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DE2449885A1 - Chemisch modifizierte haemoglobinverbindungen und verfahren zu ihrer herstellung - Google Patents

Chemisch modifizierte haemoglobinverbindungen und verfahren zu ihrer herstellung

Info

Publication number
DE2449885A1
DE2449885A1 DE19742449885 DE2449885A DE2449885A1 DE 2449885 A1 DE2449885 A1 DE 2449885A1 DE 19742449885 DE19742449885 DE 19742449885 DE 2449885 A DE2449885 A DE 2449885A DE 2449885 A1 DE2449885 A1 DE 2449885A1
Authority
DE
Grant status
Application
Patent type
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19742449885
Other languages
English (en)
Other versions
DE2449885C3 (de )
DE2449885B2 (de )
Inventor
Klaus Dipl Chem Dr Bonhard
Uwe Boyson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotest AG
Original Assignee
Biotest-Serum Institut GmbH
BIOTEST SERUM INSTITUT GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795Porphyrin- or corrin-ring-containing peptides
    • C07K14/805Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
DE19742449885 1974-10-21 1974-10-21 Expired DE2449885C3 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19742449885 DE2449885C3 (de) 1974-10-21 1974-10-21

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19742449885 DE2449885C3 (de) 1974-10-21 1974-10-21
FR7531656A FR2288528B1 (de) 1974-10-21 1975-10-16
US05624220 US4336248A (en) 1974-10-21 1975-10-20 Preparation of coupled hemoglobin molecules
GB4312275A GB1529578A (en) 1974-10-21 1975-10-21 Chemically haemoglobin compounds and a process for the production thereof
JP12598275A JPS6216932B2 (de) 1974-10-21 1975-10-21

Publications (3)

Publication Number Publication Date
DE2449885A1 true true DE2449885A1 (de) 1976-08-12
DE2449885B2 true DE2449885B2 (de) 1979-08-23
DE2449885C3 DE2449885C3 (de) 1980-04-30

Family

ID=5928743

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742449885 Expired DE2449885C3 (de) 1974-10-21 1974-10-21

Country Status (5)

