CY1912A - Tricyclo compounds a process for their production and a pharmaceutical composition containing the same - Google Patents

Tricyclo compounds a process for their production and a pharmaceutical composition containing the same

Info

Publication number
CY1912A
CY1912A CY191285A CY191285A CY1912A CY 1912 A CY1912 A CY 1912A CY 191285 A CY191285 A CY 191285A CY 191285 A CY191285 A CY 191285A CY 1912 A CY1912 A CY 1912A
Authority
CY
Cyprus
Prior art keywords
production
pharmaceutical composition
composition containing
same
tricyclo compounds
Prior art date
Application number
CY191285A
Other languages
English (en)
Inventor
Masakuni Okuhara
Hirokazu Tanaka
Toshio Goto
Tohru Kino
Hiroshi Hatanaka
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848430455A external-priority patent/GB8430455D0/en
Priority claimed from GB858502869A external-priority patent/GB8502869D0/en
Priority claimed from GB858508420A external-priority patent/GB8508420D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of CY1912A publication Critical patent/CY1912A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/55—Streptomyces hygroscopicus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/898—Streptomyces hygroscopicus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CY191285A 1984-12-03 1985-11-30 Tricyclo compounds a process for their production and a pharmaceutical composition containing the same CY1912A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB848430455A GB8430455D0 (en) 1984-12-03 1984-12-03 Fr-900506 substance
GB858502869A GB8502869D0 (en) 1985-02-05 1985-02-05 Ws 7238 substances
GB858508420A GB8508420D0 (en) 1985-04-01 1985-04-01 Fr-900506 & fr-900525 substances

Publications (1)

Publication Number Publication Date
CY1912A true CY1912A (en) 1985-11-30

Family

ID=27262535

Family Applications (1)

Application Number Title Priority Date Filing Date
CY191285A CY1912A (en) 1984-12-03 1985-11-30 Tricyclo compounds a process for their production and a pharmaceutical composition containing the same

Country Status (24)

Country Link
US (15) US4894366A (fr)
EP (1) EP0184162B1 (fr)
JP (6) JPH0372483A (fr)
KR (5) KR930010704B1 (fr)
CN (1) CN1013687B (fr)
AT (1) ATE104984T1 (fr)
AU (1) AU592067B2 (fr)
CA (1) CA1338491C (fr)
CY (1) CY1912A (fr)
DE (2) DE19575026I2 (fr)
DK (1) DK169550B1 (fr)
ES (1) ES8705038A1 (fr)
FI (2) FI87803C (fr)
GR (1) GR852904B (fr)
HK (1) HK18596A (fr)
HU (1) HU195250B (fr)
IE (1) IE62865B1 (fr)
IL (2) IL92345A (fr)
LU (1) LU90317I2 (fr)
MX (1) MX9202943A (fr)
NL (1) NL960023I2 (fr)
NO (1) NO168372C (fr)
NZ (1) NZ214407A (fr)
PT (1) PT81589B (fr)

Families Citing this family (311)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5254562A (en) * 1984-12-03 1993-10-19 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5266692A (en) * 1984-12-03 1993-11-30 Fujisawa Pharmaceutical Co., Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
GB8608080D0 (en) * 1986-04-02 1986-05-08 Fujisawa Pharmaceutical Co Solid dispersion composition
ATE98700T1 (de) * 1987-06-05 1994-01-15 Fujisawa Pharmaceutical Co Anti-fr-900506-stoffe-antikoerper und hoechstempfindliches enzym-immunoassay-verfahren.
DE3737523A1 (de) * 1987-11-05 1989-05-18 Bayer Ag Verwendung von substituierten hydroxypiperidinen als antivirale mittel
AT400808B (de) * 1987-11-09 1996-03-25 Sandoz Ag Verwendung von tricyclischen verbindungen zur herstellung von topischen arzneimitteln
PH26083A (en) * 1987-11-09 1992-02-06 Sandoz Ltd 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
DE3838035C2 (de) * 1987-11-09 1994-03-24 Sandoz Ag Neue Verwendung von 11,28-dioxa-4-azatricyclo[22.3.1.O·4··,··9·]octacos-18-en-Derivaten
US5366971A (en) * 1987-11-09 1994-11-22 Sandoz Ltd. Use of 11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them
DE3844904C2 (de) * 1987-11-09 1997-01-30 Sandoz Ag Neue Verwendung von 11,28-Dioxa-4-azatricyclo-[22.3.1.0·4·,·9·]octacos-18-en-Derivaten
ATE120466T1 (de) 1987-12-09 1995-04-15 Fisons Plc Makrozyklische verbindungen.
GB8728820D0 (en) * 1987-12-09 1988-01-27 Fisons Plc Compounds
AT407957B (de) * 1987-12-17 2001-07-25 Novartis Erfind Verwalt Gmbh Neue verwendung von 11,28-dioxa-4-azatricyclo- (22.3.1.04,9)octacos-18-en-derivaten und sie enthaltende pharmazeutische zubereitungen
EP0323865A1 (fr) * 1988-01-07 1989-07-12 Merck & Co. Inc. Agent immunopresseur
EP0349061B1 (fr) * 1988-06-29 1995-03-29 Merck & Co. Inc. Agent immuno-suppresseur
US4981792A (en) * 1988-06-29 1991-01-01 Merck & Co., Inc. Immunosuppressant compound
US5290772A (en) * 1988-06-29 1994-03-01 Merck & Co., Inc. Immunosuppressant agent
EP0353678B1 (fr) * 1988-08-01 1995-12-13 Fujisawa Pharmaceutical Co., Ltd. Dérivés FR-901154 et FR-901155, procédé pour leur production
US5202258A (en) * 1988-08-05 1993-04-13 Merck & Co., Inc. Immunosuppressant-producing culture
EP0356399A3 (fr) * 1988-08-26 1991-03-20 Sandoz Ag Dérivés substitués du 4-azatricyclo (22.3.1.04.9) octacos-18-ène, leur préparation et les compositions pharmaceutiques les contenant
EP0358508A3 (fr) * 1988-09-08 1991-03-20 Merck & Co. Inc. Composé immunosuppreseur
EP0364031B1 (fr) * 1988-10-12 1992-12-23 Merck & Co. Inc. Procédé pour le réarrangement du composé FK-506 utilisant un hydroxide comme médiateur
CA1316916C (fr) * 1988-10-12 1993-04-27 David Askin Produit du rearrangement du fk-506 par l'entremise d'un hydroxyde
US4980466A (en) * 1988-10-12 1990-12-25 Merck & Co., Inc. Hydroxide mediated FK-506 rearrangement product
FR2639637A1 (fr) * 1988-11-29 1990-06-01 Sandoz Sa Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments
US4975372A (en) * 1989-01-13 1990-12-04 Merck & Co., Inc. Microbial transformation product of L-683,590
EP0378317A3 (fr) * 1989-01-13 1990-11-28 Merck & Co. Inc. Produit de transformation microbienne L-679,934
US5268370A (en) * 1989-01-13 1993-12-07 Merck & Co., Inc. Microbial transformation product of L-679,934
EP0378320A3 (fr) * 1989-01-13 1990-11-28 Merck & Co. Inc. Produit de transformation microbienne
EP0388152B1 (fr) * 1989-03-15 1994-10-12 Merck & Co. Inc. Procédé de préparation d'un agent immunosuppressif (demethimmunomycine) mettant en oeuvre une souche mutante d'un microorganisme
US5272068A (en) * 1989-03-15 1993-12-21 Merck & Co., Inc. Process for producing immunosuppressant agent L-683942 by fermentation
EP0388153B1 (fr) * 1989-03-15 1994-12-28 Merck & Co. Inc. Agent immunosuppressif
US4940797A (en) * 1989-03-23 1990-07-10 Merck & Co., Inc. Process for synthesis of FK-506 C10-C18 intermediates
US5155228A (en) * 1989-03-23 1992-10-13 Merck & Co., Inc. FK-506 C10-C18 process intermediates
EP0399579A1 (fr) * 1989-04-21 1990-11-28 Merck & Co. Inc. Macrolides à activité immunosuppressive
US5068323A (en) * 1989-04-21 1991-11-26 Merck & Co., Inc. Thermally re-arranged FK-506 derivatives having immunosuppressant activity
US5057608A (en) * 1989-04-21 1991-10-15 Merck & Co., Inc. Immunoregulants, immunosuppressants, process to make ring expanded macrolide related to FK-506/FK-520
US5270187A (en) * 1989-05-05 1993-12-14 Merck & Co., Inc. Microbial transformation product
US4987139A (en) * 1989-05-05 1991-01-22 Merck & Co., Inc. FK-520 microbial transformation product
JPH0368583A (ja) * 1989-05-05 1991-03-25 Merck & Co Inc 新規微生物変換物質
IE64214B1 (en) * 1989-06-06 1995-07-26 Fujisawa Pharmaceutical Co Macrolides for the treatment of reversible obstructive airways diseases
US5138052A (en) * 1989-06-13 1992-08-11 Merck & Co., Inc. L-683,590 microbial transformation product
CA2018710A1 (fr) * 1989-06-13 1990-12-13 Shieh-Shung T. Chen L-683590, produits de transformation microbienne
AU641410B2 (en) * 1989-06-14 1993-09-23 Sandoz Ltd. Antiinflammatory and immunosuppressant triheterocyclic FK506-like compounds and processes for their preparation
US5164525A (en) * 1989-06-30 1992-11-17 Merck & Co., Inc. Synthetic process for fk-506 type macrolide intermediates
US5235066A (en) * 1989-06-30 1993-08-10 Merck & Co., Inc. FK-506 type macrolide intermediate
WO1991002736A1 (fr) * 1989-08-18 1991-03-07 Fisons Plc Composes macrocycliques
EP0413532A3 (en) * 1989-08-18 1991-05-15 Fisons Plc Macrocyclic compounds
US5011943A (en) * 1989-08-28 1991-04-30 Merck Frosst Canada, Inc. FK-506 C10 -C24 process intermediates
GR1001225B (el) * 1989-09-14 1993-06-30 Fisons Plc Νέαι μακροκυκλικαί ενώσεις και νέα μέ?οδος χρήσεως τους.
US5215995A (en) * 1989-10-16 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Hair revitalizing agent
DE10299040I2 (de) * 1989-11-09 2006-08-24 Novartis Ag Heteroatome enthaltende tricyclische Verbindungen
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
GB8925797D0 (en) * 1989-11-15 1990-01-04 Fisons Plc Compositions
EP0444829A3 (en) * 1990-02-27 1992-06-03 Fisons Plc Immunosuppressive compounds
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
US5260301A (en) * 1990-03-01 1993-11-09 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical solution containing FK-506
JPH05504956A (ja) * 1990-03-12 1993-07-29 藤沢薬品工業株式会社 トリシクロ化合物
US5296489A (en) * 1990-03-13 1994-03-22 Fisons Immunosuppressive macrocyclic compounds
JPH05505798A (ja) * 1990-03-13 1993-08-26 フアイソンズ・ピーエルシー 免疫抑制マクロ環状化合物
CA2040551A1 (fr) * 1990-04-30 1991-10-31 Mark T. Goulet Derives de desoxymacrolide ayant une activite immunosuppressive
WO1991017754A1 (fr) * 1990-05-11 1991-11-28 Fujisawa Pharmaceutical Co., Ltd. Procedes servant a traiter et a prevenir une inflammation des muqueuses et des vaisseaux sanguins en utilisant du fk 506 et des composes connexes
JPH05507915A (ja) * 1990-06-11 1993-11-11 藤沢薬品工業株式会社 特発性血小板減少性紫斑病およびバセドウ病治療薬製造のためのｆｋ５０６等のマクロライド化合物の用途
US5643901A (en) * 1990-06-11 1997-07-01 Fujisawa Pharmaceutical Co., Ltd. Medicament for treating idiopathic thrombocytopenic purpura
US5210030A (en) * 1990-06-25 1993-05-11 Merck & Co., Inc. Process for selectively acylating immunomycin
US5342935A (en) * 1990-06-25 1994-08-30 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
GB9014136D0 (en) * 1990-06-25 1990-08-15 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
CA2044846A1 (fr) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonistes de macrolides immunosuppresseurs
GB9014681D0 (en) * 1990-07-02 1990-08-22 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
EP0466365A3 (en) * 1990-07-03 1992-04-15 Merck & Co. Inc. Novel immunosuppressant fermentation products of a microorganism
GB2245891A (en) * 1990-07-09 1992-01-15 Fujisawa Pharmaceutical Co Tricyclo compounds
GB2246350A (en) * 1990-07-23 1992-01-29 Fujisawa Pharmaceutical Co Tricyclo compounds
US5089517A (en) * 1990-08-03 1992-02-18 The Board Of Trustees Of The Leland Stanford Junior University Neuroprotection by indolactam v and derivatives thereof
AU8394291A (en) * 1990-08-18 1992-03-17 Fisons Plc Macrocyclic compounds
GB2247620A (en) * 1990-09-07 1992-03-11 Fujisawa Pharmaceutical Co The use of macrolide compounds for cytomegalovirus infection
CA2051872A1 (fr) * 1990-09-24 1992-03-25 Kevin M. Byrne Procede de biosynthese dirigee de la prolyl-immunomycine
GB2248184A (en) * 1990-09-28 1992-04-01 Fujisawa Pharmaceutical Co New use of macrolide compounds for active oxygen-mediated diseases
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
US5233036A (en) * 1990-10-16 1993-08-03 American Home Products Corporation Rapamycin alkoxyesters
US5348966A (en) * 1990-10-24 1994-09-20 Fujisawa Pharmaceutical Co., Ltd. Method for treating pyoderma and Sezary's syndrome using FK 506 and related compounds
CA2054128A1 (fr) * 1990-10-29 1992-04-30 Kevin M. Byrne Procede de production d'analogues de l'immunomycine
PH31204A (en) * 1990-11-02 1998-05-05 Fujisawa Pharmaceutical Co Pharmaceutical composition.
CA2054983A1 (fr) * 1990-11-08 1992-05-09 Sotoo Asakura Composition suspensible et procede de fabrication
GB2249787A (en) * 1990-11-19 1992-05-20 Fujisawa Pharmaceutical Co Lactone compounds
GB9027471D0 (en) * 1990-12-19 1991-02-06 Fujisawa Pharmaceutical Co Novel compound
US5116756A (en) * 1991-01-28 1992-05-26 Merck & Co., Inc. Process for producing FK-506
US5194378A (en) * 1991-01-28 1993-03-16 Merck & Co., Inc. Process for producing fk-506
WO1992013862A1 (fr) * 1991-02-05 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Composes de lactone
US5147877A (en) * 1991-04-18 1992-09-15 Merck & Co. Inc. Semi-synthetic immunosuppressive macrolides
DE69231644T2 (de) * 1991-04-26 2001-05-23 Fujisawa Pharmaceutical Co., Ltd. Verwendung von makrolid-verbindungen gegen augenerkrankungen
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5262533A (en) * 1991-05-13 1993-11-16 Merck & Co., Inc. Amino O-aryl macrolides having immunosuppressive activity
CA2071066A1 (fr) * 1991-06-19 1992-12-20 Ali Shafiee Produits de la methylation enzymatique ou microbienne
US5225403A (en) * 1991-06-25 1993-07-06 Merck & Co., Inc. C-21 hydroxylated FK-506 antagonist
US5273979A (en) * 1991-08-01 1993-12-28 Merck & Co., Inc. C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
US5198358A (en) * 1991-08-28 1993-03-30 Merck & Co., Inc. Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
US5149701A (en) * 1991-08-01 1992-09-22 Merck & Co., Inc. C-31 methylated FR-900520 cyclic hemiketal immunosuppressant agents
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5708002A (en) * 1991-09-05 1998-01-13 Abbott Laboratories Macrocyclic immunomodulators
DE69232630T2 (de) * 1991-09-05 2003-10-09 Abbott Laboratories, Abbott Park Makrocyclische immunmodulatoren
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
ZA926812B (en) 1991-09-09 1993-04-28 Merck & Co Inc O-heteroaryl,o-alkylheteroaryl,o-alkenylheteroaryl and o-alkynylheteroaryl macrolides having immunosupressive activity
US5164495A (en) * 1991-09-18 1992-11-17 Abbott Laboratories Method for preparing a dicarboxylic acid half-acid ester of FK506
US5221625A (en) * 1992-01-10 1993-06-22 Merck & Co., Inc. Cyclcic FR-900520 microbial biotransformation agent
US5801144A (en) * 1992-01-28 1998-09-01 Karpas; Abraham Use of a compound for the manufacture of a medicament for the treatment of HIV infection
JP3140228B2 (ja) * 1992-02-17 2001-03-05 ファイザー製薬株式会社 新規な大環状ラクトンおよびその生産菌
ATE159725T1 (de) * 1992-03-02 1997-11-15 Pfizer 2-aminozuckermakrolid-derivate
DE69310721T2 (de) * 1992-03-02 1997-09-04 Pfizer Zuckerderivate von makroliden
ATE205496T1 (de) * 1992-03-02 2001-09-15 Pfizer Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel
US5612316A (en) * 1992-03-02 1997-03-18 Pfizer Inc. Fluorosugar derivatives of macrolides
ATE138807T1 (de) 1992-03-27 1996-06-15 American Home Prod 29-demethoxyrapamycin zur induktion der immunosuppression
CA2091194A1 (fr) * 1992-04-08 1993-10-09 Richard D. Connell Derives 2-oxoethyliques utilises comme immunosuppresseurs
HUT66531A (en) * 1992-05-07 1994-12-28 Sandoz Ag Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them
WO1993025533A1 (fr) * 1992-06-05 1993-12-23 Abbott Laboratories Procedes et reactifs pour le dosage d'immnosuppresseurs
US5284877A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkyl and alkenyl macrolides having immunosuppressive activity
US5284840A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkylidene macrolides having immunosuppressive activity
US5264355A (en) * 1992-07-02 1993-11-23 Merck & Co., Inc. Methlating enzyme from streptomyces MA6858
ZA935112B (en) * 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
US5324644A (en) * 1992-07-28 1994-06-28 Merck & Co., Inc. Process for producing immunosuppressant agent
ES2169068T3 (es) * 1992-08-12 2002-07-01 Fujisawa Pharmaceutical Co Anticuerpo monoclonal que reconoce una proteina que se une a fk506, metodo para analizar el nivel de proteina que se une a fk506 y kit para ello.
US5365948A (en) * 1992-08-21 1994-11-22 J & W Mcmichael Software Inc. Method for use in treating a patient with FK 506 to prevent an adverse immune response
US5290689A (en) * 1992-09-28 1994-03-01 Merck & Co., Inc. New cyclic FR-900520 microbial biotransformation agent
US5283183A (en) * 1992-09-28 1994-02-01 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5268281A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5268282A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5318895A (en) * 1992-10-05 1994-06-07 Merck & Co., Inc. Aspergillus niger mutants
GB9227055D0 (en) * 1992-12-29 1993-02-24 Fujisawa Pharmaceutical Co New use
DE4300478C2 (de) * 1993-01-11 1998-05-20 Eos Electro Optical Syst Verfahren und Vorrichtung zum Herstellen eines dreidimensionalen Objekts
EP0690713A4 (fr) * 1993-03-17 1996-04-03 Abbott Lab Immunomodulateurs macrocycliques substitues contenant des amines alicycliques
AT408520B (de) * 1993-05-27 2001-12-27 Novartis Erfind Verwalt Gmbh Galenische formulierungen
MY110603A (en) * 1993-05-27 1998-08-29 Novartis Ag Tetrahydropyran derivatives
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
GB2279006A (en) * 1993-06-03 1994-12-21 Fujisawa Pharmaceutical Co Treatment of amyotrophic lateral sclerosis
JPH06345646A (ja) * 1993-06-08 1994-12-20 Fujisawa Pharmaceut Co Ltd ローション剤
US5352783A (en) * 1993-06-09 1994-10-04 Merck & Co., Inc. Microbial transformation product having immunosuppressive activity
US5359060A (en) * 1993-07-06 1994-10-25 Pfizer, Inc. Phosponated derivatives of macrolides
CA2166892A1 (fr) * 1993-07-30 1995-02-09 Yat Sun Or Macrolactames actives, agents immunoregulateurs
GB2281294A (en) * 1993-08-23 1995-03-01 Fujisawa Pharmaceutical Co Process for producing half esters of the macrolide FK506
US5616588A (en) 1993-09-30 1997-04-01 American Home Products Corporation Rapamycin formulation for IV injection
UA41884C2 (uk) * 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5898029A (en) * 1994-04-12 1999-04-27 The John Hopkins University Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
JP4155593B2 (ja) 1994-10-26 2008-09-24 ノバルティス・アクチエンゲゼルシャフト 医薬組成物
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US5616595A (en) * 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
WO1997010806A1 (fr) * 1995-09-19 1997-03-27 Fujisawa Pharmaceutical Co., Ltd. Compositions en aerosol
JP3942641B2 (ja) 1996-07-30 2007-07-11 ノバルティス アクチエンゲゼルシャフト サイクロスポリンａおよび４０―ｏ―（２―ヒドロキシエチル）―ラパマイシンを含む移植拒絶、自己免疫疾患または炎症性状態の処置用医薬組成物
KR100244164B1 (ko) * 1997-07-15 2000-03-02 김용옥 수용성 고분자-타크로리무스 접합체 화합물 및 그의 제조 방법
US6562620B2 (en) * 1997-09-19 2003-05-13 Mcgill University Medium to promote islet cell survival
US20030129215A1 (en) 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US7399480B2 (en) 1997-09-26 2008-07-15 Abbott Laboratories Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US7357942B2 (en) 1997-09-26 2008-04-15 Abbott Laboratories Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens
US8257725B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US8394398B2 (en) 1997-09-26 2013-03-12 Abbott Laboratories Methods of administering rapamycin analogs with anti-inflammatories using medical devices
US8257726B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
US8057816B2 (en) 1997-09-26 2011-11-15 Abbott Laboratories Compositions and methods of administering paclitaxel with other drugs using medical devices
WO1999042104A1 (fr) * 1998-02-23 1999-08-26 Fujisawa Pharmaceutical Co., Ltd. Nouvel usage de composes de macrolides
AUPP223198A0 (en) * 1998-03-06 1998-04-02 Fujisawa Pharmaceutical Co., Ltd. New use
TW570814B (en) 1998-03-26 2004-01-11 Fujisawa Pharmaceutical Co Sustained-release pharmaceutical composition
EP1098897B1 (fr) 1998-07-17 2004-06-09 Agouron Pharmaceuticals, Inc. Composes, compositions et procedes de stimulation de la croissance et de l'allongement neuronaux
US7960405B2 (en) 1998-09-24 2011-06-14 Abbott Laboratories Compounds and methods for treatment and prevention of diseases
US7455853B2 (en) 1998-09-24 2008-11-25 Abbott Cardiovascular Systems Inc. Medical devices containing rapamycin analogs
US8257724B2 (en) 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6503737B1 (en) 1998-10-02 2003-01-07 Kosan Biosciences, Inc. Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster
DE19853487A1 (de) 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
CA2368463A1 (fr) * 1999-03-31 2000-10-05 Abbott Laboratories Phosphate contenant des immunomodulateurs macrocycliques
US6121257A (en) * 1999-03-31 2000-09-19 Abbott Laboratories Sulfamate containing macrocyclic immunomodulators
US20060025388A1 (en) * 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
ATE258439T1 (de) 1999-04-30 2004-02-15 Univ Michigan Verwendung von benzodiazepinen zur behandlung von apoptose-induzierten autoimmunerkrankungen
US20040176358A1 (en) * 1999-04-30 2004-09-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20030119029A1 (en) * 1999-04-30 2003-06-26 Regents Of The University Of Michigan Compositions and methods relating to novel benzodiazepine compounds and targets thereof
GB9917158D0 (en) * 1999-07-21 1999-09-22 Fujisawa Pharmaceutical Co New use
US20030018044A1 (en) * 2000-02-18 2003-01-23 Peyman Gholam A. Treatment of ocular disease
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7018405B2 (en) 2000-12-22 2006-03-28 Avantec Vascular Corporation Intravascular delivery of methylprednisolone
AR033151A1 (es) * 2001-04-12 2003-12-03 Sucampo Pharmaceuticals Inc Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares
US6656460B2 (en) 2001-11-01 2003-12-02 Yissum Research Development Method and composition for dry eye treatment
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
KR20040086369A (ko) * 2002-02-13 2004-10-08 비오갈 기오기스제르갸르 알티. 바이오매터로부터 마크롤라이드를 추출하는 방법
WO2003072026A2 (fr) * 2002-02-22 2003-09-04 3M Innovative Properties Company Procede visant a reduire et a traiter l'immunodepression induite par uv-b
AU2002321821A1 (en) * 2002-06-28 2004-01-19 Biocon Limited Solid state fermentation and fed batch for the production of an immunosuppressant
BR0314013A (pt) 2002-09-06 2005-07-12 Abbott Lab Equipamento médico contendo inibidor de hidratação
EP1594459B1 (fr) 2002-12-30 2010-02-17 Angiotech International Ag Liberation de medicaments a partir d'une composition polymere a gelification rapide
AU2003209664A1 (en) * 2003-02-10 2004-08-30 Biocon Limited Solid state fermentation and fed batch for the production of an immunosuppressant
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
WO2004089958A2 (fr) 2003-03-31 2004-10-21 TEVA Gyógyszergyár Részvénytársaság Cristallisation et purification de macrolides
WO2005004848A1 (fr) * 2003-07-09 2005-01-20 Chong Kun Dang Pharmaceutical Corp. Dispersion solide de tacrolimus
ES2297481T3 (es) * 2003-07-24 2008-05-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Metodo para purificar macrolidos.
WO2005011796A1 (fr) * 2003-08-05 2005-02-10 Kaneka Corporation Stent a mettre en place in vivo
AU2004267910B2 (en) 2003-08-29 2011-01-06 Veloxis Pharmaceuticals, Inc. Solid dispersions comprising tacrolimus
ES2376238T3 (es) 2003-08-29 2012-03-12 Veloxis Pharmaceuticals A/S Composiciones de liberación modificada comprendiendo tacrolimus.
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
WO2005038009A2 (fr) * 2003-10-17 2005-04-28 Ranbaxy Laboratories Limited Production de tacrolimus (fk-506) au moyen de nouvelles especes de streptomyces
AU2004292445B2 (en) 2003-11-21 2010-02-04 Zalicus Inc. Methods and reagents for the treatment of inflammatory disorders
EP1697383B1 (fr) * 2003-12-05 2014-04-23 Biocon Limited Procédé de purification de tacrolimus
KR100485877B1 (ko) * 2003-12-30 2005-04-28 종근당바이오 주식회사 타크롤리무스를 생산하는 미생물 및 이를 이용한타크롤리무스의 대량 생산방법
US20050176080A1 (en) * 2004-02-10 2005-08-11 Vani Bodepudi Hapten, immunogens and derivatives of ascomycin useful for preparation of antibodies and immunoassays
EP1735042B1 (fr) 2004-03-19 2011-11-23 Abbott Laboratories Administration de medicaments multiples a partir d'un ballonnet et d'une prothese
US8431145B2 (en) 2004-03-19 2013-04-30 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
WO2005098011A1 (fr) 2004-04-12 2005-10-20 Biocon Limited Procede de production de macrolides au moyen d'une nouvelle souche de streptomyces espece bicc 7752
US20090275099A1 (en) * 2004-04-27 2009-11-05 Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
JP2006014722A (ja) * 2004-06-02 2006-01-19 Keio Gijuku 遺伝子マーカー及びその利用
CA2571710A1 (fr) 2004-06-24 2006-11-02 Nicholas Valiante Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
AU2005326322B2 (en) * 2004-07-01 2009-02-05 Yale University Targeted and high density drug loaded polymeric materials
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
US20060052369A1 (en) * 2004-09-07 2006-03-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
WO2006031661A2 (fr) * 2004-09-10 2006-03-23 Ivax Pharmaceuticals S.R.O. Procede d'isolement de composes macrolides
KR20070057910A (ko) * 2004-09-10 2007-06-07 아이박스 파마슈티컬스 에스.알.오. 결정질 타크롤리무스의 분리 방법
GT200500282A (es) * 2004-10-12 2006-05-04 Heteroatomos conteniendo compuestos triciclicos.
ITMI20042098A1 (it) * 2004-11-03 2005-02-03 Antibioticos Spa Processo per la purificazione di tacrolimus
