DE2436479A1 - Verfahren zur reinigung von steroidheterosiden - Google Patents
Verfahren zur reinigung von steroidheterosidenInfo
- Publication number
- DE2436479A1 DE2436479A1 DE19742436479 DE2436479A DE2436479A1 DE 2436479 A1 DE2436479 A1 DE 2436479A1 DE 19742436479 DE19742436479 DE 19742436479 DE 2436479 A DE2436479 A DE 2436479A DE 2436479 A1 DE2436479 A1 DE 2436479A1
- Authority
- DE
- Germany
- Prior art keywords
- steroid
- heterosides
- extraction
- solvent
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003431 steroids Chemical class 0.000 title claims description 86
- 238000000034 method Methods 0.000 title claims description 41
- 238000004140 cleaning Methods 0.000 title description 4
- 239000000243 solution Substances 0.000 claims description 38
- 238000000605 extraction Methods 0.000 claims description 27
- 239000000843 powder Substances 0.000 claims description 26
- 239000012074 organic phase Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 22
- 239000002904 solvent Substances 0.000 claims description 22
- 239000008346 aqueous phase Substances 0.000 claims description 19
- 239000012141 concentrate Substances 0.000 claims description 18
- 240000000353 Ruscus aculeatus Species 0.000 claims description 17
- 235000003500 Ruscus aculeatus Nutrition 0.000 claims description 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 14
- 239000012071 phase Substances 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 14
- 239000002585 base Substances 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 238000000638 solvent extraction Methods 0.000 claims description 10
- 238000000622 liquid--liquid extraction Methods 0.000 claims description 9
- 238000000926 separation method Methods 0.000 claims description 6
- 238000000889 atomisation Methods 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 5
- 239000004458 spent grain Substances 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 229910000272 alkali metal oxide Inorganic materials 0.000 claims description 2
- 150000001340 alkali metals Chemical class 0.000 claims description 2
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000000284 extract Substances 0.000 description 24
- 241001465754 Metazoa Species 0.000 description 6
- 239000012535 impurity Substances 0.000 description 6
- 241000605385 Ruscus Species 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000013543 active substance Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- DPEYHNFHDIXMNV-UHFFFAOYSA-N (9-amino-3-bicyclo[3.3.1]nonanyl)-(4-benzyl-5-methyl-1,4-diazepan-1-yl)methanone dihydrochloride Chemical compound Cl.Cl.CC1CCN(CCN1Cc1ccccc1)C(=O)C1CC2CCCC(C1)C2N DPEYHNFHDIXMNV-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 239000003637 basic solution Substances 0.000 description 2
- 239000002021 butanolic extract Substances 0.000 description 2
- 239000003610 charcoal Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013067 intermediate product Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000010414 supernatant solution Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229930183217 Genin Natural products 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- -1 aliphatic alcohols Chemical class 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012496 blank sample Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- OILHVNROWDFZDW-UHFFFAOYSA-N prosapogenin Natural products CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6O)C(C)(C=O)C5CCC34C)C2C1)C(=O)O OILHVNROWDFZDW-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000054 salidiuretic effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000007666 subchronic toxicity Effects 0.000 description 1
- 231100000195 subchronic toxicity Toxicity 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001643 venotonic effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7402195A FR2258175A1 (en) | 1974-01-23 | 1974-01-23 | Purifying steroid heterosides by liquid-liquid extraction - esp. those from Ruscus aculeatus to give a prod. of predictable activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2436479A1 true DE2436479A1 (de) | 1975-07-24 |
Family
