DE19817438A1 - Automatic reservoir presenting specific fluid quantity to robotic pipetting system, - Google Patents

Automatic reservoir presenting specific fluid quantity to robotic pipetting system,

Info

Publication number
DE19817438A1
DE19817438A1 DE1998117438 DE19817438A DE19817438A1 DE 19817438 A1 DE19817438 A1 DE 19817438A1 DE 1998117438 DE1998117438 DE 1998117438 DE 19817438 A DE19817438 A DE 19817438A DE 19817438 A1 DE19817438 A1 DE 19817438A1
Authority
DE
Germany
Prior art keywords
pipetting system
specific fluid
fluid quantity
presenting specific
robotic pipetting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE1998117438
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JANDRATEK GMBH, 96346 WALLENFELS, DE
Original Assignee
BIOTUL BIO INSTRUMENTS GmbH
BIOTUL BIO INSTR GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOTUL BIO INSTRUMENTS GmbH, BIOTUL BIO INSTR GmbH filed Critical BIOTUL BIO INSTRUMENTS GmbH
Priority to DE1998117438 priority Critical patent/DE19817438A1/en
Publication of DE19817438A1 publication Critical patent/DE19817438A1/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0289Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16Reagents, handling or storing thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/021Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016Control of the volume dispensed or introduced

Abstract

An inverted liquid supply bottle (11) is connected to a ducted system (10) having two upper openings (14, 19). The bottle edge (17) projects into one of them.

Description

In den meisten Analysegeräten in der biologischen, medizinischen und pharmazeutischen Forschung, die mit flüssigen Analyten und Seren arbeiten, kommen automatische oder halbautomatische Pipettiersysteme zum Einsatz. In most analyzers in the biological, medical and pharmaceutical research, working with liquid analyte and serums, automatic or semi-automatic pipetting systems are used. Neben den Analyten müssen in der Regel auch Wasser und Puffer- oder Regenerationsflüssigkeiten zum Sensor oder vom Sensor transportiert werden. In addition to the analyte and water and buffer or regeneration liquids to the sensor or the sensor must be transported normally.

Hierfür befinden sich meist größere Vorratsbehälter in oder neben den Geräten. For these are usually larger reservoir in or next to the devices. Diese Flüssigkeiten werden entweder durch Pumpen oder durch Pipettieren transportiert. These fluids are transported either by pumping or by pipetting. In allen bekannten Fällen sind Füllstandskontrollen im oder außerhalb des Gerätes notwendig. In all known cases level controls are necessary in or outside of the device.

Die vorliegende Erfindung beschreibt ein System zur Bereitstellung größerer Flüssigkeitsmengen in automatischen Pipettiersystemen mit selbstregulierendem Flüssigkeitsstand. The present invention describes a system for providing greater amounts of liquid in an automated pipette system with self fluid level. Der Vorteil besteht in dem nahezu konstanten Flüssigkeitsstand in dem Entnahmebehälter. The advantage is the nearly constant liquid level in the collection container. Das heißt, die Pipettenspitze, die die Flüssigkeiten aufnimmt, muß nur an eine bestimmte, bekannte vertikale Position herangeführt werden, damit sie in die Flüssigkeiten eintauchen und sie aufnehmen kann. That is, the pipette tip which receives the fluids to be introduced only at a specific, known vertical position, so that they dip into the liquids, and it can absorb. Eine Kontrolle des Füllstandes und einer damit verbundenen Steuerung der vertikalen Position der Pipettenspitze zur Flüssigkeitsaufnahme, wie es zum Beispiel in gewöhnlichen Bechern oder Flaschen der Fall ist, entfällt. A control of the level and associated control of the vertical position of the pipette tip to the fluid intake, as is the case for example in ordinary cups or bottles, is eliminated.

Die Erfindung löst diese Aufgaben mit den Merkmalen der Fig. 1a bis 1c und Fig. 2 und der folgenden Beschreibung. The invention achieves these objects with the features of Figs. 1a to 1c and FIGS. 2 and the following description. In den Abbildungen ist folgendes skizziert. In the figures the following is outlined.

Bezugszeichenliste LIST OF REFERENCE NUMBERS

10 10

Rohrsystem pipe system

11 11

Vorratsbehälter reservoir

12 12

Abfallbehälter waste container

13 13

Vorratsflüssigkeit stock liquid

14 14

Entnahme- und Abgabeöffnung Aspiration and dispensing opening

15 15

Entnahmeeinheit withdrawal unit

16 16

Flüssigkeitsstand liquid Level

17 17

Pegelkante level edge

18 18

Ablauf procedure

19 19

Öffnung und Aufnahme der Vorrats- und Abfallbehälters Opening and receiving the supply and waste