Country Link
US (1) US4336248A (de)
JP (1) JPS6216932B2 (de)
DE (1) DE2449885C3 (de)
FR (1) FR2288528B1 (de)
GB (1) GB1529578A (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0078961A2 (de) * 1981-11-11 1983-05-18 Biotest-Serum-Institut GmbH Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US6956025B2 (en) 2000-06-29 2005-10-18 Sanguibiotech Gmbh Mammalian haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof
US9493616B2 (en) 2010-02-25 2016-11-15 Sangart, Inc. Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
DE2714252C2 (de) * 1977-03-31 1983-08-18 Biotest-Serum-Institut Gmbh, 6000 Frankfurt, De
DE3130770C2 (de) * 1981-08-04 1986-06-19 Biotest-Serum-Institut Gmbh, 6000 Frankfurt, De
US4473496A (en) * 1981-09-14 1984-09-25 The United States Of America As Represented By The Secretary Of The Army Intramolecularly crosslinked hemoglobin
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
DE3320752A1 (de) * 1983-06-09 1984-12-13 Barnikol Wolfgang Lumineszierende schichten zur verwendung in vorrichtungen zur bestimmung der sauerstoffkonzentration in gasen und dergleichen durch messung der lumineszensverringerung
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
USRE34271E (en) * 1984-06-27 1993-06-01 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4598064A (en) * 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
EP0277289B8 (de) * 1986-11-10 2003-05-21 Biopure Corporation Hochreines, halbsynthetisches Blutsurrogat
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
CA1312009C (en) * 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
US5189146A (en) * 1987-05-05 1993-02-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Pasteurizable, freeze-driable hemoglobin-based blood substitute
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
US4900780A (en) * 1988-05-25 1990-02-13 Masonic Medical Research Laboratory Acellular resuscitative fluid
US5599907A (en) 1989-05-10 1997-02-04 Somatogen, Inc. Production and use of multimeric hemoglobins
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
EP0611306B1 (de) * 1991-11-08 1998-07-08 Somatogen, Inc. Hämoglobine als arzneimittelabgabesystem
FR2650598B1 (fr) * 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
DE69130736T2 (de) * 1990-04-18 1999-07-22 Pharmacia & Upjohn Ab Methode für die präparation von pyridoxyliertem hämoglobin
US5248766A (en) * 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5900477A (en) * 1992-01-30 1999-05-04 Baxter International, Inc. Use of hemoglobin in the treatment of hemorrhagic shock
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5264555A (en) * 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5591710A (en) * 1993-08-16 1997-01-07 Hsia Jen C Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5429797A (en) * 1993-11-10 1995-07-04 Camiener; Gerald W. Safe dialdehydes useful as decontaminants, fixatives, preservatives and embalming agents
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US6458762B1 (en) 1994-03-28 2002-10-01 Baxter International, Inc. Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
US5895810A (en) * 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US6150507A (en) * 1995-03-23 2000-11-21 Biopure Corporation Method for producing a purified hemoglobin product
US5691453A (en) * 1995-06-07 1997-11-25 Biopure Corporation Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC
US5733869A (en) * 1995-10-06 1998-03-31 Baxter International, Inc. Therapeutic administration of hemoglobin in cardiac arrest
WO1997019956A1 (en) * 1995-11-30 1997-06-05 Somatogen, Inc. Method for control of functionality during cross-linking of hemoglobins
CA2239303A1 (en) 1995-12-22 1997-07-03 Somatogen, Inc. Globins containing binding domains
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
JP4583510B2 (ja) * 1997-02-28 2010-11-17 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 無細胞系による酸素輸送の最適化のための方法と組成物
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
EP2292657A1 (de) 1999-11-12 2011-03-09 Baxter Biotech Technology S.A.R.L. Hämoglobinzusammensetzungen mit verringerten Nebenwirkungen
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
EP1274719A4 (de) * 2000-04-12 2004-05-19 Human Genome Sciences Inc Albumin-fusionsproteine
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003030821A3 (en) * 2001-10-05 2003-12-11 William A Haseltine Albumin fusion proteins
EP2261250B1 (de) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin Fusionsproteine
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
EP1594530A4 (de) 2003-01-22 2006-10-11 Human Genome Sciences Inc Albuminfusionsproteine
CN1208346C (zh) * 2003-04-09 2005-06-29 中国科学院过程工程研究所 血红蛋白-人血清白蛋白偶联物制备血液代用品及其制备方法
ES2612752T3 (es) 2003-12-18 2017-05-18 Metronom Health, Inc. Biosensor implantable y métodos de uso del mismo
CN101575373B (zh) 2009-06-12 2013-03-20 中国人民解放军第三军医大学野战外科研究所 一种血红蛋白提取液的制备方法
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
WO2012125782A3 (en) 2011-03-15 2012-11-15 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925344A (en) * 1973-04-11 1975-12-09 Community Blood Council Plasma protein substitute
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4009267A (en) * 1975-09-09 1977-02-22 Diagnostic Data, Inc. Cross-linked orgotein

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0078961A2 (de) * 1981-11-11 1983-05-18 Biotest-Serum-Institut GmbH Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
EP0078961A3 (en) * 1981-11-11 1983-07-27 Biotest-Serum-Institut Gmbh Process for manufacturing a stable cross-linked preparation of haemoglobin having a high oxygen transportation capacity, and preparation of haemoglobin so obtained
US6956025B2 (en) 2000-06-29 2005-10-18 Sanguibiotech Gmbh Mammalian haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof
US9493616B2 (en) 2010-02-25 2016-11-15 Sangart, Inc. Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios

Also Published As

Publication number Publication date Type
DE2449885C3 (de) 1980-04-30 grant
GB1529578A (en) 1978-10-25 application
JPS6216932B2 (de) 1987-04-15 grant
FR2288528A1 (fr) 1976-05-21 application
JP1419272C (de) grant
JPS5163920A (de) 1976-06-02 application
US4336248A (en) 1982-06-22 grant
FR2288528B1 (de) 1979-09-21 grant
DE2449885B2 (de) 1979-08-23 application

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8327 Change in the person/name/address of the patent owner

Owner name: BIOTEST AG, 6000 FRANKFURT, DE