DE2638251A1 - Verfahren und vorrichtung zum konzentrieren und reinigen von antigenen und antikoerpern - Google Patents
Verfahren und vorrichtung zum konzentrieren und reinigen von antigenen und antikoerpernInfo
- Publication number
- DE2638251A1 DE2638251A1 DE19762638251 DE2638251A DE2638251A1 DE 2638251 A1 DE2638251 A1 DE 2638251A1 DE 19762638251 DE19762638251 DE 19762638251 DE 2638251 A DE2638251 A DE 2638251A DE 2638251 A1 DE2638251 A1 DE 2638251A1
- Authority
- DE
- Germany
- Prior art keywords
- antigen
- antibody
- substrate
- solution
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091007433 antigens Proteins 0.000 title claims abstract description 154
- 102000036639 antigens Human genes 0.000 title claims abstract description 154
- 239000000427 antigen Substances 0.000 title claims abstract description 146
- 239000000758 substrate Substances 0.000 title claims abstract description 116
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 37
- 230000001900 immune effect Effects 0.000 title claims abstract description 18
- 238000007598 dipping method Methods 0.000 title abstract 3
- 238000011091 antibody purification Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 68
- 239000012736 aqueous medium Substances 0.000 claims abstract description 47
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 32
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 32
- 239000000463 material Substances 0.000 claims abstract description 8
- 229910052751 metal Inorganic materials 0.000 claims description 21
- 239000002184 metal Substances 0.000 claims description 21
- 239000011521 glass Substances 0.000 claims description 20
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims description 13
- 229910052738 indium Inorganic materials 0.000 claims description 12
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 8
- 229910052737 gold Inorganic materials 0.000 claims description 8
- 239000010931 gold Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 7
- 238000007654 immersion Methods 0.000 claims description 6
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 229910052709 silver Inorganic materials 0.000 claims description 3
- 239000004332 silver Substances 0.000 claims description 3
- 239000011135 tin Substances 0.000 claims description 3
- 229910052718 tin Inorganic materials 0.000 claims description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 2
- 230000000737 periodic effect Effects 0.000 claims description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 2
- 239000011133 lead Substances 0.000 claims 2
- 229910044991 metal oxide Inorganic materials 0.000 claims 2
- 150000004706 metal oxides Chemical class 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 abstract description 9
- 231100000283 hepatitis Toxicity 0.000 abstract description 9
- 239000000203 mixture Substances 0.000 abstract description 5
- 230000035935 pregnancy Effects 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 abstract description 4
- 239000002609 medium Substances 0.000 abstract description 3
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 58
- 239000000243 solution Substances 0.000 description 36
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- 210000002966 serum Anatomy 0.000 description 20
- 239000000284 extract Substances 0.000 description 19
- 238000003776 cleavage reaction Methods 0.000 description 12
- 230000007017 scission Effects 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 239000000725 suspension Substances 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 239000011324 bead Substances 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 210000002700 urine Anatomy 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 241000700605 Viruses Species 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 230000008105 immune reaction Effects 0.000 description 6
- 239000004033 plastic Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 4
- 238000010668 complexation reaction Methods 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 229920002223 polystyrene Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 231100000699 Bacterial toxin Toxicity 0.000 description 3
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 108010087702 Penicillinase Proteins 0.000 description 3
- 241000711975 Vesicular stomatitis virus Species 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 239000000688 bacterial toxin Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000000536 complexating effect Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 229950009506 penicillinase Drugs 0.000 description 3
- 229910052715 tantalum Inorganic materials 0.000 description 3
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 3
- 239000004382 Amylase Substances 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 241000228212 Aspergillus Species 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 108090000317 Chymotrypsin Proteins 0.000 description 2
- 102000016607 Diphtheria Toxin Human genes 0.000 description 2
- 108010053187 Diphtheria Toxin Proteins 0.000 description 2
- 241000991587 Enterovirus C Species 0.000 description 2
- 206010018612 Gonorrhoea Diseases 0.000 description 2
- 241000588653 Neisseria Species 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 102000006382 Ribonucleases Human genes 0.000 description 2
- 108010083644 Ribonucleases Proteins 0.000 description 2
- 241000710799 Rubella virus Species 0.000 description 2
- 206010043376 Tetanus Diseases 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 229960002376 chymotrypsin Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 206010013023 diphtheria Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 208000001786 gonorrhea Diseases 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000005300 metallic glass Substances 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 229960000814 tetanus toxoid Drugs 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 102000009843 Thyroglobulin Human genes 0.000 description 1
