DE10224624A1 - Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol - Google Patents
Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-olInfo
- Publication number
- DE10224624A1 DE10224624A1 DE10224624A DE10224624A DE10224624A1 DE 10224624 A1 DE10224624 A1 DE 10224624A1 DE 10224624 A DE10224624 A DE 10224624A DE 10224624 A DE10224624 A DE 10224624A DE 10224624 A1 DE10224624 A1 DE 10224624A1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- stereoisomers
- salts
- dimethylamino
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/72—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10224624A DE10224624A1 (de) | 2002-05-30 | 2002-05-30 | Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol |
EP03732465A EP1507521A1 (fr) | 2002-05-30 | 2003-05-26 | Metabolite de 1-dimethylamino-3-(3-methoxy-phenyle)-2-methyle-pentane-3-ole et son utilisation pour traiter l'enuresie |
PCT/EP2003/005490 WO2003101440A1 (fr) | 2002-05-30 | 2003-05-26 | Metabolite de 1-dimethylamino-3-(3-methoxy-phenyle)-2-methyle-pentane-3-ole et son utilisation pour traiter l'enuresie |
AU2003238398A AU2003238398A1 (en) | 2002-05-30 | 2003-05-26 | Metabolite of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentane-3-ol and the use thereof in the treatment of urinary incontinence |
PE2003000510A PE20040521A1 (es) | 2002-05-30 | 2003-05-27 | Metabolito a partir de 1-dimetilamino-3-(3-metoxi-fenil)-2-metil-pentan-3-ol |
ARP030101885A AR039901A1 (es) | 2002-05-30 | 2003-05-29 | Metabolito a partir de 1-dimetilamino-3-(3-metoxi-fenil)-2-metil-pentan-3-ol |
US10/999,219 US20050137145A1 (en) | 2002-05-30 | 2004-11-30 | Metabolites of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol and their use in the treatment of urinary incontinence |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10224624A DE10224624A1 (de) | 2002-05-30 | 2002-05-30 | Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol |
Publications (1)
Publication Number | Publication Date |
---|---|
DE10224624A1 true DE10224624A1 (de) | 2003-12-11 |
Family
ID=29432607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10224624A Withdrawn DE10224624A1 (de) | 2002-05-30 | 2002-05-30 | Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1507521A1 (fr) |
AR (1) | AR039901A1 (fr) |
AU (1) | AU2003238398A1 (fr) |
DE (1) | DE10224624A1 (fr) |
PE (1) | PE20040521A1 (fr) |
WO (1) | WO2003101440A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
WO2002043715A2 (fr) * | 2000-11-30 | 2002-06-06 | Grünenthal GmbH | Utilisation de composes 1-phenyl-3-dimethylamino-propane pour traiter l'incontinence urinaire |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2901180A1 (de) * | 1979-01-13 | 1980-07-24 | Basf Ag | Hexahydro-1,4-oxazepine, verfahren zu deren herstellung und diese enthaltende arzneimittel |
PE20010623A1 (es) * | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
-
2002
- 2002-05-30 DE DE10224624A patent/DE10224624A1/de not_active Withdrawn
-
2003
- 2003-05-26 WO PCT/EP2003/005490 patent/WO2003101440A1/fr not_active Application Discontinuation
- 2003-05-26 AU AU2003238398A patent/AU2003238398A1/en not_active Abandoned
- 2003-05-26 EP EP03732465A patent/EP1507521A1/fr not_active Withdrawn
- 2003-05-27 PE PE2003000510A patent/PE20040521A1/es not_active Application Discontinuation
- 2003-05-29 AR ARP030101885A patent/AR039901A1/es unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
WO2002043715A2 (fr) * | 2000-11-30 | 2002-06-06 | Grünenthal GmbH | Utilisation de composes 1-phenyl-3-dimethylamino-propane pour traiter l'incontinence urinaire |
Also Published As
Publication number | Publication date |
---|---|
EP1507521A1 (fr) | 2005-02-23 |
PE20040521A1 (es) | 2004-08-24 |
WO2003101440A1 (fr) | 2003-12-11 |
AR039901A1 (es) | 2005-03-09 |
AU2003238398A1 (en) | 2003-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1429754B1 (fr) | Combinaison d'opioides specifiques et d'antagonistes muscariniques destinee a traiter l'incontinence urinaire | |
EP2117525B1 (fr) | Utilisation de composés de 1-phényl-3-diméthylamino-propane pour traiter la douleur neuropathique | |
EP3241550B1 (fr) | (1r,2r)-3-(-diméthylamino-1-éthyl-2-méthyl-propyl)-phénol pour le traitement de la douleur inflammatoire | |
DE10224107A1 (de) | Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz | |
EP1438034B1 (fr) | Utilisation de composes 1-phenyl-3-dimethylamino-propane pour traiter l'incontinence urinaire | |
US20060194860A1 (en) | Pharmaceutical compositions containing aryl or heteroaryl azolylcarbinol compounds | |
EP1337246B1 (fr) | Utilisation de composes 6-dimethylaminomethyle-1-phenyl-cyclohexane pour traiter l'incontinence urinaire | |
EP1353660B1 (fr) | Utilisation de composes 6-dimethylaminomethyle-1-phenyl-cyclohexane substitues pour traiter l'incontinence urinaire | |
EP1509216B1 (fr) | Sels de principes actifs et esters de 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol et de 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methyl-propyl)-phenol | |
DE10224624A1 (de) | Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol | |
US20050137194A1 (en) | Combination of selected opioids with other active compounds for treatment of urinary incontinence | |
US20050137145A1 (en) | Metabolites of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol and their use in the treatment of urinary incontinence | |
DE10254785A1 (de) | Kombination ausgewählter Analgetika mit COX II-Inhibitoren | |
DE10326103A1 (de) | Kombination ausgewählter Analgetika mit COX II-Inhibitoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
OM8 | Search report available as to paragraph 43 lit. 1 sentence 1 patent law | ||
8139 | Disposal/non-payment of the annual fee |