DE2440956C3 - Kanamycin B-Derivate, Verfahren zu ihrer Herstellung und solche Derivate enthaltende Arzneimittel - Google Patents

Kanamycin B-Derivate, Verfahren zu ihrer Herstellung und solche Derivate enthaltende Arzneimittel

Info

Publication number
DE2440956C3
DE2440956C3 DE2440956A DE2440956A DE2440956C3 DE 2440956 C3 DE2440956 C3 DE 2440956C3 DE 2440956 A DE2440956 A DE 2440956A DE 2440956 A DE2440956 A DE 2440956A DE 2440956 C3 DE2440956 C3 DE 2440956C3
Authority
DE
Germany
Prior art keywords
amino
kanamycin
dideoxykanamycin
acid
acylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2440956A
Other languages
German (de)
English (en)
Other versions
DE2440956B2 (de
DE2440956A1 (de
Inventor
Shinichi Yokohama Kanagawa Kondo
Kenji Maeda
Hamao Umezawa
Sumio Tokio Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of DE2440956A1 publication Critical patent/DE2440956A1/de
Publication of DE2440956B2 publication Critical patent/DE2440956B2/de
Application granted granted Critical
Publication of DE2440956C3 publication Critical patent/DE2440956C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2440956A 1973-08-29 1974-08-27 Kanamycin B-Derivate, Verfahren zu ihrer Herstellung und solche Derivate enthaltende Arzneimittel Expired DE2440956C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9617773A JPS554118B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-08-29 1973-08-29

Publications (3)

Publication Number Publication Date
DE2440956A1 DE2440956A1 (de) 1975-03-13
DE2440956B2 DE2440956B2 (de) 1979-12-13
DE2440956C3 true DE2440956C3 (de) 1980-08-14

Family

ID=14158032

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2440956A Expired DE2440956C3 (de) 1973-08-29 1974-08-27 Kanamycin B-Derivate, Verfahren zu ihrer Herstellung und solche Derivate enthaltende Arzneimittel

Country Status (5)

Country Link
US (1) US3940382A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS554118B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2440956C3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2242400B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1446082A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5635195B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1974-01-24 1981-08-15
US4169890A (en) * 1975-06-30 1979-10-02 Meiji Seika Kaisha, Ltd. Pharmaceutical composition containing 5"-amino-3',5"-dideoxy-ribostamycin and intermediate compounds
JPS5913519B2 (ja) * 1975-08-15 1984-03-30 ザイダンホウジン ビセイブツカガクケンキユウカイ １−Ｎ−（α−置換−ω−アミノアシル）−３′−デオキシ−５−ｏ−ペントフラノシルネアミン誘導体の新規な製造法
DE2759475C2 (de) * 1976-06-16 1982-03-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo Verfahren zur Herstellung von Kanamycin C
JPS52153942A (en) 1976-06-16 1977-12-21 Microbial Chem Res Found Preparation of kanamicin c deoxy derivatives and kanamicine c or its deoxy derivatives
US4339572A (en) * 1976-09-23 1982-07-13 Abbott Laboratories Fortimicin B derivatives and process for production thereof
CA1105455A (en) * 1977-09-19 1981-07-21 Junji Irisawa Aminoglycoside derivatives
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
NL8103639A (nl) * 1980-08-12 1982-03-01 Microbial Chem Res Found Nieuwe 1-n-(alfa-hydroxy-omega-aminoalkanoyl)-derivaten van 5,3',4'-trideoxy-,5,3',4'-trideoxy-6'-methyl-of 5,3',4',6"-tetradeoxykanamycine-b, en werkwijze voor het bereiden daarvan.
US4410516A (en) * 1981-07-21 1983-10-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N(αHydroxy-ω-aminoalkanoyl) derivatives of 5,3',4'-trideoxy- or 5,3', 4'-trideoxy-6'-N- methyl- or 5, 3', 4',6"-tetradeoxykannamyci B and production thereof
US5268168A (en) * 1990-02-19 1993-12-07 Sakai Engineering Co., Ltd. Antibacterial and deodorant processing agent and processing method using same
JPH03286040A (ja) * 1990-03-31 1991-12-17 Toyo Umpanki Co Ltd 車両のダイナミックダンパー
AU2002953095A0 (en) * 2002-11-29 2002-12-19 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
WO2008036763A2 (en) * 2006-09-20 2008-03-27 Pneumrx, Inc. Tissue adhesive compositions and methods thereof
EA017824B1 (ru) 2007-11-21 2013-03-29 Эйкеоджен, Инк. Антибактериальные аналоги аминогликозида
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1272911A (fr) * 1958-07-23 1961-10-06 Soc Ind Fab Antibiotiques Sifa Procédé de préparation de nouveaux dérivés d'antibiotiques basiques
US3478015A (en) * 1966-11-14 1969-11-11 Yuki Gosei Yakuhin Kogyo Kk Process for reacting amino acid and an active carbonyl sugar in a polyhydric alcohol
US3652536A (en) * 1969-06-02 1972-03-28 Upjohn Co Novenamine compounds and derivatives
US3781268A (en) * 1972-01-27 1973-12-25 Bristol Myers Co Antibiotic derivatives of kanamycin

Also Published As

Publication number Publication date
DE2440956B2 (de) 1979-12-13
JPS5047950A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-04-28
DE2440956A1 (de) 1975-03-13
US3940382A (en) 1976-02-24
JPS554118B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-01-29
FR2242400B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-10-22
GB1446082A (en) 1976-08-11
FR2242400A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-03-28

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OD Request for examination
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee