DE1770031A1 - Neue Derivate von Cephalosporin C und Verfahren zu ihrer Herstellung(1) - Google Patents

Neue Derivate von Cephalosporin C und Verfahren zu ihrer Herstellung(1)

Info

Publication number
DE1770031A1
DE1770031A1 DE19681770031 DE1770031A DE1770031A1 DE 1770031 A1 DE1770031 A1 DE 1770031A1 DE 19681770031 DE19681770031 DE 19681770031 DE 1770031 A DE1770031 A DE 1770031A DE 1770031 A1 DE1770031 A1 DE 1770031A1
Authority
DE
Germany
Prior art keywords
acid
anhydride
aromatic
connections
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19681770031
Other languages
German (de)
English (en)
Inventor
Long Alan Gibson
William Graham
Wilson Edward Mckenzie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of DE1770031A1 publication Critical patent/DE1770031A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
DE19681770031 1967-03-23 1968-03-22 Neue Derivate von Cephalosporin C und Verfahren zu ihrer Herstellung(1) Ceased DE1770031A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB03867/67A GB1208014A (en) 1967-03-23 1967-03-23 Cephalosporins

Publications (1)

Publication Number Publication Date
DE1770031A1 true DE1770031A1 (de) 1971-09-16

Family

ID=10030837

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19681770031 Ceased DE1770031A1 (de) 1967-03-23 1968-03-22 Neue Derivate von Cephalosporin C und Verfahren zu ihrer Herstellung(1)

Country Status (7)

Country Link
CH (1) CH507984A (zh)
DE (1) DE1770031A1 (zh)
DK (1) DK124265B (zh)
FR (2) FR1556822A (zh)
GB (1) GB1208014A (zh)
NL (1) NL156702B (zh)
SE (1) SE364284B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004956A1 (de) * 1978-04-26 1979-10-31 Bayer Ag Beta-Lactamantibiotika, Verfahren zu ihrer Herstellung, Futterzusatzmittel, Arzneimittel sowie Verfahren zu deren Herstellung

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5248996B1 (zh) * 1971-01-29 1977-12-14 Glaxo Lab Ltd
IE36041B1 (en) * 1971-01-29 1976-08-04 Glaxo Lab Ltd Improvements in or relating to antibiotics
GB1389194A (en) * 1971-01-29 1975-04-03 Glaxo Lab Ltd Antibiotics
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
GB1575803A (en) * 1976-03-09 1980-10-01 Fujisawa Pharmaceutical Co 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
IT1211080B (it) * 1981-07-21 1989-09-29 Craf Sud Idrazonocefem derivati biologicamente attivi.
GB8810393D0 (en) * 1988-05-03 1988-06-08 Glaxo Group Ltd Chemical process
DK2626361T3 (en) 2008-04-24 2015-01-19 F2G Ltd Pyrrol-Antimycotics
CA2982660C (en) 2014-11-21 2023-01-24 F2G Limited 2-(1,5-dimethyl-3-phenyl-1h-pyrrol-2-yl)-n-(4-(4-(5-fluoropyrimidin-2-yl)piperazine-1-yl)phenyl)-2-oxoacetamide and derivatives thereof for use as antifungal agents
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004956A1 (de) * 1978-04-26 1979-10-31 Bayer Ag Beta-Lactamantibiotika, Verfahren zu ihrer Herstellung, Futterzusatzmittel, Arzneimittel sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
FR1556822A (zh) 1969-02-07
DK124265B (da) 1972-10-02
NL6804139A (zh) 1968-09-24
CH507984A (de) 1971-05-31
GB1208014A (en) 1970-10-07
SE364284B (zh) 1974-02-18
FR7572M (zh) 1970-01-05
NL156702B (nl) 1978-05-16

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Legal Events

Date Code Title Description
8131 Rejection