DE20116125U1 - Amlodipinfumarat - Google Patents
AmlodipinfumaratInfo
- Publication number
- DE20116125U1 DE20116125U1 DE20116125U DE20116125U DE20116125U1 DE 20116125 U1 DE20116125 U1 DE 20116125U1 DE 20116125 U DE20116125 U DE 20116125U DE 20116125 U DE20116125 U DE 20116125U DE 20116125 U1 DE20116125 U1 DE 20116125U1
- Authority
- DE
- Germany
- Prior art keywords
- acid addition
- amlodipine
- addition salt
- pharmaceutical composition
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003839 salts Chemical class 0.000 claims 13
- 239000002253 acid Substances 0.000 claims 11
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 10
- 229960000528 amlodipine Drugs 0.000 claims 8
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 239000001530 fumaric acid Substances 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25860400P | 2000-12-29 | 2000-12-29 | |
US80935001A | 2001-03-16 | 2001-03-16 | |
BE2001/0710A BE1014453A6 (nl) | 2000-12-29 | 2001-11-05 | Amlodipinefumaraat. |
Publications (1)
Publication Number | Publication Date |
---|---|
DE20116125U1 true DE20116125U1 (de) | 2002-01-24 |
Family
ID=29740326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE20116125U Expired - Lifetime DE20116125U1 (de) | 2000-12-29 | 2001-10-01 | Amlodipinfumarat |
Country Status (6)
Country | Link |
---|---|
US (1) | US6518288B2 (de) |
EP (1) | EP1309556B1 (de) |
BE (1) | BE1014453A6 (de) |
CA (1) | CA2433181C (de) |
DE (1) | DE20116125U1 (de) |
WO (1) | WO2002053538A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03005882A (es) * | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
CA2433193C (en) * | 2000-12-29 | 2006-01-31 | Pfizer Limited | Amide derivative of amlodipine |
US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
PT1309555E (pt) * | 2000-12-29 | 2005-10-31 | Pfizer Ltd | Processo para a producao de maleato amlodipina |
KR100452491B1 (ko) * | 2001-03-29 | 2004-10-12 | 한미약품 주식회사 | 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법 |
KR100538641B1 (ko) | 2002-07-30 | 2005-12-22 | 씨제이 주식회사 | 암로디핀의 유기산염 |
KR100496436B1 (ko) | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | 암로디핀의 유기산염 |
KR100467669B1 (ko) * | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | 암로디핀의 유기산염 |
AU2002368531A1 (en) * | 2002-12-30 | 2004-07-22 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. | Isolation of dihydropyridine derivative and preparation salts thereof |
CN1777586A (zh) * | 2003-01-27 | 2006-05-24 | 韩美药品株式会社 | 稳定的无定形樟脑磺酸氨氯地平、其制备工艺以及其口服给药的组合物 |
US7987099B2 (en) * | 2004-02-27 | 2011-07-26 | Align Technology, Inc. | Dental data mining |
HU230877B1 (hu) | 2008-09-30 | 2018-11-29 | EGIS Gyógyszergyár NyR | Stabil kombinációs gyógyszerkészítmény |
US20120115840A1 (en) * | 2008-12-18 | 2012-05-10 | Lech Ciszewski | Hemifumarate salt of 1-[4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid |
WO2011117876A1 (en) | 2010-03-26 | 2011-09-29 | Fdc Limited | An improved process for the preparation of amlodipine free base and acid addition salts thereof |
CN104529877A (zh) * | 2015-01-22 | 2015-04-22 | 华东理工常熟研究院有限公司 | 氨氯地平-癸酸离子液体及其制备方法和用途 |
WO2018067959A1 (en) | 2016-10-07 | 2018-04-12 | Silvergate Pharmaceuticals, Inc. | Amlodipine formulations |
EP3773574A4 (de) | 2018-04-11 | 2022-03-02 | Silvergate Pharmaceuticals, Inc. | Amlodipinformulierungen |
CN112022849A (zh) * | 2020-05-17 | 2020-12-04 | 复旦大学 | 富马酸左旋氨氯地平共晶药物及其制备方法和应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK161312C (da) | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
FR2602231B1 (fr) * | 1986-08-04 | 1988-10-28 | Adir | Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
US4983740A (en) | 1986-08-04 | 1991-01-08 | Adir Et Compagnie | Process for 1,4-dihydropyridine compounds |
GB8710493D0 (en) | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
US5155120A (en) | 1991-01-14 | 1992-10-13 | Pfizer Inc | Method for treating congestive heart failure |
WO1993006082A1 (en) | 1991-09-13 | 1993-04-01 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropyridines |
US5389654A (en) | 1992-11-26 | 1995-02-14 | Lek, Tovarna, Farmacevtskih In Kemicnih . . . | 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate |
HU221810B1 (hu) | 1997-08-12 | 2003-01-28 | EGIS Gyógyszergyár Rt. | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
ZA9810320B (en) | 1997-11-14 | 2000-05-11 | Gea Farmaceutisk Fabrik As | Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose. |
PL189666B1 (pl) | 1998-04-09 | 2005-09-30 | Adamed Sp Z Oo | Sposób otrzymywania benzenosulfonianu amlodypiny |
GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
ES2151850B1 (es) | 1998-10-26 | 2001-08-16 | Esteve Quimica Sa | Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente. |
GB9827431D0 (en) | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel compound |
GB9827387D0 (en) | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel process |
NL1018760C1 (nl) * | 2001-08-15 | 2001-11-02 | Bioorg Bv | Amlodipinefumaraat. |
-
2001
- 2001-08-15 WO PCT/NL2001/000600 patent/WO2002053538A1/en active IP Right Grant
- 2001-08-15 EP EP01974982A patent/EP1309556B1/de not_active Expired - Lifetime
- 2001-08-15 CA CA002433181A patent/CA2433181C/en not_active Expired - Fee Related
- 2001-08-27 US US09/938,820 patent/US6518288B2/en not_active Expired - Fee Related
- 2001-10-01 DE DE20116125U patent/DE20116125U1/de not_active Expired - Lifetime
- 2001-11-05 BE BE2001/0710A patent/BE1014453A6/nl not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2002053538A1 (en) | 2002-07-11 |
EP1309556A1 (de) | 2003-05-14 |
US6518288B2 (en) | 2003-02-11 |
CA2433181A1 (en) | 2002-07-11 |
EP1309556B1 (de) | 2004-11-24 |
CA2433181C (en) | 2005-11-22 |
US20020123519A1 (en) | 2002-09-05 |
BE1014453A6 (nl) | 2003-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
R207 | Utility model specification |
Effective date: 20020228 |
|
R081 | Change of applicant/patentee |
Owner name: PFIZER LTD., GB Free format text: FORMER OWNER: BIOORGANICS B.V., NIJMEGEN, NL Effective date: 20030313 |
|
R081 | Change of applicant/patentee |
Owner name: PFIZER LTD., GB Free format text: FORMER OWNER: SYNTHON LICENSING, LTD., LUXEMBOURG, LU Effective date: 20030812 |
|
R150 | Utility model maintained after payment of first maintenance fee after three years |
Effective date: 20050119 |
|
R151 | Utility model maintained after payment of second maintenance fee after six years |
Effective date: 20071121 |
|
R158 | Lapse of ip right after 8 years |
Effective date: 20100501 |