CY2023014I2 - Αντι il-36r αντισωματα - Google Patents
Αντι il-36r αντισωματαInfo
- Publication number
- CY2023014I2 CY2023014I2 CY2023014C CY2023014C CY2023014I2 CY 2023014 I2 CY2023014 I2 CY 2023014I2 CY 2023014 C CY2023014 C CY 2023014C CY 2023014 C CY2023014 C CY 2023014C CY 2023014 I2 CY2023014 I2 CY 2023014I2
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- Prior art date
Links
- 101000852965 Homo sapiens Interleukin-1 receptor-like 2 Proteins 0.000 title 1
- 229940099539 IL-36 receptor antagonist Drugs 0.000 title 1
- 102100036697 Interleukin-1 receptor-like 2 Human genes 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/20—Dermatological disorders
- G01N2800/205—Scaling palpular diseases, e.g. psoriasis, pytiriasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161560554P | 2011-11-16 | 2011-11-16 | |
| US201261644111P | 2012-05-08 | 2012-05-08 | |
| US201261713713P | 2012-10-15 | 2012-10-15 | |
| PCT/US2012/064933 WO2013074569A1 (en) | 2011-11-16 | 2012-11-14 | Anti il-36r antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CY2023014I2 true CY2023014I2 (el) | 2023-11-15 |
| CY2023014I1 CY2023014I1 (el) | 2023-11-15 |
Family
ID=47215803
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191101185T CY1122278T1 (el) | 2011-11-16 | 2019-11-12 | Αντι il-36r αντισωματα |
| CY2023014C CY2023014I1 (el) | 2011-11-16 | 2023-05-23 | Αντι il-36r αντισωματα |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191101185T CY1122278T1 (el) | 2011-11-16 | 2019-11-12 | Αντι il-36r αντισωματα |
Country Status (40)
| Country | Link |
|---|---|
| US (4) | US9023995B2 (el) |
| EP (2) | EP3536710A1 (el) |
| JP (3) | JP6289375B2 (el) |
| KR (3) | KR20200110476A (el) |
| CN (5) | CN107007833B (el) |
| AP (1) | AP2014007571A0 (el) |
| AR (1) | AR089178A1 (el) |
| AU (1) | AU2012339734B2 (el) |
| BR (1) | BR112014011594B1 (el) |
| CA (1) | CA2852994C (el) |
| CL (1) | CL2014001123A1 (el) |
| CO (1) | CO7020871A2 (el) |
| CY (2) | CY1122278T1 (el) |
| DK (1) | DK2780373T3 (el) |
| EA (1) | EA031948B1 (el) |
| EC (1) | ECSP14004976A (el) |
| ES (1) | ES2755732T3 (el) |
| FI (1) | FIC20230020I1 (el) |
| FR (1) | FR23C1023I2 (el) |
| HR (1) | HRP20191835T1 (el) |
| HU (2) | HUE047437T2 (el) |
| IL (2) | IL232100B (el) |
| LT (2) | LT2780373T (el) |
| LU (1) | LUC00308I2 (el) |
| MX (1) | MX347164B (el) |
| MY (1) | MY195289A (el) |
| NL (1) | NL301233I2 (el) |
| NO (2) | NO2023024I1 (el) |
| PE (1) | PE20142041A1 (el) |
| PH (1) | PH12014501108A1 (el) |
| PL (1) | PL2780373T3 (el) |
| PT (1) | PT2780373T (el) |
| RS (1) | RS59248B1 (el) |
| SG (1) | SG11201402283PA (el) |
| SI (1) | SI2780373T1 (el) |
| TW (1) | TWI573804B (el) |
| UA (1) | UA115540C2 (el) |
| UY (1) | UY34456A (el) |
| WO (1) | WO2013074569A1 (el) |
| ZA (1) | ZA201402491B (el) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3604339T (pt) | 2011-01-14 | 2021-04-13 | Univ California | Anticorpos terapêuticos contra a proteína ror-1 e métodos para utilização dos mesmos |
| DK2780373T3 (da) | 2011-11-16 | 2019-11-04 | Boehringer Ingelheim Int | Anti-IL-36R-antistoffer |
| JP6089047B2 (ja) | 2012-02-24 | 2017-03-01 | アッヴィ・ステムセントルクス・エル・エル・シー | Ｄｌｌ３モジュレーター及び使用方法 |
