DE19624215C1 - Implantable infusion pump with coil and capacitor in resonant circuit - Google Patents

Implantable infusion pump with coil and capacitor in resonant circuit

Info

Publication number
DE19624215C1
DE19624215C1 DE1996124215 DE19624215A DE19624215C1 DE 19624215 C1 DE19624215 C1 DE 19624215C1 DE 1996124215 DE1996124215 DE 1996124215 DE 19624215 A DE19624215 A DE 19624215A DE 19624215 C1 DE19624215 C1 DE 19624215C1
Authority
DE
Grant status
Grant
Patent type
Prior art keywords
infusion pump
coil
partition
capacitor
resonant circuit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1996124215
Other languages
German (de)
Inventor
Jan G Dr Toennies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Codman Neuro Sciences Sarl
Original Assignee
Tricumed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/1684Monitoring, detecting, signalling or eliminating infusion flow anomalies by detecting the amount of infusate remaining, e.g. signalling end of infusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3317Electromagnetic, inductive or dielectric measuring means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3379Masses, volumes, levels of fluids in reservoirs, flow rates
    • A61M2205/3389Continuous level detection

Abstract

The pump has a housing (10) divided into a medicament chamber (12) and a propellant chamber (14) by a partition (16). The medicament is expelled, under the pressure of spiral springs (22) under the partition, from a bag (24) through a constriction (20) leading to a catheter (18). A compression spring (30) fixed to the partition on its propellant side acts on a variable capacitor (28) serving as a pressure gauge in conjunction with a coil (26) lying outside the bag in the medicament chamber. The frequency of resonance varies with the position of the partition between the chambers.

Description

Die Erfindung betrifft eine inplantierbare Infusionspumpe mit den Merk malen des Oberbegriffs des Anspruchs 1. The invention relates to a inplantierbare infusion pump having the characteristics set of the preamble of claim 1.

Derartige Infusionspumpen, wie sie beispielsweise aus der DE 26 04 113 C2 bekannt sind, werden Patienten im plantiert, die über einen langen Zeitraum kontinuierlich mit einem Medikament zu versorgen sind, beispielsweise Schmerzpatienten oder Spastikern. Such infusion pumps, such as are known for example from DE 26 04 113 C2, in patients implanted, which are to be supplied continuously over a long period with a drug, for example, pain or spasticity patients are.

Es ist bei erwünscht, die Menge des in der implantierten Infusionspumpe noch vorhandenen Medikaments mit einer hohen Genauigkeit erfassen zu können. It is at desirable to be able to detect the amount of remaining in the implanted infusion pump drug with a high accuracy. Dies ist zum einen für die Feststellung von Bedeutung, ob ein Austauschen oder Nachfüllen der Pumpe erforderlich ist, zum anderen aber kann ein regelmäßiges Messen des Füllstandes auch eine Aussage über die Funktion der Pumpe geben. This is the one for a finding of importance whether a replacement or refill the pump is required, on the other hand, a regular measuring the level also give a statement about the function of the pump.

Aus der DE 39 23 079 A1 ist es bekannt, den Füllstand einer Infusionsspritze durch Erfassen einer bei der Ent leerung erfolgenden Kapazitätsänderung zu messen. From DE 39 23 079 A1 it is known to measure the level of an infusion syringe by detecting an emptying in the decision taking place capacitance change.

Der Erfindung liegt die Aufgabe zugrunde, eine implan tierbare Infusionspumpe zu schaffen, bei der der jewei lige Füllstand von außen ermittelt werden kann. The invention has for its object to provide a IMPLAN tierbare infusion pump in which the jewei leaf level can be determined from the outside.

Erfindungsgemäß wird diese Aufgabe durch die Merkmale des Anspruchs 1 gelöst. According to the invention this object is solved by the features of claim 1. Die Unteransprüche gegeben vor teilhafte Ausgestaltungen der Erfindung an. The sub-claims given before some embodiments of the invention.

