DE102007005323A1 - Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source - Google Patents

Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source

Info

Publication number
DE102007005323A1
DE102007005323A1 DE102007005323A DE102007005323A DE102007005323A1 DE 102007005323 A1 DE102007005323 A1 DE 102007005323A1 DE 102007005323 A DE102007005323 A DE 102007005323A DE 102007005323 A DE102007005323 A DE 102007005323A DE 102007005323 A1 DE102007005323 A1 DE 102007005323A1
Authority
DE
Germany
Prior art keywords
suction
needles
diffuser
vacuum chamber
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102007005323A
Other languages
German (de)
Inventor
Bernd Grobshäuser
Johannes Jansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioplan Consulting GmbH
Original Assignee
Bioplan Consulting GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioplan Consulting GmbH filed Critical Bioplan Consulting GmbH
Priority to DE102007005323A priority Critical patent/DE102007005323A1/en
Publication of DE102007005323A1 publication Critical patent/DE102007005323A1/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0289Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00Cleaning or rinsing apparatus
    • B01L13/02Cleaning or rinsing apparatus for receptacle or instruments
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00364Pipettes
    • B01J2219/00367Pipettes capillary
    • B01J2219/00369Pipettes capillary in multiple or parallel arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0829Multi-well plates; Microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/086Passive control of flow resistance using baffles or other fixed flow obstructions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065Multiple transfer devices

Abstract

It is proposed a suction device containing a plurality of suction needles for aspirating fluids from sample containers. The suction needles open on the device side in a vacuum chamber, which is separated by a plate containing a plurality of small openings of an antechamber. The pre-chamber has a connection for a vacuum source, with the aid of which negative pressure is generated in the prechamber and in the vacuum chamber. By arranging the plate between the two chambers, an equalization of the flow velocity is achieved, so that the negative pressure is substantially the same for all suction needles. In this way, a uniform and thus fast emptying of the sample container is effected.

