DE202005015147U1 - Biosensor-Teststreifen mit Identifizierfunktion - Google Patents
Biosensor-Teststreifen mit Identifizierfunktion Download PDFInfo
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- DE202005015147U1 DE202005015147U1 DE200520015147 DE202005015147U DE202005015147U1 DE 202005015147 U1 DE202005015147 U1 DE 202005015147U1 DE 200520015147 DE200520015147 DE 200520015147 DE 202005015147 U DE202005015147 U DE 202005015147U DE 202005015147 U1 DE202005015147 U1 DE 202005015147U1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
- G01N33/48771—Coding of information, e.g. calibration data, lot number
Abstract
Biosensor-Teststreifen
mit Identifizierfunktion, bestehend aus
einem Substrat, auf dem eine Arbeitselektrode (15) und eine Gegenelektrode (16) vorgesehen sind,
Identifizierzonen (13), die an einem Ende des Substrates angeordnet und mit einem stromleitenden Material beschichtet sind, wobei unterschiedliches stromleitendes Material eine unterschiedliche Impedanz erzeugt, und
einer Reaktionszone (14), die am anderen Ende des Substrates angeordnet und mit der Arbeitselektrode (15) und der Gegenelektrode (16) verbunden ist.
einem Substrat, auf dem eine Arbeitselektrode (15) und eine Gegenelektrode (16) vorgesehen sind,
Identifizierzonen (13), die an einem Ende des Substrates angeordnet und mit einem stromleitenden Material beschichtet sind, wobei unterschiedliches stromleitendes Material eine unterschiedliche Impedanz erzeugt, und
einer Reaktionszone (14), die am anderen Ende des Substrates angeordnet und mit der Arbeitselektrode (15) und der Gegenelektrode (16) verbunden ist.
Description
- Technisches Gebiet
- Die Erfindung betrifft einen Biosensor-Teststreifen mit Identifizierfunktion die Identifizierzonen aufweist, die mit einem stromleitenden Material beschichtet sind, wobei unterschiedliches stromleitendes Material eine unterschiedliche Impedanz erzeugt, die geprüft wird, ob sie im vorgegebenen Impedanzbereich des Biosensor-Meßgerätes liegt, wodurch beim Messen ein Fehler vermieden werden kann.
- Stand der Technik
- Tragbare bioglogischen Meßgeräte, wie Blutzuckermeßgerät, elektronisches Ohr-Thermomenter, elektronisches Blutdruckmeßgerät, können von dem Benutzer zuhause selbst betätigt werden. Der disposible Blutzucker-Teststreifen ist ein elektrochemischer Biosensor, der die Blutzuckerkonzentration im Blut bestimmen kann.
- Die Teststreifen für Blutzucker, Cholesterin, GOT, GPT usw. sind sehr ähnlich und können beim Messen vertauscht werden, so daß ein falscher Meßwert erhalten wird.
-
1a ,1b und1c zeigen Biosensor-Teststreifen aus WO 0171328, die zum Messen von Blutzucker, Cholesterin und anderen Stoffen im Blut verwendet werden können. Der Biossensor-Teststreifen50 weist an einem Ende eine Identifizierelektrode60 , die je nach Bedarf an unterschiedlicher Stelle angeordnet ist. In1a befindet sich die Identifizierelektrode60 an der linken Seite und wird für die Blutzuckermessung verwendet. In1b befindet sich die Identifizierelektrode60 an der rechten Seite und wird für die Cholesterinmessung verwendet. In1c erstreckt sich die Identifizierelektrode60 in der Breite des Teststreifens und wird für die GOT- oder GPT-Messung verwendet. - Durch die Stelle der Identifizierelektrode
60 wird der Zweck des Teststreifens entschieden. Bei der Herstellung ist für jeden Teststreifen eine Produktionslinie erforderlich. Zudem braucht das Biosensor-Meßgerät für unterschiedlichen Teststreifen eine geeignete Prüfeinheit. Dadurch werden die Herstellungskosten erhöht. Da der Teststreifen sehr klein und die Identifizierelektrode noch kleiner ist, kann dieser Teststreifen auch vertauscht werden. - Aufgabe der Erfindung
- Die Erfindung hat die Aufgabe, einen Biosensor-Teststreifen mit Identifizierfunktion zu schaffen, die Identifizierzonen aufweist, die mit einem stromleitenden Material beschichtet sind, wobei unterschiedliches stromleitendes Material eine unterschiedliche Impedanz erzeugt, die geprüft wird, ob sie im vorgegebenen Impedanzbereich des Biosensor-Meßgerätes liegt, wodurch beim Messen ein Fehler vermieden werden kann.
