DE3026924A1 - 1,3-Di:phenoxy-propan-2-ol derivs. - used as hypolipaemics to reduce tri:glyceride and cholesterol levels in the blood - Google Patents

1,3-Di:phenoxy-propan-2-ol derivs. - used as hypolipaemics to reduce tri:glyceride and cholesterol levels in the blood

Info

Publication number
DE3026924A1
DE3026924A1 DE19803026924 DE3026924A DE3026924A1 DE 3026924 A1 DE3026924 A1 DE 3026924A1 DE 19803026924 DE19803026924 DE 19803026924 DE 3026924 A DE3026924 A DE 3026924A DE 3026924 A1 DE3026924 A1 DE 3026924A1
Authority
DE
Germany
Prior art keywords
derivs
blood
cholesterol levels
hypolipaemics
glyceride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803026924
Other languages
German (de)
Inventor
Helmut Dipl Chem Dr Grill
Roland Dr Loeser
Friedmann Dipl Chem Dr Reiter
Josef Dipl Chem Dr Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KLINGE PHARMA GMBH, 8000 MUENCHEN, DE
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Priority to DE19803026924 priority Critical patent/DE3026924A1/en
Publication of DE3026924A1 publication Critical patent/DE3026924A1/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Abstract

derivs. of formula (I) are new (where R1 is F, Cl or CMe3; A is -CH=CMe- or -CH2CHMe-; R2 is H or a physiologically acceptable cation, or 1-3C alkyl, opt. branched and opt. satd. and opt. carrying a terminal MeO gp.). (I) have a strong hypolipaemic effect, considerably greater than that of Clofibrat. (I) are well tolerated by the body and reduce the triglyceride and cholesterol levels of the blood. Suitable oral daily doses are 0.1-5, pref. 0.3-2 g.
DE19803026924 1980-07-16 1980-07-16 1,3-Di:phenoxy-propan-2-ol derivs. - used as hypolipaemics to reduce tri:glyceride and cholesterol levels in the blood Withdrawn DE3026924A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19803026924 DE3026924A1 (en) 1980-07-16 1980-07-16 1,3-Di:phenoxy-propan-2-ol derivs. - used as hypolipaemics to reduce tri:glyceride and cholesterol levels in the blood

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803026924 DE3026924A1 (en) 1980-07-16 1980-07-16 1,3-Di:phenoxy-propan-2-ol derivs. - used as hypolipaemics to reduce tri:glyceride and cholesterol levels in the blood

Publications (1)

Publication Number Publication Date
DE3026924A1 true DE3026924A1 (en) 1982-02-18

Family

ID=6107327

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803026924 Withdrawn DE3026924A1 (en) 1980-07-16 1980-07-16 1,3-Di:phenoxy-propan-2-ol derivs. - used as hypolipaemics to reduce tri:glyceride and cholesterol levels in the blood

Country Status (1)

Country Link
DE (1) DE3026924A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100812A1 (en) * 2001-04-20 2002-12-19 Eisai Co., Ltd. Carboxylic acid derivative and salt thereof
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
US8633184B2 (en) 2006-04-18 2014-01-21 Janssen Pharmaceutica N.V. Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol
US8669288B2 (en) 2005-09-14 2014-03-11 Janssen Pharmaceutica N.V. Lysine salts of 4-((phenoxyalkyl)thio)-phenoxyacetic acid derivatives
EP1791812B1 (en) * 2004-09-15 2015-11-04 Janssen Pharmaceutica NV 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
US9724322B2 (en) 2003-09-19 2017-08-08 Janssen Pharmaceutica N.V. 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100812A1 (en) * 2001-04-20 2002-12-19 Eisai Co., Ltd. Carboxylic acid derivative and salt thereof
US7544835B2 (en) 2001-04-20 2009-06-09 Eisai R&D Management Co., Ltd. Carboxylic acid derivative and salt thereof
SG161743A1 (en) * 2001-04-20 2010-06-29 Eisai R&D Man Co Ltd Carboxylic acid derivative and salt thereof
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
US9724322B2 (en) 2003-09-19 2017-08-08 Janssen Pharmaceutica N.V. 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs
EP1791812B1 (en) * 2004-09-15 2015-11-04 Janssen Pharmaceutica NV 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
US8669288B2 (en) 2005-09-14 2014-03-11 Janssen Pharmaceutica N.V. Lysine salts of 4-((phenoxyalkyl)thio)-phenoxyacetic acid derivatives
US8633184B2 (en) 2006-04-18 2014-01-21 Janssen Pharmaceutica N.V. Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: KLINGE PHARMA GMBH, 8000 MUENCHEN, DE

8139 Disposal/non-payment of the annual fee