Die Erfindung wird im folgenden anhand einer Zeichnung erläutert. The invention is explained below with reference to a drawing. Dabei zeigt die einzige Figur eine erfin dungsgemäß ausgestaltete Infusionspumpe in einer schema tischen Schnittansicht am Beispiel einer Federpumpe. The single FIGURE shows a dung OF INVENTION designed according to the infusion pump in a schematic sectional view of the example of a spring pump. Es ist jedoch zu beachten, daß die erfinderische Vorsehung eines von außen abfragbaren Schwingkreises, dessen Reso nanzfrequenz eine Funktion des jeweiligen Füllstandes der Infusionspumpe ist, auch bei einer Pumpe verwirk licht werden kann, bei der der Medikamentenraum oder der Treibmittelraum als Balg ausgebildet ist. It is noted, however, that the inventive provision of a interrogated from outside the resonant circuit, whose Reso nanzfrequenz a function of the respective filling level of the infusion pump, it can be light verwirk, wherein the medication chamber or the propellant chamber is formed as a bellows and in a pump.

Die Infusionspumpe besteht aus einem Gehäuse 10 , die einen Medikamentenraum 12 und einen Treibmittelraum 14 ausbildet, wobei die beiden Räume über eine Wandung 16 voneinander getrennt sind. The infusion pump consists of a housing 10 that forms a drug chamber 12 and a propellant chamber 14, wherein the two spaces are separated from each other by a wall 16th Im Bereich des Zentrums des Treibmittelraums ist an dem Gehäuse 10 eine Drossel strecke 20 angeordnet. In the region of the center of the propellant chamber, a throttle is attached to housing 10 Route 20.

Der Medikamentenraum 12 nimmt einen aus einem hochdruck festen Material gefertigten Beutel 24 auf, in den das über die Drosselstrecke abzugebende Medikament einge füllt ist. The medication chamber 12 takes a made of a high-pressure resistant material pouch 24 into which the dispensed via the throttle section is filled drug is. Der Beutel 24 ist über einen hochdruckfesten Schlauch zu der Drosselstrecke 20 geführt. The bag 24 is passed through a high pressure-resistant hose of the throttle section to the twentieth

Der Auslaß der Drosselstrecke 20 führt zu einem Katheter 18 , der im Körper des zu versorgenden Patienten verlegt ist. The outlet of the throttle section 20 leading to a catheter 18, which is installed in the body of the patient to be supplied.

Eine zu einem Ring geschlossene Spiralfeder 22 , deren Ebene zu der Ebene der Wandung parallel liegt und deren Windungen schräg zur Richtung der Belastung liegen, wirkt zwischen der Unterseite des Gehäuses 10 und der Wandung 16 und beaufschlagt so den Beutel 24 mit hohem Druck. A to form a ring closed helical coil spring 22 whose plane is parallel to the plane of the wall and the coils of which are oblique to the direction of load, acts between the underside of the housing 10 and the wall 16 and thus urges the bag 24 with a high pressure.

Der Treibmittelraum 14 ist weiter mit einem zum Volumen ausgleich dienenden Treibmittel gefüllt. The propellant chamber 14 is further filled with a volume serving for balancing propellant.

In dem Treibmittelraum 14 ist weiter mittig eine Druck feder 30 vorgesehen, die an der Wandung 16 befestigt ist. In the propellant chamber 14. A compression spring 30 is further provided centrally, which is attached to the wall of the sixteenth Die Druckfeder 30 wirkt auf ein kapazitives Manome ter, also einen Kondensator 28 , dessen Kapazität sich in Abhängigkeit von dem auf ihn ausgeübten Druck ändert. The compression spring 30 acts on a capacitive Manome ter, so a capacitor 28, whose capacitance varies in dependence on the pressure applied to it.

Auf der nach oben weisenden (nach Implantation also nach außen weisenden) Seite des Gehäuses 10 ist eine Spule 26 angeordnet, die über elektrische Leitungen 32 mit dem Manometer-Kondensator 28 zu einem Schwingkreis verschal tet ist. On the upwardly facing (i.e. pointing to the implant to outside) side of the housing 10, a coil 26 is arranged which is verschal tet via electrical lines 32 to the manometers capacitor 28 to a resonant circuit.