- Diese Aufgabe wird durch den erfindungsgemäßen Biosensor-Teststreifen mit Identifizierfunktion gelöst, der aus einem ersten und zweiten Substrat besteht, wobei das erste Substrat länger ist als das zweite Substrat und auf dem ersten Substrat Elektroden und Identifizierzonen vorgesehen sind, die durch das kürzere Substrat freiliegen. Die Identifizierzonen sind mit einem stromleitenden Materialbeschichtet, wobei unterschiedliches stromleitendes Material eine unterschiedliche Impedanz erzeugt, wodurch je nach Bedarf ein geeignetes stromleitendes Material verwendet werden kann. Wenn der Teststreifen in das Biosensor-Meßgerät gesteckt wird, kann das Biosensor-Meßgerät durch die Impedanz der Identifizierzonen oder die Impedanz zwiwschen einer Identifizierzone und einer Elektrode feststellen, ob der Impedanzwert in dem vorgegebenen Impedanzbereich liegen. Wenn nein, wird auf dem Display ein Fehlersignal angezeigt. Wenn ja, wird das Messen durchgeführt. Daher kann die Meßgenauigkeit gewährleistet werden.
- Die Erfindung hat die weitere Aufgabe, ein Biosensor-Meßgerät zu schaffen, das vor dem Messen die Impedanz des Teststreifens prüft, ob sie im vorgegebenden Impedanzbereich liegt, wobei, wenn die Antwort nein ist, auf dem Display ein Fehlersignal angezeigt wird, und wenn die Antwort ja ist, das Messen durchgeführt wird, so daß die Meßgenauigkeit gewährleistet werden kann.
- Kurze Beschreibung der Zeichnungen
-
1a eine Darstellung von WO 0171328 (1), -
1b eine Darstellung von WO 0171328 (2), -
1c eine Darstellung von WO 0171328 (3), -
2 eine perspektivische Darstellung der Erfindung, -
2a eine Explosionsdarstellung der Erfindung, -
2b eine Explosionsdarstellung der Erfindung, wobei die Elektroden von den Identifizierzonen getrennt sind, -
3 eine perspektivische Darstellung eines weiteren Ausführungsbeispiels der Erfindung, -
3a eine Explosionsdarstellung des weiteren Ausführungsbeispiels der Erfindung, -
3b eine Explosionsdarstellung des weiteren Ausführungsbeispiels der Erfindung, wobei die Elektroden von den Identifizierzonen getrennt sind, -
4 eine Darstellung des erfindungsgemäßen Biosensor-Meßgerätes. - Wege zur Ausführung der Erfindung
-
2 und2a zeigen das erste Ausführungsbeispiel der Erfindung, bei dem der Teststreifen10 aus einem ersten und zweiten Substrat11 ,12 besteht, wobei das erste Substrat11 länger ist als das zweite Substrat12 . Das erste und zweite Substrat11 ,12 sind beide in Form von Planplatten ausgebildet und elektrisch isolierend. Das erste und zweite Substrat11 ,12 sind an den beiden Seiten mittels eines Klebstoffs zusammengeklebt (es ist auch möglich, andere Verbindungsweise zu verwenden). Die restlichen Teile der Substrate11 ,12 , die nicht mit einer Klebschicht versehen sind, sind mit einem biologisch aktiven Reagenz versehen. An dem zweiten Substrat12 überstehenden Ende des ersten Substrates11 sind Identifizierzonen13 vorgesehen, die durch Beschichtung mit einem stromleitenden Material gebildet sind. Unterschiedliches stromleitendes Material, wie z.B. Gemisch von Kohlenschlamm (durch unterschiedliches Mischverhältnis wird ein unterschiedlicher Impedanzbereich erhalten, wie 400Ω–800Ω oder 1kΩ–3kΩ), Edelmetallegierung (Platin-, Palladiumlegierung) Edelmetall (Gold, Silber, Platin) und Indiumzinnoxyd, erzeugt eine unterschiedliche Impedanz. - Zwischen dem ersten und zweiten Substrat
11 ,12 befinden sich eine Arbeitselektrode15 und eine Gegenelektrode16 , die voneinander einen Abstand haben, an einem Ende in die Reaktionszone14 ragen und am anderen Ende wie die Identifizierzonen13 durch das kürzere zweite Substrat12 freiliegen (2a und2b ). - Wenn der Teststreifen in das Biosensor-Meßgerät gesteckt wird, erzeugen die Identifizierzonen