KR20070060144A (ko) 2004-12-01 2007-06-12 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 결정체 마크로라이드의 제조 방법
EP1835889A1 (fr) * 2004-12-15 2007-09-26 Elan Pharma International Limited Formulations renfermant des nanoparticules de tacrolimus
US20060142565A1 (en) * 2004-12-22 2006-06-29 Vilmos Keri Method of purifying tacrolimus
US7638624B2 (en) * 2005-01-03 2009-12-29 The Regents Of The University Of Michigan Compositions and methods relating to novel benzodiazepine compounds and derivatives
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
ATE532064T1 (de) * 2005-01-13 2011-11-15 Univ Keio Genmarker und dessen verwendung
ATE533520T1 (de) 2005-03-23 2011-12-15 Abbott Lab Abgabe von stark lipophilen mitteln durch medizinprodukte
JP5242374B2 (ja) 2005-03-23 2013-07-24 アボット・ラボラトリーズ 組成物ならびに長期効力を得るための医療機器を用いたラパマイシン類縁体の投与方法
JP2008545757A (ja) 2005-06-01 2008-12-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 溶媒和されていないベンゾジアゼピン組成物および方法
CN1876822B (zh) * 2005-06-06 2010-05-12 上海市农药研究所 他克莫司的产生菌株及生产方法
WO2007013017A1 (fr) * 2005-07-29 2007-02-01 Ranbaxy Laboratories Limited Processus de purification de macrolides
ITMI20051549A1 (it) * 2005-08-05 2007-02-06 Antibioticos Spa Purificazione del tacrolimus su supporti dimorigine vegetale
WO2007029082A2 (fr) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Procede de fermentation ameliore pour la preparation d'ascomycine
US20080318289A1 (en) * 2005-10-05 2008-12-25 Parveen Kumar Fermentation Processes for the Preparation of Tacrolimus
US20070105844A1 (en) * 2005-10-26 2007-05-10 Regents Of The University Of Michigan Therapeutic compositions and methods
JP5241501B2 (ja) 2005-11-01 2013-07-17 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 治療特性を有する新規の１，４−ベンゾジアゼピン−２，５−ジオン
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
US7678901B2 (en) 2006-02-28 2010-03-16 Wyeth Rapamycin analogs containing an antioxidant moiety
US7622477B2 (en) 2006-02-28 2009-11-24 Cordis Corporation Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same
JP4700022B2 (ja) * 2006-03-15 2011-06-15 アイバックス ファーマシューティカルズ スポレツノスト エス ルチェニム オメゼニム タクロリマスの精製方法
US8022188B2 (en) * 2006-04-24 2011-09-20 Abbott Laboratories Immunosuppressant binding antibodies and methods of obtaining and using same
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
MX2008015488A (es) 2006-06-09 2009-02-12 Univ Michigan Composiciones y metodos relacionados con compuestos novedosos y objetivos de los mismos.
CA2660804A1 (fr) 2006-08-31 2008-03-06 Astellas Pharma Inc. Vesicule de lipide a ciblage inverse
WO2008033466A2 (fr) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions et procédés pour le traitement de maladies virales
EP1960406A2 (fr) * 2006-11-06 2008-08-27 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Ascomycine et pimécrolimus ayant des niveaux réduits de desméthylascomycine et de 32-désoxy-32-épichloro-desméthylascomycine respectivement, et leurs procédés de préparation
EP2124898B1 (fr) 2007-01-10 2013-08-14 Board of Regents, The University of Texas System Administration amelioree de compositions medicamenteuses immunosuppressives par voie pulmonaire
US10265407B2 (en) 2007-02-15 2019-04-23 Yale University Modular nanodevices for smart adaptable vaccines
WO2008109347A2 (fr) * 2007-03-02 2008-09-12 Yale University Procédés d'administration ex vivo de médicaments à des greffons en utilisant des nanoparticules polymères
WO2008112553A1 (fr) 2007-03-09 2008-09-18 The Regents Of The University Of Michigan Compositions et procédés en rapport avec de nouveaux composés et cibles de ceux-ci
LT2167033T (lt) 2007-05-30 2017-08-10 Veloxis Pharmaceuticals A/S Kartą per dieną vartojama geriamoji vaisto forma, apimanti takrolimą
KR100891313B1 (ko) 2007-08-17 2009-03-31 (주) 제노텍 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법
WO2009036175A2 (fr) 2007-09-14 2009-03-19 The Regents Of The University Of Michigan Inhibiteur de f1f0-atpase et procédés associés
CN101918375A (zh) 2007-11-06 2010-12-15 密歇根大学董事会 在皮肤病症的治疗中有用的苯并二氮杂*酮化合物
CA2711765A1 (fr) * 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Animaux transgeniques de caspase dimerisable d'arret conditionnel
KR101003042B1 (ko) 2008-03-17 2010-12-21 종근당바이오 주식회사 고순도 타크로리무스의 정제 방법
AU2009233906A1 (en) * 2008-04-08 2009-10-15 Amyris, Inc. Expression of heterologous sequences
US9549918B2 (en) 2008-05-30 2017-01-24 Veloxis Pharmaceuticals A/S Stabilized tacrolimus composition
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010021681A2 (fr) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions et procédés pour le traitement de maladies virales
JP5567573B2 (ja) 2008-09-11 2014-08-06 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アリールグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびそれと関連する方法
KR100910165B1 (ko) 2008-09-18 2009-07-30 (주) 제노텍 은 이온 용액 추출을 이용한 불포화 알킬기를 가진 락톤 화합물 정제방법
CA2738831C (fr) * 2008-10-08 2016-05-24 Takata Seiyaku Co., Ltd. Preparation de tacrolimus pour applications externes
NZ593647A (en) 2008-12-23 2013-08-30 Gilead Pharmasset Llc Synthesis of purine nucleosides
AU2009329867B2 (en) 2008-12-23 2015-01-29 Gilead Pharmasset Llc Nucleoside phosphoramidates
CN102753563A (zh) 2008-12-23 2012-10-24 吉利德制药有限责任公司 核苷类似物
WO2010121164A2 (fr) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan Composés de 1,4-benzodiazépinone et leur utilisation dans le traitement du cancer
CN101712686B (zh) * 2009-06-22 2012-08-29 鲁南制药集团股份有限公司 一种发酵液中他克莫司的分离纯化方法
EP2272963A1 (fr) * 2009-07-09 2011-01-12 LEK Pharmaceuticals d.d. Procédé de préparation d'un tacrolimus
