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 항-cd38 항체 및 감쇠 인터페론 알파-2b와의 융합체 |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
CN105916881A (zh) | 2013-11-20 | 2016-08-31 | 瑞泽恩制药公司 | Aplnr调节剂及其用途 |
EP2915569A1 (de) | 2014-03-03 | 2015-09-09 | Cytune Pharma | Reinigungsverfahren für Il-15/Il-15Ralpha-basierte Konjugate |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
BR112017008880A2 (pt) | 2014-10-29 | 2018-07-10 | Teva Pharmaceuticals Australia Pty Ltd | variantes de interferon a2b |
JP2019131471A (ja) * | 2016-05-27 | 2019-08-08 | 国立大学法人 東京大学 | 抗TGF−beta3抗体およびその使用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1509707A (en) * | 1974-09-20 | 1978-05-04 | Searle & Co | Immunological compounds |
US4195017A (en) * | 1975-02-25 | 1980-03-25 | Samuel Bogoch | Malignin, derived from brain tumor cells, complexes and polypeptides thereof |
IL47372A (en) * | 1975-05-27 | 1979-10-31 | Yeda Res & Dev | Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same |
US4263279A (en) * | 1975-08-19 | 1981-04-21 | Yeda Research & Development Co. Ltd | Pharmaceutically active compositions containing adriamycin and daunomycin |
GB1564666A (en) * | 1978-05-31 | 1980-04-10 | Ng Mun Hon | Heterocomplexes of interferon with immunoglobulin and pharmaceutical compositions thereof |
FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
JPS5616417A (en) * | 1979-07-19 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
JPS5686121A (en) * | 1979-12-14 | 1981-07-13 | Teijin Ltd | Antitumor proten complex and its preparation |
US4423147A (en) * | 1980-04-11 | 1983-12-27 | Secher David S | Monoclonal antibody to interferon-α |
EP0044167A3 (de) * | 1980-07-14 | 1982-04-21 | The Regents Of The University Of California | Durch einen Antikörper gerichtetes zytotoxisches Mittel |
US4359457A (en) * | 1980-09-30 | 1982-11-16 | Neville Jr David M | Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumor suppressant |
FI820020L (fi) * | 1981-01-12 | 1982-07-13 | Lilly Industries Ltd | Immunoglobulinkonjugater |
FR2504010B1 (fr) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
GB2098219A (en) * | 1981-05-08 | 1982-11-17 | Erba Farmitalia | Daunorubicin-protein conjugates |
US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
ES521370A0 (es) * | 1982-04-12 | 1985-04-16 | Hybritech Inc | Un procedimiento para obtener un polidoma. |
US4520226A (en) * | 1982-07-19 | 1985-05-28 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of graft versus host disease using a mixture of T-lymphocyte specific monoclonal antibody: ricin conjugates |
DK173435B1 (da) * | 1983-08-17 | 2000-10-23 | Wellcome Found | Injicerbare præparater samt fremgangsmåder til potentiering af administrering af et hormon til normale hvirveldyr eller til |
-
1983
- 1983-09-01 GB GB08323428A patent/GB2148299B/en not_active Expired
-
1984
- 1984-08-31 AU AU33935/84A patent/AU593208B2/en not_active Ceased
- 1984-08-31 WO PCT/US1984/001389 patent/WO1985000974A1/en active IP Right Grant
- 1984-08-31 JP JP59503388A patent/JPH0717519B2/ja not_active Expired - Lifetime
- 1984-09-03 DE DE8484306027T patent/DE3485649D1/de not_active Expired - Fee Related
- 1984-09-03 EP EP84306027A patent/EP0136835B1/de not_active Expired - Lifetime
- 1984-09-03 AT AT84306027T patent/ATE74766T1/de not_active IP Right Cessation
- 1984-09-04 CA CA000462348A patent/CA1249222A/en not_active Expired
-
1985
- 1985-04-25 FI FI851635A patent/FI85441C/fi not_active IP Right Cessation
- 1985-04-29 DK DK191985A patent/DK191985D0/da not_active Application Discontinuation
-
1988