13 oder eine Identifizierzone13 und eine Elektrode (Arbeitselektrode15 oder Gegenelekrode16 ) eine Impedanz. Um den Bedarf, den Typ des Meßgerätes, die Anforderung des Bestellers zu erfüllen, können die Identifizierzonen13 mit unterschiedlichem stromleitendem Materialbeschichtet werden, um die gewünschten Impedanzwerte zu erzeugen. Daher kann der erfinudngsgemäße Teststreifen für Biosensor-Meßgeräte mit unterschiedlicher Spezifikation und Zweck verwendet werden. -
3 und3a zeigen das zweite Ausführungsbeispiel der Erfindung, bei dem der Teststreifen10 dreidimensional ausgebildet ist und aus einem ersten Substrat11 und zwei zweiten Substraten12 besteht, wobei das erste Substrat11 zwischen den beiden zweiten Substraten12 liegt und das erste Substrat11 länger ist als die beiden zweiten Substrate12 . Das erste Substrat11 und die zweiten Substrate12 sind beide in Form von Planplatten ausgebildet und elektrisch isolierend. Das erste Substrat11 und die zweiten Substrate11 ,12 sind an den beiden Seiten mittels eines Klebstoffs zusammengeklebt (es ist auch möglich, andere Verbindungsweise zu verwenden). Die restlichen Teile des ersten Substrates11 und der zweiten Substrate12 , die nicht mit einer Klebschicht versehen sind, sind mit einem biologisch aktiven Reagenz versehen. An dem den zweiten Substraten12 überstehenden Ende des ersten Substrates11 sind Identifizierzonen13 vorgesehen, die durch Beschichtung mit einem stromleitenden Material gebildet sind. Unterschiedliches stromleitendes Material, wie z.B. Gemisch von Kohlenschlamm (durch unterschiedliches Mischverhältnis wird ein unterschiedlicher Impedanzbereich erhalten, wie 400Ω–800Ω oder 1kΩ–3kΩ), Edelmetallegierung (Platin-, Palladiumlegierung) Edelmetall (Gold, Silber, Platin) oder Indiumzinnoxyd, erzeugt eine unterschiedliche Impedanz. - Zwischen dem ersten Substrat und den zweiten Substraten
11 ,12 befinden sich eine Arbeitselektrode15 und eine Gegenelektrode16 , die durch das erste Substrat11 voneinander getrennt sind, an einem Ende in die Reaktionszone14 ragen und am anderen Ende wie die Identifizierzonen13 durch die kürzeren zweiten Substrate12 freiliegen (3a und3b ). -
4 zeigt ein Biosensor-Meßgerät, das aus einem Hauptkörper100 besteht, auf dem ein Display21 vorgesehen ist. Im Maschinenkörper100 ist ein Mikroprozessor vorgesehen, der mit einem Meßelement, einem Analog-Digitl-Umsetzer, dem Display21 , einem Speichermedium und einer Stromquelle (nicht dargestellt) verbunden ist. - Beim Einsatz erfaßt das Meßelement durch die Probe ein Signal, das von dem Analog-Digital-Umsetzer in Digtialsignal umgewandelt und an den Mikroprozessor gesendet wird, der den Meßwert errechnet, diesen mit dem im Speichermedium gespeicherten Referenzwert vergleicht und auf dem Display anzeigt. (Dies ist bekannt und wird hier nicht beschrieben.) Das Meßelement weist einen Schlitz
22 auf, in dem Kontakte221 vorgesehen sind, die mit der Steuerung (nicht dargestellt) des Biosensor-Meßgerätes verbunden sind. Im vorliegenden Ausführungsbeispiel können die Kontakte221 mit den Identifizierzonen13 oder einer Elektrode (Arbeitselektrode15 oder Gegenelektrode16 ) und einer Identifizierzone13 in Kontakt gebracht werden. - Wie aus den
2 ,3 und4 ersichtlich ist, wird der Teststreifen vor dem Messen in den Schlitz22 gesteckt, damit die Identifizierzonen13 oder eine Identifizierzone13 und eine Elektrode mit den Kontakten221 in Kontakt treten, wodurch das Biosensor-Meßgerät durch die Impedanz der Identifizierzonen13 oder die Impedanz zwischen einer Identifizierzone13 und einer Elektrode feststellen kann, ob der Impedanzwert in dem vorgegebenen Impedanzbereich liegen. Wenn nein, wird auf dem Display21 ein Fehlersignal angezeigt. Wenn ja, wird das Messen durchgeführt. Daher kann die Meßgenauigkeit gewährleistet werden. - Aufgrund der obengenannten Tatsachen entspricht die Erfindung in ihrer Verfügbarkeit, Fortschrittlichkeit und Neuheit vollauf den Anforderungen für ein Gebrauchsmuster.