Description

  • The The invention relates to a suction device and a method for Emptying sample containers with a variety of suction needles.
  • It is known to use sample containers of suction needles, which are lowered into the containers and in which negative pressure is generated. It is also known by machine so that a lot of in particular parallel Suction needles simultaneously lowered and in a vacuum chamber is subjected to negative pressure. It turned out that the negative pressure in the vacuum chamber is distributed unevenly is what causes that the suction needles in the places where the negative pressure is greater, work faster. This means u. a. that for certain sample containers the liquid was already taken while the suction needles are still filled with liquid elsewhere. Then arises in the sample containers a breeze that can lead to dehydration.
  • Of the Invention is based on the object, a suction device and To provide a method by which causes a uniform emptying of the sample container can be, so the emptying altogether faster by itself can go.
  • to solution this task strikes the invention, a suction device with the mentioned in claim 1 Characteristics.
  • The Invention proposes also a method with the features mentioned in claim 9 in front. Further developments of the invention are the subject of dependent claims.
  • By the arrangement of the diffuser between the vacuum chamber and the Connection for The vacuum source is achieved that the flow within the vacuum chamber is evened out, which leads to, that the negative pressure at the arranged in the vacuum chamber End of the suction needles is the same for all suction needles. All suction needles therefore work at the same speed and are the same Time ready. One does not have to stop the suction process pay more attention to the slowest suction needle.
  • In addition to the reduction of the time required for aspiration overall arises but still the advantage that not unnecessarily air is sucked. This could with less uniform suction occur when, for example, a sample container already is empty, the other is not yet. As this case according to the invention no longer occurs, the remaining contents of the sample container before Dehydration protected, and sensitive wall coatings will resist detachment a persistent airflow protected.
  • For example you can use a diffuser that has a variety of evenly spaced openings having. The bigger the Number of openings is, the more even can the flow velocity over the Distribute vacuum chamber. Due to the size of the openings you can see the pressure drop determine that is generated by the diffuser.
  • For example the diffuser can be made of porous Material consist of a number of evenly spaced openings forms.
  • In Further development of the invention can be provided that the connection for the Low pressure source leads into an antechamber, and that the dividing wall between the second chamber, namely the prechamber, and the vacuum chamber formed by the diffuser becomes. The diffuser is therefore just as big in one dimension as the Prechamber and the vacuum chamber.
  • In Further development of the invention can be provided that the antechamber is arranged below the vacuum chamber. Below is where the Pointing tips of the suction needles.
  • There using the vacuum source not only gas, but also fluids and a mixture of air and fluid is drawn off, the fluid then flow down out of the antechamber.
  • In Development of the invention can be provided that the suction needles protrude through the diffuser. In particular, they can with a radial Play through openings protrude through the diffuser. This radial clearance thereby forms openings around the suction needles, through which the vacuum to the device side Ends of the suction needles can get. The sucked out fluid can then directly on the suction needle through this annular space be sucked off. This also has the advantage of fluids that are difficult to remove from the wall of the suction needles, the suction needles be sucked along.
  • According to the invention, in Continuing to be provided that the suction needles to each other parallel, penetrate the diffuser plate across.
  • Further features, details and advantages of the invention will become apparent from the claims and abstract, the wording of which by reference to the content of the description ge makes, the following description of preferred embodiments of the invention and from the drawing. Hereby show:
  • 1 perspective view of parts of a suction device according to the invention and
  • 2 on a larger scale a detailed view.
  • 1 shows very simplified part of a suction device. The suction device includes a housing 1 , this in 1 is shown without a lid. In the case 1 is a vacuum chamber 2 formed, which has parallel and flat top and bottom. In the vacuum chamber 1 open the device-side ends 3 the suction needles 4 on the bottom of the case 1 protrude. Below the vacuum chamber 2 is a diffuser plate 5 formed, which is the lower end of the vacuum chamber 2 forms. Below the diffuser plate 5 will then be between this and the bottom of the case 1 an antechamber formed from which a pipe connection 6 protrudes for a vacuum source. The pipe connection 6 for the vacuum source is connected via a hose or other line connection with a pump that generates the negative pressure. This negative pressure initially prevails in the antechamber 7 and from there passes through the diffuser plate 5 into the actual vacuum chamber 2 , There are the suction needles 4 arranged so that their suction holes 8th below the in 1 not shown lid of the housing 1 are arranged.
  • Further details will be apparent from the figure two, which is to be understood schematically.
  • The housing 1 contains, as already mentioned, a vacuum chamber 2 in the 2 with the lid 9 is shown. Below the vacuum chamber 2 is the antechamber 7 trained, down through the floor 10 is completed. Between the vacuum chamber 2 and the antechamber 7 is the diffuser 5 arranged in the form of a plate. From the antechamber 7 leads the connection 6 through the ground 10 through to the outside.
  • The suction device includes a plurality of suction needles 4 of which in 1 for reasons of simplified representation, only three are shown. These suction needles 4 penetrate the ground 10 of the housing 1 and are set in this gas-tight. The suction needles 4 also protrude through the diffuser plate 5 through, through openings there 11 , which are formed for example as circular holes. For reasons of simplification, these openings 11 represented larger than they really are. The diffuser plate 5 is with the exception of the openings 11 also gas-tight. Is connected to the port 6 Low pressure applied, so prevails both in the vacuum chamber 2 as well as in the antechamber 7 Negative pressure, so using the suction needles 4 a suction can be performed. Through the diffuser plate 5 with the openings 11 is ensured that the negative pressure in the vacuum chamber 2 is the same everywhere, regardless of where the connection 6 is arranged for the vacuum source. In this way, a homogenization of the intake process, and consequently a shorter processing time, since you no longer have to take into account the suction needles, at their suction 8th the smallest negative pressure prevails.
  • Instead of a diffuser plate 5 with discrete one suction needle each 4 associated openings 11 You can also use a diffuser plate, which consists of a porous material.

