DE10199049I2 - Pharmakologisch wirksame 3-substituierte 1, 5-Diaryl-pyrazole und Verfahren zu ihrer Herstellung - Google Patents
Pharmakologisch wirksame 3-substituierte 1, 5-Diaryl-pyrazole und Verfahren zu ihrer HerstellungInfo
- Publication number
- DE10199049I2 DE10199049I2 DE2001199049 DE10199049C DE10199049I2 DE 10199049 I2 DE10199049 I2 DE 10199049I2 DE 2001199049 DE2001199049 DE 2001199049 DE 10199049 C DE10199049 C DE 10199049C DE 10199049 I2 DE10199049 I2 DE 10199049I2
- Authority
- DE
- Germany
- Prior art keywords
- pyrazoles
- diaryl
- substituted
- preparation
- pharmacologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86799686A | 1986-05-29 | 1986-05-29 | |
US07/042,661 US4826868A (en) | 1986-05-29 | 1987-04-29 | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE10199049I1 DE10199049I1 (de) | 2002-01-10 |
DE10199049I2 true DE10199049I2 (de) | 2003-01-09 |
Family
ID=26719497
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE87304720T Expired - Lifetime DE3788244T2 (de) | 1986-05-29 | 1987-05-28 | Pharmakologisch wirksame 3-substituierte 1,5-Diaryl-pyrazole und Verfahren zu ihrer Herstellung. |
DE2001199049 Active DE10199049I2 (de) | 1986-05-29 | 1987-05-28 | Pharmakologisch wirksame 3-substituierte 1, 5-Diaryl-pyrazole und Verfahren zu ihrer Herstellung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE87304720T Expired - Lifetime DE3788244T2 (de) | 1986-05-29 | 1987-05-28 | Pharmakologisch wirksame 3-substituierte 1,5-Diaryl-pyrazole und Verfahren zu ihrer Herstellung. |
Country Status (21)
Country | Link |
---|---|
US (1) | US4826868A (de) |
EP (1) | EP0248594B1 (de) |
JP (1) | JP2512751B2 (de) |
KR (1) | KR960007163B1 (de) |
CN (1) | CN1028227C (de) |
AU (1) | AU596844B2 (de) |
CA (1) | CA1337122C (de) |
DE (2) | DE3788244T2 (de) |
DK (1) | DK170202B1 (de) |
ES (1) | ES2059377T3 (de) |
FI (1) | FI94340C (de) |
HK (1) | HK14094A (de) |
HU (1) | HU221300B1 (de) |
IE (1) | IE63856B1 (de) |
IL (1) | IL82671A0 (de) |
LU (1) | LU90829I2 (de) |
NL (1) | NL300057I2 (de) |
NO (2) | NO172236C (de) |
NZ (1) | NZ220353A (de) |
PH (1) | PH25126A (de) |
PT (1) | PT84964B (de) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0293221A3 (de) * | 1987-05-29 | 1990-07-04 | Ortho Pharmaceutical Corporation | Regioselektive Synthese 1,5-disubstituierter Pyrazole |
US4898952A (en) * | 1987-05-29 | 1990-02-06 | Ortho Pharmaceutical Corporation | Regioselective synthesis of a 1,5-disubstituted pyrazole |
AU611437B2 (en) * | 1987-05-29 | 1991-06-13 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamides and method for synthesizing the same |
CA1334975C (en) * | 1987-11-13 | 1995-03-28 | James H. Holms | Furan and pyrrole containing lipoxygenase inhibiting compounds |
US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
US4960787A (en) * | 1989-02-06 | 1990-10-02 | Ciba-Geigy Corporation | Certain pyrrolyl-substituted hydroxamic acid derivatives |
US4994482A (en) * | 1989-07-31 | 1991-02-19 | Bristol-Myers Squibb Company | Arylpyrazol derivatives as anti-platelet agents, compositions and use |
PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
US4956379A (en) * | 1990-02-13 | 1990-09-11 | Bristol-Myers Squibb Company | Pyrazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith |
CA2036192A1 (en) | 1990-02-13 | 1991-08-14 | Nicholas Meanwell | Heterocyclic carboxylic acids and esters |
FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
CA2052950A1 (en) * | 1990-10-10 | 1992-04-11 | David P. Evitts | Aqueous ophthalmic microemulsions of tepoxalin |
US5366987A (en) * | 1991-08-22 | 1994-11-22 | Warner-Lambert Company | Isoxazolyl-substituted alkyl amide ACAT inhibitors |
US5117054A (en) * | 1991-09-26 | 1992-05-26 | Ortho Pharmaceutical Corporation | N-hydroxy, N-methyl propanamides |
US5260458A (en) * | 1991-09-26 | 1993-11-09 | Ortho Pharmaceutical Corporation | 2-oxo tetrahydrofuran compounds |
US5550147A (en) * | 1992-02-05 | 1996-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
IL104311A (en) * | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
GB9312853D0 (en) * | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
US5387602A (en) * | 1993-08-30 | 1995-02-07 | Ortho Pharmaceutical Corporation | 1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles |
IL111613A0 (en) * | 1993-11-12 | 1995-01-24 | Rhone Poulenc Rorer Ltd | Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them |
US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
AU3815495A (en) * | 1994-11-08 | 1996-05-31 | Eisai Co. Ltd. | Pyrazole derivatives exhibiting anti-inflammatory and analgesic effects |
JP2001523213A (ja) * | 1994-12-13 | 2001-11-20 | ユーロ−セルティーク,エス.エイ. | 三置換チオキサンチン類 |
US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
CA2206287C (en) * | 1994-12-13 | 2001-03-20 | Mark Chasin | Aryl thioxanthines |
CA2223154A1 (en) | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
EP0833622B8 (de) * | 1995-06-12 | 2005-10-12 | G.D. Searle & Co. | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
US6166041A (en) * | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
US6075016A (en) * | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
US5783597A (en) * | 1997-03-04 | 1998-07-21 | Ortho Pharmaceutical Corporation | 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use |
DE19816880A1 (de) * | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
US6191147B1 (en) | 1998-12-24 | 2001-02-20 | Ppd Discovery, Inc. | Pyrazole compounds and uses thereof |
RU2243967C2 (ru) * | 1999-08-03 | 2005-01-10 | Орто-Макнейл Фармасьютикал, Инк. | Способ получения 1,5-диарил-3-замещенных пиразолов |
CN1649614A (zh) | 2002-02-22 | 2005-08-03 | 新河药品股份有限公司 | 活性剂传递系统和保护及施用活性剂的方法 |
UA79804C2 (en) * | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
AU2003265395A1 (en) * | 2002-08-14 | 2004-03-03 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
US6649638B1 (en) * | 2002-08-14 | 2003-11-18 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
EP1534279A4 (de) * | 2002-08-14 | 2006-11-08 | Ppd Discovery Inc | Prenylierungshemmer mit dimethyl-cyclobutan und verfahren zu ihrer synthese und verwendung |
AU2003275637A1 (en) * | 2002-10-24 | 2004-05-13 | Wakamoto Pharmaceutical Co., Ltd. | Pyrazole-4-alkanoate derivatives inhibiting cyclooxygenase and 5-lipoxygenase |
BR0316332A (pt) * | 2002-12-02 | 2005-09-27 | Astellas Pharma Inc | Composto pirazólico, composição farmacêutica e agente analgésico contendo o mesmo, processo para sua preparação e seu uso e pacote comercial |
US20060194807A1 (en) * | 2003-04-03 | 2006-08-31 | Cosford Nicholas D P | Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5 |
RU2005141571A (ru) * | 2003-07-02 | 2007-07-10 | Янссен Фармацевтика Н.В. (Be) | Модуляторы рецептора сск-1 |
US20050020565A1 (en) * | 2003-07-02 | 2005-01-27 | Jones Todd K. | CCK-1 receptor modulators |
BRPI0413330A (pt) * | 2003-08-29 | 2006-10-10 | Ranbaxy Lab Ltd | inibidores de fosfodiesterase do tipo iv, composição farmacêutica contendo os mesmos e processo para sua preparação |
JP2007518686A (ja) * | 2003-10-17 | 2007-07-12 | 田辺製薬株式会社 | 高コンダクタンス型カルシウム感受性kチャネル開口薬 |
WO2005051931A2 (en) * | 2003-11-26 | 2005-06-09 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
WO2005063716A1 (en) * | 2003-12-22 | 2005-07-14 | Janssen Pharmaceutica, N.V. | Imidazoles and their use cck-1 receptor modulators |
CN101023062A (zh) * | 2004-06-30 | 2007-08-22 | 詹森药业有限公司 | 由立体有择性脱水制造α,β-不饱和酯和酸 |
US7915286B2 (en) | 2005-09-16 | 2011-03-29 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
US20100029728A1 (en) * | 2006-09-22 | 2010-02-04 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
JP2010504323A (ja) * | 2006-09-22 | 2010-02-12 | ランバクシー ラボラトリーズ リミテッド | Iv型ホスホジエステラーゼの阻害物質 |
EP1958947A1 (de) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibitoren für Phosphodiesterase Typ 4 |
EP2124943A1 (de) * | 2007-03-14 | 2009-12-02 | Ranbaxy Laboratories Limited | Pyrazolo[3,4-b]pyridinderivate als phosphodiesterasehemmer |
DK2124944T3 (da) * | 2007-03-14 | 2012-04-23 | Ranbaxy Lab Ltd | Pyrazolo[3,4-b]pyridinderivater som phosphodiesteraseinhibitorer |
WO2009051772A1 (en) * | 2007-10-17 | 2009-04-23 | Duke University | Geranylgeranyl transferase inhibitors and methods of making and using the same |
EP2116539A1 (de) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon |
EP2353591A1 (de) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Verstärkung der analgesischen Wirkung von Opioden und Opiaten bei postoperativem Schmerz und zur Schwächung der Abhängigkeit davon |
EP2353598A1 (de) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Anwendung in der Vorbeugung und/oder Behandlung von postoperativem Schmerz |
EP2388005A1 (de) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma-Liganden zur Vorbeugung und/oder Behandlung von Erbrechen infolge von Chemotherapie oder Strahlentherapie |
EP2395003A1 (de) * | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazolverbindungen als Sigmarezeptor-Inhibitoren |
WO2011161615A1 (en) * | 2010-06-24 | 2011-12-29 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
WO2011161645A1 (en) * | 2010-06-25 | 2011-12-29 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
EP2585453A4 (de) * | 2010-06-28 | 2014-10-22 | Harvard College | Verbindungen zur hemmung einer zellproliferation |
US8492424B2 (en) * | 2010-07-01 | 2013-07-23 | Allergan, Inc. | Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response |
EP2415471A1 (de) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Verwendung von Sigmaliganden bei opioidinduzierter Hyperalgesie |
EP2524694A1 (de) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Verwendung von Sigmaliganden bei Schmerz im Zusammenhang mit Typ-2-Diabetes |
EP2861562B1 (de) * | 2012-06-14 | 2018-05-09 | Mayo Foundation For Medical Education And Research | Pyrazolderivate als hemmer von stat3 |
KR20160097366A (ko) | 2013-12-17 | 2016-08-17 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 세로토닌-노르에피네프린 재흡수 억제제들(SNRIs) 및 시그마 리셉터 리간드들 조합 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE755924A (fr) * | 1969-09-12 | 1971-02-15 | Byk Gulden Lomberg Chem Fab | Derives d'acide pyrazole-4-acetique, leur procede de preparation et medicaments en contenant |
GB1373212A (en) * | 1970-12-07 | 1974-11-06 | Wyeth John & Brother Ltd | Pyrazole compounds |
US3974176A (en) * | 1973-08-16 | 1976-08-10 | Byk-Gulden Lomberg Chemische Fabrik Gmbh | Halogen pyrazoles derivatives, a method for producing these halogen pyrazole derivatives and medicaments containing them |
DE2633992A1 (de) * | 1975-08-08 | 1978-02-09 | Schering Ag | Neue pyrazol-derivate, ihre herstellung und verwendung |
DE2906252A1 (de) * | 1979-02-19 | 1980-08-28 | Merck Patent Gmbh | Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
DE3205187A1 (de) * | 1982-02-13 | 1983-08-25 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylpyrazolderivate, verfahren zu ihrer herstellung, arzneimittel auf basis dieser verbindungen, sowie deren verwendung |
-
1987
- 1987-04-29 US US07/042,661 patent/US4826868A/en not_active Expired - Lifetime
- 1987-05-18 NZ NZ220353A patent/NZ220353A/xx unknown
- 1987-05-27 IL IL82671A patent/IL82671A0/xx unknown
- 1987-05-27 CA CA000538137A patent/CA1337122C/en not_active Expired - Lifetime
- 1987-05-27 NO NO872228A patent/NO172236C/no not_active IP Right Cessation
- 1987-05-27 DK DK273587A patent/DK170202B1/da active Protection Beyond IP Right Term
- 1987-05-27 AU AU73608/87A patent/AU596844B2/en not_active Expired
- 1987-05-28 ES ES87304720T patent/ES2059377T3/es not_active Expired - Lifetime
- 1987-05-28 DE DE87304720T patent/DE3788244T2/de not_active Expired - Lifetime
- 1987-05-28 EP EP87304720A patent/EP0248594B1/de not_active Expired - Lifetime
- 1987-05-28 FI FI872379A patent/FI94340C/fi not_active IP Right Cessation
- 1987-05-28 PH PH35317A patent/PH25126A/en unknown
- 1987-05-28 PT PT84964A patent/PT84964B/pt unknown
- 1987-05-28 HU HU466/87A patent/HU221300B1/hu unknown
- 1987-05-28 DE DE2001199049 patent/DE10199049I2/de active Active
- 1987-05-28 IE IE140387A patent/IE63856B1/en not_active IP Right Cessation
- 1987-05-29 JP JP62134789A patent/JP2512751B2/ja not_active Expired - Lifetime
- 1987-05-29 KR KR1019870005383A patent/KR960007163B1/ko not_active IP Right Cessation
- 1987-05-29 CN CN87103953A patent/CN1028227C/zh not_active Expired - Lifetime
-
1994
- 1994-02-24 HK HK140/94A patent/HK14094A/xx not_active IP Right Cessation
-
2001
- 2001-09-10 NO NO2001016C patent/NO2001016I1/no unknown
- 2001-09-10 LU LU90829C patent/LU90829I2/fr unknown
- 2001-09-10 NL NL300057C patent/NL300057I2/nl unknown
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