CZ49498A3 - Delousing preparations, repellent mixtures for repelling insects, liquid creams and sprays - Google Patents

Abstract

Insect repellent blends, lotions, and sprays are provided. The insect repellent blend includes crystalline 3,8 P-menthanediol (Chinese crystal), and at least two of citronella, geraniol, terpineol and rhodinol. For mosquito and tick repellency, the blend is dissolved or dispersed in a conveying medium so that the resulting product preferably has weight percentages of approximately 0.05 % citronella, approximately 0.06 % geraniol, approximately 0.08 to 0.5 % crystalline 3,8 P- menthanediol approximately 0.06 % terpineol and/or approximately 0.08 % rhodinol. For lice treatment, the blend is preferably dissolved or dispersed in a water based conveying medium so that the resulting product has weight percentages of approximately 0.36 % citronella, approximately 0.43 % geraniol, approximately 2 % crystalline 3,8 P-menthanediol, approximately 0.43 % terpineol and/or approximately 0.57 % rhodinol.

Description

• ·· ··· ·· ·· · ·

Desinfectants, insect repellents, liquid creams and sprays

Technical field

The invention relates to repellents including anti-lice compositions. In particular, they are synergistic mixtures of natural insect repellents which can be used together with the carrier as insecticidal repellents, liquid creams or sprays or for desulphurization. The repellent compositions, when deposited on a carrier, are suitable for application to humans and animals, being non-toxic in the form of liquid cream, sprays, and particularly suitable for treating (including but not limited to) mosquito repellent and lice repellent and / or killing. and limiting the development of their eggs (nits).

BACKGROUND OF THE INVENTION

To date, a wide range of liquid creams and sprays have been utilized in the development of insect repellents which contain N, N, -diethylm-toluamide (DEET) as active ingredients. Although DEET is an effective repellent, it does not have a pleasant odor, it can burn when applied and has a number of undesirable side effects, especially on humans. DEET irritates eyes, mucous membranes and sensitive skin, and since it is absorbed through the skin and can thus penetrate the skin through the skin, consequences in the form of toxic systemic reactions are also possible. Many of these side effects have been reported in the literature and are mainly associated with topical application of DEET. Other symptoms and drawbacks associated with repeated use of DEET include irritability, confusion, insomnia, encephalopathy and coma. This results in warning data obtained by state organizations when using DEET.

The potential risks associated with the use of DEET-containing products as an active substance indicate that there is a great need to develop a comparable replicate product that will not be as dangerous to the objects being treated.

Various plant (leaf and / or flower) extracts are known to be useful in repelling insects. For example, lemon oil is generally known in the literature as an insect repellent, although it is not as effective as DEET.

Co-owned US Patents 5,227,406 and 5,446,922, which are hereby incorporated by reference, disclose a non-toxic, fully natural insecticidal repellent comprising terpinol ("T"), citronella ("C") and one or both extra rhodinols ( "R" and / or geraniol ("G") as active ingredients which are contained in a carrier medium. The active ingredients are preferably used in small concentrations, e.g. at concentrations of 0.01%, preferably at concentrations of 0.05 to 0.08%, and even more preferably at concentrations of less than 1%, which are synergistically effective, particularly against mosquitoes and with some probability also against other insects such as ticks carrying Lyme disease. The carrier medium may be selected as a cosmetic moisturizer, with or without a sunscreen factor. For sprays, the carrier medium may be water or may be alcohol-based. A pleasant and unobtrusive fragrance is achieved at about 0.4% of the repellent product since such a low concentration of odor of the active ingredient is well maskable (against human perception). The liquid creams or sprays of these patents are safely applicable in any amounts to humans and animals, with no undesirable side effects such as skin irritation. In the control tests, the combination of the T, C, G and R components was found to be effective due to the synergistic interaction between the individual components, and that the sub combinations, only T with C and R or T with C and G are themselves synergistic. The best results are obtained with a repellent having the following concentrations of the individual components: 0.06% T, 0.05% C, 0.08% R and 0.06% G.