WO2011035124A1 (fr) 2009-09-18 2011-03-24 The Regents Of The University Of Michigan Composés de benzodiazépinone et méthodes de traitement les utilisant
WO2011062765A2 (fr) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazépine-2,5-diones et composés apparentés présentant des propriétés thérapeutiques
CN102753544A (zh) 2009-11-17 2012-10-24 密执安大学评议会 具有治疗性能的1，4-苯并二氮杂*-2，5-二酮和相关化合物
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
US8951595B2 (en) 2009-12-11 2015-02-10 Abbott Cardiovascular Systems Inc. Coatings with tunable molecular architecture for drug-coated balloon
US8480620B2 (en) 2009-12-11 2013-07-09 Abbott Cardiovascular Systems Inc. Coatings with tunable solubility profile for drug-coated balloon
BR112012024884A2 (pt) 2010-03-31 2016-10-18 Gilead Pharmasset Llc síntese estereosseletiva de ativos contendo fósforo
US20110318277A1 (en) 2010-06-25 2011-12-29 APT Pharmaceuticals, Inc. University of Maryland, Baltimore Tacrolimus compositions for aerosol administration
KR101261131B1 (ko) 2010-08-24 2013-05-06 이화여자대학교 산학협력단 신규 타크롤리무스 유도체, 상기 유도체를 포함하는 신경 보호용 조성물, 상기 유도체를 포함하는 면역 억제용 조성물, 상기 유도체의 생산 방법 및 상기 유도체의 생산 균주
MA34586B1 (fr) 2010-08-25 2013-10-02 Medis Lab Particules cristallines de tacrolimus micronise a surface modifiee et compositions pharmaceutiques associees
US10117411B2 (en) 2010-10-06 2018-11-06 Dow Agrosciences Llc Maize cytoplasmic male sterility (CMS) C-type restorer RF4 gene, molecular markers and their use
ES2733646T3 (es) 2011-03-11 2019-12-02 Beth Israel Deaconess Medical Ct Inc Anticuerpos anti-CD40 y usos de los mismos
EP2841098A4 (fr) 2012-04-23 2016-03-02 Allertein Therapeutics Llc Nanoparticules pour le traitement d'allergies
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
DK2970101T3 (en) 2013-03-14 2018-08-20 Alkermes Pharma Ireland Ltd PRO-DRUGS OF FUMARATES AND THEIR USE IN TREATING DIFFERENT DISEASES
JP2016516754A (ja) 2013-04-03 2016-06-09 アラーテイン・セラピューティクス・リミテッド・ライアビリティ・カンパニーＡｌｌｅｒｔｅｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ 新規のナノ粒子組成物
WO2015073691A1 (fr) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Procédés pour traiter le cancer par activation de la signalisation bmp
CN104650112B (zh) * 2013-11-18 2018-07-31 山东新时代药业有限公司 他克莫司8-丙基类似物的制备方法
UY35927A (es) 2013-12-31 2015-07-31 Dow Agrosciences Llc ?gen restaurador rf3 de tipo s de la esterilidad masculina citoplasmática del maíz (cms), marcadores moleculares y sus usos?.
CA2935801A1 (fr) 2014-01-13 2015-07-16 Amplyx Pharmaceuticals, Inc. Composes antifongiques
EP3094314B1 (fr) 2014-01-16 2021-06-23 MUSC Foundation For Research Development Nanosupports ciblés pour l'administration d'agents immunosuppresseurs
AU2015218587B2 (en) 2014-02-24 2017-04-27 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
KR101694879B1 (ko) * 2014-08-01 2017-01-12 주식회사 인트론바이오테크놀로지 면역억제활성 없이 신경재생활성이 유지되는 fk506 유도체 및 그의 용도
EP3977995A1 (fr) 2014-10-28 2022-04-06 Koushi Yamaguchi Tacrolimus pour améliorer les conditions de la grossesse
WO2017031105A1 (fr) 2015-08-19 2017-02-23 Selten Pharma, Inc. Formulations pharmaceutiques
CA3002789A1 (fr) 2015-09-04 2017-03-09 Primatope Therapeutics Inc. Anticorps humanises anti-cd40 et leurs utilisations
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法
CN108384819B (zh) * 2017-02-03 2021-06-25 上海医药工业研究院 一种用于发酵他克莫司的培养基以及发酵方法
RU2686779C1 (ru) * 2018-07-26 2019-04-30 Общество с ограниченной ответственностью "Изварино Фарма" Штамм streptomyces tsukubensis - продуцент такролимуса и способ получения такролимуса
US20210228551A1 (en) 2018-08-10 2021-07-29 Koushi Yamaguchi Therapeutic agent for humoral immunity-related diseases in maternofetal relationship
WO2020076738A2 (fr) * 2018-10-12 2020-04-16 Bellicum Pharmaceuticals, Inc Composés à liaison protéinique
WO2020117134A1 (fr) 2018-12-04 2020-06-11 İlko İlaç Sanayi̇ Ve Ti̇caret A.Ş. Formulation de pommade à base de tacrolimus stable pour le traitement topique d'affections cutanées
EP3900729A4 (fr) 2018-12-18 2022-09-07 Koushi Yamaguchi Agent permettant de traiter l'infertilité, les fausses couches récurrentes et d'améliorer la grossesse
KR102135527B1 (ko) * 2018-12-18 2020-07-20 이문수 발가락 습기 제거 양말
GR1009790B (el) 2019-03-20 2020-08-03 Φαρματεν Α.Β.Ε.Ε. Σκευασμα παρατεταμενης αποδεσμευσης που περιλαμβανει τακρολιμους
CN117177749A (zh) 2021-03-03 2023-12-05 萨那生物科技公司 与心肌细胞疗法一起使用的免疫抑制疗法以及相关的方法和组合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
JPS54110000A (en) * 1978-02-17 1979-08-29 Kaken Pharmaceut Co Ltd Novel streptovaricin c derivative
US4309504A (en) * 1980-01-28 1982-01-05 Eli Lilly And Company Process for preparing narasin
US4654334A (en) * 1980-10-08 1987-03-31 International Minerals & Chemical Corp. Manganese-containing antibiotic agents
US4390546A (en) * 1981-12-07 1983-06-28 Merck & Co., Inc. Antiparasitic macrolide from a strain of Streptomyces hygroscopicus
US4415669A (en) * 1981-12-07 1983-11-15 Merck & Co., Inc. Substance and process for its production
US4510317A (en) * 1983-07-28 1985-04-09 Hoffmann-La Roche Inc. Antibiotic X-14934A
GB8430455D0 (en) * 1984-12-03 1985-01-09 Fujisawa Pharmaceutical Co Fr-900506 substance
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5266692A (en) * 1984-12-03 1993-11-30 Fujisawa Pharmaceutical Co., Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5254562A (en) * 1984-12-03 1993-10-19 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
PH26083A (en) * 1987-11-09 1992-02-06 Sandoz Ltd 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
US5956352A (en) * 1992-04-24 1999-09-21 Digital Equipment Corporation Adjustable filter for error detecting and correcting system