| EA201691765A1 (ru) * | 2014-03-14 | 2016-12-30 | Новартис Аг | Молекулы антител против lag-3 и их применения |
| RU2582569C2 (ru) * | 2014-07-24 | 2016-04-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Днк, кодирующая полноразмерный антагонист рецептора интерлейкина-36 человека, днк, кодирующая полноразмерный антагонист рецептора интерлейкина-36 человека с с-концевым полигистидиновым тагом, плазмидный экспрессионный вектор (варианты), штамм бактерий escherichia coli bl21 star[de3] (рет-il36raf), - продуцент полноразмерного рецепторного антагониста интерлейкина-36 и штамм бактерий escherichia coli bl21 star[de3] (pet-il36raf-his), - продуцент полноразмерного рецепторного антагониста интерлейкина-36 с с-концевым полигистидиновым тагом |
| KR102711906B1 (ko) | 2015-04-01 | 2024-09-27 | 아납티스바이오, 아이엔씨. | T 세포 면역글로불린 및 뮤신 단백질 3 (tim-3)에 대한 항체 |
| WO2016168542A1 (en) | 2015-04-15 | 2016-10-20 | Anaptysbio, Inc. | Antibodies directed against interleukin 36 receptor (il-36r) |
| WO2016201282A2 (en) * | 2015-06-12 | 2016-12-15 | Ludwig Institute For Cancer Research Ltd | TGF-β3 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF |
| JP6654773B2 (ja) * | 2015-12-25 | 2020-02-26 | 国立大学法人名古屋大学 | インターロイキン３６受容体アンタゴニスト欠損症の治療薬 |
| WO2018085469A2 (en) | 2016-11-01 | 2018-05-11 | Anaptysbio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| CA3049536A1 (en) | 2017-01-09 | 2018-07-12 | Tesaro, Inc. | Methods of treating cancer with anti-tim-3 antibodies |
| JP2020512344A (ja) * | 2017-03-27 | 2020-04-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗ｉｌ−３６ｒ抗体併用治療 |
| US11207294B2 (en) * | 2018-01-08 | 2021-12-28 | Chemocentryx, Inc. | Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2 |
| CN112272674A (zh) | 2018-03-14 | 2021-01-26 | 勃林格殷格翰国际有限公司 | 抗-il-36r抗体用于治疗泛发性脓疱性银屑病的用途 |
| US20190284273A1 (en) * | 2018-03-14 | 2019-09-19 | Boehringer Ingelheim International Gmbh | Use of anti-il-36r antibodies for treatment of inflammatory bowel disease |
| SG11202012360YA (en) * | 2018-07-16 | 2021-01-28 | Regeneron Pharma | Anti-il36r antibodies |
| WO2020018511A1 (en) * | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
| EP3837283B1 (en) | 2018-08-16 | 2024-04-17 | Cantargia AB | Anti-il1rap antibody compositions |
| JP2022503865A (ja) * | 2018-09-28 | 2022-01-12 | 協和キリン株式会社 | Ｉｌ－３６抗体とその用途 |
| EP3898673A1 (en) * | 2018-12-21 | 2021-10-27 | 23Andme, Inc. | Anti-il-36 antibodies and methods of use thereof |
| CA3124996A1 (en) | 2018-12-27 | 2020-07-02 | Boehringer Ingelheim International Gmbh | Il-36r antibodies for treatment of palmoplantar pustulosis |
| MX2021010783A (es) * | 2019-03-08 | 2021-09-30 | Boehringer Ingelheim Int | Formulaciones de anticuerpo anti-il-36r. |
| WO2021112196A1 (ja) * | 2019-12-05 | 2021-06-10 | 学校法人東京薬科大学 | 筋組織の減少を抑制するための組成物 |
| AR120913A1 (es) * | 2019-12-27 | 2022-03-30 | Teijin Pharma Ltd | Anticuerpo que inhibe específicamente la señalización de il-36r |
| WO2021236496A1 (en) | 2020-05-19 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Anti-il-36r antibodies for the treatment of atopic dermatitis |
| JP2023534955A (ja) | 2020-07-17 | 2023-08-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 好中球性皮膚症の処置のための抗ｉｌ－３６ｒ抗体 |
| WO2022026829A1 (en) | 2020-07-30 | 2022-02-03 | Anaptysbio, Inc. | Anti-interleukin 36 receptor (il-36r) therapy for skin toxicity |
| EP4188441A1 (en) * | 2020-07-30 | 2023-06-07 | AnaptysBio, Inc. | Anti-interleukin 36 receptor (il-36r) therapy for ichthyosis |
| WO2022072267A1 (en) | 2020-09-30 | 2022-04-07 | Boehringer Ingelheim International Gmbh | Anti-il-36r antibodies for treatment of chronic inflammatory pain |
| CN112094349B (zh) * | 2020-11-04 | 2021-02-09 | 上海华奥泰生物药业股份有限公司 | 靶向于白介素36r的抗体及其制备方法和应用 |
| CN116685605A (zh) * | 2020-12-17 | 2023-09-01 | 上海华奥泰生物药业股份有限公司 | 靶向il-17a和il-36r的双特异性抗体及其应用 |
| WO2022150642A1 (en) | 2021-01-08 | 2022-07-14 | Anaptysbio, Inc. | Anti-interleukin 36 receptor (il-36r) therapy for hidradenitis suppurativa |
| WO2022150644A1 (en) | 2021-01-08 | 2022-07-14 | Anaptysbio, Inc. | Anti-interleukin 36 receptor (il-36r) therapy for acne |
| CN114907477A (zh) * | 2021-02-08 | 2022-08-16 | 上海普铭生物科技有限公司 | 抗人il-36r抗体及其应用 |
| US20220281987A1 (en) | 2021-03-04 | 2022-09-08 | Boehringer Ingelheim International Gmbh | Methods for the treatment of gpp |
| WO2022192531A2 (en) | 2021-03-12 | 2022-09-15 | Boehringer Ingelheim International Gmbh | Biomarkers associated with anti-il-36r antibody treatment in generalized pustular psoriasis |
| TW202309087A (zh) * | 2021-05-03 | 2023-03-01 | 德商百靈佳殷格翰國際股份有限公司 | 製備spesolimab之方法 |
| CA3221648A1 (en) * | 2021-06-18 | 2022-12-22 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Anti-il-36r antibody and use thereof |
| WO2023285362A1 (en) | 2021-07-12 | 2023-01-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of il-36 inhibitors for the treatment of netherton syndrome |
| WO2023019232A1 (en) | 2021-08-13 | 2023-02-16 | Boehringer Ingelheim International Gmbh | Anti-il-36r antibodies for the treatment of a fibrotic condition |
| EP4409592A2 (en) | 2021-09-28 | 2024-08-07 | Boehringer Ingelheim International Gmbh | System and method for assessing severity of neutrophilic dermatoses with visible skin manifestation |
| MX2024005072A (es) | 2021-10-28 | 2024-09-06 | Abbvie Inc | Anticuerpos anti-amiloide beta y métodos de uso de los mismos. |
| CN115724975A (zh) * | 2022-10-20 | 2023-03-03 | 江苏荃信生物医药股份有限公司 | 抗人白介素36受体单克隆抗体及其应用 |
| AU2024233450A1 (en) | 2023-03-09 | 2025-08-14 | Boehringer Ingelheim International Gmbh | Use of anti-il-36r antibodies for the treatment of hidradentitis suppurativa (hs) |
| US20240409646A1 (en) | 2023-06-09 | 2024-12-12 | Boehringer Ingelheim International Gmbh | Methods for the treatment and prevention of gpp |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| EP0435911B1 (en) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| US6407213B1 (en) | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
| AU687755B2 (en) | 1992-08-21 | 1998-03-05 | Genentech Inc. | Method for treating an LFA-1-mediated disorder |
| EP0752248B1 (en) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| ES2274574T3 (es) | 1997-08-01 | 2007-05-16 | Schering Corporation | Proteinas de membrana celular de mamifero; reactivos relacionados. |
| US6416973B1 (en) | 1997-08-01 | 2002-07-09 | Schering Corporation | Nucleic acids encoding mammalian cell membrane protein MDL-1 |
| KR20020093029A (ko) * | 2000-04-11 | 2002-12-12 | 제넨테크, 인크. | 다가 항체 및 그의 용도 |
| EP1627927A3 (en) * | 2001-03-01 | 2006-06-07 | Epigenomics AG | Methods, systems and computer program products for determining the biological effect and/or activity of drugs, chemical substances and/or pharmaceutical compositions based on their effect on the methylation status of the DNA |
| US20040110930A1 (en) * | 2002-10-03 | 2004-06-10 | Reinl Stephen J. | Multimeric protein engineering |
| US20070041905A1 (en) | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| EP2495257A3 (en) * | 2005-08-19 | 2012-10-17 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US8034771B2 (en) | 2006-09-08 | 2011-10-11 | Amgen Inc. | IL-1F6 polypeptides |
| WO2008133857A1 (en) | 2007-04-23 | 2008-11-06 | Schering Corporation | Anti-mdl-1 antibodies |
| US20100221252A1 (en) | 2007-06-29 | 2010-09-02 | Schering Corporation | Mdl-1 uses |
| US20110159011A1 (en) | 2008-08-28 | 2011-06-30 | Wyeth Llc | Uses of il-22, il-17, and il-1 family cytokines in autoimmune diseases |
| DK2780373T3 (da) | 2011-11-16 | 2019-11-04 | Boehringer Ingelheim Int | Anti-IL-36R-antistoffer |
| WO2016168542A1 (en) | 2015-04-15 | 2016-10-20 | Anaptysbio, Inc. | Antibodies directed against interleukin 36 receptor (il-36r) |
-
2012
- 2012-11-14 DK DK12788410T patent/DK2780373T3/da active
- 2012-11-14 HU HUE12788410A patent/HUE047437T2/hu unknown
- 2012-11-14 UA UAA201406586A patent/UA115540C2/uk unknown
- 2012-11-14 CN CN201610916419.0A patent/CN107007833B/zh active Active
- 2012-11-14 BR BR112014011594-0A patent/BR112014011594B1/pt active IP Right Grant
- 2012-11-14 CA CA2852994A patent/CA2852994C/en active Active
- 2012-11-14 KR KR1020207026736A patent/KR20200110476A/ko not_active Ceased
- 2012-11-14 EP EP19169065.0A patent/EP3536710A1/en active Pending
- 2012-11-14 EA EA201400579A patent/EA031948B1/ru not_active IP Right Cessation
- 2012-11-14 HR HRP20191835TT patent/HRP20191835T1/hr unknown
- 2012-11-14 CN CN201280054425.XA patent/CN104080808B/zh active Active
- 2012-11-14 MY MYPI2019000058A patent/MY195289A/en unknown
- 2012-11-14 KR KR1020197030980A patent/KR102159109B1/ko active Active
- 2012-11-14 WO PCT/US2012/064933 patent/WO2013074569A1/en active Application Filing
- 2012-11-14 ES ES12788410T patent/ES2755732T3/es active Active
- 2012-11-14 MX MX2014005759A patent/MX347164B/es active IP Right Grant
- 2012-11-14 EP EP12788410.4A patent/EP2780373B1/en active Active
- 2012-11-14 PL PL12788410T patent/PL2780373T3/pl unknown
- 2012-11-14 US US13/676,511 patent/US9023995B2/en active Active
- 2012-11-14 CN CN202410673234.6A patent/CN118515766A/zh active Pending
- 2012-11-14 SG SG11201402283PA patent/SG11201402283PA/en unknown
- 2012-11-14 CN CN202011390234.3A patent/CN112812183B/zh active Active
- 2012-11-14 PE PE2014000705A patent/PE20142041A1/es active IP Right Grant
- 2012-11-14 RS RSP20191179 patent/RS59248B1/sr unknown
- 2012-11-14 AP AP2014007571A patent/AP2014007571A0/xx unknown
- 2012-11-14 JP JP2014542388A patent/JP6289375B2/ja active Active
