DE10301026A1 - Stent to be used for percutaneous insertion of artificial heart valve, comprising hook-shaped elements for exact positioning - Google Patents

Stent to be used for percutaneous insertion of artificial heart valve, comprising hook-shaped elements for exact positioning

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Publication number
DE10301026A1
DE10301026A1 DE2003101026 DE10301026A DE10301026A1 DE 10301026 A1 DE10301026 A1 DE 10301026A1 DE 2003101026 DE2003101026 DE 2003101026 DE 10301026 A DE10301026 A DE 10301026A DE 10301026 A1 DE10301026 A1 DE 10301026A1
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Germany
Prior art keywords
stent
heart valve
valve
implantation
used
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2003101026
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German (de)
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DE10301026B4 (en
Inventor
Markus Dr.med. Dr.disc.pol. Ferrari
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JENAVALVE TECHNOLOGY INC., WILMINGTON, DEL., US
Original Assignee
Markus Dr.med. Dr.disc.pol. Ferrari
Figulla, Hans-Reiner, Prof. Dr.med.
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Priority to DE10237573.9 priority Critical
Priority to DE10237573 priority
Application filed by Markus Dr.med. Dr.disc.pol. Ferrari, Figulla, Hans-Reiner, Prof. Dr.med. filed Critical Markus Dr.med. Dr.disc.pol. Ferrari
Priority claimed from DE20321838U external-priority patent/DE20321838U1/en
Priority to DE2003101026 priority patent/DE10301026B4/en
Publication of DE10301026A1 publication Critical patent/DE10301026A1/en
Publication of DE10301026B4 publication Critical patent/DE10301026B4/en
Application granted granted Critical
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2427Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436Deployment by retracting a sheath
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • A61F2220/0016Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028Shapes in the form of latin or greek characters
    • A61F2230/0054V-shaped

Abstract

The folded stent is moved through a catheter to the left ventricle where it is partially released, facilitating the hooks to unfold and to move into a radial position. The elements are gently pushed into the pockets of the aortic valve in order to create a reliable connection like a paper clip holding a sheet of paper, allowing the exact positioning of the stent and preventing a dislocation of same towards the left ventricle.

