DE19817438A1 - Automatic reservoir presenting specific fluid quantity to robotic pipetting system, - Google Patents

Automatic reservoir presenting specific fluid quantity to robotic pipetting system,

Info

Publication number
DE19817438A1
DE19817438A1 DE1998117438 DE19817438A DE19817438A1 DE 19817438 A1 DE19817438 A1 DE 19817438A1 DE 1998117438 DE1998117438 DE 1998117438 DE 19817438 A DE19817438 A DE 19817438A DE 19817438 A1 DE19817438 A1 DE 19817438A1
Authority
DE
Germany
Prior art keywords
pipetting system
specific fluid
fluid quantity
liquid
presenting specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE1998117438
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JANDRATEK GMBH, 96346 WALLENFELS, DE
Original Assignee
BIOTUL BIO INSTR GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOTUL BIO INSTR GmbH filed Critical BIOTUL BIO INSTR GmbH
Priority to DE1998117438 priority Critical patent/DE19817438A1/en
Priority to AU38194/99A priority patent/AU3819499A/en
Priority to PCT/EP1999/002662 priority patent/WO1999054042A1/en
Priority to EP99920718A priority patent/EP1212139A1/en
Publication of DE19817438A1 publication Critical patent/DE19817438A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced

Abstract

An inverted liquid supply bottle (11) is connected to a ducted system (10) having two upper openings (14, 19). The bottle edge (17) projects into one of them.

Description

In den meisten Analysegeräten in der biologischen, medizinischen und pharmazeutischen Forschung, die mit flüssigen Analyten und Seren arbeiten, kommen automatische oder halbautomatische Pipettiersysteme zum Einsatz. Neben den Analyten müssen in der Regel auch Wasser und Puffer- oder Regenerationsflüssigkeiten zum Sensor oder vom Sensor transportiert werden.In most analyzers in biological, medical and pharmaceutical research working with liquid analytes and sera, automatic or semi-automatic pipetting systems are used. Next the analytes usually also need water and buffer or Regeneration fluids are transported to or from the sensor.

Hierfür befinden sich meist größere Vorratsbehälter in oder neben den Geräten. Diese Flüssigkeiten werden entweder durch Pumpen oder durch Pipettieren transportiert. In allen bekannten Fällen sind Füllstandskontrollen im oder außerhalb des Gerätes notwendig.For this purpose there are usually larger storage containers in or next to the devices. These liquids are either pumped or pipetted transported. In all known cases, level controls are inside or outside of the device necessary.

Die vorliegende Erfindung beschreibt ein System zur Bereitstellung größerer Flüssigkeitsmengen in automatischen Pipettiersystemen mit selbstregulierendem Flüssigkeitsstand. Der Vorteil besteht in dem nahezu konstanten Flüssigkeitsstand in dem Entnahmebehälter. Das heißt, die Pipettenspitze, die die Flüssigkeiten aufnimmt, muß nur an eine bestimmte, bekannte vertikale Position herangeführt werden, damit sie in die Flüssigkeiten eintauchen und sie aufnehmen kann. Eine Kontrolle des Füllstandes und einer damit verbundenen Steuerung der vertikalen Position der Pipettenspitze zur Flüssigkeitsaufnahme, wie es zum Beispiel in gewöhnlichen Bechern oder Flaschen der Fall ist, entfällt.The present invention describes a system for providing larger ones Liquid quantities in automatic pipetting systems with self-regulating Fluid level. The advantage is the almost constant liquid level in the removal container. That is, the pipette tip that holds the liquids picks up only needs to be brought up to a certain, known vertical position so that they can be immersed in and absorbed by the liquids. A Checking the fill level and the associated control of the vertical Position of the pipette tip for liquid absorption, as for example in ordinary cups or bottles is omitted.

Die Erfindung löst diese Aufgaben mit den Merkmalen der Fig. 1a bis 1c und Fig. 2 und der folgenden Beschreibung. In den Abbildungen ist folgendes skizziert.The invention achieves these objects with the features of FIGS. 1a to 1c and FIG. 2 and the following description. The following is outlined in the figures.

BezugszeichenlisteReference list

1010th

Rohrsystem
Pipe system

1111

Vorratsbehälter
Storage container

1212th

Abfallbehälter
Waste bin

1313

Vorratsflüssigkeit
Storage liquid

1414

Entnahme- und Abgabeöffnung
Removal and dispensing opening

1515

Entnahmeeinheit
Extraction unit

1616

Flüssigkeitsstand
Fluid level

1717th

Pegelkante
Level edge

1818th

Ablauf
procedure

1919th

Öffnung und Aufnahme der Vorrats- und Abfallbehälters
Opening and receiving the storage and waste containers