• 999 ·

It has been reported in the literature that derivatives derived from a plant, known as "Chinese crystals," are also effective plant insect repellents. Chinese crystal, a naturally occurring component of essential oil obtained from China, is commercially available from Shaw Mudge & Company, Stamford, CT under the name "Chinese Botanical I". This substance is a crystalline compound, commonly known as 3,8-p-menthanediol (also known as 2-hydroxy-α, α, 4-trimethylcyclohexanmentane), which has the structure of the molecule shown below by Structural Formula I:

SUMMARY OF THE INVENTION

As is apparent from the foregoing, it is an object of the present invention to provide effective and safe compositions for controlling insects and repellents containing such compositions and a carrier medium. Another object of the invention is to: find an effective insecticidally repellent composition which is dispersed or dissolved in a carrier medium or used in conjunction with the medium, the medium being liquid creams, sprays and the like, solving an effective insecticidal repellent having pleasant smell based on mixtures, sprays and creams, which effectively repels mosquitoes and other insects, and which effectively repels lice and limits the development of their eggs (nits). Another object of the invention is to find a safe and effective insect repellent composition in a carrier medium that can be applied arbitrarily to the faces, skin, hair and clothing of a person. Another object is to provide safe and effective insect repellents for use in animals. Another goal is to find an insect repellent or a method of insect repellent · ·

Lice removal using generally safe plant and flower extracts or natural oils but achieving efficacy comparable to DEET and to solve insect repellents that can be impregnated into the product or plastic, incorporated into sprayable fluids and used for other purposes such as surface treatment.

These objects are solved according to the invention by an insect repellent composition comprising a Chinese crystal (CC) and at least two components selected from the group consisting of citronella (C), geraniol (G), terpinol (T) and rhodinol (extra) (R). For insect repellents such as mosquitoes or ticks, the composition of the invention preferably comprises about 5% to 25% C, about 5% to 25% G, about 30% to 75% CC and T and / or R at a concentration of about 5% % to 30% by weight, wherein the percentages of the components are based on the sum of the components of the mixture which is 100% by weight. The composition is usually dispersed or dissolved in a carrier medium such as a cream, spray or the like. When dispersed or dissolved in this way, the concentration of the components in the overall formulation generally ranges from about 0.01 to 1 weight percent of each of the components C, G and T and / or R, and 0.01 to 5 weight percent CC, the remainder being supplemented with carrier medium. The carrier medium may contain one or more humectants, sun protection agents, perfumes and other additives.

According to a further aspect of the invention, the insect repellent composition comprises CC and at least two of C, G, T and R are used at higher concentrations (greater than 1% and preferably 2% to 5% based on the total formulation) for lice removal. . In particular, an embodiment is preferred wherein the insect repellent and lice removal composition comprises about 7% citronella, about 9% gerol, about 9% terpinol, and about 75% Chinese crystal. The mixture is then supplemented with a carrier, wherein the content of the active mixture in the formulation is about 4% by weight. A preferred carrier is leave in hair conditioner

or a spray skin conditioner comprising water, hair and skin conditioner (s), moisturizer (s), lubricant (s), stabilizer (s) and emulsifier (s).

Other objects and advantages of the invention are advantages which will be elucidated in other exemplary embodiments, and will be apparent to those skilled in the art from the information obtained from the detailed description in conjunction with the accompanying drawings.

Brief Description of the Drawings

Giant. 1 is a graphical representation of the mean repellent activity as a percentage of the number of punctures compared to the control in the mosquito repellent test, for each embodiment of the invention and for each component separately.

Giant. 2 is a graph of the intervals at which the reading is 95% probable (hereinafter "95% confidence intervals") and theoretical values assuming mere additive efficacy ("additive model") for another particular embodiment of the repellent of the invention.

Giant. 3 is a graph of 95% confidence intervals and theoretical values for an additive model for another particular embodiment of a repellent according to the invention.

Giant. 4 is a graph of 95% confidence and sensitivity intervals of a test object for one particular embodiment of a repellent according to the invention

Giant. 5 is a graph of 95% confidence and sensitivity intervals of a test object for yet another particular embodiment of a repellent according to the invention.

• · · ·

Giant. Figures 6a to 6f are graphical representations of the numbers of live eggs (nits) and lice and dead eggs (nits) and lice in six subjects tested over a test period of several days.

Detailed Description of Examples of Preferred Embodiments

The insect repellent composition of the present invention comprises a combination of a Chinese crystal, at least two components from the group comprising citronella, geraniol and carpineol or rhodinol (extra). Preferably it comprises a mixture of CC, C, G and T and / or R. The mixture is usually dispersed or dissolved in a carrier medium such as a cream, spray or the like. For the purpose of mosquito repellency, 4 embodiments of the invention were tested in comparison to individual components of all embodiments and with untreated control. Table 1 lists the individual components (1 to 6) contained in particular embodiments of the invention and their percentages by weight, based on the carrier without the antifouling agent, of the Lubriderm ™ skin care cream. Table 1 also lists four embodiments of the invention (Nos. 7 to 10), indicating the concentration of the active ingredients in each embodiment by weight based on the carrier, again formed by the Lubriderm ™ skin cream without perfuming agents. The first two embodiments, represented by combination 1A (No. 7 in Table 1) and combination 1B (No. 8 in Table 1), contain CC, C, G and T as components and differ only in a CC concentration of 0.5% in one case and 0.08% in the other The two other embodiments represented by combination 2A (No. 9 in Table 1) and combination 2B (No. 10 in Table 1) contain CC, C, G and R and differ only from each other. at a CC concentration of 0.5% in one case and 0.08% in the other case No. 11 in Table 1 represents a control experiment, consisting of 100% Lubriderm ™ •

Table 1: Overview of ingredients, combinations and control experiments:

Component

Concentration (%)

1) Citronella 0.05 2) Geraniol 0.06 3) Rhodinol Extra 0.08 4) Terpinol 0.06 5) Chinese crystal 0, 08 6) Chinese crystal 0.05 7) Combination 1A: Chinese crystal 0.5 Citronella 0.05 Geraniol 0, 06 Terpinol 0.06 8) Combination 1B: Chinese crystal 0, 08 Citronella 0.05 Geraniol 0.06 Terpinol 0, 06 9) Combination 2A: Chinese crystal 0.5 Citronella 0.05 Geraniol 0.06 Rhodinol Extra 0.08 10 ) Combination 2B: Chinese crystal 0.08 Citronella 0.05 Geraniol 0.06 Rhodinol Extra 0, 08

11) Lubriderm ™ perfume-free (control) 100

Each of the components, combinations and controls listed in Table 1 was tested in a manner in which people were manually treated with one milliliter of the mixture and subjected to a mosquito attack (Aedes aegypti). The mosquitoes were housed in cubic plexiglass (Plexiglas ™) cages (0.3 m cube edge) in which 200 mosquitoes were placed per sweetened water per cage. The tests were performed by placing the treated subject's hand in the cage and counting the number of punctures over 15 seconds. Tests were performed for each HOx component as well as for each combination and for each control. Testing was performed on 7 subjects. The hands of the test subjects were washed with a mild soap between each two tests. Treatments of the test subjects were performed randomly and individually. The number of punctures treated with the control mixture over a 15 second period varied between 5-33 for all 110 control mixture tests, with an average of 17.33 and a standard deviation of 6.65. Data from 1210 tests were collected from various test subjects and subjected to mathematical processing. Average values were calculated at 95% confidence intervals. The 95% confidence interval is the range obtained from the data set within which it is assumed to place the next predicted result of the experiment with a probability of 95% under the same experimental conditions. Table 2 shows the calculated results for each treatment, expressed as% of the number of punctures compared to the control. Obviously, a lower value of these% means a higher repellent effect.

Table 2: Mean repellent values and 95% confidence intervals for each component and combination, expressed as% of stab count versus control

Treatment Bottom 95% limit I.S. Diameter Upper me from 9 5% I.S. 1) Citronella 0.05% 69, 8 81 91.4 2) Geraniol 0,06% 73 81.5 90 3) Rhodinol E. 0.08% 73 82 90 4) Terpinol 0,06% 74 85 95 5) Chinese crystal 0.5 45.4 52.6 59, 8 6) Chinese crystal 0.08 60 67.1 74.3 7) Combination 1A (CC 0.5%) 9.2 11.3 13.4 8) Combination 1B (CC 0.08%) 14.8 17.7 20.7 9) Combination 2A (CC 0.5%) 10.3 13.1 15.8 10) Combination 2B (CC 0.08%) 13.3 17.7 22.0

As shown in Table 2, the average repellent effect of C, G, R and T in individual testing varies between 81-85% of the number of punctures compared to the control. CC (rows 6 and 7) showed a better repellent effect, having this value of about 52 to 67% of the punctures compared to the control. Each of the combinations (lines 7 to 10) exhibits a significantly better repellent effect than the individual components themselves, i.e., " the effect on the combinations is about 11 to 18% of the punctures compared to control.

The mean values shown in Table 2 are shown graphically in Figure 1. From Table 2 and Figure 1, it can be seen that the most effective treatment was achieved by combination 1A (line 7).

Table 2 and Fig. 1), which contained about 0.06% T, about 0.05% C, about 0.06% G and 0.5% CC, and which had a median repellent effect of 11.3%. Combination 2A (line 9 of Table 2 and Fig. 1) containing about 0.08% R, about 0.05% C, about 0.06% G, and about 0.5% CC was almost as effective as the combination previous, and showed an average repellent efficiency of 13.1%. Combination 1B (line 8 of Table 2 and Fig. 1) containing about 0.06% T, about 0.05% C, about 0.06% G and about 0.08% CC, and combination 2B (line 10 of Table 2) and Fig. 1), which contained about 0.08% R, about 0.05% C, about 0.06% G and about 0.08% CC, had the same average efficiency, i.e. 17.7%. These results indicate that increasing the Chinese crystal concentration significantly increases the repellent effect and that the proportion of Rhodinol Extra in the effect is substantially the same as that of Terpinol.

Analytically processed data from 1210 experiments were analyzed using a factorial additivity model. Using this model, and determining the 95% confidence interval for each component, all combinations were synergistic, mathematically effective to each other, as if the benefits of the components were only additive. The resulting mean and the "predicted additive effect" determine the mean and confidence interval that would be expected for combinations if each component were simply additive.

Thus, the expected mean additive repellent effect of combination 1A was calculated by adding up the observed mean repellent effects of each component of combination 1A. Referring to Table 2, this value of expected average repellent effect of combination 1A is 29.52% = (81% x81.5% x85% x52.6%). Similarly, the expected 95% confidence interval (assuming additive efficacy) for combination 1A is 17.12% to 46.73%. Obviously, the observed average repellent effects of Combination 1A were 11.3%, a value much lower than the expected ratio at 4 &apos;. &quot; 4 &quot; · Assuming an additive efficacy of 29.52%. In addition, the confidence interval of the observed 1A treatment results (9.2% to 13.4%) is well below the confidence interval for the expected value, that is, 17.2% to 46.73%. A comparison of the observed mean and confidence interval for the 1A combination and the expected average assuming additivity is shown graphically in Figure 2. The fact that these confidence ranges do not overlap anywhere for the 1A combination and the additivity assumption model shows that the difference between the model and the data obtained for combination 1A, p <0.05 is significant. In other words, the interaction between the components of combination 1A is likely to be synergistic rather than additive.

(at least 95%

The same mathematical analysis was followed by data obtained for combination 1B and its result is shown graphically in Figure 3. With reference to Table 2, it can be seen that the expected mean repellent effects of combination 1B are 37.65% = (81% x 81.5 % x 85% x 67.1%). The expected 95% confidence interval (assuming additivity) for combination 1B is 22.62 to 58.06%. It can be seen that the observed average repellent effect of combination 1B was in fact 17.7%, which is much less than the expected effect of 37.65%. Furthermore, it should be noted that the confidence interval of the observed results when treated with combination 1B (14.8% to 20.7%) is well below the expected confidence interval of 22.62% to 58.06%, and these values do not overlap anywhere. These results indicate that the components in combination 1B are at least 95% likely to act synergistically rather than additively.

Figure 4, referring to Table 2, shows the average repellent effects of combination 2A, with an average value of 28.47%. The expected 95% confidence interval (assuming additivity) for combination 2A is 18.69% to 44.27%. Obviously, the observed average repellent effect of combination 2A was actually 13.1%, which is much less than the expected average

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of the invention take many forms. For example, the insect repellent of the invention may be incorporated into carriers including, but not limited to, liquid creams, sprays, foams, liquids, fat creams, powders, soaps, perfumes, etc. In practice, such creams, sprays, soaps, powders, perfumes and the like can be added to other active ingredients, e.g., sunscreen, sunscreen, moisturizer, and the like. Likewise, the insect repellent of the invention can be impregnated into the article or plastic by methods well known in the art, the carrier medium being in that case said product or plastic. Further, the insect repellent of the invention can be used in other applications such as surface treatment and incorporation of the repellent in waxes or other surface coatings and compositions. In addition, it should also be noted that although particular embodiments of the invention have been described for use on human skin and tested for repellent activity against mosquitoes, the insect repellent effect is also expected to be against other insect species (as discussed below with reference to FIG. 6a to 6f) and can be used on animals in addition to humans.

According to another aspect of the invention, the insect repellent composition comprises CC, and one or more components selected from the group consisting of C, G, T and R, and can be used in higher corrections (e.g. greater than 1% and preferably 2% to 5%). % of the total formulation) for lice control. A particularly preferred embodiment is a lice control insect repellent composition comprising about 7% citronella, about 9% geraniol, about 9% terpinol, and about 75% Chinese crystal. The composition is solved in combination with a carrier, wherein the content of the active compound mixture is about 3% by weight of the total formulation. A preferred carrier is a leave in hair and skin conditioner spray comprising water, hair and skin conditioner (s), a moisturizer (s), a lubricant (s), a stabilizer (s) and an emulsifier (s). Conditioners act to improve hair (and skin) properties by binding to hair (and skin) proteins. The humectants hold water in the hair (including insect repellent compositions that are emulsified and / or dissolved in water). Lubricants work to give hair better combability. The stabilizers counteract the breakdown of proteins that may be present in the conditioners. Emulsifiers emulsify the repellent mixture, the lubricant and other additives with water.

In lice control, another aspect of the invention is a repellent composition that has been prepared from about 7% C, about 9% G, about 9% T, and about 75% CC by weight. The mixture in combination with the flavoring agent, which acts as a masking agent, was added to the aqueous sprayable medium (carrier) to form the resulting formulation. A leave-in carrier was used, a hair spray conditioner containing water, hair and skin conditioners, humectants, lubricants, stabilizers and emulsifiers known in the art. The formulation ingredients in weight percent were as follows:

water 91, 41 % conditioners 2.53 % humectants 1.59 % lubricants 0.12 % stabilizers 0.11 % emulsifiers 0, 99 % aroma (mask) 0.33 0 O repel. mixture 3.22 %

Using the lice control formulation thus prepared, tests were performed on 6 subjects using the following procedure. On the first day, the back of the scalp of each test subject's head was scored for the number of nits and lice occurring at 20 folds, and the samples were stored for microscopic examination to determine the number of live and dead nits and lice. The anti-lice conditioner was applied as a hair spray while the hair was continually moistened. On the third and the next day, the hair was re-combed, the obtained samples were stored and evaluated, and the conditioner was re-applied in the same manner as above. 6 people have used • · · · · · ·

the conditioner and comb are subjected to other applications daily during the tests.

and only 2 people were

Before explaining Figures 6a to 6f, it should be noted that the figures given are mere samples and may not be the only values applicable to the population. In addition, some people lived in households in which the environment and other family members were contaminated, so that some people could be recruited after starting treatment. It should further be noted that freshly laid eggs hatch after 7 to 11 days and maturity is manifested about 8 days afterwards. In Figures 6a to 6f it can be seen that the information had an effect on all persons on the first, third, fifth day and in the case of person # 1 (Fig. 6a) on the 10th day. It should be noted that in almost no cases dead eggs (except for person # 6) were found and live individuals (except for person # 4) were found and live eggs (except for person # 5). On day 3, live lice were exterminated in persons # 1, # 2, and # 6, but in person # 1 they reappear on day 5 and were suppressed on day 10. In addition, on day 5, live lice and live eggs were suppressed in all persons except person # 1, who were suppressed on day 10.

In the first screening tests for lice activity, the following results were obtained. The combing and use of anti-lice compositions reduces the number of new eggs on the test subjects hair to zero, and all six persons had no newly laid eggs for at least two weeks after the test described. The combing alone was not able to eliminate the attack, since not all hair, including the scalp, was combed, and twenty combing is a small number to achieve this effect. Many individuals responded to the treatment by moving from the skin to the top of the head elsewhere, making it easier to remove them. In addition, as reported by all individuals who had the first lice removal experience, spray application made it easier for them to comb and remove lice.

• · · · · · · · · · · · · ·

A second test of the prepared composition was carried out with a pregnant female lice which was allowed to lay 9 eggs on the hair near the shoulders of the test subject. Five of these eggs were treated with the conditioner of the invention, while the remaining four were left untreated. The eggs were kept separately in petri dishes with filter paper layers. All untreated eggs showed normal development. None of the treated eggs further developed.

Tests on lice that have been performed show that treatment with the composition of the invention has at least partially been manifested as oval mortality (ovicidal effect). The absence of subsequent infestation in six subjects at the first test indicates that no live eggs were present at the time of application and that the use of re-treatment, especially after an interval roughly corresponding to the time of insect development, had a significant infestation-reducing effect.

A synergistic insect repellent has been described comprising a composition comprising Chinese crystal, citronella, geraniol and either terpinol or rhodinol (extra), which can be dispersed or dissolved in a carrier medium such as a liquid cream or spray, wherein the mixture can include a small amount of carrier medium. . Although specific embodiments have been described, these examples are not to be construed as limiting the invention to them. The invention is as broad as possible within the scope of the art and use. Thus, although preferred active agent concentrations and preferred concentration ranges have been reported, it will be apparent to those skilled in the art that even different relative percentages of active ingredients within or outside these preferred ranges may also be used, and it is not known which combination is of these preferred embodiments is most preferred. In addition, although insect repellent activity has been tested and the tests described in the description are directed to mosquitoes and lice, it is to be assumed that the repellent activity is also effective against other insect and mite species including ticks. Accordingly, it is not difficult for a person skilled in the art to make further modifications without departing from the spirit of the invention and without departing from the scope as protected by the following claims.

Claims (21)

PATENT REQUIREMENTS modified ·· * i • · An insect repellent comprising: a mixture of crystalline 3,8-p-menthanediol and at least two of the group consisting of citronella, geraniol, terpinol and rhodinol. Insect repellent according to claim 1, characterized in that said at least 2 substances from the group comprising citronella, geraniol, terpinol and rhodinol are citronella, geraniol and terpinol and / or rhodinol. 3. An insect repellent according to claim 2, comprising: geraniol in an amount of about 5% to 25% by weight of said composition, citronella in an amount of about 5% to 25% by weight of said composition, crystalline 3,8-p-menthanediol in an amount of about 30% to 75% by weight of said mixture and terpinol and / or rhodinol in an amount of about 5% to 50% based on the total amount of the mixture. The insect repellent of claim 1, further comprising a carrier medium, wherein the active ingredient mixture is dispersed, dissolved or carried in said carrier medium. An insect repellent according to claim 2, further comprising a carrier medium in which said mixture is dispersed, dissolved or otherwise contained, wherein the geraniol is present in an amount of at least 0.01% based on the insect repellent. citronella is at least 0.01%, repellent, terpinol and / or rhodinol is at least 0.01% repellent, and crystalline 3,8-p-menthanediol at least 0.01% insect repellent, all of said insect repellents. percentages are by weight. Insect repellent according to claim 5, characterized in that it contains geraníol in an amount of not more than 1% of the insect repellent, citronella in an amount of not more than 1% of the insect repellent, terpinol and / or rhodinol in an amount of not more than 2% of the insect repellent. crystalline 3,8-p-menthanediol in an amount of not more than 5% of the insect repellent, all percentages being by weight. 7. An insect repellent according to claim 5, characterized in that: geraníol is present in an amount of about 0.01% to 1% based on the total amount of the repellent, citronella is present in an amount of about 0.01% to 1% of the repellent, terpinol and / or rhodinol is present in an amount of about 0.01% to 2% and crystalline 3,8-p-menthanediol in an amount of about 0.01% to 5% based on the total weight of the insect repellent, all percentages being by weight. 8. An insect repellent according to claim 7, comprising 3,8-p-menthanediol in an amount of about 0.08% by weight based on the total weight of the insect repellent. team An insect repellent according to claim 7, characterized in that it contains 3,8-p-menthanediol in an amount 9. about 0.5% by weight based on the total weight of the insect repellent. 10. An insect repellent according to claim 7, comprising 3,8-p-menthanediol in an amount of about 1 to 3% by weight based on the total weight of the insect repellent. Insect repellent according to claim 8, characterized in that it contains geraniol in an amount of about 0.06% by weight based on the total weight of the insect repellent, citronella in an amount of about 0.05% by weight based on the total weight of the insect repellent and terpinol and / or rhodinol in an amount of about 0.06% to 0.014% by weight based on the total weight of the insect repellent. Insect repellent according to claim 9, characterized in that it contains geraniol in an amount of about 0.06% by weight based on the total weight of the insect repellent, citronella in an amount of about 0.05% by weight based on the total weight of the insect repellent and terpinol and / or rhodinol in an amount of about 0.06 to 0.014 weight based on the total weight of the insect repellent. Insect repellent according to claim 10, characterized in that it contains geraniol in an amount of about 0.4% by weight based on the total weight of the insect repellent, citronella in an amount of about 0.4% by weight based on the total weight of the insect repellent, terpinol and / or or rhodinol in an amount of about 0.4 to 1% by weight based on the total weight of the insect repellent and 3,8-p-menthanediol in an amount of about 2% by weight based on the total weight of the insect repellent. • «s e e e s e 14. A decongestant comprising: a mixture of crystalline 3,8-p-menthanediol with at least two substances selected from the group consisting of citronella, geraniol, terpinol and rhodinol, all supported by a carrier. 15. The luminous composition of claim 14, wherein said at least two substances selected from the group consisting of citronella, geraniol, terpinol and rhodinol include citronella, geraniol and terpinol and / or rhodinol. 16. The luminous composition according to claim 15, wherein geraniol is present in an amount of about 0.01% to 1% by weight based on the weight of the composition used, citronella is present in an amount of about 0.01% to 1% by weight the device used, 3,8-p-menthanediol is present in an amount of 0.01% to 5% by weight of the composition used, terpinol and / or rhodinol is present in an amount of about 0.01% to 2% by weight of the composition used and carrier the medium comprises a substantially equilibrium amount of the louse agent. 17. The luminant composition of claim 15, wherein said carrier is an aqueous sprayable medium. 18. The luminous composition of claim 17, wherein the carrier comprises water, a hair conditioner, a moisturizer, and an emulsifier. 29. The luminant composition of claim 18, wherein said carrier medium further comprises a lubricant and a stabilizer. 9,999 ·· ···· »» « 20. The luminous composition of claim 18, wherein said carrier further comprises an aromatic masking agent that substantially masks the unpleasant odor of geraniol, citronella, 3,8-pmenthandiol, and terpinol and / or rhodinol. 21. A method for desulphurisation, comprising treating a space infested with crystalline 3,8-p-menthanediol and at least one of the group consisting of citronella, geraniol, terpinol and rhodinol, all of which are supported. 22. The method of claim 21, wherein the carrier is a water-based carrier and wherein the lice area is moistened in the treatment.