DD157344A5 - Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren - Google Patents

Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren Download PDF

Info

Publication number
DD157344A5
DD157344A5 DD80221832A DD22183280A DD157344A5 DD 157344 A5 DD157344 A5 DD 157344A5 DD 80221832 A DD80221832 A DD 80221832A DD 22183280 A DD22183280 A DD 22183280A DD 157344 A5 DD157344 A5 DD 157344A5
Authority
DD
German Democratic Republic
Prior art keywords
compounds
iii
compound
medium
flask
Prior art date
Application number
DD80221832A
Other languages
German (de)
English (en)
Inventor
Richard L Monaghan
Alfred W Alberts
Carl H Hoffmann
George Albers-Schonberg
Henry Joshua
Maria B Lopez
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD157344(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/048,946 external-priority patent/US4231938A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DD157344A5 publication Critical patent/DD157344A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DD80221832A 1979-06-15 1980-06-13 Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren DD157344A5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/048,946 US4231938A (en) 1979-06-15 1979-06-15 Hypocholesteremic fermentation products and process of preparation
US7780779A 1979-09-21 1979-09-21
US11445980A 1980-01-23 1980-01-23

Publications (1)

Publication Number Publication Date
DD157344A5 true DD157344A5 (de) 1982-11-03

Family

ID=27367450

Family Applications (1)

Application Number Title Priority Date Filing Date
DD80221832A DD157344A5 (de) 1979-06-15 1980-06-13 Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren

Country Status (20)

Country Link
EP (1) EP0022478B1 (ro)
AR (1) AR224008A1 (ro)
AT (1) ATE2620T1 (ro)
AU (1) AU535944B2 (ro)
CA (1) CA1161380A (ro)
DD (1) DD157344A5 (ro)
DE (1) DE3062122D1 (ro)
DK (1) DK149003C (ro)
EG (1) EG16957A (ro)
ES (1) ES8105389A1 (ro)
FI (1) FI67231C (ro)
GR (1) GR69216B (ro)
IE (1) IE49685B1 (ro)
IL (1) IL60219A (ro)
NO (1) NO155699C (ro)
NZ (1) NZ193922A (ro)
PL (1) PL125843B1 (ro)
PT (1) PT71371B (ro)
RO (1) RO79487A (ro)
ZW (1) ZW13480A1 (ro)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4395515T1 (de) * 1992-11-04 1994-12-01 Biogal Gyogyszergyar Verfahren zur Isolierung und Reinigung von Mevinolin

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
DE8533814U1 (de) * 1985-11-30 1986-01-16 Beiersdorf Ag, 2000 Hamburg Vorrichtung zum Spülen des Darmes
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
DE3739882A1 (de) * 1987-11-25 1989-06-08 Bayer Ag Substituierte hydroxylamine
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
AU618158B2 (en) * 1989-01-07 1991-12-12 Bayer Aktiengesellschaft New substituted pyrido(2,3-d)pyrimidines
DE3911064A1 (de) * 1989-04-06 1990-10-11 Bayer Ag Substituierte 1,8-naphthyridine
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
NZ245713A (en) * 1992-02-10 1994-12-22 Novopharm Ltd Production of the antibiotic lovastatin from genetically engineered aspergillus strains
CA2062023A1 (en) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
EP0629184A1 (en) * 1992-03-04 1994-12-21 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
DE4244029A1 (de) * 1992-12-24 1994-06-30 Bayer Ag Neue substituierte Pyridine
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
HUP9601808A3 (en) * 1995-07-03 2000-06-28 Sankyo Co Treatment of arteriosclerosis and xanthoma
CN1171400A (zh) * 1996-03-05 1998-01-28 武田药品工业株式会社 呫吨衍生物,其制备和用途
EP2256211A3 (en) * 1997-02-20 2011-02-16 DSM IP Assets B.V. Fermentative production of valuable compounds on an industrial scale using chemically defined media
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
ES2489265T3 (es) 2006-07-05 2014-09-01 Takeda Gmbh Asociación de inhibidores de la HMG-CoA reductasa atorvastatina o simvastatina con un inhibidor de la fosfodiesterasa 4, tal como roflumilast para el tratamiento de enfermedades pulmonares inflamatorias
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4395515T1 (de) * 1992-11-04 1994-12-01 Biogal Gyogyszergyar Verfahren zur Isolierung und Reinigung von Mevinolin
DE4395515C2 (de) * 1992-11-04 1999-06-17 Biogal Gyogyszergyar Verfahren zur Isolierung und Reinigung von Mevinolin