- 108010034949 Thyroglobulin Proteins 0.000 description 1
- 241000223997 Toxoplasma gondii Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229960004407 chorionic gonadotrophin Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 230000001456 gonadotroph Effects 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002052 molecular layer Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 101710135378 pH 6 antigen Proteins 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000005315 stained glass Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940118701 toxoplasma gondii Drugs 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 208000005925 vesicular stomatitis Diseases 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Materials Engineering (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/608,329 US4172827A (en) | 1972-06-26 | 1975-08-27 | Method for concentration and purification of antigens and antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2638251A1 true DE2638251A1 (de) | 1977-06-08 |
| DE2638251C2 DE2638251C2 (enrdf_load_stackoverflow) | 1987-08-27 |
Family
ID=24435996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762638251 Granted DE2638251A1 (de) | 1975-08-27 | 1976-08-25 | Verfahren und vorrichtung zum konzentrieren und reinigen von antigenen und antikoerpern |
Country Status (3)
| Country | Link |
|---|---|
| BR (1) | BR7605742A (enrdf_load_stackoverflow) |
| DE (1) | DE2638251A1 (enrdf_load_stackoverflow) |
| IT (1) | IT1064968B (enrdf_load_stackoverflow) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2330702A1 (de) * | 1972-06-26 | 1974-01-10 | Gen Electric | Verfahren und apparat fuer den nachweis und die reinigung von proteinen und antikoerpern |
| DE2433246A1 (de) * | 1973-07-30 | 1975-02-13 | Gen Electric | Verbessertes verfahren fuer den nachweis und die reinigung von proteinen und antikoerpern und vorrichtung zu dessen durchfuehrung |
-
1976
- 1976-08-25 DE DE19762638251 patent/DE2638251A1/de active Granted
- 1976-08-26 IT IT2657076A patent/IT1064968B/it active
- 1976-08-27 BR BR7605742A patent/BR7605742A/pt unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2330702A1 (de) * | 1972-06-26 | 1974-01-10 | Gen Electric | Verfahren und apparat fuer den nachweis und die reinigung von proteinen und antikoerpern |
| DE2433246A1 (de) * | 1973-07-30 | 1975-02-13 | Gen Electric | Verbessertes verfahren fuer den nachweis und die reinigung von proteinen und antikoerpern und vorrichtung zu dessen durchfuehrung |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1064968B (it) | 1985-02-25 |
| BR7605742A (pt) | 1977-08-23 |
| DE2638251C2 (enrdf_load_stackoverflow) | 1987-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2436010C2 (enrdf_load_stackoverflow) | ||
| DE2330702C2 (de) | Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologischen Probe und Vorrichtung zur Durchführung des Verfahrens | |
| DE2536572C2 (de) | Diagnostisches Verfahren zum Nachweisen der An- oder Abwesenheit eines ausgewählten Antigens oder Antikörpers in einer biologischen Flüssigkeitsprobe | |
| DE69328120T2 (de) | Prüfungsstreifen für immunoassays | |
| DE69936916T2 (de) | Liganden-bindetest und kit mit einer abtrennzone für störende probenkomponenten | |
| DE2512730C2 (de) | Vorrichtung zum Durchführen immunologischer Nachweisreaktionen und Verfahren unter Verwendung einer solchen Vorrichtung | |
| DE10009503A1 (de) | Verfahren zur Immobilisierung von Konjugaten in diagnostischen Tests | |
| DE69106002T2 (de) | Testverfahren und reagenziensatz dafür. | |
| DE2548427A1 (de) | Als einheit ausgebildete immunoanalysenausruestung in fester phase und verfahren zu ihrer herstellung | |
| DE1648999C3 (de) | Verfahren zur immunochemischen Bestimmung von Antigenen und Antikörpern | |
| DE3105555C2 (enrdf_load_stackoverflow) | ||
| DE2523207A1 (de) | Verfahren zur bestimmung von antikoerpern | |
| DE2440367C2 (de) | Verfahren zum Herstellen multimolekularer Schichten aus immunologisch komplexierten Proteinen auf einem Substrat | |
| DE2433246C2 (de) | Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologischen Probe | |
| DE2638250C2 (de) | Diagnostisches Verfahren zum Bestimmen der Anwesenheit oder Abwesenheit eines spezifischen Proteins in einer biologischen Probe, sowie Vorrichtung zur Durchführung des Verfahrens | |
| EP0249877B1 (de) | Verfahren zur Herstellung eines immunreaktiven Trägermaterials für die heterogene immunologische Analyse | |
| DE2638251A1 (de) | Verfahren und vorrichtung zum konzentrieren und reinigen von antigenen und antikoerpern | |
| CH608811A5 (en) | Method and device for concentrating and purifying antigens and antibodies | |
| DE2638207C2 (de) | Verfahren zum Bilden multimolekularer immunologisch komplexierter Filme | |
| DE69117097T2 (de) | Testvorrichtungen | |
| DE4123263C2 (de) | Verfahren zur selektiven quantitativen Bestimmung der Konzentration von Lektinen, insbesondere Mistel-Lektinen | |
| CH601797A5 (en) | Contrast strengthening for immunological film proofs | |
| CH579777A5 (en) | Proteins identificn and purificn - using substrates with monomolecular pro-tein layers | |
| DE3036184A1 (de) | Reagenz und verfahren zur bestimmung von human-muskeltyp-aldolase | |
| CH598279A5 (en) | Proteins identificn and purificn |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8120 | Willingness to grant licences paragraph 23 | ||
| 8125 | Change of the main classification |
Ipc: C07G 7/00 |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |