DE19580261D2 - Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction - Google Patents

Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction

Info

Publication number
DE19580261D2
DE19580261D2 DE1995180261 DE19580261A DE19580261D2 DE 19580261 D2 DE19580261 D2 DE 19580261D2 DE 1995180261 DE1995180261 DE 1995180261 DE 19580261 A DE19580261 A DE 19580261A DE 19580261 D2 DE19580261 D2 DE 19580261D2
Authority
DE
Grant status
Grant
Patent type
Prior art keywords
prevention
treatment
endothelial dysfunction
pharmaceutical drugs
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1995180261
Other languages
German (de)
Inventor
Eike Albrecht Prof Dr Me Noack
Georg Dr Rer Nat Kojda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpharma Isis GmbH and Co KG
Original Assignee
Isis Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/556Angiotensin converting enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
DE1995180261 1994-03-30 1995-03-28 Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction Expired - Lifetime DE19580261D2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19944410997 DE4410997A1 (en) 1994-03-30 1994-03-30 Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction
PCT/DE1995/000421 WO1995026725A1 (en) 1994-03-30 1995-03-28 Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction
DE1995180261 DE19580261D2 (en) 1994-03-30 1995-03-28 Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1995180261 DE19580261D2 (en) 1994-03-30 1995-03-28 Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction

Publications (1)

Publication Number Publication Date
DE19580261D2 true DE19580261D2 (en) 1997-05-28

Family

ID=6514213

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19944410997 Withdrawn DE4410997A1 (en) 1994-03-30 1994-03-30 Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction
DE1995180261 Expired - Lifetime DE19580261D2 (en) 1994-03-30 1995-03-28 Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19944410997 Withdrawn DE4410997A1 (en) 1994-03-30 1994-03-30 Pharmaceutical drugs for the prevention and treatment of endothelial dysfunction

Country Status (7)

Country Link
EP (1) EP0752858A1 (en)
JP (1) JPH09510979A (en)
CN (1) CN1150387A (en)
CA (1) CA2186783A1 (en)
DE (2) DE4410997A1 (en)
FI (1) FI963883A0 (en)
WO (1) WO1995026725A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423868D0 (en) * 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
DE19604361C2 (en) * 1996-02-07 1999-01-14 Sanol Arznei Schwarz Gmbh Use of gas-tight primary packaging for pharmaceutical compositions
DE19654895C2 (en) * 1996-02-07 2000-07-27 Sanol Arznei Schwarz Gmbh detection method
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
DE19726812A1 (en) * 1997-06-25 1999-01-07 Isis Pharma Gmbh New nitryl-oxy-methyl derivatives derived from pentaerythritol
DE19745622A1 (en) * 1997-10-16 1999-04-22 Isis Pharma Gmbh New nitric acid ester derivatives of pentaerythritol
DE69838042T2 (en) * 1997-10-17 2008-03-06 Ark Therapeutics Ltd. Use of inhibitors of the renin-angiotensin system
WO1999067430A3 (en) * 1998-06-24 2000-05-04 Isis Pharma Gmbh Analytic substrates and antioxidative agents
CA2383974A1 (en) 1999-09-08 2001-03-15 Nitromed Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
EP1244455B1 (en) 1999-10-29 2009-07-22 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
ES2258365B1 (en) * 2003-10-03 2007-12-01 Lacer, S.A. Disulfide derivatives, sulfide, sulfoxide and sulfone cyclic sugar and their uses.
US20100144864A1 (en) * 2007-04-05 2010-06-10 Ironwood Pharmaceuticals, Inc. Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders
RU2467748C1 (en) * 2011-08-08 2012-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" 3-(2,2,2-trimethylhydrazinium) propionate derivative - 3-(2,2,2-trimethylhydrazinium) potassium propionate glycinate exhibiting endothelioprotective activity
JP5360939B2 (en) * 2011-09-28 2013-12-04 国立大学法人徳島大学 Arteriosclerosis therapeutic agent comprising as an active ingredient a nitroso nifedipine derivative

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR984523A (en) * 1949-02-10 1951-07-06 Trinitro-phosphate triethanolamine and preparation method
DE1695897C3 (en) * 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
GB1356374A (en) * 1971-04-29 1974-06-12 American Home Prod Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
DE2532124C3 (en) * 1975-07-18 1979-04-19 Cassella Ag, 6000 Frankfurt
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE2623800C3 (en) * 1976-05-28 1978-11-23 Sanol Schwarz-Monheim Gmbh, 4000 Duesseldorf
US4065488A (en) * 1977-02-24 1977-12-27 American Home Products Corporation Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate
DE2903927C2 (en) * 1979-02-02 1981-03-12 Sanol Schwarz-Monheim Gmbh, 4019 Monheim, De
DE3028873C2 (en) * 1980-07-30 1983-10-27 Boehringer Mannheim Gmbh, 6800 Mannheim, De
DE3102947A1 (en) * 1981-01-29 1982-09-02 Mack Chem Pharm A process for the preparation of isosorbide-5-nitrate
FR2500835B1 (en) * 1981-02-27 1983-10-21 Poudres & Explosifs Ste Nale
DE3117612A1 (en) * 1981-05-05 1982-11-25 Cassella Ag A process for the preparation of isosorbide-5-nitrate
DE3124410A1 (en) * 1981-06-22 1983-01-05 Mack Chem Pharm A process for the preparation of isosorbide-2-nitrate
JPS5910513A (en) * 1982-07-12 1984-01-20 Nitto Electric Ind Co Ltd Pharmaceutical preparation of drug
DE3325652C2 (en) * 1983-07-15 1993-04-01 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim, De
DE3328094A1 (en) * 1983-08-04 1985-02-21 Trommsdorff Gmbh & Co H Desensitised pharmaceutical formulation of explosive nitric acid esters
EP0143507B1 (en) * 1983-11-25 1989-09-20 TOSHIN CHEMICAL CO., Ltd. A method for the preparation of isosorbide-5-nitrate and sodium isosorbide-5-nitrate hydrate as a precursor thereof
US5284872A (en) * 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
DE4007705C1 (en) * 1990-03-10 1991-09-26 G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De
DE4038203C2 (en) * 1990-11-30 1992-11-26 Kali-Chemie Pharma Gmbh, 3000 Hannover, De
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia

Also Published As

Publication number Publication date Type
FI963883A0 (en) 1996-09-27 application
EP0752858A1 (en) 1997-01-15 application
DE4410997A1 (en) 1995-10-26 application
CA2186783A1 (en) 1995-10-12 application
JPH09510979A (en) 1997-11-04 application
WO1995026725A1 (en) 1995-10-12 application
FI963883D0 (en) grant
CN1150387A (en) 1997-05-21 application
FI963883A (en) 1996-09-27 application

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: ALPHARMA-ISIS GMBH & CO. KG, 40764 LANGENFELD, DE

8130 Withdrawal