Die Erfindung besteht aus einem beidseitig geschlossenen Rohr oder Rohrsystem ( 10 ) mit zwei obenliegenden Öffnungen ( 14 , 19 ). The invention consists of a double-sidedly closed tube or pipe system (10) with two overhead openings (14, 19). In die eine Öffnung ( 19 ) wird eine gewöhnliche Flasche ( 11 ) mit Standardschraubgewinden oder einem anderen Verschlussmechanismus eingeschraubt. In an opening (19) an ordinary bottle (11) with Standardschraubgewinden or other closure mechanism is screwed. Der Rand der Flasche ragt dabei ein Stück (ca. 3-10 mm oder auch mehr) in das Rohr hinein ( 17 ). The rim of the bottle protrudes a little (about 3-10 mm or more) into the pipe (17). Durch die zweite Öffnung ( 14 ) kann mittels der Pipettenspitze oder einer anderen Entnahmeeinheit ( 15 ) Flüssigkeit entnommen werden. Through the second opening (14) can be removed (15) liquid by means of the pipette tip or other removal unit. Der Flüssigkeitsstand ( 16 ) wird durch die Höhe des Randes der Flasche ( 17 ) im Rohr bestimmt. The fluid level (16) is determined by the height of the rim of the bottle (17) determined in the tube. Die Flüssigkeit steigt bis zum Rand an. The liquid rises to the top. Wird nun Flüssigkeit entnommen, sinkt der Pegel und es kann unter den Rand der Flasche Luft in die Flasche eindringen, wodurch Flüssigkeit solange aus der Flasche fließt, bis der Pegel im Rohr den Rand der Flasche wieder erreicht hat. Will now be taken from the liquid, the level decreases and it can allow air to enter the bottle, so long as liquid flows from the bottle until the level reaches the rim of the bottle again in the tube under the edge of the bottle. Dadurch ist gewährleistet, daß der Pegel im Rohr nahezu konstant bleibt. This ensures that the level remains nearly constant inside the pipe. Hier sei noch angemerkt, daß die geometrische Form des Entnahmebereiches keinen Einfluß auf die Funktionalität der Erfindung hat. Here it should be noted, that the geometric shape of the extraction area does not affect the functionality of the invention. Der Abfallbehälter ( 12 ) wird von unten in das Rohrsystem ( 10 ) eingeschraubt. The waste container (12) is screwed from below into the pipe system (10). Über den Ablauf ( 18 ) fließt die Flüssigkeit in den Abfallbehälter ( 12 ). About the outlet (18) the liquid flows into the waste container (12). Die Skizze ( Fig. 1c und 2) zeigt ein Rohrsystem mit Flaschen von drei unabhängigen Entnahme- bzw. Abgabesystemen. The sketch (Fig. 1c and 2) shows a pipe system with bottles of three independent removal or delivery systems.

Claims (1)

  1. Vorrichtung zur Bereitstellung einer bestimmten Flüssig keitsmenge in einem automatischen Pipettiersystem mit mindestens einem Vorratsbehälter für eine Flüssigkeit, und einem Rohrsystem vorzugsweise mit zwei obenliegenden Öffnungen, wobei in eine Öffnung der Vorratsbehälter mit der Mündung nach unten weisend derart einsetzbar ist, daß der Rand der Flasche mindestens teilweise in das Rohr hineinragt. An apparatus for providing a particular liquid keitsmenge in an automatic pipetting system with at least one storage container for a liquid, and a pipe system preferably having two overhead apertures, into an opening of the reservoir is indicative insertable with the mouth downwards, that the edge of the bottle at least partially projects into the tube.
DE1998117438 1998-04-20 1998-04-20 Automatic reservoir presenting specific fluid quantity to robotic pipetting system, Withdrawn DE19817438A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1998117438 DE19817438A1 (en) 1998-04-20 1998-04-20 Automatic reservoir presenting specific fluid quantity to robotic pipetting system,

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE1998117438 DE19817438A1 (en) 1998-04-20 1998-04-20 Automatic reservoir presenting specific fluid quantity to robotic pipetting system,
AU38194/99A AU3819499A (en) 1998-04-20 1999-04-20 Device for providing liquids for pipetting systems
PCT/EP1999/002662 WO1999054042A1 (en) 1998-04-20 1999-04-20 Device for providing liquids for pipetting systems
EP19990920718 EP1212139A1 (en) 1998-04-20 1999-04-20 Device for providing liquids for pipetting systems

Publications (1)

Publication Number Publication Date
DE19817438A1 true DE19817438A1 (en) 1999-10-21

Family

ID=7865097

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1998117438 Withdrawn DE19817438A1 (en) 1998-04-20 1998-04-20 Automatic reservoir presenting specific fluid quantity to robotic pipetting system,

Country Status (4)

Country Link
EP (1) EP1212139A1 (en)
AU (1) AU3819499A (en)
DE (1) DE19817438A1 (en)
WO (1) WO1999054042A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH512730A (en) * 1969-03-31 1971-09-15 Greiner Electronic Ag metering
DE3818238C2 (en) * 1988-05-28 1992-03-26 Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De
GB2248891A (en) * 1990-10-18 1992-04-22 Westonbridge Int Ltd Membrane micropump
BR9710052A (en) * 1996-06-28 2000-01-11 Caliper Techn Corp System microfluidic with compensation for electrophoretic bias, eletropipetador, processes for introducing materials from a variety of sources into a microfluidic system for delivering controllable manner a stream of fluid and to transport sample fluid sampling system employing a substrate , use of a microfluidic system and the substrate.

Also Published As

Publication number Publication date
WO1999054042A1 (en) 1999-10-28
EP1212139A1 (en) 2002-06-12
AU3819499A (en) 1999-11-08

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Legal Events

Date Code Title Description
8181 Inventor (new situation)

Free format text: BRINK, GUNNAR, DR., 80339 MUENCHEN, DE TITTEL, JAKOB, DR., 81667 MUENCHEN, DE

8127 New person/name/address of the applicant

Owner name: BIOTUL AG, 80339 MUENCHEN, DE

8127 New person/name/address of the applicant

Owner name: JANDRATEK GMBH, 96346 WALLENFELS, DE

8130 Withdrawal