Description

  • Gegenwärtiger Stand der Technik: Current state of the art:
  • Das derzeitige Standardverfahren zum Ersatz menschlicher Herzklappen verwendet gegenwärtig biologische oder mechanische Herzklappenprothesen, welche über eine operative Eröffnung des Brustkorbs nach Entfernung der kranken Herzklappe im Herzklappenbett festgenäht werden. The current standard method for replacement human heart valves currently used biological or mechanical heart valve prostheses which are sewn via an operating opening of the chest after removal of the diseased heart valve in the heart valves bed. Damit eine Herzklappe eingenäht werden kann, muß der Kreislauf des Patienten durch eine Herz-Lungen-Maschine getragen werden. For a heart valve can be sewn, the circulation of the patient must be supported by a cardiopulmonary bypass. Es wird ein Herzstillstand induziert und während des Herzstillstandes die Herzklappenprothese eingenäht. It is caused by a cardiac arrest and sewed the heart valve prosthesis during cardiac arrest. Es handelt sich folglich um einen sehr großen chirurgischen Eingriff mit entsprechenden Risiken für den Patienten und eine lange postoperative Behandlungsphase. There is consequently a very invasive surgical procedure with associated risks for the patient and a long postoperative treatment phase. Der Eingriff ist somit auf jüngere und möglichst gesunde Patienten beschränkt. The intervention is therefore limited to younger and healthy as possible patients. Sehr alten Patienten und sehr herzschwachen Patienten kann dieser Eingriff nicht mehr zugemutet werden. The very elderly and very weak heart patients can not be expected this intervention.
  • Daher wurde in den letzten Jahren vermehrt nach Verfahren gesucht, welche die erkrankte Herzklappe mittels Katheter perkutan, transluminal ersetzen können. It was therefore sought in recent years increasingly looking for methods which the diseased heart valve percutaneously via catheter, can replace transluminal. Zu diesem Verfahren, bei welchem eine Herzklappe mittels eines Stents durch einen Katheter am schlagenden herzen minimal-invasiv implantiert werden kann, sind mehrere nationale und internationale Patentente, Patentanmeldung und Gebrauchsmuster erteilt bzw. eingereicht auf die an dieser Stelle verwiesen wird. For this method in which a heart valve can be implanted through a catheter on a beating heart in a minimally invasive means of a stent, several national and international patent duck, patent application and utility models are granted or filed to which reference is made at this point.
  • Grundlagen des transluminalen Herzklappenersatzes: Basics of transluminal cardiac valve replacement:
  • Allen Verfahren des perkutanen, transluminalen Herzklappenersatzes gemeinsam ist das Vorbringen der zu implantierenden Herzklappenprothese mit einem Katheter, der über ein peripheres Gefäß minimal-invasiv, perkutan eingeführt wird. common to all methods of percutaneous transluminal cardiac valve replacement arguments of the heart valve prosthesis to be implanted with a catheter, which is a peripheral vessel in a minimally invasive, percutaneously inserted. Die Klappenprothese ist in ein Träger-Stütz-System (Stent) eingebracht, welches aus einem Drahtgeflecht besteht und das bei der Implantation von selbst aufspringt (= selbstexpandierend) oder von einem Ballon aufgelehnt wird (= Ballon expandierbar). The valve prosthesis is introduced into a carrier support system (stent) which consists of a wire mesh and the jumps (= self-expanding) in the implantation of itself or is revolted by a balloon (= balloon expandable). Unter Kontrolle von Röntgendurchleuchtung (Herzkatheterlabor = HKL) und Ultraschall (transösophageales Echokardiogramm = TEE) wird über einem Führungsdraht, der zuvor als Leitschiene platziert wurde, der Einführkatheter und die darin befindliche Herzklappen-Stent-Einheit zur Implantationsstelle vorgebracht, wo sich die erkrankte zu ersetzende Klappe befindet. Under control of X-ray fluoroscopy (cath lab = HKL) and ultrasound (Transesophageal Echocardiogram = TEE) is raised over a guidewire which has been previously placed as a guide rail of the insertion catheter and the therein heart valve stent assembly for implantation location where the diseased to be replaced door is. Hier wird der Stent frei gegeben und durch die Stent-Expansion die neu Klappenprothese aufgespannt. Here, the stent is released and spanned by the stent expansion, the new valve prosthesis.
  • Nachleile des derzeitigen Verfahrens: Nachleile the current procedure:
  • Als ein zwei wesentliche Nachteile des derzeitigen Verfahrens sind zum einen Probleme bei der sicheren Positionierung des Stents zu sehen, die trotz hoher Auflösung im HKL und des TEE die Gefahr- von Fehlimplantationen birgt. As a two major drawbacks of the current procedure can be seen on the one hand problems in the secure positioning of the stent which holds the hazardous faulty implants in spite of high resolution in the HVAC and the TEE. Eine Implantation des Herzklappen-Stents zu weit in der Herzkammer (Ventrikel) führt zur Undichtigkeit (Klappeninsuffizienz) und erheblichen Belastung des Ventrikels. Implantation of heart valve stent too far into the heart chamber (ventricle) leads to leakage (regurgitation) and substantial burden on the ventricle. Eine Fehlimplantation zu weit oberhalb der eigentlichen Klappenebene kann zum Verschluss der Abgänge der Herzkranzgefäße (Koronarien) und damit zu einer tödlichen Koronarischämie mit Herzinfarkt führen. A faulty implant too far above the actual valve plane can to close the outlets of the coronary arteries (coronary arteries), leading to a fatal coronary ischemia with myocardial infarction.
  • Des Weiteren muss eine Aortenklappenprothese erhebliche Kräfte während der Diastole aushalten, die eine sichere Verankerung des Herzklappen-Stents voraussetzt, damit dieser nicht in den Ventrikel disloziert. Furthermore, it must withstand considerable forces aortic valve during diastole, which requires a secure anchoring of the heart valve stent to prevent it from dislocating in the ventricle. Eine solche Verankerung bieten Widerhaken, welche sich in der Wand der Aorta abstutzen, wie dies in dem deutschen Patent Nr. 195 466 92 dargestellt ist. Such anchoring offer barbs which are braced in the wall of the aorta, as shown in German patent no. 195466 92nd Eine zusätzliche Veraukerung oder Abstützung wäre jedoch aus Sicherheitsgründen hier wünschenswert. An additional Veraukerung or support would be desirable for security here.
  • Darstellung der Erfindung Summary of the Invention
  • Der im Patentanspruch angegebenen Erfindung liegen die og Probleme bei der transluminalen Herzklappenimplantation zugrunde, dass Bedarf für die Weiterentwicklung dieses Verfahrens eine sicher Positionierung bei der Implantation und eine zusätzliche Abstützung des Herzklappen-Stents gegen eine ventrikelwärts gerichtete Dislokation besteht. The invention stated in claim are based on the above-mentioned problems in the transluminal cardiac valve implantation, that need for the further development of this method is a safe positioning during implantation and an additional support of the heart valve stent against the ventricle directed dislocation.
  • Dazu wurde eine Modifikation der derzeitig verfügbaren Stents hinsichtlich der Bauart und damit des Verhaltens bei Implantation und hinsichtlich der Verankerung vorgenommen. To a modification of the stents currently available in terms of design and the behavior upon implantation and in terms of anchoring has been made. Diese Modifikation sieht Bügel / Streben bzw. Ausarbeitungen des Stents vor, welche bei der Implantation in die Taschen der alten Klappe hinein geschoben werden ( This modification provides Ironing / struts or elaborations of the stent before, which are pushed in the implantation into the pockets of the old door into ( 1 1 ). ). Wie bei der og Implantationstechnik wird der Katheter über einen Führungsdraht mit seinem distalen Ende, in dein sich der Herzklappen-Stent in zusammengefalteten Zustand befindet, bis in den linken Ventrikel vorgeschoben ( As with the above-mentioned implantation technique of the catheter over a guide wire with its distal end in your heart valve stent is in the collapsed state, is advanced into the left ventricle ( 2 2 ). ). Dort wird zunächst nur ein Teil des Stents freigegeben, so dass sich die Bügel / Streben /Ausarbeitungen des Stents im Bereich der Aortenwurzel radial nach außen stellen. There, only a portion of the stent is released first, so that represent the strap / struts / elaborations of the stent in the region of the aortic root radially outward. Durch vorsichtiges Vorschieben werden diese in die "Taschen der Aortenklappe eingeschoben, wo sie eine sichere und exakte Plazierung des Herzklappen-Stents ermöglichen. Nach Freigabe des übrigen Herzklappen-Stents Spannt sich dieser mit seinen distalen Bügeln im linksventrikulären Ausflusstrakt, mit dem klappentragenden Segment im Bereich der alten Herzklappe und dem proximalen Anteil in der Aortenwurzel auf. Die Bügel / Streben / Ausarbeitungen des Stents verankern das System und verhindern eine Dislokation in den linken Ventrikel ( By carefully advancing these are inserted into the "pockets of the aortic valve, where they allow a safe and accurate placement of the heart valve stent. After release of the other heart valve stent tightens this with its distal ironing in the left ventricular outflow tract, with the valved segment in the old heart valve and the proximal portion of the aortic root in. the strap / strut / elaborations of the stent anchor the system and prevent dislocation in the left ventricle ( 3 3 + + 4 4 ). ). Wie „Papier zwischen den Bügeln einer Büroklammer" werden die Taschen der alten Klappe zwischen die Bügel / Streben / Ausarbeitungen des Stents und den klappentragenden Anteil des Stents gedrückt. As "paper between the arms of a paper clip" to hold the pockets of the old valve between the brackets / struts / elaborations of the stent and the valved portion of the stent.
  • Die Bügel / Streben / Ausarbeitungen des Stents gewährleisten somit während der Implantation eine sichere Positionierung durch die anatomischen Strukturen der Taschen der alten Klappe, die neben der Kontrolle im HKL und mittels TEE die exakte Implantation des Herzklappen-Stents erlaubt. The strap / struts / elaborations of the stent thus ensuring a secure positioning through the anatomical structures of the pockets of the old valve, which allows the exact implantation of the heart valve stent in addition to the control in the HVAC and TEA means during implantation. Außerdem gewährleistet dieses Konstruktionsmerkmal eine zusätzliche Abstützung in den Taschen und damit am Klappenring der alten Herzklappe, wodurch eine Dislokation des Herzklappen-Stents in Richtung der linken Herzkammer verhindert wird. In addition, this design feature provides additional support in the pockets, and thus the valve ring of the old heart valve, whereby a dislocation of the heart valve stent is prevented in the direction of the left ventricle.
  • Diese Konstruktionsmerkmale des Stents bieten die gleichen Vorzüge auch bei transluminalen Ersatz der Pulmonalklappe. These design features of the stent offer the same benefits even if transluminal replacement of the pulmonary valve. Somit soll das og Verfahren und die beschriebenen Konstruktionsmerkmale des Herzklappen-Stents in Analogie für den Einsatz an der rechten Herzkammer (rechter Ventrikel, Pulmonalklappe, Arteria pulmonalis) gelten. Thus, the above-described method and the design characteristics of the heart valve stent in analogy for use in the right ventricle (right ventricle, pulmonary artery, pulmonary artery) is to apply.