ID=9133854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742436479 Withdrawn DE2436479A1 (de) | 1974-01-23 | 1974-07-29 | Verfahren zur reinigung von steroidheterosiden |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE2436479A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2258175A1 (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19709924A1 (de) * | 1997-03-11 | 1998-09-24 | Skf Gmbh | Vorrichtung zum Abstützen von kegeligen Rotationskörpern in Maschinen zur Bearbeitung oder Prüfung der Rotationsflächen |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2779348B1 (fr) * | 1998-06-04 | 2001-06-08 | Fabre Pierre Dermo Cosmetique | Nouvelle composition pharmaceutique ou cosmetique, notamment capillaire et procede de traitement cosmetique des affections relevant des desordres angiogeniques |
| FR2836383B1 (fr) * | 2002-02-26 | 2004-10-15 | Fabre Pierre Dermo Cosmetique | Utilisation de neoruscine pour la preparation d'une composition capillaire destine au traitement de l'alopecie |
-
1974
- 1974-01-23 FR FR7402195A patent/FR2258175A1/fr active Granted
- 1974-07-29 DE DE19742436479 patent/DE2436479A1/de not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19709924A1 (de) * | 1997-03-11 | 1998-09-24 | Skf Gmbh | Vorrichtung zum Abstützen von kegeligen Rotationskörpern in Maschinen zur Bearbeitung oder Prüfung der Rotationsflächen |
| DE19709924C2 (de) * | 1997-03-11 | 2001-09-13 | Skf Gmbh | Vorrichtung zum Abstützen von kegeligen Rotationskörpern in Maschinen zur Bearbeitung oder Prüfung der Rotationsflächen |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2258175B1 (enrdf_load_stackoverflow) | 1978-08-11 |
| FR2258175A1 (en) | 1975-08-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69021019T2 (de) | Ein Verfahren zur Herstellung eines Extraktes aus Gingko biloba-Blättern. | |
| DE69031481T2 (de) | Verfahren zur Gewinnung von Ginkgoliden aus Ginkgoblättern und ihre Reinigung | |
| DE19756848C2 (de) | Extrakte aus Blättern von Ginkgo biloba mit vermindertem Gehalt an 4'-O-Methylpyridoxin und Biflavonen | |
| DE1767098C2 (de) | Verfahren zur Gewinnung eines vasoaktiven Arzneimittels aus den Blättern von Ginkgo biloba | |
| CH663153A5 (de) | Arzneimittel in form eines tannin-gemisches und seine herstellung. | |
| DE1467800A1 (de) | Verfahren zur Behandlung von insbesondere saponinhaltigen Pflanzen | |
| DE2943167C2 (enrdf_load_stackoverflow) | ||
| DE2436479A1 (de) | Verfahren zur reinigung von steroidheterosiden | |
| DE2656602B2 (de) | Verfahren zum Extrahieren von 2-Hydroxymethyl-3,43-trihydroxypiperidin aus Maulbeerpflanzen | |
| EP0234019B1 (de) | Verwendung von wässrigen Auszügen von Epilobium angustifolium L. zu einer neuen medizinischen Indikation | |
| DE69213886T2 (de) | Pflanzliches antineoplastisches chemotherapeutikum, mit hoher selektivitaet und sehr reduzierter toxizitaet, und verfahren zur herstellung | |
| DE1493618A1 (de) | Cumarinderivate und ein Verfahren zu ihrer Herstellung | |
| EP0374890A1 (de) | Verfahren zur Herstellung von Anthrachinon-Derivaten | |
| DE3213095C2 (enrdf_load_stackoverflow) | ||
| DE745383C (de) | Verfahren zur Gewinnung des antipernicioesen Wirkstoffs der Leber und eines neuen Aktivators dieses Wirkstoffs | |
| DE1695781C3 (de) | Psychotropes Arzneimittel | |
| DE950027C (de) | Verfahren zur Herstellung injizierbarer Extrakte der Rosskastanie | |
| DE2515084A1 (de) | Verfahren zur herstellung von mono- o-beta-hydroxyaethyl-7 rutin | |
| DE752754C (de) | Verfahren zur Herstellung von wirksamen, kristallisierten Glucosiden aus Sennesdrogen | |
| DE1670378A1 (de) | Verfahren zur Herstellung einer Verbindung aus Phenylbutazon und ss-Diaethylaminoaethylamid der p-Chlorphenoxyessigsaeure | |
| DE761043C (de) | Verfahren zur Gewinnung von Toxiferin ó±und ó� aus der Rinde von Strychnos toxifera | |
| DE1617413C (de) | Verfahren zur Herstellung von äscinreichen Roßkastanienextrakten | |
| DE2259388C3 (de) | Verfahren zur Gewinnung von Vincristin | |
| AT203629B (de) | Verfahren zur Herstellung von biologisch aktiven Verbindungen aus Oleaceen | |
| AT295034B (de) | Verfahren zur Herstellung von Extrakten von Roßkastaniensamen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee | ||
| 8180 | Miscellaneous part 1 |
Free format text: KURZFRISTIGE WIEDEREINSETZUNG WEGEN FALSCH VEROEFFENTLICHTEM ERLEDIGUNGSGRUND. DIE VEROEFFFENTLICHUNG DES ZUTREFFENDEN ERLEDIGUNGSGRUNDES ERFOLGT IM NAECHSTEN PATENTBLATT. |
|
| 8141 | Disposal/no request for examination |