DE2860053D1 - Deuterated 1,1-difluoro-2,2-dihaloethyl-difluoromethyl ethers, a process for their preparation and their use in anesthetics - Google Patents

Deuterated 1,1-difluoro-2,2-dihaloethyl-difluoromethyl ethers, a process for their preparation and their use in anesthetics

Info

Publication number
DE2860053D1
DE2860053D1 DE7878100004T DE2860053T DE2860053D1 DE 2860053 D1 DE2860053 D1 DE 2860053D1 DE 7878100004 T DE7878100004 T DE 7878100004T DE 2860053 T DE2860053 T DE 2860053T DE 2860053 D1 DE2860053 D1 DE 2860053D1
Authority
DE
Germany
Prior art keywords
dihaloethyl
anesthetics
deuterated
difluoro
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7878100004T
Other languages
English (en)
Inventor
Eric Russell Larsen
Leslie Paul Mccarty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of DE2860053D1 publication Critical patent/DE2860053D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE7878100004T 1977-06-06 1978-06-01 Deuterated 1,1-difluoro-2,2-dihaloethyl-difluoromethyl ethers, a process for their preparation and their use in anesthetics Expired DE2860053D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80392677A 1977-06-06 1977-06-06

Publications (1)

Publication Number Publication Date
DE2860053D1 true DE2860053D1 (en) 1980-11-13

Family

ID=25187772

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7878100004T Expired DE2860053D1 (en) 1977-06-06 1978-06-01 Deuterated 1,1-difluoro-2,2-dihaloethyl-difluoromethyl ethers, a process for their preparation and their use in anesthetics

Country Status (8)

Country Link
US (1) US4154971A (de)
EP (1) EP0000323B1 (de)
JP (1) JPS543004A (de)
AU (1) AU515390B2 (de)
CA (1) CA1079752A (de)
DE (1) DE2860053D1 (de)
DK (1) DK248878A (de)
IT (1) IT1094874B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220664A (en) * 1979-01-29 1980-09-02 The Dow Chemical Company Deuterated isoflurane as an anesthetic agent
CA1158224A (en) * 1981-12-04 1983-12-06 Edward A. Symons Process for the exchange of hydrogen isotopes between streams of liquid water and gaseous halohydrocarbon and an apparatus therefor
CA1236483A (en) * 1984-03-19 1988-05-10 Commonwealth Of Australia (The) Labelling of organic molecules
US5492111A (en) * 1993-01-28 1996-02-20 University Of Iowa Research Foundation Method of elimination of volatile degradation products of sevoflurane during anesthesia
US5391579A (en) * 1993-01-28 1995-02-21 University Of Iowa Research Foundation Deuterated sevoflurane as an inhalational anesthetic
WO1994017016A1 (en) * 1993-01-28 1994-08-04 University Of Iowa Research Foundation Deuterated sevoflurane as an inhalational anesthetic
US20030232064A1 (en) * 2001-10-17 2003-12-18 Burns William H. Suppression of human activity in an enclosed space

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3527812A (en) * 1966-10-03 1970-09-08 Air Reduction 1,1 - difluoro - 2,2 - dichloroethyl difluoromethyl ether and its method of preparation
US3527811A (en) * 1966-10-03 1970-09-08 Air Reduction 1,1,2 - trifluoro - 2 - bromoethyl difluoromethyl ether and its methods of preparation
US3527813A (en) * 1966-10-03 1970-09-08 Air Reduction 1,1,2 - trifluoro - 2 - chloroethyl difluoromethyl ether and its method of preparation
US3469011A (en) * 1966-10-03 1969-09-23 Air Reduction 1,1,2-trifluoro-2-chloroethyl-difluoromethyl ether as an anesthetic agent
US4069346A (en) * 1977-02-14 1978-01-17 The Dow Chemical Company Compositions and methods for anesthetizing an animal using deuterated analogues of halothane and chloroform

Also Published As

Publication number Publication date
IT7823951A0 (it) 1978-05-30
AU515390B2 (en) 1981-04-02
DK248878A (da) 1978-12-07
US4154971A (en) 1979-05-15
AU3563078A (en) 1979-11-08
IT1094874B (it) 1985-08-10
CA1079752A (en) 1980-06-17
EP0000323B1 (de) 1980-07-23
JPS543004A (en) 1979-01-11
EP0000323A1 (de) 1979-01-24

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Free format text: LARSEN, ERIC RUSSELL, ERIC RUSSELL, MIDLAND, COUNTY OF MIDLAND, MICHIGAN, US MCCARTY, LESLIE PAUL, LESLIE PAUL, MIDLAND,COUNTY OF BAY,MICHIGAN, US

8339 Ceased/non-payment of the annual fee