  • Gegenüber den bisherigen Herzklappenprothesen für einen transluminalen Klappenersatz zeichnet sich die Erfindung dadurch aus: Compared with the previous heart valve prostheses for transluminal valve replacement, the invention is characterized in:
    • 1. Daß der Herzklappen-Stent um Bügel / Streben / Ausarbeitungen ergänzt wird. 1. The fact that the heart valve stent to strap / strut / drafts is completed.
    • 2. Daß diese Bügel / Streben / Ausarbeitungen während der ersten Phase der Implantation aus dem Katheter im Bereich der Hauptschlagader (Aortenwiirzel) bzw. im proximalen Anteil der Lungenschlagader (Arteria pulmonalis) freigegeben werden. 2. The fact that this strap / struts / elaborations during the first phase of the implantation of the catheter in the region of the aorta (Aortenwiirzel) or in the proximal portion of the pulmonary artery (pulmonary artery) to be released.
    • 3. Daß diese Bügel / Streben / Ausarbeitungen während der Implantation in die Taschen der alten Herzklappe hinein geschoben werden. 3. That this strap / strut / elaborations are pushed during implantation into the pockets of the old heart valve inside.
    • 4. Daß die Bügel / Streben / Ausarbeitungen eine exaktere Implantation des Herzklappen-Stents ermöglichen. 4. That the strap / strut / elaborations allow a more precise implantation of the heart valve stent.
    • 5. Daß durch diese Modifikation der Bauart des Herzklappen-Stents eine zusätzliche Verankerung des Systems gegen eine Dislokation ermöglicht.. 5. That by this modification of the design of the heart valve stent additional anchoring of the system against a dislocation allows ..
    • 6. Daß diese Modifikation der Bauart des Herzklappen-Stents beim transluminalen Ersatz der Aorten- wie auch der Pulinonalklappe Verwendung finden kann. 6. The fact that this modification of the design of the heart valve stent can be accessed by transluminal replacement of the aortic as well as the Pulinonalklappe use.
  • Ausführungsbeispiele der Erfindung sind in den Embodiments of the invention are shown in 1 1 - 4 4 dargestellt: shown:
  • 1 1 : Die dargestellte Ausarbeitung des Stents mit zusätzlichen Bügeln / Streben / Ausarbeitungen dienen der mechanischen Stabilisierung und exakten Positionierung des Herzklappen tragenden Stents bei transluminalen Herzklappenersatz. : The development of the stent shown with additional ironing / struts / elaborations are used for mechanical stabilization and the exact positioning of the heart valve stent carrying at transluminal cardiac valve replacement.
  • 2 2 : Bei der perkutanen, transluminalen Implantation des Herzklappen-Stents werden die zusätzlichen Bügeln / Streben / Ausarbeitungen in die Taschen der alten zu ersetzenden Klappe vorgeschoben. : In percutaneous transluminal implantation of heart valve stents are the advanced additional brackets / struts / elaborations into the pockets of the old valve being replaced. Nach weiterer Freigabe des Stents aus dem Katheter wird die neue Herzklappenprothese aufgespannt und gleichzeitig die alte Klappe gegen die Wand gepresst. After further release of the stent from the catheter, the new prosthetic heart valve is clamped and pressed at the same time the old flap against the wall.
  • 3a 3a & & b b : Nach Einbringen des Implantationskatheters bis auf Ebene der zu ersetzenden, alten Herzklappe wird der distale Teil des Stents freigegeben. After insertion of the catheter implantation to be replaced down to the level of the old heart valve, the distal portion of the stent is released. Dadurch stellen sich die Bügel / Streben / Ausarbeitungen des Stents (*) im Bereich der Aortenwurzel radial nach außen auf. Thereby, the strap / struts / elaborations of the stent filters (*) in the region of the aortic root radially outward. Durch leichtes Vorschieben werden die Bügel / Streben / Ausarbeitungen des Stents in die Taschen der alten Klappe hinein geschoben und ermöglichen durch die Abstützung an den anatomischen Strukturen der Klappentaschen eine exakte Plazierung des Herzklappen-Stents. By gently feeding the strap / struts / elaborations of the stent to be pushed into the pockets of the old lid into and allow through the support on the anatomical structures of the flap pockets exact placement of the heart valve stent.
  • 4a 4a & & b b : Durch Stern (*) sind die zusätzlichen Bügeln / Streben / Ausarbeitungen des Herzklappen-Stents gekennzeichnet, die in die Taschen der alten, zu ersetzenden Klappe vorgeschoben werden und dort eine exakte Positionierung und zusätzliche Abstützung / Verankerung gewährleisten. : By asterisk (*) are the additional straps / braces in / elaborations of the heart valve stents that are advanced into the pockets of the old valve being replaced and there ensure an exact positioning and additional support / anchoring. Nach weiterer Freigabe des Stents aus dem des Implantationskatheters werden die Taschen der alten Klappe wie „Papier zwischen den Bügeln einer Büroklammer" zwischen den Bügel / Streben / Ausarbeitungen des Stents und dem sich jetzt aufspannenden, klappentragenden Anteil des Stents eingeklemmt. Nach kompletter Freigabe des Stents ist die darin Eingebrachte Herzklappenprothese in der Position der erkrankten Klappe aufgespannt. After further release of the stent from the implant catheter, the pockets of the old flap as "paper between the brackets of a paper clip" between the strap / struts / elaborations of the stent and which spanning now valved portion of the stent are clamped. After complete release of the stent the introduced therein heart valve prosthesis is clamped in the position of the diseased valve.

