DE2619246A1 - Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel - Google Patents
Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittelInfo
- Publication number
- DE2619246A1 DE2619246A1 DE19762619246 DE2619246A DE2619246A1 DE 2619246 A1 DE2619246 A1 DE 2619246A1 DE 19762619246 DE19762619246 DE 19762619246 DE 2619246 A DE2619246 A DE 2619246A DE 2619246 A1 DE2619246 A1 DE 2619246A1
- Authority
- DE
- Germany
- Prior art keywords
- bpti
- derivatives
- desamino
- solution
- trypsin inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 238000000034 method Methods 0.000 title claims description 21
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- 238000004519 manufacturing process Methods 0.000 title claims description 6
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- 101000984722 Bos taurus Pancreatic trypsin inhibitor Proteins 0.000 claims description 127
- 230000005764 inhibitory process Effects 0.000 claims description 52
- 238000006243 chemical reaction Methods 0.000 claims description 27
- 108010067372 Pancreatic elastase Proteins 0.000 claims description 22
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- 150000001989 diazonium salts Chemical class 0.000 claims description 16
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 15
- 210000000056 organ Anatomy 0.000 claims description 13
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- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 claims description 11
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- LXRZVMYMQHNYJB-UNXOBOICSA-N [(1R,2S,4R)-4-[[5-[4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate Chemical compound CC1=C(C=C(S1)C(=O)C1=C(N[C@H]2C[C@H](O)[C@@H](COS(N)(=O)=O)C2)N=CN=C1)[C@@H]1NCCC2=C1C=C(Cl)C=C2 LXRZVMYMQHNYJB-UNXOBOICSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762619246 DE2619246A1 (de) | 1976-04-30 | 1976-04-30 | Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| GB17095/77A GB1533358A (en) | 1976-04-30 | 1977-04-25 | Deamino derivatives of the kallikrein-trypsin inhibitor processes for their preparation and their use as medicament |
| CH517977A CH635514A5 (de) | 1976-04-30 | 1977-04-26 | Verfahren zur herstellung neuer desamino-derivate des kallikrein-trypsin-inhibitors. |
| SE7704928A SE442301B (sv) | 1976-04-30 | 1977-04-28 | Sett att framstella deaminoderivat av kallikrein-trypsin-inhibitor fran notorgan |
| JP4859777A JPS52134009A (en) | 1976-04-30 | 1977-04-28 | Deaminooderivative of kallikreinntrypsin inhibitor and its production and medical application |
| NL7704690A NL7704690A (nl) | 1976-04-30 | 1977-04-28 | Werkwijze voor het bereiden van desaminoderivaten van de callicreine-trypsine-inhibitor, alsmede toepassen van deze desaminoderivaten als genees- middel. |
| DK188077A DK188077A (da) | 1976-04-30 | 1977-04-29 | Desaminoderivater af en kallikrein trypsininhibitor deres fremstilling og anvendelse |
| AT305477A AT361118B (de) | 1976-04-30 | 1977-04-29 | Desamino-derivate des kallikrein-trypsin- -inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US05/792,296 US4118481A (en) | 1976-04-30 | 1977-04-29 | Deamino derivatives of the kallikrein-trypsin inhibitor |
| FR7713037A FR2349598A1 (fr) | 1976-04-30 | 1977-04-29 | Derives de desamination de l'inhibiteur de trypsine-kallikreine, procede pour leur production et leur application comme medicament |
| BE177127A BE854102A (fr) | 1976-04-30 | 1977-04-29 | Derives de desamination de l'inhibiteur de trypsinekallikreine, procede pour leur production et leur application comme medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762619246 DE2619246A1 (de) | 1976-04-30 | 1976-04-30 | Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2619246A1 true DE2619246A1 (de) | 1977-11-10 |
Family
ID=5976820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762619246 Withdrawn DE2619246A1 (de) | 1976-04-30 | 1976-04-30 | Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4118481A (https=) |
| JP (1) | JPS52134009A (https=) |
| AT (1) | AT361118B (https=) |
| BE (1) | BE854102A (https=) |
| CH (1) | CH635514A5 (https=) |
| DE (1) | DE2619246A1 (https=) |
| DK (1) | DK188077A (https=) |
| FR (1) | FR2349598A1 (https=) |
| GB (1) | GB1533358A (https=) |