- Die Erfindung betrifft einen Biosensor-Teststreifen mit Identifizierfunktion, der aus einem ersten und zweiten Substrat (
11 ,12 ) besteht, wobei das erste Substrat (11 ) länger ist als das zweite Substrat (12 ) und auf dem ersten Substrat (11 ) Elektroden (15 ,16 ) und Identifizierzonen (13 ) vorgesehen sind, die durch das kürzere zweite Substrat (12 ) freiliegen. Die Identifizierzonen (13 ) sind mit einem stromleitenden Material beschichtet, wobei unterschiedliches stromleitendes Material eine unterschiedliche Impedanz erzeugt, wodurch je nach Bedarf ein geeignetes stromleitendes Material verwendet werden kann. Wenn der Teststreifen in das Biosensor-Meßgerät gesteckt wird, kann das Biosensor-Meßgerät durch die Impedanz der Identifizierzonen (13 ) oder die Impedanz zwischen einer Identifizierzone (13 ) und einer Elektrode feststellen, ob der Impedanzwert in dem vorgegebenen Impedanzbereich liegen. Wenn nein, wird auf dem Display (21 ) ein Fehlersignal angezeigt. Wenn ja, wird das Messen durchgeführt. Daher kann die Meßgenauigkeit gewährleistet werden.
Claims (8)
- Biosensor-Teststreifen mit Identifizierfunktion, bestehend aus einem Substrat, auf dem eine Arbeitselektrode (
15 ) und eine Gegenelektrode (16 ) vorgesehen sind, Identifizierzonen (13 ), die an einem Ende des Substrates angeordnet und mit einem stromleitenden Material beschichtet sind, wobei unterschiedliches stromleitendes Material eine unterschiedliche Impedanz erzeugt, und einer Reaktionszone (14 ), die am anderen Ende des Substrates angeordnet und mit der Arbeitselektrode (15 ) und der Gegenelektrode (16 ) verbunden ist. - Biosensor-Teststreifen nach Anspruch 1, dadurch gekennzeichnet, dass das stromleitende Material ein stromleitender Kohlenschlamm sein kann.
- Biosensor-Teststreifen nach Anspruch 1, dadurch gekennzeichnet, dass das stromleitende Material Edelmetallegierung (Platin-, Palladiumlegierung), Edelmetall (Gold, Silber, Platin) oder Indiumzinnoxyd sein kann.
- Biosensor-Teststreifen nach Anspruch 1, dadurch gekennzeichnet, dass das Substrat ein erstes und zweites Substrat (
11 ,12 ) umfaßt, die in Form von Planplatten ausgebildet und elektrisch isolierend sind, wobei das erste und zweite Substrat (11 ,12 ) an den beiden Seiten mittels eines Klebstoffs zusammengeklebt sind und die restlichen Teile der Substrate (11 ,12 ), die nicht mit einer Klebschicht versehen sind, mit einem biologisch aktiven Reagenz versehen sind. - Biosensor-Teststreifen nach Anspruch 1, dadurch gekennzeichnet, dass das Substrat ein erstes Substrat (
11 ) und zwei zweite Substrate (12 ) an den beiden Seiten des ersten Substrates (11 ) umfaßt, die in Form von Planplatten ausgebildet und elektrisch isolierend sind, wobei das erste und zweite Substrat (11 ,12 ) an den beiden Seiten mittels eines Klebstoffs zusammengeklebt sind und die restlichen Teile der Substrate (11 ,12 ), die nicht mit einer Klebschicht versehen sind, mit einem biologisch aktiven Reagenz versehen sind. - Biosensor-Meßgerät, das einen Schlitz (
22 ) aufweist, in dem Kontakte (221 ) vorgesehen sind und in den der Biosensor-Teststreifen gesteckt wird, wodurch das Biosensor-Meßgerät durch die Impedanz der Identifizierzonen (13 ) feststellen kann, ob der Impedanzwert in dem vorgegebenen Impedanzbereich liegen, wobei, wenn die Antwort nein ist, auf dem Display (21 ) ein Fehlersignal angezeigt wird, und wenn die Antwort ja ist, das Messen durchgeführt wird, so daß die Meßgenauigkeit gewährleistet werden kann. - Biosensor-Meßgerät nach Anspruch 6, dadurch gekennzeichnet, dass die Kontakte (
221 ) mit den Identifizierzonen (13 ) in Kontakt treten. - Biosensor-Meßgerät nach Anspruch 6, dadurch gekennzeichnet, dass die Kontakte (
221 ) mit einer Identifizierzone (13 ) und der Arbeitselektrode (15 ) oder der Gegenelektrode (16 ) in Kontakt treten.
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