Die Resonanzfrequenz des durch die Spule 26 und den Kon densator 28 gebildeten Schwingkreises wird durch die je weilige Kapazität des Kondensators 28 bestimmt, die wie derum von dem Druck abhängig ist, der von der Druckfeder 30 auf diesen ausgeübt wird. The resonant frequency of through the coil 26 and the capacitor 28 formed Kon resonant circuit is determined by the eg large capacitance of the capacitor 28, which is as derum dependent on the pressure exerted by the compression spring 30 thereon. Da die Druckfeder 30 an der Wandung 16 befestigt ist, ist der Druck auf das Kondensator-Manometer 28 aufgrund des hook′schen Geset zes von dem Abstand der Wandung 16 von dem Kondensator-Manometer 28 abhängig. Since the pressure spring is fastened to the wall of 16 30, the pressure on the condenser pressure gauge 28 due to the Hooke's Geset zes is dependent on the distance of the wall 16 of the capacitor manometer 28th Da die Wandung 16 sich mit zuneh mender Abgabe des Medikaments aus dem Beutel 12 durch die Drosselstrecke 20 und das Katheter 18 in den Körper des Patienten hinein zunehmend vergrößert, ist der Druck, der von der Druckfeder 30 auf das Kondensator-Manometer 28 ausgeübt wird, ein Maß für den Füllstand. Since the wall is increasingly enlarged 16 with increas mender delivery of the drug from the bag 12 through the throttle section 20 and the catheter 18 in the patient's body into it, the pressure exerted by the compression spring 30 to the condenser pressure gauge 28, a measure of the level.

Der Druck, den die Feder 30 auf das Kondensator-Manometer 28 ausübt, kann von außen ermittelt werden, in dem die Resonanzfrequenz des durch die Bauelemente 26 , 28 gebildeten Schwingkreises abgefragt wird. The pressure which the spring 30 exerts on the condenser pressure gauge 28 can be determined from the outside, in which the resonance frequency of the queries by the components 26, 28 formed resonant circuit. Dies er folgt dadurch, daß von außen eine veränderliche Wechsel spannung aufgegeben wird und der Strom, der zur Auf rechterhaltung der Schwingung erforderlich ist, gemessen wird. This he follows the fact that a variable AC voltage is given from the outside and the current right to conservation is required on the vibration is measured. Bei Erreichen der Resonanzfrequenz nimmt der Blindwiderstand des Schwingkreises erheblich zu (bei ei ner Parallelschaltung der Bauelemente 26 , 28 bzw. erheb lich ab (bei einer Serienschaltung der Bauelemente 26 , 28 ). Diese Resonanzfrequenz wird ermittelt und der Füll stand, dem die jeweilige Resonanzfrequenz des Schwing kreises entspricht, bestimmt. Upon reaching the resonant frequency of the reactance of the resonant circuit increases significantly (in egg ner parallel connection of the components 26, 28 and fixed Lich (by a series connection of the components 26, 28). This resonant frequency is determined and the filling level, the respective resonance frequency of the resonant circuit corresponds is determined.

Es versteht sich, daß statt des kapazitiven Manometers 28 auch ein induktives Manometer 26 verwendet werden könnte. It is understood that instead of the capacitive pressure gauge 28 and an inductive pressure gauge could be used 26th Weiter kann auch statt einer Druckfeder 30 eine Zugfeder verwendet werden. Next, a tension spring may be used instead of a compression spring 30th

Die Erfindung kann weiter auch die Verwendung von berüh rungslos arbeitenden induktiven oder kapazitiven Wegmeß systemen verwirklicht werden. The invention may further include the use of berüh rungslos working inductive or capacitive path measuring systems can be realized.

Die Erfindung ist weiter nicht auf die Verwendung einer Spiralfeder 22 als den Druck auf die Wandung 16 erzeu gendes Element beschränkt, es kann auch - wie üblich - ein Balg, der ein Treibmittel aufnimmt, verwendet wer den. The invention is further not limited to the use of a coil spring 22 as the pressure on the wall 16 erzeu constricting element, it can also - as usual - a bellows which accommodates a blowing agent, who used the.

Claims (3)