- 1988-08-19 US US07/234,224 patent/US5055289A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI851635A0 (fi) | 1985-04-25 |
GB2148299B (en) | 1988-01-06 |
ATE74766T1 (de) | 1992-05-15 |
FI85441C (fi) | 1992-04-27 |
AU3393584A (en) | 1985-03-29 |
WO1985000974A1 (en) | 1985-03-14 |
FI851635L (fi) | 1985-04-25 |
DK191985A (da) | 1985-04-29 |
GB8323428D0 (en) | 1983-10-05 |
US5055289A (en) | 1991-10-08 |
GB2148299A (en) | 1985-05-30 |
FI85441B (fi) | 1992-01-15 |
EP0136835B1 (de) | 1992-04-15 |
DK191985D0 (da) | 1985-04-29 |
EP0136835A3 (en) | 1986-10-08 |
JPS60502104A (ja) | 1985-12-05 |
EP0136835A2 (de) | 1985-04-10 |
JPH0717519B2 (ja) | 1995-03-01 |
AU593208B2 (en) | 1990-02-08 |
CA1249222A (en) | 1989-01-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3485649D1 (de) | Verfahren zur herstellung von antikoerperzusammensetzungen von therapeutischen mitteln mit verlaengerter serumhalbwertzeit. | |
ATE160583T1 (de) | Steigerungsverfahren der transmembranförderung von exogenen molekülen | |
DD128170A5 (de) | Verfahren zur herstellung von praeparaten mit geregelter wirkstoffabgabe | |
MX7235E (es) | Procedimiento para preparar una solucion inyectable intravenosamente de globulina de suero inmune | |
ATE123227T1 (de) | Kationisierte antikörper für das austragen durch die blut-gehirn-schranke. | |
DD129788A5 (de) | Verfahren zur herstellung von 3',3'',5',5''-tetrachlorphenol-3,4,5,6-tetrabromsulfophthalein bzw.3',3''-dibrom-5',5''-dichlorphenol-3,4,5,6-tetrachlorsulfophthalein | |
ATE866T1 (de) | Immunserumglobulin (isg)-praeparate und verfahren zu ihrer herstellung. | |
ATE98631T1 (de) | Verfahren zur herstellung von komplexverbindungen. | |
AT339267B (de) | Verfahren zur selektiven herstellung von alkyl-tert.butylathern | |
ATE57694T1 (de) | Verfahren zur herstellung von 2,5dicetopiperazinen. | |
ATA395576A (de) | Verfahren zur herstellung von nicht mehr antikomplementaer wirksamen nativ-human- -immunglobulin zur intravenoesen verabreichung mit natuerlicher halbwertszeit | |
SE7609055L (sv) | Veterinerkompositioner | |
JPS5547627A (en) | Manufacture of immune globulin solution good for intravenous application | |
AT359197B (de) | Verfahren zur herstellung von pharmazeutischen praeparaten | |
DK398483D0 (da) | Substiuerede tert.butanolderivater, fremgangsmader til fremstilling deraf samt antimykotiske midler indeholdende disse forbindelser | |
ATE124268T1 (de) | Verfahren zur herstellung von therapeutischen rhenium-phosphonat-mitteln. | |
AT344885B (de) | Verfahren zur herstellung von 18-arabinosyl-2-n-butyl-3,7,11,15,19,21,23,25,27,37-dekahydroxy-4,16,32,34,36-pentamethyl-tetrakonta-16,32-dien-35-o-lacton-40-guanidiniumsulfat(debrycin) enthaltenden pharmazeutischen praeparaten | |
JPS5235277A (en) | Process for producing fiberrreinforced hoseeshaped object composed of chemically denatured protein plastic | |
ES8601694A1 (es) | Procedimiento para preparar un compuesto de inclusion a base de n,n-dimetil-2-cloro-5(3-metil-2-(fenilimino)-4-tiazolin-4-il)-fenilsulfonamida y b-ciclodextrina | |
NL7603461A (nl) | D-homosteroiden en werkwijze voor de bereiding daarvan. | |
AT238704B (de) | Verfahren zur Herstellung von dimerem Bis-(cyclopentadienyl)-buten-(2) | |
ES381207A1 (es) | Un procedimiento para preparar nuevas 1,2-difenil-3,5-dioxo-pirazolidinas sustituidas en la posicion 4. | |
GB1136039A (en) | Improvements relating to immunosuppressive agents | |
DE69426149D1 (de) | Ecdysone zur verbesserung der produktivität von wiederkäuern | |
ES8505513A1 (es) | Procedimiento para la fabricacion de aminoacetonitrilos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |