DD251785A5 - Verfahren zur Herstellung eines menschlichen, physiologisch aktiven Polypeptids mit Tnf-Aktivität - Google Patents
Verfahren zur Herstellung eines menschlichen, physiologisch aktiven Polypeptids mit Tnf-Aktivität Download PDFInfo
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- DD251785A5 DD251785A5 DD27489385A DD27489385A DD251785A5 DD 251785 A5 DD251785 A5 DD 251785A5 DD 27489385 A DD27489385 A DD 27489385A DD 27489385 A DD27489385 A DD 27489385A DD 251785 A5 DD251785 A5 DD 251785A5
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- German Democratic Republic
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- dna
- tnf
- residue
- physiologically active
- transformant
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Image Analysis (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/597,372 US4879226A (en) | 1984-04-06 | 1984-04-06 | Novel human physiologically active polypeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD251785A5 true DD251785A5 (de) | 1987-11-25 |
Family
ID=24391235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD27489385A DD251785A5 (de) | 1984-04-06 | 1985-04-04 | Verfahren zur Herstellung eines menschlichen, physiologisch aktiven Polypeptids mit Tnf-Aktivität |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US4879226A (no) |
| EP (2) | EP0354592A1 (no) |
| JP (1) | JPS60252496A (no) |
| KR (1) | KR920007399B1 (no) |
| AR (1) | AR240475A1 (no) |
| AU (2) | AU595480B2 (no) |
| BE (1) | BE902119A (no) |
| BG (1) | BG43355A3 (no) |
| BR (1) | BR8501624A (no) |
| CA (1) | CA1341348C (no) |
| CH (2) | CH672790A5 (no) |
| DD (1) | DD251785A5 (no) |
| DK (1) | DK151985A (no) |
| EG (1) | EG17965A (no) |
| ES (1) | ES8704976A1 (no) |
| FI (1) | FI86992C (no) |
| FR (1) | FR2564097B1 (no) |
| GB (1) | GB2158829B (no) |
| GR (1) | GR850836B (no) |
| HK (1) | HK102192A (no) |
| HU (1) | HUT37813A (no) |
| IE (1) | IE58833B1 (no) |
| IL (1) | IL74804A (no) |
| IN (1) | IN163653B (no) |
| IT (1) | IT1218469B (no) |
| JO (1) | JO1365B1 (no) |
| LU (1) | LU85835A1 (no) |
| MA (1) | MA20402A1 (no) |
| MT (1) | MTP963B (no) |
| MY (1) | MY101887A (no) |
| NO (1) | NO174473C (no) |
| NZ (2) | NZ211666A (no) |
| OA (1) | OA07983A (no) |
| PL (1) | PL156392B1 (no) |
| PT (1) | PT80239B (no) |
| RO (1) | RO93650B (no) |
| SG (1) | SG77892G (no) |
| YU (1) | YU57885A (no) |
| ZA (1) | ZA852563B (no) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0695939B2 (ja) * | 1983-12-02 | 1994-11-30 | 大日本製薬株式会社 | ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ |
| DE19975063I2 (de) * | 1984-03-06 | 2005-08-18 | Dainippon Pharmaceutical Co | DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d. |
| US5288852A (en) * | 1984-03-06 | 1994-02-22 | Dainippon Pharmaceutical Co., Ltd. | Human tumor necrosis factor polypeptides |
| JP2584206B2 (ja) * | 1984-08-17 | 1997-02-26 | 大日本製薬株式会社 | ヒト癌壊死因子 |
| US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| JPS60228297A (ja) * | 1984-04-24 | 1985-11-13 | 株式会社 東京タツノ | 給油装置 |
| US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US6686455B1 (en) * | 1984-07-05 | 2004-02-03 | Genentech, Inc. | Tumor necrosis factor |
| GR851626B (no) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
| WO1986002381A1 (en) * | 1984-10-15 | 1986-04-24 | Cetus Corporation | Human tumor necrosis factor |
| JP2675294B2 (ja) * | 1984-10-15 | 1997-11-12 | カイロン コーポレイション | ヒト腫瘍壊死因子 |
| US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| JPS61124392A (ja) * | 1984-11-22 | 1986-06-12 | Asahi Chem Ind Co Ltd | 遺伝子組換体の産生する生理活性物質の精製法 |
| IL73883A (en) * | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
| EP0368367A1 (en) * | 1984-12-21 | 1990-05-16 | Biogen, Inc. | Purification, production and use of tumor necrosis factors |
| JPS6248634A (ja) * | 1985-07-23 | 1987-03-03 | Mochida Pharmaceut Co Ltd | 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物 |
| JPH0698004B2 (ja) * | 1985-09-30 | 1994-12-07 | サントリー株式会社 | Ｔｎｆ発現用新規プラスミド |
| US5059530A (en) * | 1985-09-30 | 1991-10-22 | Suntory Ltd. | Expression vector for human TNF |
| US4677197A (en) * | 1985-10-30 | 1987-06-30 | Cetus Corporation | Purification method for tumor necrosis factor |
| US4894439A (en) * | 1986-05-22 | 1990-01-16 | Cetus Corporation | N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes |
| US4828830A (en) * | 1986-01-24 | 1989-05-09 | Genentech, Inc. | Method and composition for prophylaxis and treatment of viral infections |
| US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| CA1310924C (en) * | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Infective drug delivery system |
| PT84869B (pt) * | 1986-07-31 | 1990-11-07 | Genentech Inc | Metodo para a profilaxia e tratamento de infeccoes por retrovirus e processo para a preparacao de composicoes para esse fim, contendo factor de necrose tumoral |
| DE3716513A1 (de) * | 1987-05-16 | 1988-11-24 | Basf Ag | Proteine mit tnf-wirkung |
| GB2217325B (en) * | 1988-04-08 | 1991-11-20 | British Bio Technology | Synthetic gene for tumour necrosis factor alpha. |
| US5071834A (en) * | 1988-09-16 | 1991-12-10 | Genentech, Inc. | Purified activin B composition |
| US5342613A (en) * | 1988-12-27 | 1994-08-30 | Health Research Inc. | Pharmaceutical compositions and use thereof in the treatment of psoriasis |
| CA2003981C (en) * | 1988-12-27 | 2000-06-13 | Hiroshi Ishimaru | Pharmaceutical compositions and use thereof in the treatment of psoriasis |
| DK0461200T3 (da) * | 1989-02-21 | 1997-03-10 | Univ Washington | Modificerede former af reproduktionshormoner |
| EP0750037A3 (en) | 1989-08-16 | 1997-01-15 | Cetus Oncology Corporation | TNF-convertase and method measuring inhibition of TNF convertase |
| US6586222B1 (en) | 1989-08-16 | 2003-07-01 | Chiron Corporation | Recombinant PR-3 and compositions thereof |
| US5843693A (en) * | 1989-08-16 | 1998-12-01 | Chiron Corporation | Assay method for screening for inhibitors of proTNF conversion |
| US5998378A (en) * | 1989-08-16 | 1999-12-07 | Chiron Corporation | Compositions for the inhibition of TNF hormone formation and uses thereof |
| DE69033710T2 (de) * | 1989-10-24 | 2001-06-13 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Sekretion vom mit Gamma-Interferon Signalpeptid gebundenen humänen Protein |
| US5653974A (en) * | 1990-10-18 | 1997-08-05 | Board Of Regents,The University Of Texas System | Preparation and characterization of liposomal formulations of tumor necrosis factor |
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