  1. 1. Implantierbare Infusionspumpe mit einem Gehäuse ( 10 ), einem Medikamentenraum ( 12 ), einem Treibmittel raum ( 14 ), einer den Medikamentenraum ( 12 ) von dem Treibmittelraum ( 14 ) trennenden Wandung ( 16 ) und einer mit dem Medikamentenraum ( 12 ) kommunizierenden und zu einem in dem Körper des Patienten zu verlegenden Kathe ter ( 18 ) führenden Drosselstrecke ( 20 ), Communicating 1. An implantable infusion pump having a housing (10), a medication chamber (12), a propellant chamber (14), one of the drug chamber (12) from the propellant chamber (14) separating wall (16) and one with the medication chamber (12) and a to be installed in the patient's body Kathe ter (18) leading throttle section (20),
    gekennzeichnet durch einen durch eine Spule ( 26 ) und einen Kondensator ( 28 ) gebildeten elektrischen Schwing kreis, wobei entweder die Spule ( 26 ) oder der Konden sator ( 28 ) an seiner einen Seite zu dem Gehäuse ( 10 ) unbeweglich fixiert und an seiner anderen Seite an die Wandung ( 16 ) angekoppelt ist und so als in Abhängigkeit von dem Ort der Wandung ( 16 ) relativ zu dem Gehäuse ( 10 ) die Resonanzfrequenz des Schwingkreises bestimmen des Element ausgebildet ist. characterized by a by a coil (26) and a capacitor (28) formed electrical resonant circuit, wherein one of the coil (26) or the condensate sator (28) at its one side to the housing (10) immovably fixed and at its other side is coupled to the wall (16) and so as a function of the location of the wall (16) relative to the housing (10) determine the resonant frequency of the resonant circuit of the element is formed.
  2. 2. Infusionspumpe nach Anspruch 1, dadurch gekenn zeichnet, daß das Element ein Kondensator-Manometer ( 28 ) ist, dessen andere Seite über eine Feder ( 30 ) an die Wandung ( 16 ) angesetzt ist. 2. An infusion pump as in claim 1, characterized in that the element is a capacitor-pressure gauge (28), the other side via a spring (30) is attached to the wall (16).
  3. 3. Infusionspumpe nach Anspruch 1 oder 2, dadurch ge kennzeichnet, daß die Spule ( 26 ) als Antenne ausgebil det ist, die eine von außen zum Abfragen der Resonanz frequenz des Schwingkreises aufgebrachte Wechselspan nung aufnimmt. 3. The infusion pump according to claim 1 or 2, characterized in that the coil (26) is ausgebil det as an antenna which receives an externally applied frequency of visits to the resonance of the resonant circuit changes clamping voltage.
DE1996124215 1996-06-18 1996-06-18 Implantable infusion pump with coil and capacitor in resonant circuit Expired - Lifetime DE19624215C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1996124215 DE19624215C1 (en) 1996-06-18 1996-06-18 Implantable infusion pump with coil and capacitor in resonant circuit

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1996124215 DE19624215C1 (en) 1996-06-18 1996-06-18 Implantable infusion pump with coil and capacitor in resonant circuit

Publications (1)

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DE19624215C1 true DE19624215C1 (en) 1997-04-03

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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924031A1 (en) * 1999-05-26 2000-11-30 Tricumed Medizintechnik Gmbh Implantable infusion pump with level measurement
US6755814B2 (en) 1999-05-26 2004-06-29 Codman Neuro Sciences Sarl Implantable infusion pump with level measurement
WO2010078207A1 (en) * 2008-12-31 2010-07-08 Deka Products Limited Partnership Split ring resonator antenna adapted for use in wirelessly controlled medical device
US8449624B2 (en) 2007-02-06 2013-05-28 Deka Products Limited Partnership Arm prosthetic device
US8453340B2 (en) 2007-02-06 2013-06-04 Deka Products Limited Partnership System, method and apparatus for orientation control
DE102012004469A1 (en) 2012-03-08 2013-09-12 Tricumed Medizintechnik Gmbh Method for determination of fluid level of implantable medicament infusion pump, involves determining fluid level in pump based on spring force acting on elastic element by pressure difference between propellant gas- and medicament spaces
US8821587B2 (en) 2007-02-06 2014-09-02 Deka Products Limited Partnership Apparatus for control of a prosthetic
US8864845B2 (en) 2007-02-06 2014-10-21 DEKA Limited Partnership System for control of a prosthetic device
US8870970B2 (en) 2007-02-06 2014-10-28 Deka Products Limited Partnership Dynamic support apparatus
US8882852B2 (en) 2007-02-06 2014-11-11 Deka Products Limited Partnership Dynamic support apparatus and system
US8900188B2 (en) 2007-12-31 2014-12-02 Deka Products Limited Partnership Split ring resonator antenna adapted for use in wirelessly controlled medical device
US8956421B2 (en) 2007-02-06 2015-02-17 Deka Products Limited Partnership Dynamic support apparatus and system
US8979943B2 (en) 2007-02-06 2015-03-17 Deka Products Limited Partnership Arm prosthetic device
US9114028B2 (en) 2007-02-06 2015-08-25 Deka Products Limited Partnership Arm prosthetic device
US9114030B2 (en) 2007-02-06 2015-08-25 Deka Products Limited Partnership System for control of a prosthetic device
EP3127566A1 (en) 2015-08-03 2017-02-08 Tricumed Medizintechnik GmbH Implantable infusion pump with fill level sensor
US9844447B2 (en) 2010-04-09 2017-12-19 Deka Products Limited Partnership System and apparatus for robotic device and methods of using thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2604113C2 (en) * 1975-04-07 1982-03-25 Metal Bellows Co., Sharon, Mass., Us
DE3923079A1 (en) * 1989-07-13 1991-01-24 Fresenius Ag Measuring level of electrically conducting liquid - has measuring of infusion liquid or blood from change in capacitance of electrodes in measurement liquid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2604113C2 (en) * 1975-04-07 1982-03-25 Metal Bellows Co., Sharon, Mass., Us
DE3923079A1 (en) * 1989-07-13 1991-01-24 Fresenius Ag Measuring level of electrically conducting liquid - has measuring of infusion liquid or blood from change in capacitance of electrodes in measurement liquid