| NL (1) | NL7704690A (https=) |
| SE (1) | SE442301B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0001774A1 (de) * | 1977-10-27 | 1979-05-16 | Bayer Ag | Neue Derivate des BPTI(basic pancreatic trypsin-inhibitor), Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP0001773A1 (de) * | 1977-10-27 | 1979-05-16 | Bayer Ag | Neue Derivate des BPTI(basic pancreatic trypsin-inhibitor), Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4997537A (en) * | 1986-10-21 | 1991-03-05 | Northeastern University | High performance microcapillary gel electrophoresis |
| US5665216A (en) * | 1986-10-21 | 1997-09-09 | Northeastern University | Capillary column for high performance electrophoretic separation and detection of SDS proteins and system and using the same |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| PT739355E (pt) * | 1994-01-11 | 2005-01-31 | Dyax Corp | Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos |
| ES2229236T3 (es) | 1994-01-11 | 2005-04-16 | Dyax Corporation | Inhibidores de la plasmina humana derivados de los dominios de kunitz. |
| US20040054082A1 (en) * | 2001-12-03 | 2004-03-18 | Bank David H | Toughened polymer blends with improved surface properties |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
| JP2005537006A (ja) * | 2002-08-28 | 2005-12-08 | ダイアックス、コープ | 臓器及び組織の保存方法 |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| US20070213275A1 (en) * | 2006-03-10 | 2007-09-13 | Dyax Corp. | Formulations for ecallantide |
| CA2696208A1 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| CA2695012A1 (en) * | 2007-08-23 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| CA2744235A1 (en) * | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| EP3459564B1 (en) | 2010-01-06 | 2021-10-27 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
| CA2823776A1 (en) | 2011-01-06 | 2012-07-12 | Dyax Corp. | Plasma kallikrein binding proteins |
| IL295414B2 (en) | 2014-03-27 | 2026-02-01 | Takeda Pharmaceuticals Co | Compositions and methods for treating macular edema due to diabetes |
| AU2016366557B2 (en) | 2015-12-11 | 2024-01-25 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| US12528880B2 (en) | 2020-01-13 | 2026-01-20 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
-
1976
- 1976-04-30 DE DE19762619246 patent/DE2619246A1/de not_active Withdrawn
-
1977
- 1977-04-25 GB GB17095/77A patent/GB1533358A/en not_active Expired
- 1977-04-26 CH CH517977A patent/CH635514A5/de not_active IP Right Cessation
- 1977-04-28 JP JP4859777A patent/JPS52134009A/ja active Pending
- 1977-04-28 SE SE7704928A patent/SE442301B/xx not_active IP Right Cessation
- 1977-04-28 NL NL7704690A patent/NL7704690A/xx not_active Application Discontinuation
- 1977-04-29 FR FR7713037A patent/FR2349598A1/fr active Granted
- 1977-04-29 BE BE177127A patent/BE854102A/xx not_active IP Right Cessation
- 1977-04-29 DK DK188077A patent/DK188077A/da not_active Application Discontinuation
- 1977-04-29 US US05/792,296 patent/US4118481A/en not_active Expired - Lifetime
- 1977-04-29 AT AT305477A patent/AT361118B/de not_active IP Right Cessation
Non-Patent Citations (3)
| Title |
|---|
| Angew.Chem., 86, 1974, 21-40 * |
| Chemical Abstracts, 69, 1969, 92924e * |
| Pharmazie, 29, 1974, 81-89 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0001774A1 (de) * | 1977-10-27 | 1979-05-16 | Bayer Ag | Neue Derivate des BPTI(basic pancreatic trypsin-inhibitor), Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP0001773A1 (de) * | 1977-10-27 | 1979-05-16 | Bayer Ag | Neue Derivate des BPTI(basic pancreatic trypsin-inhibitor), Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
Also Published As
| Publication number | Publication date |
|---|---|
| CH635514A5 (de) | 1983-04-15 |
| FR2349598B1 (https=) | 1980-02-22 |
| GB1533358A (en) | 1978-11-22 |
| NL7704690A (nl) | 1977-11-01 |
| SE442301B (sv) | 1985-12-16 |
| AT361118B (de) | 1981-02-25 |
| US4118481A (en) | 1978-10-03 |
| BE854102A (fr) | 1977-10-31 |
| FR2349598A1 (fr) | 1977-11-25 |
| SE7704928L (sv) | 1977-10-31 |
| JPS52134009A (en) | 1977-11-09 |
| ATA305477A (de) | 1980-07-15 |
| DK188077A (da) | 1977-10-31 |
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