DE167140C - - Google Patents
Info
- Publication number
- DE167140C DE167140C DE1905167140D DE167140DA DE167140C DE 167140 C DE167140 C DE 167140C DE 1905167140 D DE1905167140 D DE 1905167140D DE 167140D A DE167140D A DE 167140DA DE 167140 C DE167140 C DE 167140C
- Authority
- DE
- Germany
- Prior art keywords
- sodium
- salicylate
- theobromine
- barium
- molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
Bei weiterer Bearbeitung des dem Patent 164424 zugrunde liegenden Erfindungsgedankens wurde festgestellt, daß man zur Herstellung des löslichen Doppelsalzes von Theobrominbarium mit Natriumsalicylat auch so verfahren kann, daß man die Bildung des Theobrominbariums und eines Teiles des zur Entstehung der löslichen Verbindung erforderlichen Natriumsalicylates in der Weise in einer Operation vereinigt, daß man Theobrominnatrium in wässeriger Lösung mit der äquivalenten Menge salicylsaurem Barium zusammenbringt. Es bildet sich dabei Theobrominbarium und 2 Moleküle salicylsaures Natrium. Da nun, wie in dem Hauptpatent gezeigt ist, zur Gewinnung des löslichen Doppelsalzes auf 1 Molekül Theobromin 2 Moleküle Natriumsalicylat erforderlich sind (also auf 1 Molekül Theobrominbarium [C7 Hn N4 O2J2 Ba, 4 Moleküle Natriumsalicylat), so hat man nur nötig, zu dem oben angegebenen Ansatz aus Theobrominnatrium (2 Moleküle) und Bariumsalicylat (1 Molekül) noch 2 Moleküle salicylsaures Natrium hinzuzufügen, um sogleich, die wässerige Lösung des gewünschten Doppelsalzes zu erhalten, die durch Eindampfen im Vakuum leicht in trockene Pulverform übergeführt werden kann.In further processing of the inventive idea on which the patent 164424 is based, it was found that, for the preparation of the soluble double salt of theobromine barium with sodium salicylate, one can also proceed in such a way that the formation of the theobromine barium and part of the sodium salicylate required for the formation of the soluble compound is as follows combined in an operation that one brings theobromine sodium in aqueous solution with the equivalent amount of salicylic acid barium together. Theobrominbarium and 2 molecules of sodium salicylate are formed. Since, as shown in the main patent, 2 molecules of sodium salicylate are required for 1 molecule of theobromine to obtain the soluble double salt (i.e. for 1 molecule of theobrominbarium [C 7 H n N 4 O 2 I 2 Ba , 4 molecules of sodium salicylate), so has it is only necessary to add 2 molecules of sodium salicylate to the above-mentioned mixture of theobromine sodium (2 molecules) and barium salicylate (1 molecule) in order to immediately obtain the aqueous solution of the desired double salt, which is easily converted into dry powder form by evaporation in a vacuum can be.
Man verfährt am zweckmäßigsten so, daß man die Lösung von Theobrominnatrium mit der nach obigem erforderlichen Menge Na-, triumsalicylat versetzt, sodann die Lösung der berechneten Menge Bariumsalicylat einträgt und die Flüssigkeit im Vakuum eindampft. One proceeds most expediently so that the solution of theobromine sodium with the amount of sodium, trium salicylate required according to the above is added, then the solution the calculated amount of barium salicylate enters and the liquid evaporates in vacuo.
Vor dem im Hauptpatent beschriebenen Verfahren, bestehend in der Einwirkung eines anorganischen Bariumsalzes, z. B. Chlorbarium, auf Theobrominnatrium in Gegenwart von Natriumsalicylat, hat das oben beschriebene Verfahren den Vorzug, daß das durch unmittelbares Eindampfen erhaltene Doppelsalz nicht durch anorganische Natriumsalze verunreinigt ist, welche bei dem im Hauptpatent beschriebenen Verfahren durch die Wechselwirkung der anorganischen Säure des Bariumsalzes mit dem Natrium des Theobrominnatriums entstehen.Before the process described in the main patent, consisting in the action of a inorganic barium salt, e.g. B. Chlorbarium, on theobromine sodium in the presence of sodium salicylate, the process described above has the advantage that that obtained by direct evaporation Double salt is not contaminated by inorganic sodium salts, which in the case of the im Main patent process described by the interaction of the inorganic acid of the barium salt with the sodium of theobromine sodium arise.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT26085D AT26085B (en) | 1905-03-06 | 1905-08-30 | Process for the production of an easily soluble double salt from theobromine barium and sodium salicylate. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE167140T |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE167140C true DE167140C (en) |
Family
ID=33035647
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1904164424D Expired - Lifetime DE164424C (en) | 1904-05-24 | 1904-05-24 | |
| DE1905167140D Expired - Lifetime DE167140C (en) | 1905-03-06 | 1905-03-06 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1904164424D Expired - Lifetime DE164424C (en) | 1904-05-24 | 1904-05-24 |
Country Status (1)
| Country | Link |
|---|---|
| DE (2) | DE164424C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE944518C (en) * | 1950-08-20 | 1956-06-14 | Byk Gulden Lomberg Chem Fab | Process for the preparation of solutions of xanthines substituted in the 1,3-position |
-
1904
- 1904-05-24 DE DE1904164424D patent/DE164424C/de not_active Expired - Lifetime
-
1905
- 1905-03-06 DE DE1905167140D patent/DE167140C/de not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE944518C (en) * | 1950-08-20 | 1956-06-14 | Byk Gulden Lomberg Chem Fab | Process for the preparation of solutions of xanthines substituted in the 1,3-position |
Also Published As
| Publication number | Publication date |
|---|---|
| DE164424C (en) |
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