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924031A1 (en) * 1999-05-26 2000-11-30 Tricumed Medizintechnik Gmbh Implantable infusion pump with level measurement
WO2000072899A1 (en) * 1999-05-26 2000-12-07 Tricumed Medizintechnick Gmbh Implantable infusion pump with level measuring
DE19924031C2 (en) * 1999-05-26 2003-04-10 Codman Neuro Sciences Sarl Le Implantable infusion pump with level measurement
US6755814B2 (en) 1999-05-26 2004-06-29 Codman Neuro Sciences Sarl Implantable infusion pump with level measurement
US8956421B2 (en) 2007-02-06 2015-02-17 Deka Products Limited Partnership Dynamic support apparatus and system
US8449624B2 (en) 2007-02-06 2013-05-28 Deka Products Limited Partnership Arm prosthetic device
US8453340B2 (en) 2007-02-06 2013-06-04 Deka Products Limited Partnership System, method and apparatus for orientation control
US9114028B2 (en) 2007-02-06 2015-08-25 Deka Products Limited Partnership Arm prosthetic device
US8821587B2 (en) 2007-02-06 2014-09-02 Deka Products Limited Partnership Apparatus for control of a prosthetic
US8864845B2 (en) 2007-02-06 2014-10-21 DEKA Limited Partnership System for control of a prosthetic device
US9114030B2 (en) 2007-02-06 2015-08-25 Deka Products Limited Partnership System for control of a prosthetic device
US8882852B2 (en) 2007-02-06 2014-11-11 Deka Products Limited Partnership Dynamic support apparatus and system
US8979943B2 (en) 2007-02-06 2015-03-17 Deka Products Limited Partnership Arm prosthetic device
US8870970B2 (en) 2007-02-06 2014-10-28 Deka Products Limited Partnership Dynamic support apparatus
US8900188B2 (en) 2007-12-31 2014-12-02 Deka Products Limited Partnership Split ring resonator antenna adapted for use in wirelessly controlled medical device
WO2010078207A1 (en) * 2008-12-31 2010-07-08 Deka Products Limited Partnership Split ring resonator antenna adapted for use in wirelessly controlled medical device
US9844447B2 (en) 2010-04-09 2017-12-19 Deka Products Limited Partnership System and apparatus for robotic device and methods of using thereof
DE102012004469A1 (en) 2012-03-08 2013-09-12 Tricumed Medizintechnik Gmbh Method for determination of fluid level of implantable medicament infusion pump, involves determining fluid level in pump based on spring force acting on elastic element by pressure difference between propellant gas- and medicament spaces
EP3127566A1 (en) 2015-08-03 2017-02-08 Tricumed Medizintechnik GmbH Implantable infusion pump with fill level sensor
DE102015010063A1 (en) 2015-08-03 2017-02-09 Tricumed Medizintechnik Gmbh Implantable infusion pump with level meter

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Owner name: TRICUMED MEDIZINTECHNIK GMBH, 24143 KIEL, DE

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Owner name: CODMAN NEURO SCIENCES SARL, LE LOCLE, CH

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Free format text: PATENT- UND RECHTSANWAELTE BARDEHLE, PAGENBERG, DOST, ALTENBURG, GEISSLER, ISENBRUCK, 81679 MUENCHEN

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