- 2012-11-14 SI SI201231692T patent/SI2780373T1/sl unknown
- 2012-11-14 KR KR1020147013267A patent/KR102038310B1/ko active Active
- 2012-11-14 PT PT127884104T patent/PT2780373T/pt unknown
- 2012-11-14 AU AU2012339734A patent/AU2012339734B2/en active Active
- 2012-11-14 CN CN202410673612.0A patent/CN118496365A/zh active Pending
- 2012-11-14 LT LTEP12788410.4T patent/LT2780373T/lt unknown
- 2012-11-15 TW TW101142698A patent/TWI573804B/zh active
- 2012-11-15 AR ARP120104313A patent/AR089178A1/es active IP Right Grant
- 2012-11-16 UY UY0001034456A patent/UY34456A/es active IP Right Grant
-
2014
- 2014-04-04 ZA ZA2014/02491A patent/ZA201402491B/en unknown
- 2014-04-13 IL IL232100A patent/IL232100B/en active IP Right Grant
- 2014-04-29 CL CL2014001123A patent/CL2014001123A1/es unknown
- 2014-05-14 CO CO14103887A patent/CO7020871A2/es unknown
- 2014-05-16 PH PH12014501108A patent/PH12014501108A1/en unknown
- 2014-06-13 EC ECIEPI20144976A patent/ECSP14004976A/es unknown
-
2015
- 2015-04-01 US US14/676,365 patent/US10550189B2/en active Active
-
2018
- 2018-02-06 JP JP2018019080A patent/JP6719490B2/ja active Active
-
2019
- 2019-11-12 CY CY20191101185T patent/CY1122278T1/el unknown
- 2019-12-17 US US16/717,413 patent/US20200231684A1/en not_active Abandoned
-
2020
- 2020-01-14 IL IL272035A patent/IL272035A/en unknown
- 2020-06-16 JP JP2020103873A patent/JP2020156506A/ja active Pending
-
2023
- 2023-05-23 CY CY2023014C patent/CY2023014I1/el unknown
- 2023-05-26 LT LTPA2023518C patent/LTC2780373I2/lt unknown
- 2023-05-30 NO NO2023024C patent/NO2023024I1/no unknown
- 2023-05-31 FR FR23C1023C patent/FR23C1023I2/fr active Active
- 2023-05-31 NL NL301233C patent/NL301233I2/nl unknown
- 2023-05-31 LU LU00308C patent/LUC00308I2/fr unknown
- 2023-06-01 FI FIC20230020C patent/FIC20230020I1/fi unknown
- 2023-06-05 HU HUS2300021C patent/HUS2300021I1/hu unknown
-
2024
- 2024-08-27 US US18/815,907 patent/US20240409648A1/en active Pending
-
2025
- 2025-01-03 NO NO2025001C patent/NO2025001I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY2023014I2 (el) | Αντι il-36r αντισωματα | |
| CY2024011I2 (el) | Αντισωματα anti-fcrn | |
| EP2714735A4 (en) | SPECIFIC ANTIBODIES OF TGF BETA | |
| CO6811812A2 (es) | Anticuerpo anti-b7-h3 | |
| CR20140127A (es) | Anticuerpo anti-abtcr | |
| HUE036229T2 (hu) | CEA antitestek | |
| DK3275892T3 (da) | Præfusions-rsv-f-antigener | |
| DK2934584T3 (da) | Anti-gdf15-antistoffer | |
| DK3842456T3 (da) | Monoklonalt Interleukin-31-antistof | |
| HRP20181646T1 (hr) | Konjugati pirolobenzodiazepin - anti-psma protutijela | |
| HUE036663T2 (hu) | Készítmény anti-alfa4béta7 antitesthez | |
| HUE036664T2 (hu) | Készítmény anti-alfa4béta7 antitesthez | |
| PL3415531T3 (pl) | Białka wiążące antygen | |
| PL2691417T5 (pl) | Warianty fc przeciwciała | |
| PL2663506T3 (pl) | Zamknięcie | |
| BR112013015122A2 (pt) | anticorpos anti-notch1 | |
| DK3521315T3 (da) | Anti-transglutaminase-2-antistoffer | |
| DK2828292T3 (da) | Jcv-neutraliserende antistoffer | |
| DK2935330T3 (da) | Anti-notch3-antistoffer | |
| LT2742068T (lt) | Nauji antikūnai prieš fosforilcholiną | |
| CO6841994A2 (es) | Anticuerpos |