Die Erfindung besteht aus einem beidseitig geschlossenen Rohr oder Rohrsystem (10) mit zwei obenliegenden Öffnungen (14, 19). In die eine Öffnung (19) wird eine gewöhnliche Flasche (11) mit Standardschraubgewinden oder einem anderen Verschlussmechanismus eingeschraubt. Der Rand der Flasche ragt dabei ein Stück (ca. 3-10 mm oder auch mehr) in das Rohr hinein (17). Durch die zweite Öffnung (14) kann mittels der Pipettenspitze oder einer anderen Entnahmeeinheit (15) Flüssigkeit entnommen werden. Der Flüssigkeitsstand (16) wird durch die Höhe des Randes der Flasche (17) im Rohr bestimmt. Die Flüssigkeit steigt bis zum Rand an. Wird nun Flüssigkeit entnommen, sinkt der Pegel und es kann unter den Rand der Flasche Luft in die Flasche eindringen, wodurch Flüssigkeit solange aus der Flasche fließt, bis der Pegel im Rohr den Rand der Flasche wieder erreicht hat. Dadurch ist gewährleistet, daß der Pegel im Rohr nahezu konstant bleibt. Hier sei noch angemerkt, daß die geometrische Form des Entnahmebereiches keinen Einfluß auf die Funktionalität der Erfindung hat. Der Abfallbehälter (12) wird von unten in das Rohrsystem (10) eingeschraubt. Über den Ablauf (18) fließt die Flüssigkeit in den Abfallbehälter (12). Die Skizze (Fig. 1c und 2) zeigt ein Rohrsystem mit Flaschen von drei unabhängigen Entnahme- bzw. Abgabesystemen.The invention consists of a pipe or pipe system ( 10 ) closed on both sides with two openings ( 14 , 19 ) on top. An ordinary bottle ( 11 ) with standard screw threads or another locking mechanism is screwed into one opening ( 19 ). The edge of the bottle protrudes a bit (approx. 3-10 mm or more) into the tube ( 17 ). Liquid can be removed through the second opening ( 14 ) by means of the pipette tip or another removal unit ( 15 ). The liquid level ( 16 ) is determined by the height of the edge of the bottle ( 17 ) in the tube. The liquid rises to the edge. If liquid is now removed, the level drops and air can penetrate under the edge of the bottle, causing liquid to flow out of the bottle until the level in the tube has reached the edge of the bottle again. This ensures that the level in the pipe remains almost constant. It should also be noted here that the geometric shape of the removal area has no influence on the functionality of the invention. The waste container ( 12 ) is screwed into the pipe system ( 10 ) from below. The liquid flows into the waste container ( 12 ) via the outlet ( 18 ). The sketch ( Fig. 1c and 2) shows a pipe system with bottles from three independent removal or delivery systems.

Claims (1)

Vorrichtung zur Bereitstellung einer bestimmten Flüssig­ keitsmenge in einem automatischen Pipettiersystem mit mindestens einem Vorratsbehälter für eine Flüssigkeit, und einem Rohrsystem vorzugsweise mit zwei obenliegenden Öffnungen, wobei in eine Öffnung der Vorratsbehälter mit der Mündung nach unten weisend derart einsetzbar ist, daß der Rand der Flasche mindestens teilweise in das Rohr hineinragt.Device for supplying a specific liquid quantity in an automatic pipetting system at least one storage container for a liquid, and a pipe system preferably with two overhead Openings, with in an opening of the reservoir the mouth facing downwards can be used in this way, that the edge of the bottle at least partially in the Pipe protrudes.
DE1998117438 1998-04-20 1998-04-20 Automatic reservoir presenting specific fluid quantity to robotic pipetting system, Withdrawn DE19817438A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE1998117438 DE19817438A1 (en) 1998-04-20 1998-04-20 Automatic reservoir presenting specific fluid quantity to robotic pipetting system,
AU38194/99A AU3819499A (en) 1998-04-20 1999-04-20 Device for providing liquids for pipetting systems
PCT/EP1999/002662 WO1999054042A1 (en) 1998-04-20 1999-04-20 Device for providing liquids for pipetting systems
EP99920718A EP1212139A1 (en) 1998-04-20 1999-04-20 Device for providing liquids for pipetting systems

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1998117438 DE19817438A1 (en) 1998-04-20 1998-04-20 Automatic reservoir presenting specific fluid quantity to robotic pipetting system,

Publications (1)

Publication Number Publication Date
DE19817438A1 true DE19817438A1 (en) 1999-10-21

Family

ID=7865097

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1998117438 Withdrawn DE19817438A1 (en) 1998-04-20 1998-04-20 Automatic reservoir presenting specific fluid quantity to robotic pipetting system,

Country Status (4)

Country Link
EP (1) EP1212139A1 (en)
AU (1) AU3819499A (en)
DE (1) DE19817438A1 (en)
WO (1) WO1999054042A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH512730A (en) * 1969-03-31 1971-09-15 Greiner Electronic Ag Dosing device
DE3818238A1 (en) * 1988-05-28 1989-11-30 Eppendorf Geraetebau Netheler METHOD FOR REMOVING LIQUID FROM LARGE-VOLUME, DEEP VESSELS AND DEVICE FOR IMPLEMENTING THE METHOD BY SUCTION VESSELS WITH SHORT SUCTION PIECES AS SUCTION AID
GB2248891A (en) * 1990-10-18 1992-04-22 Westonbridge Int Ltd Membrane micropump
CN1329729C (en) * 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 Electropipettor and compensation means for electrophoretic bias

Also Published As

Publication number Publication date
AU3819499A (en) 1999-11-08
WO1999054042A1 (en) 1999-10-28
EP1212139A1 (en) 2002-06-12

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Legal Events

Date Code Title Description
8181 Inventor (new situation)

Free format text: BRINK, GUNNAR, DR., 80339 MUENCHEN, DE TITTEL, JAKOB, DR., 81667 MUENCHEN, DE

8127 New person/name/address of the applicant

Owner name: BIOTUL AG, 80339 MUENCHEN, DE

8127 New person/name/address of the applicant

Owner name: JANDRATEK GMBH, 96346 WALLENFELS, DE

8130 Withdrawal