Claims (13)

  1. Extraction device, with 1.1 a variety of suction needles ( 4 ), 1.2 a vacuum chamber ( 2 ), 1.3 in which the suction needles ( 4 ), 1.4 a connection ( 6 ) for a vacuum source, the 1.5 with the vacuum chamber ( 2 ) as well as 1.6 a diffuser ( 5 ) between the vacuum chamber ( 2 ) and the connection ( 6 ) for the vacuum source.
  2. Suction device according to Claim 1, in which the diffuser ( 5 ) a plurality of evenly distributed openings ( 11 ) having.
  3. Suction device according to claim 1 or 2, wherein the diffuser ( 5 ) consists of porous material.
  4. Suction device according to one of the preceding claims, in which the connection ( 6 ) for the vacuum source into a second chamber ( 7 ) and the partition wall between the second chamber ( 7 ) and the vacuum chamber ( 2 ) from the diffuser ( 5 ) is formed.
  5. Suction device according to claim 4, wherein the pre-chamber ( 7 ) below the vacuum chamber ( 2 ) is arranged.
  6. Suction device according to one of the preceding claims, in which the suction needles ( 4 ) through the diffuser ( 5 protrude through.
  7. Suction device according to one of the preceding claims, in which the suction needles ( 4 ) across the diffuser ( 5 ) are arranged.
  8. Suction device according to one of the preceding claims, in which the suction needles ( 4 ) by the preferably flat plate formed as a diffuser ( 5 ) protrude with radial play.
  9. Method for aspirating fluids from sample containers using suction needles ( 4 ), in which 9.1 the device-side suction openings ( 8th ) of the suction needles ( 4 ) 9.2 the negative pressure generated by a vacuum source and 9.3 to the suction openings (9) 8th ) of the suction needles ( 4 9.4, the flow rate of the suction between the suction needles ( 4 ) and the connection ( 6 ) is made uniform for the vacuum source.
  10. Method according to Claim 9, in which the equalization of the flow through a diffuser ( 5 ) is effected.
  11. Method according to Claim 10, in which the negative pressure is applied to an antechamber ( 7 ), which depends on the suction openings ( 8th ) of the suction needles ( 4 ) containing negative pressure chamber ( 2 ) through the diffuser ( 5 ) is disconnected.
  12. Method according to claim 10 or 11, in which a diffuser ( 5 ) is used made of a porous material.
  13. Method according to one of claims 10 to 12, wherein a diffuser ( 5 ) with a plurality of over the surface of the diffuser ( 5 ) distributed through openings ( 11 ) is used.
DE102007005323A 2007-01-29 2007-01-29 Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source Withdrawn DE102007005323A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE102007005323A DE102007005323A1 (en) 2007-01-29 2007-01-29 Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007005323A DE102007005323A1 (en) 2007-01-29 2007-01-29 Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source
PCT/EP2008/000317 WO2008092570A1 (en) 2007-01-29 2008-01-17 Suction device

Publications (1)

Publication Number Publication Date
DE102007005323A1 true DE102007005323A1 (en) 2008-07-31

Family

ID=39367143

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102007005323A Withdrawn DE102007005323A1 (en) 2007-01-29 2007-01-29 Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source

Country Status (2)

Country Link
DE (1) DE102007005323A1 (en)
WO (1) WO2008092570A1 (en)

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3572552A (en) * 1969-07-25 1971-03-30 Perry W Guinn Diaphragm dispenser
US3982438A (en) * 1975-06-23 1976-09-28 The Salk Institute For Biological Studies Multiple sample pipetting apparatus
US4302338A (en) * 1978-07-28 1981-11-24 Metallgesellschaft Aktiengesellschaft Apparatus for metering and/or distributing liquid media
DE3220444A1 (en) * 1981-10-02 1983-04-21 Culture Tek Corp Pipette sampler
US4537231A (en) * 1983-08-29 1985-08-27 Becton, Dickinson And Company Dispenser apparatus for simultaneously dispensing predetermined equal volumes of liquid including a disposable dispenser module
US4565100A (en) * 1981-10-02 1986-01-21 Culture-Tek Pipette device
DE29603462U1 (en) * 1995-02-27 1996-04-25 Slt Labinstruments Gmbh A device for suctioning a liquid from the cavities of a microtiter plate
US6165417A (en) * 1998-10-26 2000-12-26 The Regents Of The University Of California Integrated titer plate-injector head for microdrop array preparation, storage and transfer
US6326212B1 (en) * 1999-10-12 2001-12-04 Arden Systems, Inc. Membrane dispensing head apparatus and method for dispensing liquid
US20020025582A1 (en) * 2000-04-05 2002-02-28 Allyn Hubbard Methods and devices for storing and dispensing liquids
WO2002049763A2 (en) * 2000-12-18 2002-06-27 Institut für Physikalische Hochtechnologie e.V. Device for receiving and discharging liquid substances
US20020114740A1 (en) * 2001-01-31 2002-08-22 Shimadzu Corporation Liquid transfer apparatus and reaction vessel
WO2002092228A2 (en) * 2001-05-11 2002-11-21 Allegro Research Limited A method and device for dispensing of droplets
DE69621608T2 (en) * 1995-03-21 2003-02-06 Aclara Biosciences Inc Apparatus and method for capillary electrophoresis
US20030228241A1 (en) * 1999-08-13 2003-12-11 Legge Coulton Heath Apparatus for liquid sample handling
US20040018119A1 (en) * 2002-07-23 2004-01-29 Peter Massaro Liquid handling tool having porous plunger
US6841130B2 (en) * 2000-12-15 2005-01-11 Wallac Oy Pipetting method and multichannel pipetting apparatus