Also Published As

Publication number Publication date
DK254180A (da) 1980-12-16
AU535944B2 (en) 1984-04-12
IL60219A (en) 1985-05-31
AU5901780A (en) 1980-12-18
ES492384A0 (es) 1981-06-01
ES8105389A1 (es) 1981-06-01
AR224008A1 (es) 1981-10-15
PT71371B (en) 1981-10-21
PL224920A1 (ro) 1981-03-27
ATE2620T1 (de) 1983-03-15
IE49685B1 (en) 1985-11-27
FI801857A (fi) 1980-12-16
CA1161380A (en) 1984-01-31
EG16957A (en) 1990-06-30
FI67231B (fi) 1984-10-31
GR69216B (ro) 1982-05-07
NZ193922A (en) 1982-05-25
DK149003B (da) 1985-12-16
ZW13480A1 (en) 1982-02-03
DE3062122D1 (en) 1983-03-31
NO155699C (no) 1987-05-13
NO155699B (no) 1987-02-02
RO79487A (ro) 1982-07-06
PL125843B1 (en) 1983-06-30
NO801775L (no) 1980-12-16
IE801232L (en) 1980-12-15
IL60219A0 (en) 1980-09-16
EP0022478A1 (en) 1981-01-21
DK149003C (da) 1986-08-18
FI67231C (fi) 1985-02-11
PT71371A (en) 1980-07-01
EP0022478B1 (en) 1983-02-23

Similar Documents

Publication Publication Date Title
DD157344A5 (de) Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren
US4342767A (en) Hypocholesteremic fermentation products
US4319039A (en) Preparation of ammonium salt of hypocholesteremic fermentation product
KR830002438B1 (ko) 저 콜레스테린 혈증성 발효 생성물의 제법
DE69018529T2 (de) Phospholipase A2-Inhibitor, Mikroorganismen, die diesen Inhibitor erzeugen und mehrere Verfahren zu seiner Herstellung.
US4294926A (en) Hypocholesteremic fermentation products and process of preparation
US4294846A (en) Hypocholesteremic fermentation products and products of preparation
DE68914495T2 (de) Antihypercholesterolemisches Mittel.
CA1046439A (en) Physiologically active substances from penicillium citrinum
GB2046737A (en) Antihypercholesteraemic Agent, Monacolin K, and Its Preparation
DE3147726A1 (de) Antibiotische komplexe, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten
CH645891A5 (de) Verfahren zur herstellung von monacolin k.
DE69221251T2 (de) Fungizides Mittel, seine Herstellung und Mikroorganismus dafür
US4420491A (en) Hypocholesteremic fermentation products and process of preparation
DE68902670T2 (de) Ks-506 verbindungen und verfahren zu deren herstellung.
DE60019898T2 (de) Mikrobielles verfahren zur herstellung von pravastatin
CH647749A5 (de) Salze und ester von monacolin-k, verfahren zu ihrer herstellung und pharmazeutische praeparate.
DE3112566C2 (ro)
DE3114242A1 (de) Carbonsaeurederivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
GB2111989A (en) New compounds having cholesterol-reducing activity
AU673560B2 (en) Antibiotic agents
DE2517853A1 (de) Azdimycin
US5304485A (en) Antibiotic producing microorganism
DE3788761T2 (de) Physiologisch aktive Substanz FA-4283, Derivate und ihre Herstellung.
WO1994008940A1 (en) Acyclic tricarboxylic acid compounds