DE10358387A1 - Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung - Google Patents

Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung Download PDF

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Publication number
DE10358387A1
DE10358387A1 DE10358387A DE10358387A DE10358387A1 DE 10358387 A1 DE10358387 A1 DE 10358387A1 DE 10358387 A DE10358387 A DE 10358387A DE 10358387 A DE10358387 A DE 10358387A DE 10358387 A1 DE10358387 A1 DE 10358387A1
Authority
DE
Germany
Prior art keywords
spray
molecular weight
dried powder
low molecular
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10358387A
Other languages
German (de)
English (en)
Inventor
Richard Fuhrherr
Karoline Bechtold-Peters
Wolfgang Friess
Stefan Bassarab
Patrick Garidel
Torsten Schultz-Fademrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE10358387A priority Critical patent/DE10358387A1/de
Priority to US10/999,471 priority patent/US20050191246A1/en
Priority to JP2006543462A priority patent/JP2007514664A/ja
Priority to SG200808989-8A priority patent/SG148997A1/en
Priority to EP04803615.6A priority patent/EP1694306B1/de
Priority to PCT/EP2004/013938 priority patent/WO2005055976A2/de
Priority to CA002548132A priority patent/CA2548132A1/en
Priority to KR1020067014006A priority patent/KR20070014113A/ko
Priority to TW093138444A priority patent/TW200529863A/zh
Publication of DE10358387A1 publication Critical patent/DE10358387A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE10358387A 2003-12-13 2003-12-13 Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung Withdrawn DE10358387A1 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE10358387A DE10358387A1 (de) 2003-12-13 2003-12-13 Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung
US10/999,471 US20050191246A1 (en) 2003-12-13 2004-11-30 Powders comprising low molecular dextran and methods of producing those powders
JP2006543462A JP2007514664A (ja) 2003-12-13 2004-12-08 低分子量デキストランを含む粉末及びこれらの粉末の製造方法
SG200808989-8A SG148997A1 (en) 2003-12-13 2004-12-08 Powders comprising low molecular dextran and methods of producing those powders
EP04803615.6A EP1694306B1 (de) 2003-12-13 2004-12-08 Pulver enthaltend niedermolekulares dextran und verfahren zu deren herstellung
PCT/EP2004/013938 WO2005055976A2 (de) 2003-12-13 2004-12-08 Pulver enthaltend niedermolekulares dextran und verfahren zu deren herstellung
CA002548132A CA2548132A1 (en) 2003-12-13 2004-12-08 Powder containing low-molecular dextran and method for producing the same
KR1020067014006A KR20070014113A (ko) 2003-12-13 2004-12-08 저분자 덱스트란을 함유하는 분말 및 이의 제조방법
TW093138444A TW200529863A (en) 2003-12-13 2004-12-10 Powders comprising low molecular dextran and methods of producing those powders

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10358387A DE10358387A1 (de) 2003-12-13 2003-12-13 Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung

Publications (1)

Publication Number Publication Date
DE10358387A1 true DE10358387A1 (de) 2005-07-07

Family

ID=34638656

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10358387A Withdrawn DE10358387A1 (de) 2003-12-13 2003-12-13 Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung

Country Status (8)

Country Link
EP (1) EP1694306B1 (https=)
JP (1) JP2007514664A (https=)
KR (1) KR20070014113A (https=)
CA (1) CA2548132A1 (https=)
DE (1) DE10358387A1 (https=)
SG (1) SG148997A1 (https=)
TW (1) TW200529863A (https=)
WO (1) WO2005055976A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2074141T3 (en) 2006-09-22 2016-11-28 Novo Nordisk As The protease resistant insulin analogues.
JP5508859B2 (ja) * 2007-01-26 2014-06-04 アイエスピー インヴェストメンツ インコーポレイテッド 噴霧乾燥製品を製造するための調剤処理方法
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
CN102037008B (zh) 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、酰化胰岛素类似物
WO2010102065A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives
WO2010111132A2 (en) 2009-03-27 2010-09-30 Bend Research, Inc. Spray-drying process
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
WO2010132827A1 (en) * 2009-05-15 2010-11-18 Bend Research, Inc. Low-molecular dextran for powder inhalations
WO2010133294A2 (de) 2009-05-18 2010-11-25 Boehringer Ingelheim International Gmbh Adapter, inhalationseinrichtung und zerstäuber
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
EA026241B1 (ru) 2009-11-25 2017-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Распылитель
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011160932A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Nebulizer
US9084976B2 (en) 2010-09-03 2015-07-21 Bend Research, Inc. Spray-drying apparatus and methods of using the same
PT2611530T (pt) 2010-09-03 2019-05-09 Bend Res Inc Aparelho de secagem por pulverização e métodos de utilização do mesmo
WO2012040502A1 (en) 2010-09-24 2012-03-29 Bend Research, Inc. High-temperature spray drying process and apparatus
ES2688591T3 (es) * 2011-03-28 2018-11-05 Ablynx N.V. Método para producir formulaciones sólidas que comprenden dominios variables individuales de inmunoglobulina
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces
EP2709646A4 (en) * 2011-05-19 2015-05-13 Savara Inc DRY POWDER VANCOMYCIN COMPOSITIONS AND RELATED METHODS
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
PL2835146T3 (pl) 2013-08-09 2021-04-06 Boehringer Ingelheim International Gmbh Nebulizator
EP3030298B1 (en) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nebulizer
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
EA035261B1 (ru) 2014-05-07 2020-05-21 Бёрингер Ингельхайм Интернациональ Гмбх Небулайзер и контейнер
HUE055604T2 (hu) 2014-05-07 2021-12-28 Boehringer Ingelheim Int Porlasztó
AU2015257878B2 (en) 2014-05-07 2019-08-08 Boehringer Ingelheim International Gmbh Container, nebulizer and use
WO2016067132A1 (en) 2014-10-31 2016-05-06 Bend Research Inc. Process for forming active domains dispersed in a matrix
WO2016067252A1 (en) 2014-10-31 2016-05-06 Glaxosmithkline Intellectual Property Development Limited Powder formulation
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60025019T2 (de) * 1999-10-29 2006-08-24 Nektar Therapeutics, San Carlos Trockenpulverzusammensetzungen mit verbesserter dispersivität
EP1184032A1 (en) * 2000-08-31 2002-03-06 OctoPlus B.V. Dextran hydrogels
KR100508911B1 (ko) * 2002-05-09 2005-08-18 주식회사 펩트론 서방성 단백질 약물 제형 및 이의 제조방법

Also Published As

Publication number Publication date
JP2007514664A (ja) 2007-06-07
CA2548132A1 (en) 2005-06-23
SG148997A1 (en) 2009-01-29
EP1694306A2 (de) 2006-08-30
WO2005055976A2 (de) 2005-06-23
KR20070014113A (ko) 2007-01-31
WO2005055976A3 (de) 2006-02-16
TW200529863A (en) 2005-09-16
EP1694306B1 (de) 2018-09-12

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Legal Events

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8141 Disposal/no request for examination