Claims (5)

  1. Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen dadurch gekennzeichnet, daß dieser zum transluminalen, perkutanen, minimal-invasiven Ersatz einer erkrankten Taschenklappe (Aorten- oder Pulmonalklappe) dient. Device for anchoring and orientation of prosthetic heart valves characterized in that this for transluminal percutaneous, minimally invasive replacement of a diseased pocket flap (aortic or pulmonary valve) is used.
  2. Vorrichtung nach Anspruch 1 dadurch gekennzeichnet, daß diese der exakten Positionierung des Herzklappen-Stents während des Implantationsvorganges dient. Device according to claim 1, that these exact positioning of the heart valve stent during the implantation process is used.
  3. Vorrichtung nach Anspruch 1 oder 2 dadurch gekennzeichnet, daß bei der Implantation die Bügel / Streben / Ausarbeitungen des Stents in die Taschen der zu ersetzenden Herzklappe hinein geschoben werden und dort das System abstutzen. Device according to claim 1 or 2 that, in the implantation, the bracket / struts / elaborations of the stent to be pushed into the pockets of the heart valve to be replaced in, and there are braced the system.
  4. Vorrichtung nach Anspruch 1, 2 oder 3 dadurch gekennzeichnet, daß die Bügel / Streben / Ausarbeitungen des Herzklappen-Stents nach der Implantation den Stent gegen eine Dislokation zusätzlich abstützen. Device according to claim 1, 2 or 3, that the strap / struts / elaborations of the heart valve stents are supported in addition to the stent dislocation after implantation.
  5. Vorrichtung nach Anspruch 1 bis 4 dadurch gekennzeichnet, daß sie zusammenfaltbar und damit in einem Katheter zu implantieren ist. Device according to claim 1 to 4, that they can be folded and to be implanted into a catheter.
DE2003101026 2002-08-13 2003-01-14 Device for anchoring and orientation of prosthetic heart valves Active DE10301026B4 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE10237573.9 2002-08-13
DE10237573 2002-08-13
DE2003101026 DE10301026B4 (en) 2002-08-13 2003-01-14 Device for anchoring and orientation of prosthetic heart valves

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Application Number Priority Date Filing Date Title
DE2003101026 DE10301026B4 (en) 2002-08-13 2003-01-14 Device for anchoring and orientation of prosthetic heart valves
DE20321838U DE20321838U1 (en) 2002-08-13 2003-01-14 Device for anchoring and orientation of prosthetic heart valves

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DE10301026B4 DE10301026B4 (en) 2014-10-30

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WO2007048529A1 (en) * 2005-10-28 2007-05-03 Jenavalve Technology Inc. Device for implanting and fastening heart valve prostheses
EP2201911A3 (en) * 2008-12-23 2010-11-17 Sorin Biomedica Cardio S.r.l. Expandable prosthetic valve having anchoring appendages
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US8062355B2 (en) 2005-11-04 2011-11-22 Jenavalve Technology, Inc. Self-expandable medical instrument for treating defects in a patient's heart
US8109996B2 (en) 2004-03-03 2012-02-07 Sorin Biomedica Cardio, S.R.L. Minimally-invasive cardiac-valve prosthesis
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US8468667B2 (en) 2009-05-15 2013-06-25 Jenavalve Technology, Inc. Device for compressing a stent
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
US8540768B2 (en) 2005-02-10 2013-09-24 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US8679174B2 (en) 2005-01-20 2014-03-25 JenaValve Technology, GmbH Catheter for the transvascular implantation of prosthetic heart valves
US8685084B2 (en) 2011-12-29 2014-04-01 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
US8840661B2 (en) 2008-05-16 2014-09-23 Sorin Group Italia S.R.L. Atraumatic prosthetic heart valve prosthesis
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
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