DE2251713A1 - Verfahren zur herstellung von pge tief 2 oder dessen racemat zur enteralen oder parenteralen verabreichung - Google Patents
Verfahren zur herstellung von pge tief 2 oder dessen racemat zur enteralen oder parenteralen verabreichungInfo
- Publication number
- DE2251713A1 DE2251713A1 DE2251713A DE2251713A DE2251713A1 DE 2251713 A1 DE2251713 A1 DE 2251713A1 DE 2251713 A DE2251713 A DE 2251713A DE 2251713 A DE2251713 A DE 2251713A DE 2251713 A1 DE2251713 A1 DE 2251713A1
- Authority
- DE
- Germany
- Prior art keywords
- water
- anhydrous
- pge
- solution
- racemate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 10
- 238000007911 parenteral administration Methods 0.000 title description 6
- 238000004519 manufacturing process Methods 0.000 title description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000002904 solvent Substances 0.000 claims description 13
- 239000000010 aprotic solvent Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000011287 therapeutic dose Methods 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940113088 dimethylacetamide Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 description 17
- 239000011550 stock solution Substances 0.000 description 7
- 230000018044 dehydration Effects 0.000 description 6
- 238000006297 dehydration reaction Methods 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 239000003978 infusion fluid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- SYBYTAAJFKOIEJ-UHFFFAOYSA-N 3-Methylbutan-2-one Chemical compound CC(C)C(C)=O SYBYTAAJFKOIEJ-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 206010000210 abortion Diseases 0.000 description 2
- 231100000176 abortion Toxicity 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 239000002511 suppository base Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 description 1
- -1 SuIfolane Chemical compound 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19468671A | 1971-11-01 | 1971-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2251713A1 true DE2251713A1 (de) | 1973-05-10 |
Family
ID=22718538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2251713A Pending DE2251713A1 (de) | 1971-11-01 | 1972-10-21 | Verfahren zur herstellung von pge tief 2 oder dessen racemat zur enteralen oder parenteralen verabreichung |
Country Status (9)
| Country | Link |
|---|---|
| AU (1) | AU474378B2 (fr) |
| BE (1) | BE790840A (fr) |
| DE (1) | DE2251713A1 (fr) |
| FR (1) | FR2158405B1 (fr) |
| GB (1) | GB1367550A (fr) |
| IL (1) | IL40517A (fr) |
| NL (1) | NL7214204A (fr) |
| PH (1) | PH9756A (fr) |
| ZA (1) | ZA727077B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2740953A1 (de) * | 1977-09-12 | 1979-03-22 | Thera Ges Fuer Patente | Verwendung von prostaglandinen zur senkung des blutzuckerspiegels |
| US6323241B1 (en) * | 2000-01-10 | 2001-11-27 | Nexmed (Holdings) Inc. | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
| US6693135B2 (en) | 2000-01-10 | 2004-02-17 | Nexmed (Holdings) Incorporated | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
| US7105571B2 (en) | 2000-01-10 | 2006-09-12 | Nexmed Holdings, Inc. | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
| EP2408444A4 (fr) * | 2009-03-19 | 2012-09-26 | Fate Therapeutics Inc | Compositions comprenant des activateurs d'amp cyclique et/ou des ligands d'ep, et procédés de préparation et utilisation de ceux-ci |
-
0
- BE BE790840D patent/BE790840A/fr unknown
-
1972
- 1972-10-03 GB GB4558472A patent/GB1367550A/en not_active Expired
- 1972-10-03 ZA ZA727077A patent/ZA727077B/xx unknown
- 1972-10-06 IL IL40517A patent/IL40517A/xx unknown
- 1972-10-16 AU AU47778/72A patent/AU474378B2/en not_active Expired
- 1972-10-18 PH PH14023A patent/PH9756A/en unknown
- 1972-10-20 NL NL7214204A patent/NL7214204A/xx not_active Application Discontinuation
- 1972-10-21 DE DE2251713A patent/DE2251713A1/de active Pending
- 1972-10-31 FR FR7238622A patent/FR2158405B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU4777872A (en) | 1974-04-26 |
| FR2158405B1 (fr) | 1976-07-02 |
| PH9756A (en) | 1976-03-12 |
| ZA727077B (en) | 1973-06-27 |
| NL7214204A (fr) | 1973-05-03 |
| AU474378B2 (en) | 1976-07-22 |
| BE790840A (fr) | 1973-04-30 |
| IL40517A (en) | 1975-03-13 |
| GB1367550A (en) | 1974-09-18 |
| IL40517A0 (en) | 1972-12-29 |
| FR2158405A1 (fr) | 1973-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHN | Withdrawal |