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US4167875A (en) * 1976-08-05 1979-09-18 Meakin John C Filtration method and apparatus
DE3138176C2 (en) * 1981-09-25 1984-06-07 Mathias 4815 Schloss Holte De Mitter
US4649967A (en) * 1983-09-08 1987-03-17 University Of Cincinnati Multiple efflux apparatuses for transferring fluid
DK492788D0 (en) * 1988-09-02 1988-09-05 Morten Meldal Peptide Synthesis Unit
US5334352A (en) * 1992-09-23 1994-08-02 Icn Biomedicals, Inc. Manifold construction
JP2008512645A (en) * 2004-08-04 2008-04-24 アイアールエム エルエルシー Multi-well container processing system, system components, and related methods

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3572552A (en) * 1969-07-25 1971-03-30 Perry W Guinn Diaphragm dispenser
US3982438A (en) * 1975-06-23 1976-09-28 The Salk Institute For Biological Studies Multiple sample pipetting apparatus
US4302338A (en) * 1978-07-28 1981-11-24 Metallgesellschaft Aktiengesellschaft Apparatus for metering and/or distributing liquid media
US4565100A (en) * 1981-10-02 1986-01-21 Culture-Tek Pipette device
DE3220444A1 (en) * 1981-10-02 1983-04-21 Culture Tek Corp Pipette sampler
US4537231A (en) * 1983-08-29 1985-08-27 Becton, Dickinson And Company Dispenser apparatus for simultaneously dispensing predetermined equal volumes of liquid including a disposable dispenser module
DE29603462U1 (en) * 1995-02-27 1996-04-25 Slt Labinstruments Gmbh A device for suctioning a liquid from the cavities of a microtiter plate
DE69621608T2 (en) * 1995-03-21 2003-02-06 Aclara Biosciences Inc Apparatus and method for capillary electrophoresis
US6165417A (en) * 1998-10-26 2000-12-26 The Regents Of The University Of California Integrated titer plate-injector head for microdrop array preparation, storage and transfer
US20030228241A1 (en) * 1999-08-13 2003-12-11 Legge Coulton Heath Apparatus for liquid sample handling
US6326212B1 (en) * 1999-10-12 2001-12-04 Arden Systems, Inc. Membrane dispensing head apparatus and method for dispensing liquid
US20020025582A1 (en) * 2000-04-05 2002-02-28 Allyn Hubbard Methods and devices for storing and dispensing liquids
US6905657B2 (en) * 2000-04-05 2005-06-14 Bioprocessors Corp. Methods and devices for storing and dispensing liquids
US6841130B2 (en) * 2000-12-15 2005-01-11 Wallac Oy Pipetting method and multichannel pipetting apparatus
WO2002049763A2 (en) * 2000-12-18 2002-06-27 Institut für Physikalische Hochtechnologie e.V. Device for receiving and discharging liquid substances
US20020114740A1 (en) * 2001-01-31 2002-08-22 Shimadzu Corporation Liquid transfer apparatus and reaction vessel
WO2002092228A2 (en) * 2001-05-11 2002-11-21 Allegro Research Limited A method and device for dispensing of droplets
US20040018119A1 (en) * 2002-07-23 2004-01-29 Peter Massaro Liquid handling tool having porous plunger

Also Published As

Publication number Publication date
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8139 Disposal/non-payment of the annual fee