Also Published As

Publication number Publication date
IL77222A (en) 1991-06-10
DE3587806D1 (de) 1994-06-01
HUT41842A (en) 1987-05-28
NZ214407A (en) 1989-11-28
EP0184162A3 (en) 1989-02-08
US20030229115A1 (en) 2003-12-11
ES8705038A1 (es) 1987-04-16
FI864527A (fi) 1986-11-07
FI85977B (fi) 1992-03-13
US5110811A (en) 1992-05-05
JPH0372484A (ja) 1991-03-27
CN85109492A (zh) 1986-06-10
US5565559A (en) 1996-10-15
HU195250B (en) 1988-04-28
IL92345A (en) 1991-06-10
DE19575026I2 (de) 2002-03-28
FI87803C (fi) 1993-02-25
PT81589A (en) 1986-01-01
AU5059685A (en) 1986-06-12
NO854833L (no) 1986-06-04
US4956352A (en) 1990-09-11
DK169550B1 (da) 1994-11-28
MX9202943A (es) 1992-06-30
LU90317I2 (fr) 1999-01-11
JPH0372483A (ja) 1991-03-27
US6201005B1 (en) 2001-03-13
US20040029908A1 (en) 2004-02-12
NL960023I1 (nl) 1996-12-02
US6482845B1 (en) 2002-11-19
ATE104984T1 (de) 1994-05-15
ES549478A0 (es) 1987-04-16
HK18596A (en) 1996-02-09
IE62865B1 (en) 1995-03-08
KR930010707B1 (ko) 1993-11-08
US20050124646A1 (en) 2005-06-09
JP2746134B2 (ja) 1998-04-28
JP2976966B2 (ja) 1999-11-10
NO168372C (no) 1992-02-12
US4894366A (en) 1990-01-16
JPH11343294A (ja) 1999-12-14
JPH0720970B2 (ja) 1995-03-08
NO168372B (no) 1991-11-04
NL960023I2 (nl) 1997-06-02
KR930010705B1 (ko) 1993-11-08
US5624842A (en) 1997-04-29
FI864527A0 (fi) 1986-11-07
DK556285D0 (da) 1985-11-29
GR852904B (fr) 1986-04-01
JPH07224066A (ja) 1995-08-22
DE3587806T2 (de) 1994-08-25
EP0184162A2 (fr) 1986-06-11
US5496727A (en) 1996-03-05
US4929611A (en) 1990-05-29
JP3211891B2 (ja) 2001-09-25
JPH0346445B2 (fr) 1991-07-16
IE852971L (en) 1986-06-03
JPH1112281A (ja) 1999-01-19
FI87803B (fi) 1992-11-13
KR930010706B1 (ko) 1993-11-08
US5830717A (en) 1998-11-03
EP0184162B1 (fr) 1994-04-27
DK556285A (da) 1986-06-04
FI85977C (fi) 1992-06-25
FI854731A0 (fi) 1985-11-29
JP2828091B2 (ja) 1998-11-25
US20030170831A1 (en) 2003-09-11
US6028097A (en) 2000-02-22
CA1338491C (fr) 1996-07-30
FI854731A (fi) 1986-06-04
KR930010708B1 (ko) 1993-11-08
JPH1067783A (ja) 1998-03-10
PT81589B (pt) 1987-10-20
KR860004918A (ko) 1986-07-16
KR930010704B1 (ko) 1993-11-08
AU592067B2 (en) 1990-01-04
CN1013687B (zh) 1991-08-28

Similar Documents

Publication Publication Date Title
CY1912A (en) Tricyclo compounds a process for their production and a pharmaceutical composition containing the same
IL77396A (en) Pharmaceutical compositions containing bicyclic heteroarylpiperazine derivatives,certain such novel compounds and their preparation
PT78751B (en) Preparation process of 2-pyrimidinyl-1-piperazine derivatives and medicines containing them
ES8800272A1 (es) Un procedimiento para la preparacion de polipeptidos.
ES8106891A1 (es) Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas
ES8801242A1 (es) Un procedimiento para la preparacion de metanosulfonatos de dioxolano.
ES8606347A1 (es) Un procedimiento para preparar derivados de purina
ES8407322A1 (es) Procedimiento para la preparacion de 7 -aciltio-15,16-metilen-3-oxo-17 -pregna-1,4-dien-21,17-carbolactonas
ES8308471A1 (es) "un procedimiento para la preparacion de composiciones efectivas contra acaros".
DE3660959D1 (de) Benz-trisubstituted 2-aminotetralins
ES8604491A1 (es) Procedimiento para la obtencion de derivados de diaril-eti- lamino